DK147304C - Analogifremgangsmaade til fremstilling af (-) daunosaminyl-4-demethoxydaunomycinon som en blanding af (7s : 9r) og (7r : 9r) alfa-anomere - Google Patents

Analogifremgangsmaade til fremstilling af (-) daunosaminyl-4-demethoxydaunomycinon som en blanding af (7s : 9r) og (7r : 9r) alfa-anomere

Info

Publication number
DK147304C
DK147304C DK256875A DK256875A DK147304C DK 147304 C DK147304 C DK 147304C DK 256875 A DK256875 A DK 256875A DK 256875 A DK256875 A DK 256875A DK 147304 C DK147304 C DK 147304C
Authority
DK
Denmark
Prior art keywords
demethoxydaunomycinon
daunosaminyl
anomers
alfa
analogue
Prior art date
Application number
DK256875A
Other languages
English (en)
Other versions
DK147304B (da
DK256875A (da
Inventor
Bianca Patelli
Luigi Bernardi
Federico Arcamone
Aurelio Di Marco
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of DK256875A publication Critical patent/DK256875A/da
Publication of DK147304B publication Critical patent/DK147304B/da
Application granted granted Critical
Publication of DK147304C publication Critical patent/DK147304C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK256875A 1974-06-12 1975-06-09 Analogifremgangsmaade til fremstilling af (-) daunosaminyl-4-demethoxydaunomycinon som en blanding af (7s : 9r) og (7r : 9r) alfa-anomere DK147304C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2608374 1974-06-12
GB2608374A GB1467383A (en) 1974-06-12 1974-06-12 Daunomycin analogues

Publications (3)

Publication Number Publication Date
DK256875A DK256875A (da) 1975-12-13
DK147304B DK147304B (da) 1984-06-12
DK147304C true DK147304C (da) 1984-12-17

Family

ID=10238087

Family Applications (1)

Application Number Title Priority Date Filing Date
DK256875A DK147304C (da) 1974-06-12 1975-06-09 Analogifremgangsmaade til fremstilling af (-) daunosaminyl-4-demethoxydaunomycinon som en blanding af (7s : 9r) og (7r : 9r) alfa-anomere

Country Status (17)

Country Link
US (1) US4046878A (da)
JP (1) JPS5840557B2 (da)
AT (1) AT337363B (da)
BE (1) BE830090A (da)
BG (1) BG61059B2 (da)
CH (1) CH611317A5 (da)
DE (2) DE2525633A1 (da)
DK (1) DK147304C (da)
ES (1) ES438431A1 (da)
FR (1) FR2274629A1 (da)
GB (1) GB1467383A (da)
HK (1) HK982A (da)
MY (1) MY103666A (da)
NL (1) NL173272C (da)
SE (1) SE423633B (da)
SU (1) SU645588A3 (da)
ZA (1) ZA753722B (da)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1506200A (en) * 1975-04-30 1978-04-05 Farmaceutici Italia Glycosides
GB1509875A (en) * 1976-06-14 1978-05-04 Farmaceutici Italia Optically active anthracyclinones and anthracycline glycosides
US4161480A (en) * 1978-06-05 1979-07-17 G. D. Searle & Co. Intermediates for the synthesis of 4-demethoxydaunorubicin
US4201773A (en) * 1978-07-26 1980-05-06 The United States Of America As Represented By The Department Of Health, Education And Welfare 7-O-(2,6-Dideoxy-α-L-lyxo-hexopyranosyl)-daunomycinone, desmethoxy daunomycinone, adriamycinone, and carminomycinone
IL55431A (en) * 1978-08-24 1982-07-30 Yeda Res & Dev Anthracycline type antibiotics,their preparation and pharmaceutical compositions comprising them
NL8001417A (nl) * 1979-03-17 1980-09-19 Erba Farmitalia Antitumorglycosiden.
BE884828A (fr) * 1979-08-20 1981-02-19 Hoffmann La Roche Derives de naphtacene
ATE1101T1 (de) * 1979-09-01 1982-06-15 Farmitalia Carlo Erba S.P.A. Anthracyclin-glycoside, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzung.
DE3100968A1 (de) * 1980-01-16 1982-01-14 Farmitalia Carlo Erba S.p.A., 20159 Milano Anthracyclinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4348388A (en) * 1980-04-02 1982-09-07 G.D. Searle & Co. 11-Amino-11-deoxydaunorubicin and analogs
ZA814722B (en) * 1980-07-18 1982-07-28 Hoffmann La Roche Novel anthracycline glycosides
GB8317037D0 (en) * 1983-06-23 1983-07-27 Erba Farmitalia 6-deoxyanthracyclines
US5138042A (en) * 1981-05-28 1992-08-11 Farmitalia Carlo Erba S.P.A. 6-deoxyanthracyclines
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.
US4563444A (en) * 1982-05-26 1986-01-07 Farmitalia Carlo Erba S.P.A. Anthracycline glycosides, use and compositions containing same
US4604381A (en) * 1982-07-16 1986-08-05 Farmitalia Carlo Erba S.P.A. 4-demethoxy-13-dihydrodaunorubicin and use thereof
US4562177A (en) * 1982-08-17 1985-12-31 The Ohio State University Research Foundation 3'-Amino-2' halo-anthracycline antibiotics
US4564674A (en) * 1983-10-31 1986-01-14 Sagami Chemical Research Center Process for an anthracycline derivative, and an anthracyclinone derivative useful for the process
US4496485A (en) * 1983-11-25 1985-01-29 G. D. Searle & Co. Asymmetric 7-O-(substituted acetyl)-4-demethoxydaunomycinones
US4537882A (en) * 1984-05-10 1985-08-27 Ohio State University 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same
US4697005A (en) * 1985-03-20 1987-09-29 Ohio State University Research Foundation 1-fluoro, 4-fluoro, and 1,4-difluoro anthracycline anticancer antibiotics
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
NZ224252A (en) * 1987-04-21 1991-09-25 Erba Carlo Spa An anthracycline glycoside and its preparation
JPS63191263U (da) * 1987-05-29 1988-12-09
GB2212154B (en) * 1987-11-10 1991-03-27 Erba Carlo Spa New 4-demethoxy anthracycline derivatives
GB8803301D0 (en) * 1988-02-12 1988-03-09 Erba Carlo Spa Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB8808475D0 (en) * 1988-04-11 1988-05-11 Erba Carlo Spa Process for preparing 4-demethoxydauno-mycinone
GB8818167D0 (en) * 1988-07-29 1988-09-01 Erba Carlo Spa Novel 4-substituted anthracyclinones & process for their preparation
WO1993018050A1 (en) * 1992-03-02 1993-09-16 Pfizer Inc. Sugar derivatives of macrolides
AU2003299378A1 (en) * 2002-10-11 2004-05-04 Board Of Regents, The University Of Texas System Method and compounds for inhibiting hec1 activity for the treatment of proliferative diseases
CN101146532B (zh) 2005-01-21 2012-05-09 阿斯泰克斯治疗有限公司 药物化合物
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
EP2073803B1 (en) 2006-10-12 2018-09-19 Astex Therapeutics Limited Pharmaceutical combinations
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
CL2009002207A1 (es) * 2008-12-23 2011-02-18 Gilead Pharmasset Llc Compuestos derivados de 3-hidroxi-5-(9h-purin-9-il)tetrahidrofuran-2-il, inhibidor de la replicacion de arn viral dependiente de arn; composicion farmaceutica; uso para el tratamiento de hepatitis c.
CL2009002208A1 (es) * 2008-12-23 2010-10-29 Gilead Pharmasset Llc Un compuesto (2s)-2-((((2r,3r,4r,5r)-5-(2-amino-6-etoxi-9h-purin-9-il)-4-fluoro-3-hidroxi-4-metiltetrahidrofuran-2-il)metoxi)(hidroxi)fosforilamino)propanoico, inhibidores de la replicacion de arn viral; composicion farmaceutica; y su uso en el tratamiento de infeccion por hepatitis c, virus del nilo occidental, entre otras.
KR20110104074A (ko) 2008-12-23 2011-09-21 파마셋 인코포레이티드 퓨린 뉴클레오시드의 합성
KR101806323B1 (ko) 2009-11-13 2017-12-07 다이이치 산쿄 유럽 게엠베하 Ｈｅｒ-３ 관련 질병을 치료하거나 예방하기 위한 물질 및 방법
MX2012011171A (es) 2010-03-31 2013-02-01 Gilead Pharmasset Llc Fosforamidatos de nucleosido.
US20120156130A1 (en) 2010-08-06 2012-06-21 Thore Hettmann Use of her3 binding agents in prostate treatment
DE102011113652A1 (de) 2011-09-19 2013-03-21 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Idarubicinhydrochlorid
ES2673957T5 (es) 2011-10-03 2021-12-15 Croda Int Plc Nanopartículas, procedimiento para la preparación y utilización de las mismas como portadoras de moléculas anfipáticas o hidrofóbicas en el campo de la medicina, incluyendo el tratamiento del cáncer, y compuestos de tipo alimentario
WO2014163558A1 (en) 2013-04-01 2014-10-09 Moreinx Ab Nanoparticles, composed of sterol and saponin from quillaja saponaria molina process for preparation and use thereof as carrier for amphipatic of hydrphobic molecules in fields of medicine including cancer treatment and food related compounds
EP3669890A1 (en) 2018-12-18 2020-06-24 Croda International PLC Filamentous nanoparticles having vaccine adjuvant effect

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3427300A (en) * 1965-11-12 1969-02-11 Merck & Co Inc Anti-inflammatory steroid 2'-acetamido-2'-deoxy-glucoside compounds
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
US3686163A (en) * 1968-05-14 1972-08-22 Farmaceutici Italia Dihydrodaunomycin antibiotic and derivatives thereof

Also Published As

Publication number Publication date
ZA753722B (en) 1976-09-29
DE2525633C3 (da) 1979-10-18
SE423633B (sv) 1982-05-17
ATA437375A (de) 1976-10-15
FR2274629A1 (fr) 1976-01-09
SE7506589L (sv) 1975-12-15
DK147304B (da) 1984-06-12
DK256875A (da) 1975-12-13
AU8197975A (en) 1976-12-16
HK982A (en) 1982-01-22
AT337363B (de) 1977-06-27
FR2274629B1 (da) 1980-01-11
MY103666A (en) 1993-08-28
DE2525633A1 (de) 1976-01-02
SU645588A3 (ru) 1979-01-30
ES438431A1 (es) 1977-02-01
NL173272C (nl) 1984-01-02
BE830090A (fr) 1975-12-11
US4046878A (en) 1977-09-06
CH611317A5 (da) 1979-05-31
DE19375027I2 (de) 2002-06-13
BG61059B2 (bg) 1996-09-30
GB1467383A (en) 1977-03-16
DE2525633B2 (da) 1979-03-01
JPS518260A (da) 1976-01-23
NL173272B (nl) 1983-08-01
JPS5840557B2 (ja) 1983-09-06
NL7506745A (nl) 1975-12-16

Similar Documents

Publication Publication Date Title
DK147304C (da) Analogifremgangsmaade til fremstilling af (-) daunosaminyl-4-demethoxydaunomycinon som en blanding af (7s : 9r) og (7r : 9r) alfa-anomere
NO142175C (no) Analogifremgangsmaate for fremstilling av sulfonater av s-adenosil-l-methionin
RO68184A (ro) Procedeu de preparare a unor acizi benzil-fenoxi-alcan-carboxilici
ZA756036B (en) Method of preparing mercaptans
SE426171B (sv) Forfarande for framstellning av d-(-)-alfa-amino-alfa-(p-acyloxifenyl) acetamidocefalosporansyror
PH12881A (en) A method of preparing plaster
RO68141A (ro) Procedeu pentru prepararea unor 3a-fenildecahidroizochinoline
GB1545962A (en) Method of preparing airfoil-shaped bodies
JPS5211623A (en) Method of executing ceiling inspection port
GR59205B (en) New preparation method of methoxy-2-benzamides derivative
DK153759C (da) Analogifremgangsmaade til fremstilling af prostansyrederivater
BG23900A3 (bg) Метод за получаване на 2-карбалкокси-амино- бензимидазолил-5(6)-сулфоновокисели фенилестери
DK143556C (da) Analogifremgangsmaade til fremstilling af substituerede phenylisothiourinstoffer
DK214578A (da) Cementblanding og fremgangsmaade til fremstilling deraf
RO66020A (ro) Procedeu pentru prepararea unor 3-piperazinoizochinoline
JPS51125089A (en) Preparation method of piperazinopyrimidine derivatives
JPS51120027A (en) Execution method of planeelike tile
DK136728C (da) Fremgangsmaade til fremstilling af et lipaseholdigt enzympraeparat
DK585875A (da) Fremgangsmade til fremstilling af substituerede 3-methylencephamsulfoxider
DK150672C (da) Fremgangsmaade til inkubering af hoenseaeg
JPS51125088A (en) Preparation method of new benzhydryloxyyalkylamine derivatives
SU755197A3 (en) Method of preparing thiazole derivatives
IL47355A0 (en) Method for preparation of (dl)-13-substituted sulfinyl-prostaglandin-like compounds
RO72878A (ro) Procedeu pentru prepararea 2-dezoxistreptaminoaminoglicozidelor
JPS5260819A (en) Method of production of fiberrreinforced cement member

Legal Events

Date Code Title Description
PUP Patent expired