BG60624B1 - Ендогенна модификация на генната експресия чрез регулаторен елемент - Google Patents

Ендогенна модификация на генната експресия чрез регулаторен елемент Download PDF

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Publication number
BG60624B1
BG60624B1 BG96515A BG9651592A BG60624B1 BG 60624 B1 BG60624 B1 BG 60624B1 BG 96515 A BG96515 A BG 96515A BG 9651592 A BG9651592 A BG 9651592A BG 60624 B1 BG60624 B1 BG 60624B1
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Bulgaria
Prior art keywords
gene
dna
cell line
given
expression
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BG96515A
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Bulgarian (bg)
English (en)
Inventor
Scott C Chappel
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Applied Research Systems
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Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of BG60624B1 publication Critical patent/BG60624B1/bg

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
BG96515A 1989-12-22 1992-06-22 Ендогенна модификация на генната експресия чрез регулаторен елемент BG60624B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45478389A 1989-12-22 1989-12-22
PCT/US1990/007642 WO1991009955A1 (en) 1989-12-22 1990-12-21 Endogenous gene expression modification with regulatory element

Publications (1)

Publication Number Publication Date
BG60624B1 true BG60624B1 (bg) 1995-10-31

Family

ID=23806064

Family Applications (1)

Application Number Title Priority Date Filing Date
BG96515A BG60624B1 (bg) 1989-12-22 1992-06-22 Ендогенна модификация на генната експресия чрез регулаторен елемент

Country Status (26)

Country Link
EP (5) EP1375666A3 (xx)
JP (3) JP3501286B2 (xx)
KR (1) KR0176693B1 (xx)
AR (1) AR245776A1 (xx)
AT (2) ATE156189T1 (xx)
AU (1) AU645294B2 (xx)
BG (1) BG60624B1 (xx)
BR (1) BR9007937A (xx)
CA (1) CA2071989C (xx)
DE (3) DE69031172T2 (xx)
DK (2) DK0779362T4 (xx)
ES (2) ES2104690T3 (xx)
FI (1) FI107391B (xx)
GR (1) GR3025057T3 (xx)
HK (2) HK1000547A1 (xx)
HU (1) HU217212B (xx)
IL (4) IL96765A0 (xx)
LT (1) LT3998B (xx)
LV (1) LV10655B (xx)
NO (1) NO311896B1 (xx)
OA (1) OA09594A (xx)
RO (1) RO109864B1 (xx)
RU (1) RU2128227C1 (xx)
UA (1) UA42675C2 (xx)
WO (1) WO1991009955A1 (xx)
ZA (1) ZA9010392B (xx)

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