BG60556B1 - Амиди на циклометилен-1,2-дикарбоксилни киселинис терапевтична активност,методи за получаването им и фармацевтични състави, които ги съдържат - Google Patents

Амиди на циклометилен-1,2-дикарбоксилни киселинис терапевтична активност,методи за получаването им и фармацевтични състави, които ги съдържат Download PDF

Info

Publication number
BG60556B1
BG60556B1 BG88028A BG8802889A BG60556B1 BG 60556 B1 BG60556 B1 BG 60556B1 BG 88028 A BG88028 A BG 88028A BG 8802889 A BG8802889 A BG 8802889A BG 60556 B1 BG60556 B1 BG 60556B1
Authority
BG
Bulgaria
Prior art keywords
carbonyl
oxoethyl
hydroxyamino
cyclohexanecarboxylic acid
cis
Prior art date
Application number
BG88028A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG88028A (bg
Inventor
Luigi Turbanti
Guido Cerbai
Marco Criscuoli
Original Assignee
Laboratori Guidotti S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratori Guidotti S.P.A. filed Critical Laboratori Guidotti S.P.A.
Publication of BG88028A publication Critical patent/BG88028A/bg
Publication of BG60556B1 publication Critical patent/BG60556B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/61—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Eyeglasses (AREA)
  • Polyamides (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
BG88028A 1988-04-12 1989-04-12 Амиди на циклометилен-1,2-дикарбоксилни киселинис терапевтична активност,методи за получаването им и фармацевтични състави, които ги съдържат BG60556B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8820172A IT1224627B (it) 1988-04-12 1988-04-12 Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono.

Publications (2)

Publication Number Publication Date
BG88028A BG88028A (bg) 1993-12-24
BG60556B1 true BG60556B1 (bg) 1995-08-28

Family

ID=11164400

Family Applications (1)

Application Number Title Priority Date Filing Date
BG88028A BG60556B1 (bg) 1988-04-12 1989-04-12 Амиди на циклометилен-1,2-дикарбоксилни киселинис терапевтична активност,методи за получаването им и фармацевтични състави, които ги съдържат

Country Status (28)

Country Link
US (1) US5095137A (de)
EP (1) EP0337348B1 (de)
JP (1) JPH026452A (de)
KR (1) KR900016097A (de)
CN (1) CN1037344A (de)
AT (1) ATE101126T1 (de)
AU (1) AU611796B2 (de)
BG (1) BG60556B1 (de)
CA (1) CA1314903C (de)
DD (1) DD294014A5 (de)
DE (1) DE68912811T2 (de)
DK (1) DK173689A (de)
ES (1) ES2061759T3 (de)
FI (1) FI891712A (de)
HU (1) HU206194B (de)
IL (1) IL89895A0 (de)
IN (2) IN169836B (de)
IT (1) IT1224627B (de)
MX (1) MX15635A (de)
NO (1) NO177851C (de)
NZ (1) NZ228688A (de)
PL (1) PL159413B1 (de)
PT (1) PT90254B (de)
RO (1) RO104347B1 (de)
RU (2) RU2004538C1 (de)
UA (1) UA15920A (de)
YU (1) YU73889A (de)
ZA (1) ZA892674B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1252708B (it) * 1991-12-23 1995-06-26 Guidotti & C Spa Labor Sali stabili dell'acido (+)-(1r,2s)-2((n-(2-idrossilammino-2-ossoetil)-n-metilammino)carbonil)cicloesan-1-carbossilico,ad attivita' ace inibitrice, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
US5977160A (en) * 1992-04-10 1999-11-02 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
IT1264860B1 (it) * 1993-06-21 1996-10-17 Guidotti & C Spa Labor Derivati di acidi cis- e trans-2(((2-(isdrossiammino)-2-ossoetil)- alchilammino)carbonil)cicloesancarbossilici
US5639746A (en) * 1994-12-29 1997-06-17 The Procter & Gamble Company Hydroxamic acid-containing inhibitors of matrix metalloproteases
US6028213A (en) * 1998-04-16 2000-02-22 Eastman Chemical Company Optically active cis-1,3-cyclohexanedicarboxylic acid monoesters with high enantiomeric purity and process for their preparation
WO2008012524A1 (en) * 2006-07-24 2008-01-31 Ucb Pharma S.A. Substituted aniline derivatives
US20100168243A1 (en) * 2007-06-20 2010-07-01 Baldwin John J Renin Inhibitors
WO2008156816A2 (en) 2007-06-20 2008-12-24 Vitae Pharmaceuticals, Inc. Renin inhibitors
BRPI0907612A2 (pt) 2008-01-08 2015-07-21 Lantheus Medical Imaging Inc Conjugados de n-coxiamida como agentes de imageamento
US8877157B2 (en) 2009-07-08 2014-11-04 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4077998A (en) * 1975-10-28 1978-03-07 Morton-Norwich Products, Inc. Phthaloyl amino acid hydroxamic acids
US4687841A (en) * 1985-10-18 1987-08-18 Monsanto Company Peptide hydroxamic acid derivatives

Also Published As

Publication number Publication date
AU3265589A (en) 1989-10-19
JPH026452A (ja) 1990-01-10
NO177851B (no) 1995-08-28
DD294014A5 (de) 1991-09-19
IN169836B (de) 1991-12-28
IN172059B (de) 1993-03-27
NO177851C (no) 1995-12-06
BG88028A (bg) 1993-12-24
EP0337348B1 (de) 1994-02-02
NO891484D0 (no) 1989-04-11
IL89895A0 (en) 1989-12-15
FI891712A0 (fi) 1989-04-11
DE68912811D1 (de) 1994-03-17
IT8820172A0 (it) 1988-04-12
KR900016097A (ko) 1990-11-12
ATE101126T1 (de) 1994-02-15
CA1314903C (en) 1993-03-23
UA15920A (uk) 1997-06-30
PL159413B1 (pl) 1992-12-31
RU2004538C1 (ru) 1993-12-15
MX15635A (es) 1993-12-01
AU611796B2 (en) 1991-06-20
PT90254A (pt) 1989-11-10
RO104347B1 (en) 1993-04-15
EP0337348A2 (de) 1989-10-18
ES2061759T3 (es) 1994-12-16
HUT50105A (en) 1989-12-28
IT1224627B (it) 1990-10-04
RU1838294C (ru) 1993-08-30
ZA892674B (en) 1989-12-27
HU206194B (en) 1992-09-28
PL278804A1 (en) 1990-01-08
DK173689D0 (da) 1989-04-11
NO891484L (no) 1989-10-13
YU73889A (en) 1991-04-30
EP0337348A3 (en) 1990-05-30
FI891712A (fi) 1989-10-13
US5095137A (en) 1992-03-10
DE68912811T2 (de) 1994-06-16
NZ228688A (en) 1992-03-26
DK173689A (da) 1989-10-13
PT90254B (pt) 1994-07-29
CN1037344A (zh) 1989-11-22

Similar Documents

Publication Publication Date Title
EP0184550B1 (de) 5-Amino-4-hydroxyvalerylamid-Derivate
DE69309686T2 (de) Hydroxamsaürederivate als mettalloproteinase-inhibitoren
US4591598A (en) Derivatives of 2-azabicyclo[3.1.0]hexane-3-carboxylic acid, and hypotensive use thereof
JPH0587504B2 (de)
MXPA98001093A (en) Inhibitors of proteinase c for the treatment of diseases related to the overproduction of colag
BG60556B1 (bg) Амиди на циклометилен-1,2-дикарбоксилни киселинис терапевтична активност,методи за получаването им и фармацевтични състави, които ги съдържат
US5359086A (en) Process for preparing alkyl-L-alanyl-L-proline derivatives
EP0144290A2 (de) Substituierte Aethylendiaminderivate
US5886046A (en) Dicarbonyl-containing compounds
CA2006115A1 (en) Capsaicin derivatives
SK18998A3 (en) Prolylendopeptidase inhibitors, pharmaceutical compositions containing the same and a method for producing same
DE69016760T2 (de) Heterozyklische Acylaminodiol-beta-aminosäure-Derivate.
US4921941A (en) Orally active antiandrogens
JPH0517439A (ja) 光学的に活性な二環式イミノ−α−カルボン酸エステルのラセミ体の分割法で得られた化合物
JPH01125357A (ja) トリペプチドの誘導体
EP0053017A1 (de) Amid-Derivate
JP2001515061A (ja) ３−アリール−スクシンアミド−ヒドロキサム酸、その生産方法及び医薬剤
HU203119B (en) Process for producing new dipeptides and pharmaceutical compositions comprising same
JP2002505320A (ja) マトリックスメタロプロテイナーゼ阻害剤
US6518458B1 (en) (Aminoiminomethyl) amino) alkane-carboxamides and their applications in therapy
FR2594831A1 (fr) Derives de proline, leur procede de preparation, composition pharmaceutique en comportant et procede d'inhibition de l'enzyme transformant l'angiotensine
EP0309261B1 (de) Butensäure-Amide, deren Salze, diese enthaltende pharmazeutische Zusammensetzungen und Verfahren zu deren Herstellung
JPH11263783A (ja) エポキシスクシナム酸誘導体
EP0326240B1 (de) 2-Aminoacetamid Derivate
JP3579120B2 (ja) Ｈｉｖプロテアーゼ阻害剤