BG50162A3 - Метод за получаване на алкандиол дикарбоксилати - Google Patents

Метод за получаване на алкандиол дикарбоксилати

Info

Publication number
BG50162A3
BG50162A3 BG089819A BG8981982A BG50162A3 BG 50162 A3 BG50162 A3 BG 50162A3 BG 089819 A BG089819 A BG 089819A BG 8981982 A BG8981982 A BG 8981982A BG 50162 A3 BG50162 A3 BG 50162A3
Authority
BG
Bulgaria
Prior art keywords
denotes
compound
group
general formula
indicated above
Prior art date
Application number
BG089819A
Other languages
English (en)
Inventor
Vytautas Jasys
Michael Kellogg
Original Assignee
Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware filed Critical Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware
Publication of BG50162A3 publication Critical patent/BG50162A3/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C07D499/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

По метода се получават съединения, които се използват в медицината и проявяват добра антибактериална активност ин виво при бозайници, включително и при човека.те имат следната формулав която а означава алкилен с 1 до 8 въглеродни атома, (сн3)3с, фенилен или циклохексилен;r група в със следната формула:r1 означава водород, бензил или група в с посоченото по-горе значение и техните фармацевтично приемливи соли. Получават се при взаимодействие на съединение собща формула: всоом, в която в има посоченото по-горе значение и м означава образуващ карбоксилат катион със съединение с обща формула:в която а и r1 имат посочените по-горе значения и х означава хлор, бром, йод или групите: сн3sо2о или сн3с6н4sо2о. Взаимодействието се осъществява в полярен органичен разтворител при температура от 0 до 800с, за предпочитане от 25 до 500с. 3 претенции
BG089819A 1981-12-22 1982-12-01 Метод за получаване на алкандиол дикарбоксилати BG50162A3 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33402281A 1981-12-22 1981-12-22
US06/429,915 US4457924A (en) 1981-12-22 1982-09-30 1,1-Alkanediol dicarboxylate linked antibacterial agents

Publications (1)

Publication Number Publication Date
BG50162A3 true BG50162A3 (bg) 1992-05-15

Family

ID=26989011

Family Applications (4)

Application Number Title Priority Date Filing Date
BG089819A BG50162A3 (bg) 1981-12-22 1982-12-01 Метод за получаване на алкандиол дикарбоксилати
BG089818A BG50161A3 (bg) 1981-12-22 1982-12-01 Метод за получаване на алкандиол дикарбоксилати
BG089817A BG50160A3 (bg) 1981-12-22 1982-12-01 Метод за получаване на алкандиол дикарбоксилати
BG058979A BG48694A3 (bg) 1981-12-22 1982-12-21 Метод за получаване на алкандиол дикарбоксилати

Family Applications After (3)

Application Number Title Priority Date Filing Date
BG089818A BG50161A3 (bg) 1981-12-22 1982-12-01 Метод за получаване на алкандиол дикарбоксилати
BG089817A BG50160A3 (bg) 1981-12-22 1982-12-01 Метод за получаване на алкандиол дикарбоксилати
BG058979A BG48694A3 (bg) 1981-12-22 1982-12-21 Метод за получаване на алкандиол дикарбоксилати

Country Status (25)

Country Link
US (1) US4457924A (bg)
EP (1) EP0083484B1 (bg)
JP (1) JPH02270881A (bg)
KR (1) KR860001370B1 (bg)
AU (1) AU537214B2 (bg)
BG (4) BG50162A3 (bg)
CA (1) CA1213582A (bg)
DD (1) DD207379A5 (bg)
DE (1) DE3269267D1 (bg)
DK (3) DK565482A (bg)
ES (3) ES8402310A1 (bg)
FI (1) FI80039C (bg)
GR (1) GR77066B (bg)
GT (1) GT198200058A (bg)
HU (1) HU187737B (bg)
IE (1) IE54333B1 (bg)
IL (1) IL67530A (bg)
NO (1) NO824305L (bg)
NZ (1) NZ202670A (bg)
PH (1) PH18311A (bg)
PL (3) PL141306B1 (bg)
PT (1) PT76012B (bg)
RO (2) RO84911B (bg)
SU (1) SU1405704A3 (bg)
YU (2) YU43111B (bg)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675186A (en) 1985-04-18 1987-06-23 Pfizer Inc. 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives
LU87821A1 (fr) * 1990-10-12 1992-05-25 Cird Galderma Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique
DK0508943T3 (da) * 1991-03-11 1995-01-30 Schweizerhall Saeurefab Fremgangsmåde til fremstilling af halogenerede carboxylsyreestere
DK0504107T3 (da) * 1991-03-11 1995-02-13 Schweizerhall Saeurefab Fremgangsmåde til fremstilling af chlorerede carboxylsyreestere
AU2003301426A1 (en) * 2002-10-18 2004-05-04 Meiji Seika Kaisha, Ltd. Malonic acid monoesters and process for producing the same
WO2011068138A1 (ja) * 2009-12-01 2011-06-09 住友化学株式会社 シクロアルカンジカルボン酸モノエステルの製造方法
US7973194B1 (en) 2010-03-18 2011-07-05 Eastman Chemical Company High solvating cyclohexane dicarboxylate diesters plasticizers
CN115385934A (zh) * 2022-10-26 2022-11-25 北京纳百生物科技有限公司 一种舒巴坦半抗原及其合成方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985648A (en) * 1958-10-06 1961-05-23 Doyle Frank Peter Alpha-aminobenzylpenicillins
DE1249280B (de) * 1962-11-02 1967-09-07 Beecham GrouD Limited, Brentford Middlesex (Großbritannien) Verfahren zur Herstellung von Hydroxybenzyl y amino-pemciUmen
US3520876A (en) * 1967-11-01 1970-07-21 American Home Prod Process for the preparation of 6-(alpha-aminoacylamino)penicillanic acids
ES436565A1 (es) * 1974-06-05 1977-04-01 Bristol Myers Co Un procedimiento para la preparacion de acidos acetamidope- nicilanicos.
FR2290443A1 (fr) * 1974-11-06 1976-06-04 Aries Robert Nouveaux esters bispenicillaniques
FR2309570A1 (fr) * 1975-04-29 1976-11-26 Aries Robert Derives polymeriques des penicillines et cephalosporines
GB1569421A (en) * 1976-06-11 1980-06-18 Beecham Group Ltd Penicillin compositions
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
IE49881B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd B-lactam intermediates
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4309347A (en) * 1979-05-16 1982-01-05 Pfizer Inc. Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide

Also Published As

Publication number Publication date
PT76012A (en) 1983-01-01
JPH02270881A (ja) 1990-11-05
ES8530002A1 (es) 1985-02-01
EP0083484B1 (en) 1986-02-19
NO824305L (no) 1983-06-23
PL239651A1 (en) 1985-01-16
PT76012B (en) 1985-12-13
PL141306B1 (en) 1987-07-31
YU43111B (en) 1989-02-28
RO84911B (ro) 1984-09-30
KR860001370B1 (ko) 1986-09-17
DK69092A (da) 1992-05-26
ES518425A0 (es) 1984-02-01
FI824409L (fi) 1983-06-23
IE54333B1 (en) 1989-08-30
IE823034L (en) 1983-06-22
DD207379A5 (de) 1984-02-29
DE3269267D1 (en) 1986-03-27
SU1405704A3 (ru) 1988-06-23
ES524895A0 (es) 1985-02-01
EP0083484A1 (en) 1983-07-13
FI824409A0 (fi) 1982-12-21
RO87709A (ro) 1985-10-31
PH18311A (en) 1985-05-29
HU187737B (en) 1986-02-28
PL140291B1 (en) 1987-04-30
DK69192D0 (da) 1992-05-26
YU183084A (en) 1986-10-31
GR77066B (bg) 1984-04-05
YU284482A (en) 1985-03-20
FI80039B (fi) 1989-12-29
BG50160A3 (bg) 1992-05-15
DK565482A (da) 1983-06-23
AU9172182A (en) 1983-06-30
ES8503001A1 (es) 1985-02-01
GT198200058A (es) 1984-06-09
NZ202670A (en) 1985-12-13
US4457924A (en) 1984-07-03
BG48694A3 (bg) 1991-04-15
PL145927B1 (en) 1988-11-30
IL67530A (en) 1986-02-28
ES524894A0 (es) 1985-02-01
ES8402310A1 (es) 1984-02-01
AU537214B2 (en) 1984-06-14
CA1213582A (en) 1986-11-04
IL67530A0 (en) 1983-05-15
DK69192A (da) 1992-05-26
RO84911A (ro) 1984-08-17
BG50161A3 (bg) 1992-05-15
DK69092D0 (da) 1992-05-26
YU43992B (en) 1990-02-28
KR840002840A (ko) 1984-07-21
FI80039C (fi) 1990-04-10
PL248637A1 (en) 1985-02-27
RO87709B (ro) 1985-10-01

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