BG24805A3 - Method of obtaining isobutyl ester of 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid - Google Patents
Method of obtaining isobutyl ester of 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acidInfo
- Publication number
- BG24805A3 BG24805A3 BG035345A BG3534576A BG24805A3 BG 24805 A3 BG24805 A3 BG 24805A3 BG 035345 A BG035345 A BG 035345A BG 3534576 A BG3534576 A BG 3534576A BG 24805 A3 BG24805 A3 BG 24805A3
- Authority
- BG
- Bulgaria
- Prior art keywords
- dihydropyridine
- methoxycarbonyl
- nitrophenyl
- dimethyl
- obtaining
- Prior art date
Links
- IGTNUCYFOBDUEF-UHFFFAOYSA-N 5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid Chemical compound COC(=O)C1=C(C)NC(C)=C(C(O)=O)C1C1=CC=CC=C1[N+]([O-])=O IGTNUCYFOBDUEF-UHFFFAOYSA-N 0.000 title 1
- -1 isobutyl ester Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2549568A DE2549568C3 (de) | 1975-11-05 | 1975-11-05 | 2,6-Dimethyl-3-methoxycarbonyl-4- (2'-nitrophenyl)-1,4-dihydropyridin-5- carbonsäureisobutylester, mehrere Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG24805A3 true BG24805A3 (en) | 1978-05-12 |
Family
ID=5960951
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG035341A BG25078A3 (en) | 1975-11-05 | 1976-11-01 | A method of obtaining isobutyl ester of 2,6-dimethyl-3-metoxycarbonyl-4-(2'-nitrophenyl)-1,4-dichidropiridin-5-carbonic acid |
| BG035345A BG24805A3 (en) | 1975-11-05 | 1976-11-01 | Method of obtaining isobutyl ester of 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid |
| BG034575A BG24668A3 (en) | 1975-11-05 | 1976-11-01 | Method of preparing isobutyl ester of 2,6-dimeth l-3-methoxycarbonyl-4-(2-nitrophenyl)-1,4-dihydropyridi e-5-ca-boxylic acid |
| BG035342A BG25079A3 (en) | 1975-11-05 | 1976-11-01 | A method of obtaining isobutyl ester ob 2,6-dimethyl-3-metoxycarbonyl-4-(2'-nitrophenyl)-1,4-dichidropiridin-5-carbonic acid |
| BG035343A BG24803A3 (en) | 1975-11-05 | 1976-11-01 | Method of obtaining isobutyl ester of 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid |
| BG035344A BG24804A3 (en) | 1975-11-05 | 1976-11-01 | Method of obtaining isobutyl ester of 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridiny-5-carboxylic acid |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG035341A BG25078A3 (en) | 1975-11-05 | 1976-11-01 | A method of obtaining isobutyl ester of 2,6-dimethyl-3-metoxycarbonyl-4-(2'-nitrophenyl)-1,4-dichidropiridin-5-carbonic acid |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG034575A BG24668A3 (en) | 1975-11-05 | 1976-11-01 | Method of preparing isobutyl ester of 2,6-dimeth l-3-methoxycarbonyl-4-(2-nitrophenyl)-1,4-dihydropyridi e-5-ca-boxylic acid |
| BG035342A BG25079A3 (en) | 1975-11-05 | 1976-11-01 | A method of obtaining isobutyl ester ob 2,6-dimethyl-3-metoxycarbonyl-4-(2'-nitrophenyl)-1,4-dichidropiridin-5-carbonic acid |
| BG035343A BG24803A3 (en) | 1975-11-05 | 1976-11-01 | Method of obtaining isobutyl ester of 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid |
| BG035344A BG24804A3 (en) | 1975-11-05 | 1976-11-01 | Method of obtaining isobutyl ester of 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridiny-5-carboxylic acid |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS5259161A (fi) |
| AT (1) | AT352129B (fi) |
| AU (1) | AU498964B2 (fi) |
| BE (1) | BE847968A (fi) |
| BG (6) | BG25078A3 (fi) |
| CA (1) | CA1085406A (fi) |
| CH (2) | CH623038A5 (fi) |
| CS (1) | CS200499B2 (fi) |
| DE (1) | DE2549568C3 (fi) |
| DK (1) | DK146762C (fi) |
| ES (2) | ES452986A1 (fi) |
| FI (1) | FI60704C (fi) |
| FR (1) | FR2330395A1 (fi) |
| GB (1) | GB1516793A (fi) |
| GR (1) | GR61241B (fi) |
| HK (1) | HK12681A (fi) |
| IE (1) | IE43984B1 (fi) |
| IL (1) | IL50817A (fi) |
| LU (2) | LU76133A1 (fi) |
| NL (2) | NL175915C (fi) |
| NO (1) | NO145574C (fi) |
| NZ (1) | NZ182502A (fi) |
| PL (2) | PL105940B1 (fi) |
| PT (1) | PT65797B (fi) |
| RO (1) | RO70295A (fi) |
| SE (1) | SE423542B (fi) |
| ZA (1) | ZA766622B (fi) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4146630A (en) * | 1976-11-12 | 1979-03-27 | Boehringer Mannheim Gmbh | Blood pressure lowering and adrenergic β-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers |
| JPS55301A (en) * | 1978-02-14 | 1980-01-05 | Yamanouchi Pharmaceut Co Ltd | 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation |
| DE3212736A1 (de) * | 1982-04-06 | 1983-10-13 | Bayer Ag, 5090 Leverkusen | Verwendung von dihydropyridinen in arzneimitteln mit salidiuretischer wirkung |
| DE3222367A1 (de) * | 1982-06-15 | 1983-12-15 | Bayer Ag, 5090 Leverkusen | Verwendung von 1,4-dihydropyridinen in antiarteriosklerotika und deren herstellung |
| JPS5982192U (ja) * | 1982-11-27 | 1984-06-02 | エムケ−精工株式会社 | 扉 |
| DE3312216A1 (de) * | 1983-04-05 | 1984-10-11 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von symmetrischen 1,4-dihydropyridincarbonsaeureestern |
| DE3312283A1 (de) * | 1983-04-05 | 1984-10-18 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von unsymmetrischen 1,4-dihydropyridincarbonsaeureestern |
| US4794111A (en) * | 1984-05-23 | 1988-12-27 | Bayer Aktiengesellschaft | Dihydropyridine preparations containing β-blockers |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2117571C3 (de) * | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
-
1975
- 1975-11-05 DE DE2549568A patent/DE2549568C3/de not_active Expired
-
1976
- 1976-10-22 NO NO763608A patent/NO145574C/no unknown
- 1976-10-29 JP JP51129540A patent/JPS5259161A/ja active Granted
- 1976-11-01 BG BG035341A patent/BG25078A3/xx unknown
- 1976-11-01 BG BG035345A patent/BG24805A3/xx unknown
- 1976-11-01 BG BG034575A patent/BG24668A3/xx unknown
- 1976-11-01 BG BG035342A patent/BG25079A3/xx unknown
- 1976-11-01 BG BG035343A patent/BG24803A3/xx unknown
- 1976-11-01 BG BG035344A patent/BG24804A3/xx unknown
- 1976-11-02 CS CS767068A patent/CS200499B2/cs unknown
- 1976-11-02 RO RO7688294A patent/RO70295A/ro unknown
- 1976-11-02 CH CH1381976A patent/CH623038A5/de not_active IP Right Cessation
- 1976-11-02 GB GB45501/76A patent/GB1516793A/en not_active Expired
- 1976-11-02 IL IL50817A patent/IL50817A/xx unknown
- 1976-11-02 NZ NZ182502A patent/NZ182502A/xx unknown
- 1976-11-03 FI FI763160A patent/FI60704C/fi not_active IP Right Cessation
- 1976-11-03 NL NLAANVRAGE7612198,A patent/NL175915C/xx not_active IP Right Cessation
- 1976-11-03 PL PL1976201800A patent/PL105940B1/pl unknown
- 1976-11-03 PL PL1976193438A patent/PL106084B1/pl unknown
- 1976-11-03 AT AT814276A patent/AT352129B/de not_active IP Right Cessation
- 1976-11-04 PT PT65797A patent/PT65797B/pt unknown
- 1976-11-04 LU LU76133A patent/LU76133A1/xx active Protection Beyond IP Right Term
- 1976-11-04 DK DK498476A patent/DK146762C/da not_active IP Right Cessation
- 1976-11-04 LU LU88275C patent/LU88275I2/xx unknown
- 1976-11-04 SE SE7612308A patent/SE423542B/xx not_active IP Right Cessation
- 1976-11-04 IE IE2458/76A patent/IE43984B1/en not_active IP Right Cessation
- 1976-11-04 BE BE172063A patent/BE847968A/xx not_active IP Right Cessation
- 1976-11-04 CA CA264,921A patent/CA1085406A/en not_active Expired
- 1976-11-04 GR GR52093A patent/GR61241B/el unknown
- 1976-11-04 ZA ZA766622A patent/ZA766622B/xx unknown
- 1976-11-04 ES ES452986A patent/ES452986A1/es not_active Expired
- 1976-11-05 AU AU19358/76A patent/AU498964B2/en not_active Expired
- 1976-11-05 FR FR7633488A patent/FR2330395A1/fr active Granted
-
1977
- 1977-10-13 ES ES463166A patent/ES463166A1/es not_active Expired
-
1980
- 1980-07-23 CH CH567880A patent/CH622779A5/de not_active IP Right Cessation
-
1981
- 1981-04-02 HK HK126/81A patent/HK12681A/xx unknown
-
1993
- 1993-05-24 NL NL930035C patent/NL930035I2/nl unknown
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