BG22831A3 - Метод за получаване на амидни производни на винбластин - Google Patents

Метод за получаване на амидни производни на винбластин

Info

Publication number
BG22831A3
BG22831A3 BG026279A BG2627974A BG22831A3 BG 22831 A3 BG22831 A3 BG 22831A3 BG 026279 A BG026279 A BG 026279A BG 2627974 A BG2627974 A BG 2627974A BG 22831 A3 BG22831 A3 BG 22831A3
Authority
BG
Bulgaria
Prior art keywords
vinblastine
amide derivatives
obtaining amide
obtaining
derivatives
Prior art date
Application number
BG026279A
Other languages
Bulgarian (bg)
English (en)
Inventor
George Cullinan
Koert Gerzon
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of BG22831A3 publication Critical patent/BG22831A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fodder In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BG026279A 1973-04-02 1974-04-02 Метод за получаване на амидни производни на винбластин BG22831A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34727573A 1973-04-02 1973-04-02

Publications (1)

Publication Number Publication Date
BG22831A3 true BG22831A3 (bg) 1977-04-20

Family

ID=23363051

Family Applications (3)

Application Number Title Priority Date Filing Date
BG028513A BG21612A3 (bg) 1973-04-02 1974-04-02 Метод за получаване на амидни производни на леврокристин
BG028514A BG21235A3 (bg) 1973-04-02 1974-04-02 Метод за получаване на амидни производни на леврозидина
BG026279A BG22831A3 (bg) 1973-04-02 1974-04-02 Метод за получаване на амидни производни на винбластин

Family Applications Before (2)

Application Number Title Priority Date Filing Date
BG028513A BG21612A3 (bg) 1973-04-02 1974-04-02 Метод за получаване на амидни производни на леврокристин
BG028514A BG21235A3 (bg) 1973-04-02 1974-04-02 Метод за получаване на амидни производни на леврозидина

Country Status (28)

Country Link
JP (2) JPS5919117B2 (nl)
AR (2) AR204004A1 (nl)
AT (1) AT340605B (nl)
BE (1) BE813168A (nl)
BG (3) BG21612A3 (nl)
CA (1) CA1042428A (nl)
CH (1) CH603669A5 (nl)
CS (1) CS185223B2 (nl)
CY (1) CY1044A (nl)
DD (1) DD113538A5 (nl)
DE (1) DE2415980A1 (nl)
DK (1) DK141511B (nl)
ES (2) ES424882A1 (nl)
FR (1) FR2223044B1 (nl)
GB (1) GB1463575A (nl)
HK (1) HK20180A (nl)
HU (1) HU171572B (nl)
IE (1) IE39071B1 (nl)
IL (1) IL44415A (nl)
KE (1) KE3028A (nl)
MY (1) MY8100025A (nl)
NL (1) NL181079C (nl)
PH (1) PH13623A (nl)
RO (2) RO77533A (nl)
SE (1) SE416206B (nl)
SU (4) SU731900A3 (nl)
YU (3) YU39719B (nl)
ZA (1) ZA741674B (nl)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
GR69783B (nl) * 1976-09-08 1982-07-07 Lilly Co Eli
USRE30561E (en) 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
US4096148A (en) * 1976-12-06 1978-06-20 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
USRE30560E (en) * 1976-12-06 1981-03-31 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
US4203898A (en) 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) * 1978-05-15 1980-04-22 Eli Lilly And Company Bridged cathranthus alkaloid dimers
US4357334A (en) 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
LU83822A1 (fr) 1981-12-08 1983-09-01 Omnichem Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
OA06421A (fr) * 1980-06-10 1981-09-30 Omnium Chimique Sa Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
FR2623504B1 (fr) * 1987-11-25 1990-03-09 Adir Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6326402B1 (en) 1998-08-12 2001-12-04 Octamer, Inc. Methods for treating viral infections using a compound capable of inhibiting microtubules
US20080161251A1 (en) 2005-01-21 2008-07-03 Astex Therapeutics Limited Pharmaceutical Compounds
CA2615374A1 (en) 2005-07-18 2007-01-25 Ernest Kun Kun Treatment of cancer
AU2007292306A1 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by PARP inhibitors and methods of treatment thereof
JP2010502730A (ja) 2006-09-05 2010-01-28 バイパー サイエンシズ，インコーポレイティド 癌の治療法
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
CN103169973A (zh) 2007-11-12 2013-06-26 彼帕科学公司 使用4-碘-3-硝基苯甲酰胺化合物与抗肿瘤剂组合治疗乳腺癌
CN105121447B (zh) * 2013-04-19 2018-02-02 暨南大学 长春碱类衍生物及其制备方法和应用
CN113456797B (zh) * 2021-06-18 2024-03-08 暨南大学 长春碱类衍生物在制备治疗骨肉瘤和/或软组织肉瘤药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine

Also Published As

Publication number Publication date
AR203882A1 (es) 1975-10-31
AU6671974A (en) 1975-09-18
YU39719B (en) 1985-04-30
IE39071L (en) 1974-10-02
DD113538A5 (nl) 1975-06-12
CS185223B2 (en) 1978-09-15
CA1042428A (en) 1978-11-14
ES446571A1 (es) 1977-06-16
YU81774A (en) 1982-05-31
HK20180A (en) 1980-04-25
YU39876B (en) 1985-04-30
AT340605B (de) 1977-12-27
HU171572B (hu) 1978-02-28
RO73524B (ro) 1984-11-30
GB1463575A (en) 1977-02-02
ES424882A1 (es) 1976-12-16
RO77533A (ro) 1982-02-01
DE2415980A1 (de) 1974-10-10
CH603669A5 (nl) 1978-08-31
JPS59193895A (ja) 1984-11-02
SU623522A3 (ru) 1978-09-05
AR204004A1 (es) 1975-11-12
BE813168A (fr) 1974-10-02
JPS5919117B2 (ja) 1984-05-02
YU39875B (en) 1985-04-30
PH13623A (en) 1980-08-07
RO73524A (ro) 1984-10-31
BG21235A3 (bg) 1976-03-20
IE39071B1 (en) 1978-08-02
JPS6033837B2 (ja) 1985-08-05
NL181079C (nl) 1987-06-16
NL181079B (nl) 1987-01-16
MY8100025A (en) 1981-12-31
YU113880A (en) 1982-05-31
JPS49128000A (nl) 1974-12-07
DE2415980C2 (nl) 1989-11-09
IL44415A (en) 1978-08-31
FR2223044B1 (nl) 1978-06-30
ZA741674B (en) 1975-10-29
KE3028A (en) 1980-03-28
DK141511B (da) 1980-04-08
SU784783A3 (ru) 1980-11-30
FR2223044A1 (nl) 1974-10-25
SE416206B (sv) 1980-12-08
SU731900A3 (ru) 1980-04-30
NL7404423A (nl) 1974-10-04
DK141511C (nl) 1980-09-29
CY1044A (en) 1980-08-01
IL44415A0 (en) 1974-06-30
SU652896A3 (ru) 1979-03-15
YU113980A (en) 1982-05-31
ATA267974A (de) 1977-04-15
BG21612A3 (bg) 1976-07-20

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