BE813168A - Nouveaux derives amides de la vincaleucoblastine et de la leurocristine - Google Patents

Nouveaux derives amides de la vincaleucoblastine et de la leurocristine

Info

Publication number
BE813168A
BE813168A BE1005847A BE1005847A BE813168A BE 813168 A BE813168 A BE 813168A BE 1005847 A BE1005847 A BE 1005847A BE 1005847 A BE1005847 A BE 1005847A BE 813168 A BE813168 A BE 813168A
Authority
BE
Belgium
Prior art keywords
leurocristine
vincaleucoblastine
amid derivatives
new
new amid
Prior art date
Application number
BE1005847A
Other languages
English (en)
French (fr)
Inventor
G J Cullinan
K Gerzon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BE813168A publication Critical patent/BE813168A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04Dimeric indole alkaloids, e.g. vincaleucoblastine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fodder In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BE1005847A 1973-04-02 1974-04-02 Nouveaux derives amides de la vincaleucoblastine et de la leurocristine BE813168A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34727573A 1973-04-02 1973-04-02

Publications (1)

Publication Number Publication Date
BE813168A true BE813168A (fr) 1974-10-02

Family

ID=23363051

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1005847A BE813168A (fr) 1973-04-02 1974-04-02 Nouveaux derives amides de la vincaleucoblastine et de la leurocristine

Country Status (28)

Country Link
JP (2) JPS5919117B2 (nl)
AR (2) AR204004A1 (nl)
AT (1) AT340605B (nl)
BE (1) BE813168A (nl)
BG (3) BG21612A3 (nl)
CA (1) CA1042428A (nl)
CH (1) CH603669A5 (nl)
CS (1) CS185223B2 (nl)
CY (1) CY1044A (nl)
DD (1) DD113538A5 (nl)
DE (1) DE2415980A1 (nl)
DK (1) DK141511B (nl)
ES (2) ES424882A1 (nl)
FR (1) FR2223044B1 (nl)
GB (1) GB1463575A (nl)
HK (1) HK20180A (nl)
HU (1) HU171572B (nl)
IE (1) IE39071B1 (nl)
IL (1) IL44415A (nl)
KE (1) KE3028A (nl)
MY (1) MY8100025A (nl)
NL (1) NL181079C (nl)
PH (1) PH13623A (nl)
RO (2) RO77533A (nl)
SE (1) SE416206B (nl)
SU (4) SU731900A3 (nl)
YU (3) YU39719B (nl)
ZA (1) ZA741674B (nl)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203898A (en) 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
EP0041935A1 (fr) * 1980-06-10 1981-12-16 OMNICHEM Société anonyme Dérivés n-(vinblastinoyl-23) d'acides aminés et de peptides ainsi que leur préparation
DE3245269A1 (de) 1981-12-08 1983-07-21 Omnichem, 1150 Bruxelles N-(vinblastinoyl-23)-derivate von aminosaeuren, ihre herstellung und therapeutische anwendung
US6326402B1 (en) 1998-08-12 2001-12-04 Octamer, Inc. Methods for treating viral infections using a compound capable of inhibiting microtubules

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
GR69783B (nl) * 1976-09-08 1982-07-07 Lilly Co Eli
USRE30561E (en) 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
US4096148A (en) * 1976-12-06 1978-06-20 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
USRE30560E (en) * 1976-12-06 1981-03-31 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
US4199504A (en) * 1978-05-15 1980-04-22 Eli Lilly And Company Bridged cathranthus alkaloid dimers
US4357334A (en) 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
FR2623504B1 (fr) * 1987-11-25 1990-03-09 Adir Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US20080161251A1 (en) 2005-01-21 2008-07-03 Astex Therapeutics Limited Pharmaceutical Compounds
CA2615374A1 (en) 2005-07-18 2007-01-25 Ernest Kun Kun Treatment of cancer
AU2007292306A1 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by PARP inhibitors and methods of treatment thereof
JP2010502730A (ja) 2006-09-05 2010-01-28 バイパー サイエンシズ,インコーポレイティド 癌の治療法
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
CN103169973A (zh) 2007-11-12 2013-06-26 彼帕科学公司 使用4-碘-3-硝基苯甲酰胺化合物与抗肿瘤剂组合治疗乳腺癌
CN105121447B (zh) * 2013-04-19 2018-02-02 暨南大学 长春碱类衍生物及其制备方法和应用
CN113456797B (zh) * 2021-06-18 2024-03-08 暨南大学 长春碱类衍生物在制备治疗骨肉瘤和/或软组织肉瘤药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203898A (en) 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
EP0041935A1 (fr) * 1980-06-10 1981-12-16 OMNICHEM Société anonyme Dérivés n-(vinblastinoyl-23) d'acides aminés et de peptides ainsi que leur préparation
DE3245269A1 (de) 1981-12-08 1983-07-21 Omnichem, 1150 Bruxelles N-(vinblastinoyl-23)-derivate von aminosaeuren, ihre herstellung und therapeutische anwendung
US6326402B1 (en) 1998-08-12 2001-12-04 Octamer, Inc. Methods for treating viral infections using a compound capable of inhibiting microtubules

Also Published As

Publication number Publication date
AR203882A1 (es) 1975-10-31
AU6671974A (en) 1975-09-18
YU39719B (en) 1985-04-30
IE39071L (en) 1974-10-02
DD113538A5 (nl) 1975-06-12
CS185223B2 (en) 1978-09-15
CA1042428A (en) 1978-11-14
ES446571A1 (es) 1977-06-16
YU81774A (en) 1982-05-31
HK20180A (en) 1980-04-25
YU39876B (en) 1985-04-30
AT340605B (de) 1977-12-27
HU171572B (hu) 1978-02-28
RO73524B (ro) 1984-11-30
GB1463575A (en) 1977-02-02
ES424882A1 (es) 1976-12-16
RO77533A (ro) 1982-02-01
DE2415980A1 (de) 1974-10-10
CH603669A5 (nl) 1978-08-31
JPS59193895A (ja) 1984-11-02
SU623522A3 (ru) 1978-09-05
AR204004A1 (es) 1975-11-12
BG22831A3 (bg) 1977-04-20
JPS5919117B2 (ja) 1984-05-02
YU39875B (en) 1985-04-30
PH13623A (en) 1980-08-07
RO73524A (ro) 1984-10-31
BG21235A3 (bg) 1976-03-20
IE39071B1 (en) 1978-08-02
JPS6033837B2 (ja) 1985-08-05
NL181079C (nl) 1987-06-16
NL181079B (nl) 1987-01-16
MY8100025A (en) 1981-12-31
YU113880A (en) 1982-05-31
JPS49128000A (nl) 1974-12-07
DE2415980C2 (nl) 1989-11-09
IL44415A (en) 1978-08-31
FR2223044B1 (nl) 1978-06-30
ZA741674B (en) 1975-10-29
KE3028A (en) 1980-03-28
DK141511B (da) 1980-04-08
SU784783A3 (ru) 1980-11-30
FR2223044A1 (nl) 1974-10-25
SE416206B (sv) 1980-12-08
SU731900A3 (ru) 1980-04-30
NL7404423A (nl) 1974-10-04
DK141511C (nl) 1980-09-29
CY1044A (en) 1980-08-01
IL44415A0 (en) 1974-06-30
SU652896A3 (ru) 1979-03-15
YU113980A (en) 1982-05-31
ATA267974A (de) 1977-04-15
BG21612A3 (bg) 1976-07-20

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: ELI LILLY AND CY

Effective date: 19940402