BG107277A - Използване на заместени триазолопиримидини като противоракови средства - Google Patents

Използване на заместени триазолопиримидини като противоракови средства Download PDF

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Publication number
BG107277A
BG107277A BG107277A BG10727702A BG107277A BG 107277 A BG107277 A BG 107277A BG 107277 A BG107277 A BG 107277A BG 10727702 A BG10727702 A BG 10727702A BG 107277 A BG107277 A BG 107277A
Authority
BG
Bulgaria
Prior art keywords
chloro
triazolo
carbon atoms
pyrimidine
amine
Prior art date
Application number
BG107277A
Other languages
Bulgarian (bg)
English (en)
Inventor
Mark R. Schmitt
Donald R. Kirsch
Jane E. Harris
Carl F. Beyer
Klaus-Juergen Pees
Paul Carter
Waldemar Pfrengle
Guido Albert
Original Assignee
Wyeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth filed Critical Wyeth
Publication of BG107277A publication Critical patent/BG107277A/bg

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG107277A 2000-06-30 2002-11-15 Използване на заместени триазолопиримидини като противоракови средства BG107277A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21558500P 2000-06-30 2000-06-30
PCT/US2001/020672 WO2002002563A2 (en) 2000-06-30 2001-06-28 Substituted-triazolopyrimidines as anticancer agents

Publications (1)

Publication Number Publication Date
BG107277A true BG107277A (bg) 2004-01-30

Family

ID=22803554

Family Applications (1)

Application Number Title Priority Date Filing Date
BG107277A BG107277A (bg) 2000-06-30 2002-11-15 Използване на заместени триазолопиримидини като противоракови средства

Country Status (24)

Country Link
US (1) US7329663B2 (sk)
EP (1) EP1307200A2 (sk)
JP (1) JP2004502691A (sk)
KR (1) KR20030013475A (sk)
CN (1) CN1592624A (sk)
AR (1) AR034553A1 (sk)
AU (2) AU7306201A (sk)
BG (1) BG107277A (sk)
BR (1) BR0112038A (sk)
CA (1) CA2413802A1 (sk)
CZ (1) CZ20024150A3 (sk)
EA (1) EA006483B1 (sk)
GE (1) GEP20053688B (sk)
HK (1) HK1052646A1 (sk)
HU (1) HUP0300798A3 (sk)
IL (1) IL152869A0 (sk)
IN (1) IN2003KO00001A (sk)
MX (1) MXPA02011913A (sk)
NO (1) NO20026195L (sk)
NZ (1) NZ523807A (sk)
PL (1) PL360027A1 (sk)
SK (1) SK18412002A3 (sk)
WO (1) WO2002002563A2 (sk)
ZA (1) ZA200300793B (sk)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
EP1368351A2 (de) * 2000-11-13 2003-12-10 Basf Aktiengesellschaft 7-(r)-amino-triazolopyrimidine, deren herstellung und verwendung zur bekämpfung von pflanzenpathogenen pilzen
EE200300499A (et) * 2001-04-11 2003-12-15 Basf Aktiengesellschaft 5-halogeen-6-fenüül-7-fluoroalküülaminotriasolopürimidiinid
EP1381610B1 (en) * 2001-04-11 2004-08-25 Basf Aktiengesellschaft 6-(2-chloro-6-fluoro-phenyl)-triazolopyrimidines
DE10121101A1 (de) * 2001-04-27 2002-10-31 Bayer Ag Triazolopyrimidine
DE10121162A1 (de) * 2001-04-30 2002-10-31 Bayer Ag Triazolopyrimidine
DE10124208A1 (de) 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
CN1271071C (zh) * 2001-07-18 2006-08-23 巴斯福股份公司 作为杀真菌剂的取代的6－(2－甲苯基)－三唑并嘧啶
PL372978A1 (en) * 2002-03-21 2005-08-08 Basf Aktiengesellschaft Fungicidal triazolopyrimidines, methods for producing the same, use thereof for combating harmful fungi and agents containing said substances
WO2004011467A1 (ja) * 2002-07-29 2004-02-05 Hokko Chemical Industry Co., Ltd. トリアゾロピリミジン誘導体および農園芸用殺菌剤
UA80304C2 (en) * 2002-11-07 2007-09-10 Basf Ag Substituted 6-(2-halogenphenyl)triazolopyrimidines
AU2004226233A1 (en) * 2003-03-31 2004-10-14 Basf Aktiengesellschaft 7-alkenylamino-triazolopyrimidines, method for the production thereof and use thereof in controlling harmful fungi and substances containing said triazolopyrimidines
DE10325133A1 (de) * 2003-06-04 2004-12-23 Bayer Cropscience Ag Triazolopyrimidine
US20070275961A1 (en) * 2003-06-04 2007-11-29 Vernalis (Cambridge) Limited. Triazolo ' 1, 5-A ! Pyrimidines and Their Use in Medicine
DE10328173A1 (de) * 2003-06-24 2005-01-13 Bayer Cropscience Ag Triazolopyrimidine
DE10328171A1 (de) * 2003-06-24 2005-01-13 Bayer Cropscience Ag Triazolopyrimidine
DE10328481A1 (de) * 2003-06-25 2005-01-13 Bayer Ag Triazolopyrimidine
JP4695595B2 (ja) 2003-09-24 2011-06-08 ワイス・ホールディングズ・コーポレイション 抗癌剤としての６−アリール−７−ハロ−イミダゾ［１，２−ａ］ピリミジン類
DE602004004295T8 (de) 2003-09-24 2007-09-20 Wyeth Holdings Corp. 6-[(Substituiertes)]Triazolopyrimidine als Antikrebsmittel
US7419982B2 (en) 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
JPWO2005037837A1 (ja) * 2003-10-17 2006-12-28 日本化薬株式会社 置換２−アミノ−［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体及びその用途
JP4606015B2 (ja) * 2003-11-25 2011-01-05 日本化薬株式会社 ［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体の新規医薬用途
MY179926A (en) 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
CN1894254A (zh) * 2003-12-17 2007-01-10 巴斯福股份公司 用于防治病原性真菌的6－(2,3,6－三氟苯基)三唑并嘧啶
JP2007514680A (ja) * 2003-12-17 2007-06-07 ビーエーエスエフ　アクチェンゲゼルシャフト ６−（２，４，６−トリハロフェニル）トリアゾロピリミジン、その製造方法、および植物病原性真菌類を防除するためのその使用、ならびにその物質を含有している農薬
WO2005095404A2 (de) * 2004-03-30 2005-10-13 Basf Aktiengesellschaft 6-(2-fluorphenyl)-triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
EP1751162A1 (de) * 2004-05-17 2007-02-14 Basf Aktiengesellschaft Triazolopyrimidin-verbindungen und ihre verwendung zur bekämpfung von schadpilzen
US20070249634A1 (en) * 2004-06-09 2007-10-25 Carsten Blettner Triazolopyrimidine Compounds and Use Thereof for Controlling Harmful Fungi
EP1761544A1 (de) * 2004-06-25 2007-03-14 Basf Aktiengesellschaft Triazolopyrimidin-verbindungen und ihre verwendung zur bekämpfung von schadpilzen
JP5463034B2 (ja) * 2005-05-20 2014-04-09 アラントス・フアーマシユーテイカルズ・ホールデイング・インコーポレイテツド ピリミジン若しくはトリアジン縮合二環式メタロプロテアーゼ阻害薬
US20070155738A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
WO2007011759A2 (en) * 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
CA2633962A1 (en) * 2005-12-16 2007-07-05 Wyeth Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents
WO2007099092A1 (de) * 2006-02-28 2007-09-07 Basf Se Substituierte 6-phenyl-7-amino-[1,2,4]-triazolo[1,5-a]pyrimidine und deren verwendung zur bekämpfung von schadpilzen
WO2007116011A2 (de) * 2006-04-10 2007-10-18 Basf Se Substituierte triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
JP5231829B2 (ja) 2007-02-15 2013-07-10 石原産業株式会社 ピリジル−トリアゾロピリミジン誘導体又はその塩、それらを含有する有害生物防除剤並びにそれらの製造方法
UY31293A1 (es) 2007-08-14 2009-03-31 Pirimidinas biciclicas fusionadas
CN103889428A (zh) 2010-10-04 2014-06-25 肝炎与病毒研究所 乙型肝炎病毒抗原分泌的新型抑制剂
JP6311603B2 (ja) 2012-06-22 2018-04-18 住友化学株式会社 縮合複素環化合物
CN103360398B (zh) * 2013-07-22 2015-03-25 山东大学 一种三唑并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
GB201504565D0 (en) 2015-03-18 2015-05-06 Takeda Pharmaceutical Novel compounds
KR101995533B1 (ko) * 2017-03-21 2019-07-02 한국화학연구원 [1,2,4]트리아졸로[4,3-a]퀴노잘린 아미노 페닐 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물
WO2020159942A1 (en) * 2019-01-29 2020-08-06 Tosk, Inc. Pyrazolopyrimidine modulators of ras gtpase
EP4136089A4 (en) * 2020-04-14 2024-05-29 The Trustees of The University of Pennsylvania SUBSTITUTED {1,2,4,} TRIAZOLO{1,5-A} PYRIMIDINE COMPOUNDS AND USE IN STABILIZATION OF MICROTUBULES
CN115698009A (zh) * 2020-05-01 2023-02-03 吉利德科学公司 抑制cd73的2,4-二氧代嘧啶化合物
US20230279006A1 (en) * 2020-07-08 2023-09-07 Klotho Therapeutics, Inc. Novel compounds and methods for increasing klotho gene expression
CN118201941A (zh) 2021-10-29 2024-06-14 吉利德科学公司 Cd73化合物
WO2023143194A1 (zh) * 2022-01-25 2023-08-03 瑞石生物医药有限公司 一种ccr4小分子拮抗剂及其用途

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE55956C (de) CH. GROOMBRIDGE und W. A. SOUTH in London, 40 New Bond Street Bremskurbel für Pferdebahn- und andere Wagen
DD61269A (sk) *
DD55956A (sk) *
DE61269C (de) 1891-04-01 1892-03-23 J. NEWBURG in Berlin O., Am Schlesischen Bahnhof Nr. 5 Waschmaschine
JPS5827773B2 (ja) * 1980-02-08 1983-06-11 持田製薬株式会社 癌転移抑制剤
US4444774A (en) * 1982-07-29 1984-04-24 American Cyanamid Company 7-Heteroaryl[1,2,4]triazolo[1,5-a]pyrimidines
GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds
JPH02212488A (ja) * 1989-02-13 1990-08-23 Shinichiro Shimizu トリアゾールピリミジン誘導体
US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
US5387747A (en) * 1992-02-24 1995-02-07 Laboratoires Upsa Triazolopyrimidine derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present
IL108747A (en) * 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
GB9321162D0 (en) * 1993-10-13 1993-12-01 Boots Co Plc Therapeutic agents
US5869486A (en) * 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
US6117876A (en) * 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5948783A (en) * 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5994360A (en) * 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
US6020338A (en) * 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
US6380202B1 (en) * 1998-09-25 2002-04-30 Basf Aktiengesellschaft Fungicidal fluoro-substituted 7-heterocyclyl-triazolopyrimidines
FR2784380B1 (fr) * 1998-09-25 2002-09-06 American Cyanamid Co Triazolopyrimidines 7-oxy- et 7-thio-substituees fongicides
US6165940A (en) * 1998-09-25 2000-12-26 American Cyanamid Co. Non-aqueous suspension concentrate
MY125533A (en) * 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
JP2001322933A (ja) * 2000-05-15 2001-11-20 Ucb Sa Ｃｄ４０シグナル遮断剤
DE10121101A1 (de) * 2001-04-27 2002-10-31 Bayer Ag Triazolopyrimidine
DE10121102A1 (de) * 2001-04-27 2002-11-07 Bayer Ag Triazolopyrimidine
DE10121162A1 (de) * 2001-04-30 2002-10-31 Bayer Ag Triazolopyrimidine
US7037902B2 (en) * 2002-07-03 2006-05-02 Receptron, Inc. Affinity small molecules for the EPO receptor
DE602004004295T8 (de) * 2003-09-24 2007-09-20 Wyeth Holdings Corp. 6-[(Substituiertes)]Triazolopyrimidine als Antikrebsmittel
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts

Also Published As

Publication number Publication date
IN2003KO00001A (sk) 2005-12-02
GEP20053688B (en) 2005-12-12
AR034553A1 (es) 2004-03-03
KR20030013475A (ko) 2003-02-14
EA006483B1 (ru) 2005-12-29
EA200300091A1 (ru) 2003-08-28
AU7306201A (en) 2002-01-14
AU2001273062B2 (en) 2005-11-24
SK18412002A3 (sk) 2003-06-03
JP2004502691A (ja) 2004-01-29
NO20026195L (no) 2003-02-27
ZA200300793B (en) 2004-07-20
CA2413802A1 (en) 2002-01-10
CN1592624A (zh) 2005-03-09
WO2002002563A2 (en) 2002-01-10
HK1052646A1 (zh) 2003-09-26
US20020068744A1 (en) 2002-06-06
NO20026195D0 (no) 2002-12-23
WO2002002563A3 (en) 2003-01-03
US7329663B2 (en) 2008-02-12
CZ20024150A3 (cs) 2003-09-17
PL360027A1 (en) 2004-09-06
BR0112038A (pt) 2003-04-01
HUP0300798A2 (hu) 2003-07-28
EP1307200A2 (en) 2003-05-07
HUP0300798A3 (en) 2006-02-28
IL152869A0 (en) 2003-06-24
MXPA02011913A (es) 2003-04-22
NZ523807A (en) 2004-09-24

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