BG107277A - Използване на заместени триазолопиримидини като противоракови средства - Google Patents
Използване на заместени триазолопиримидини като противоракови средства Download PDFInfo
- Publication number
- BG107277A BG107277A BG107277A BG10727702A BG107277A BG 107277 A BG107277 A BG 107277A BG 107277 A BG107277 A BG 107277A BG 10727702 A BG10727702 A BG 10727702A BG 107277 A BG107277 A BG 107277A
- Authority
- BG
- Bulgaria
- Prior art keywords
- chloro
- triazolo
- carbon atoms
- pyrimidine
- amine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21558500P | 2000-06-30 | 2000-06-30 | |
PCT/US2001/020672 WO2002002563A2 (en) | 2000-06-30 | 2001-06-28 | Substituted-triazolopyrimidines as anticancer agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BG107277A true BG107277A (bg) | 2004-01-30 |
Family
ID=22803554
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG107277A BG107277A (bg) | 2000-06-30 | 2002-11-15 | Използване на заместени триазолопиримидини като противоракови средства |
Country Status (24)
Country | Link |
---|---|
US (1) | US7329663B2 (sk) |
EP (1) | EP1307200A2 (sk) |
JP (1) | JP2004502691A (sk) |
KR (1) | KR20030013475A (sk) |
CN (1) | CN1592624A (sk) |
AR (1) | AR034553A1 (sk) |
AU (2) | AU7306201A (sk) |
BG (1) | BG107277A (sk) |
BR (1) | BR0112038A (sk) |
CA (1) | CA2413802A1 (sk) |
CZ (1) | CZ20024150A3 (sk) |
EA (1) | EA006483B1 (sk) |
GE (1) | GEP20053688B (sk) |
HK (1) | HK1052646A1 (sk) |
HU (1) | HUP0300798A3 (sk) |
IL (1) | IL152869A0 (sk) |
IN (1) | IN2003KO00001A (sk) |
MX (1) | MXPA02011913A (sk) |
NO (1) | NO20026195L (sk) |
NZ (1) | NZ523807A (sk) |
PL (1) | PL360027A1 (sk) |
SK (1) | SK18412002A3 (sk) |
WO (1) | WO2002002563A2 (sk) |
ZA (1) | ZA200300793B (sk) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6255309B1 (en) * | 1999-03-19 | 2001-07-03 | American Cyanomid Co. | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
EP1368351A2 (de) * | 2000-11-13 | 2003-12-10 | Basf Aktiengesellschaft | 7-(r)-amino-triazolopyrimidine, deren herstellung und verwendung zur bekämpfung von pflanzenpathogenen pilzen |
EE200300499A (et) * | 2001-04-11 | 2003-12-15 | Basf Aktiengesellschaft | 5-halogeen-6-fenüül-7-fluoroalküülaminotriasolopürimidiinid |
EP1381610B1 (en) * | 2001-04-11 | 2004-08-25 | Basf Aktiengesellschaft | 6-(2-chloro-6-fluoro-phenyl)-triazolopyrimidines |
DE10121101A1 (de) * | 2001-04-27 | 2002-10-31 | Bayer Ag | Triazolopyrimidine |
DE10121162A1 (de) * | 2001-04-30 | 2002-10-31 | Bayer Ag | Triazolopyrimidine |
DE10124208A1 (de) | 2001-05-18 | 2002-11-21 | Bayer Ag | Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide |
CN1271071C (zh) * | 2001-07-18 | 2006-08-23 | 巴斯福股份公司 | 作为杀真菌剂的取代的6-(2-甲苯基)-三唑并嘧啶 |
PL372978A1 (en) * | 2002-03-21 | 2005-08-08 | Basf Aktiengesellschaft | Fungicidal triazolopyrimidines, methods for producing the same, use thereof for combating harmful fungi and agents containing said substances |
WO2004011467A1 (ja) * | 2002-07-29 | 2004-02-05 | Hokko Chemical Industry Co., Ltd. | トリアゾロピリミジン誘導体および農園芸用殺菌剤 |
UA80304C2 (en) * | 2002-11-07 | 2007-09-10 | Basf Ag | Substituted 6-(2-halogenphenyl)triazolopyrimidines |
AU2004226233A1 (en) * | 2003-03-31 | 2004-10-14 | Basf Aktiengesellschaft | 7-alkenylamino-triazolopyrimidines, method for the production thereof and use thereof in controlling harmful fungi and substances containing said triazolopyrimidines |
DE10325133A1 (de) * | 2003-06-04 | 2004-12-23 | Bayer Cropscience Ag | Triazolopyrimidine |
US20070275961A1 (en) * | 2003-06-04 | 2007-11-29 | Vernalis (Cambridge) Limited. | Triazolo ' 1, 5-A ! Pyrimidines and Their Use in Medicine |
DE10328173A1 (de) * | 2003-06-24 | 2005-01-13 | Bayer Cropscience Ag | Triazolopyrimidine |
DE10328171A1 (de) * | 2003-06-24 | 2005-01-13 | Bayer Cropscience Ag | Triazolopyrimidine |
DE10328481A1 (de) * | 2003-06-25 | 2005-01-13 | Bayer Ag | Triazolopyrimidine |
JP4695595B2 (ja) | 2003-09-24 | 2011-06-08 | ワイス・ホールディングズ・コーポレイション | 抗癌剤としての6−アリール−7−ハロ−イミダゾ[1,2−a]ピリミジン類 |
DE602004004295T8 (de) | 2003-09-24 | 2007-09-20 | Wyeth Holdings Corp. | 6-[(Substituiertes)]Triazolopyrimidine als Antikrebsmittel |
US7419982B2 (en) | 2003-09-24 | 2008-09-02 | Wyeth Holdings Corporation | Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts |
JPWO2005037837A1 (ja) * | 2003-10-17 | 2006-12-28 | 日本化薬株式会社 | 置換2−アミノ−[1,2,4]トリアゾロ[1,5−a]ピリミジン誘導体及びその用途 |
JP4606015B2 (ja) * | 2003-11-25 | 2011-01-05 | 日本化薬株式会社 | [1,2,4]トリアゾロ[1,5−a]ピリミジン誘導体の新規医薬用途 |
MY179926A (en) | 2003-12-08 | 2020-11-19 | Wyeth Corp | Process for the preparation of tubulin inhibitors |
CN1894254A (zh) * | 2003-12-17 | 2007-01-10 | 巴斯福股份公司 | 用于防治病原性真菌的6-(2,3,6-三氟苯基)三唑并嘧啶 |
JP2007514680A (ja) * | 2003-12-17 | 2007-06-07 | ビーエーエスエフ アクチェンゲゼルシャフト | 6−(2,4,6−トリハロフェニル)トリアゾロピリミジン、その製造方法、および植物病原性真菌類を防除するためのその使用、ならびにその物質を含有している農薬 |
WO2005095404A2 (de) * | 2004-03-30 | 2005-10-13 | Basf Aktiengesellschaft | 6-(2-fluorphenyl)-triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel |
EP1751162A1 (de) * | 2004-05-17 | 2007-02-14 | Basf Aktiengesellschaft | Triazolopyrimidin-verbindungen und ihre verwendung zur bekämpfung von schadpilzen |
US20070249634A1 (en) * | 2004-06-09 | 2007-10-25 | Carsten Blettner | Triazolopyrimidine Compounds and Use Thereof for Controlling Harmful Fungi |
EP1761544A1 (de) * | 2004-06-25 | 2007-03-14 | Basf Aktiengesellschaft | Triazolopyrimidin-verbindungen und ihre verwendung zur bekämpfung von schadpilzen |
JP5463034B2 (ja) * | 2005-05-20 | 2014-04-09 | アラントス・フアーマシユーテイカルズ・ホールデイング・インコーポレイテツド | ピリミジン若しくはトリアジン縮合二環式メタロプロテアーゼ阻害薬 |
US20070155738A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
WO2007011759A2 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
CA2633962A1 (en) * | 2005-12-16 | 2007-07-05 | Wyeth | Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents |
WO2007099092A1 (de) * | 2006-02-28 | 2007-09-07 | Basf Se | Substituierte 6-phenyl-7-amino-[1,2,4]-triazolo[1,5-a]pyrimidine und deren verwendung zur bekämpfung von schadpilzen |
WO2007116011A2 (de) * | 2006-04-10 | 2007-10-18 | Basf Se | Substituierte triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel |
JP5231829B2 (ja) | 2007-02-15 | 2013-07-10 | 石原産業株式会社 | ピリジル−トリアゾロピリミジン誘導体又はその塩、それらを含有する有害生物防除剤並びにそれらの製造方法 |
UY31293A1 (es) | 2007-08-14 | 2009-03-31 | Pirimidinas biciclicas fusionadas | |
CN103889428A (zh) | 2010-10-04 | 2014-06-25 | 肝炎与病毒研究所 | 乙型肝炎病毒抗原分泌的新型抑制剂 |
JP6311603B2 (ja) | 2012-06-22 | 2018-04-18 | 住友化学株式会社 | 縮合複素環化合物 |
CN103360398B (zh) * | 2013-07-22 | 2015-03-25 | 山东大学 | 一种三唑并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用 |
GB201504565D0 (en) | 2015-03-18 | 2015-05-06 | Takeda Pharmaceutical | Novel compounds |
KR101995533B1 (ko) * | 2017-03-21 | 2019-07-02 | 한국화학연구원 | [1,2,4]트리아졸로[4,3-a]퀴노잘린 아미노 페닐 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물 |
WO2020159942A1 (en) * | 2019-01-29 | 2020-08-06 | Tosk, Inc. | Pyrazolopyrimidine modulators of ras gtpase |
EP4136089A4 (en) * | 2020-04-14 | 2024-05-29 | The Trustees of The University of Pennsylvania | SUBSTITUTED {1,2,4,} TRIAZOLO{1,5-A} PYRIMIDINE COMPOUNDS AND USE IN STABILIZATION OF MICROTUBULES |
CN115698009A (zh) * | 2020-05-01 | 2023-02-03 | 吉利德科学公司 | 抑制cd73的2,4-二氧代嘧啶化合物 |
US20230279006A1 (en) * | 2020-07-08 | 2023-09-07 | Klotho Therapeutics, Inc. | Novel compounds and methods for increasing klotho gene expression |
CN118201941A (zh) | 2021-10-29 | 2024-06-14 | 吉利德科学公司 | Cd73化合物 |
WO2023143194A1 (zh) * | 2022-01-25 | 2023-08-03 | 瑞石生物医药有限公司 | 一种ccr4小分子拮抗剂及其用途 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE55956C (de) | CH. GROOMBRIDGE und W. A. SOUTH in London, 40 New Bond Street | Bremskurbel für Pferdebahn- und andere Wagen | ||
DD61269A (sk) * | ||||
DD55956A (sk) * | ||||
DE61269C (de) | 1891-04-01 | 1892-03-23 | J. NEWBURG in Berlin O., Am Schlesischen Bahnhof Nr. 5 | Waschmaschine |
JPS5827773B2 (ja) * | 1980-02-08 | 1983-06-11 | 持田製薬株式会社 | 癌転移抑制剤 |
US4444774A (en) * | 1982-07-29 | 1984-04-24 | American Cyanamid Company | 7-Heteroaryl[1,2,4]triazolo[1,5-a]pyrimidines |
GB8719368D0 (en) * | 1987-08-15 | 1987-09-23 | Wellcome Found | Heterocyclic compounds |
JPH02212488A (ja) * | 1989-02-13 | 1990-08-23 | Shinichiro Shimizu | トリアゾールピリミジン誘導体 |
US5593996A (en) * | 1991-12-30 | 1997-01-14 | American Cyanamid Company | Triazolopyrimidine derivatives |
US5387747A (en) * | 1992-02-24 | 1995-02-07 | Laboratoires Upsa | Triazolopyrimidine derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present |
IL108747A (en) * | 1993-03-04 | 1999-03-12 | Shell Int Research | Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation |
GB9321162D0 (en) * | 1993-10-13 | 1993-12-01 | Boots Co Plc | Therapeutic agents |
US5869486A (en) * | 1995-02-24 | 1999-02-09 | Ono Pharmaceutical Co., Ltd. | Fused pyrimidines and pyriazines as pharmaceutical compounds |
US6117876A (en) * | 1997-04-14 | 2000-09-12 | American Cyanamid Company | Fungicidal trifluorophenyl-triazolopyrimidines |
US6255309B1 (en) * | 1999-03-19 | 2001-07-03 | American Cyanomid Co. | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
US5948783A (en) * | 1997-04-14 | 1999-09-07 | American Cyanamid Company | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
US5994360A (en) * | 1997-07-14 | 1999-11-30 | American Cyanamid Company | Fungicidal 5-alkyl-triazolopyrimidines |
US6020338A (en) * | 1998-02-11 | 2000-02-01 | American Cyanamid Company | Fungicidal 7-alkyl-triazolopyrimidines |
US6380202B1 (en) * | 1998-09-25 | 2002-04-30 | Basf Aktiengesellschaft | Fungicidal fluoro-substituted 7-heterocyclyl-triazolopyrimidines |
FR2784380B1 (fr) * | 1998-09-25 | 2002-09-06 | American Cyanamid Co | Triazolopyrimidines 7-oxy- et 7-thio-substituees fongicides |
US6165940A (en) * | 1998-09-25 | 2000-12-26 | American Cyanamid Co. | Non-aqueous suspension concentrate |
MY125533A (en) * | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
JP2001322933A (ja) * | 2000-05-15 | 2001-11-20 | Ucb Sa | Cd40シグナル遮断剤 |
DE10121101A1 (de) * | 2001-04-27 | 2002-10-31 | Bayer Ag | Triazolopyrimidine |
DE10121102A1 (de) * | 2001-04-27 | 2002-11-07 | Bayer Ag | Triazolopyrimidine |
DE10121162A1 (de) * | 2001-04-30 | 2002-10-31 | Bayer Ag | Triazolopyrimidine |
US7037902B2 (en) * | 2002-07-03 | 2006-05-02 | Receptron, Inc. | Affinity small molecules for the EPO receptor |
DE602004004295T8 (de) * | 2003-09-24 | 2007-09-20 | Wyeth Holdings Corp. | 6-[(Substituiertes)]Triazolopyrimidine als Antikrebsmittel |
US7419982B2 (en) * | 2003-09-24 | 2008-09-02 | Wyeth Holdings Corporation | Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts |
-
2001
- 2001-06-28 SK SK1841-2002A patent/SK18412002A3/sk not_active Application Discontinuation
- 2001-06-28 JP JP2002507815A patent/JP2004502691A/ja active Pending
- 2001-06-28 CZ CZ20024150A patent/CZ20024150A3/cs unknown
- 2001-06-28 BR BR0112038-7A patent/BR0112038A/pt not_active IP Right Cessation
- 2001-06-28 EA EA200300091A patent/EA006483B1/ru not_active IP Right Cessation
- 2001-06-28 NZ NZ523807A patent/NZ523807A/en unknown
- 2001-06-28 AU AU7306201A patent/AU7306201A/xx active Pending
- 2001-06-28 WO PCT/US2001/020672 patent/WO2002002563A2/en not_active Application Discontinuation
- 2001-06-28 CN CNA018120555A patent/CN1592624A/zh active Pending
- 2001-06-28 EP EP01952295A patent/EP1307200A2/en not_active Withdrawn
- 2001-06-28 PL PL36002701A patent/PL360027A1/xx not_active Application Discontinuation
- 2001-06-28 MX MXPA02011913A patent/MXPA02011913A/es not_active Application Discontinuation
- 2001-06-28 KR KR1020027017998A patent/KR20030013475A/ko not_active Application Discontinuation
- 2001-06-28 CA CA002413802A patent/CA2413802A1/en not_active Abandoned
- 2001-06-28 AU AU2001273062A patent/AU2001273062B2/en not_active Ceased
- 2001-06-28 HU HU0300798A patent/HUP0300798A3/hu unknown
- 2001-06-28 GE GE5104A patent/GEP20053688B/en unknown
- 2001-06-28 IL IL15286901A patent/IL152869A0/xx unknown
- 2001-06-29 US US09/895,975 patent/US7329663B2/en not_active Expired - Fee Related
- 2001-06-29 AR ARP010103116A patent/AR034553A1/es not_active Application Discontinuation
-
2002
- 2002-11-15 BG BG107277A patent/BG107277A/bg unknown
- 2002-12-23 NO NO20026195A patent/NO20026195L/no not_active Application Discontinuation
-
2003
- 2003-01-01 IN IN1KO2003 patent/IN2003KO00001A/en unknown
- 2003-01-29 ZA ZA200300793A patent/ZA200300793B/xx unknown
- 2003-07-07 HK HK03104812.5A patent/HK1052646A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
IN2003KO00001A (sk) | 2005-12-02 |
GEP20053688B (en) | 2005-12-12 |
AR034553A1 (es) | 2004-03-03 |
KR20030013475A (ko) | 2003-02-14 |
EA006483B1 (ru) | 2005-12-29 |
EA200300091A1 (ru) | 2003-08-28 |
AU7306201A (en) | 2002-01-14 |
AU2001273062B2 (en) | 2005-11-24 |
SK18412002A3 (sk) | 2003-06-03 |
JP2004502691A (ja) | 2004-01-29 |
NO20026195L (no) | 2003-02-27 |
ZA200300793B (en) | 2004-07-20 |
CA2413802A1 (en) | 2002-01-10 |
CN1592624A (zh) | 2005-03-09 |
WO2002002563A2 (en) | 2002-01-10 |
HK1052646A1 (zh) | 2003-09-26 |
US20020068744A1 (en) | 2002-06-06 |
NO20026195D0 (no) | 2002-12-23 |
WO2002002563A3 (en) | 2003-01-03 |
US7329663B2 (en) | 2008-02-12 |
CZ20024150A3 (cs) | 2003-09-17 |
PL360027A1 (en) | 2004-09-06 |
BR0112038A (pt) | 2003-04-01 |
HUP0300798A2 (hu) | 2003-07-28 |
EP1307200A2 (en) | 2003-05-07 |
HUP0300798A3 (en) | 2006-02-28 |
IL152869A0 (en) | 2003-06-24 |
MXPA02011913A (es) | 2003-04-22 |
NZ523807A (en) | 2004-09-24 |
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