BG107050A - Method for the preparation of citalopram - Google Patents

Method for the preparation of citalopram

Info

Publication number
BG107050A
BG107050A BG107050A BG10705002A BG107050A BG 107050 A BG107050 A BG 107050A BG 107050 A BG107050 A BG 107050A BG 10705002 A BG10705002 A BG 10705002A BG 107050 A BG107050 A BG 107050A
Authority
BG
Bulgaria
Prior art keywords
halogen
citalopram
formula
dimethylamino
followed
Prior art date
Application number
BG107050A
Other languages
Bulgarian (bg)
English (en)
Inventor
Michael Rock
Haleh Ahmadian
Original Assignee
H.Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H.Lundbeck A/S filed Critical H.Lundbeck A/S
Publication of BG107050A publication Critical patent/BG107050A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BG107050A 2000-03-03 2002-09-02 Method for the preparation of citalopram BG107050A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200000353 2000-03-03
PCT/DK2001/000140 WO2001051478A1 (en) 2000-03-03 2001-03-01 Method for the preparation of citalopram

Publications (1)

Publication Number Publication Date
BG107050A true BG107050A (en) 2003-05-30

Family

ID=8159277

Family Applications (1)

Application Number Title Priority Date Filing Date
BG107050A BG107050A (en) 2000-03-03 2002-09-02 Method for the preparation of citalopram

Country Status (29)

Country Link
US (1) US6768011B2 (hr)
EP (1) EP1263750A1 (hr)
JP (1) JP2003519692A (hr)
KR (1) KR20020080450A (hr)
CN (1) CN1411454A (hr)
AR (1) AR027559A1 (hr)
AU (1) AU2001240469A1 (hr)
BE (1) BE1011481A6 (hr)
BG (1) BG107050A (hr)
BR (1) BR0109022A (hr)
CA (1) CA2401374A1 (hr)
EA (1) EA005491B1 (hr)
FR (1) FR2805814A1 (hr)
GR (1) GR1003795B (hr)
HR (1) HRP20020742A2 (hr)
HU (1) HUP0300060A3 (hr)
IE (1) IES20010157A2 (hr)
IL (1) IL151467A0 (hr)
IS (1) IS6526A (hr)
IT (1) ITMI20010444A1 (hr)
MX (1) MXPA02008634A (hr)
NL (1) NL1017417C1 (hr)
NO (1) NO20024180L (hr)
NZ (1) NZ521200A (hr)
PL (1) PL358543A1 (hr)
SK (1) SK14152002A3 (hr)
TR (1) TR200202096T2 (hr)
WO (1) WO2001051478A1 (hr)
ZA (1) ZA200206846B (hr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA004033B1 (ru) * 1999-04-14 2003-12-25 Х.Лундбекк А/С Способ получения циталопрама
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
CN1429219A (zh) 2000-03-13 2003-07-09 H·隆德贝克有限公司 制备西酞普兰的方法
WO2001068629A1 (en) * 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
TR200400611T4 (tr) 2000-03-14 2004-04-21 H.Lundbeck A/S Sitalopramın preparasyon metodu
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
RU2004117211A (ru) * 2001-11-08 2005-03-27 Сепракор, Инк. (Us) Способы лечения депресии и других рассстройств цнс с использованием энантиомерно обогащшенных десметил-и дидесметилметаболитов циталопрама
TWI306846B (en) 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (hr) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
CZ291440B6 (cs) 1997-07-08 2003-03-12 H. Lundbeck A/S Způsob výroby citalopramu
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
ES2149734T3 (es) 1997-11-11 2003-02-16 Lundbeck & Co As H Metodo para la preparacion de citalopram.
SK285719B6 (sk) 1998-10-20 2007-07-06 H. Lundbeck A/S Spôsob prípravy citalopramu a medziprodukty
DE69906580T2 (de) 1998-12-23 2004-02-12 H. Lundbeck A/S Verfahren zur herstellung von 5-cyanophthalid
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
EA004033B1 (ru) 1999-04-14 2003-12-25 Х.Лундбекк А/С Способ получения циталопрама
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
WO2000012044A2 (en) 1999-10-25 2000-03-09 H. Lundbeck A/S Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
PL355532A1 (en) 1999-12-28 2004-05-04 H.Lundbeck A/S Method for the preparation of citalopram
IL150367A0 (en) 1999-12-30 2002-12-01 Lundbeck & Co As H Method for the preparation of citalopram
SK286879B6 (sk) 2000-01-14 2009-07-06 H. Lundbeck A/S Spôsob prípravy 5-kyanoftalidu
IT1317729B1 (it) 2000-01-18 2003-07-15 Norpharma S P A Procedimento per la preparazione della 5-carbossiftalide.
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
FR2805812A1 (fr) * 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
GB2357762B (en) 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
CN1429219A (zh) 2000-03-13 2003-07-09 H·隆德贝克有限公司 制备西酞普兰的方法
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
WO2001068629A1 (en) 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
TR200400611T4 (tr) 2000-03-14 2004-04-21 H.Lundbeck A/S Sitalopramın preparasyon metodu
DE10190485T1 (de) 2000-03-16 2002-03-21 Lundbeck & Co As H Verfahren zur Herstellung von 5-Cyano-1-(4-fluorphenyl)-1,3-dihydroisobenzofuranen
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
SK3362002A3 (en) 2000-07-06 2002-08-06 Lundbeck & Co As H Method for the preparation of citalopram
CA2354880C (en) 2000-08-18 2003-06-03 H. Lundbeck A/S Method for the preparation of citalopram
EP1181713B1 (en) 2000-12-22 2004-09-29 H. Lundbeck A/S Method for the preparation of pure citalopram
TR200200018T1 (tr) 2000-12-28 2002-06-21 H. Lundbeck A/S Saf sitalopram hazırlanması için yöntem.

Also Published As

Publication number Publication date
NL1017417C1 (nl) 2001-03-16
EP1263750A1 (en) 2002-12-11
NO20024180D0 (no) 2002-09-02
BR0109022A (pt) 2003-06-03
GR1003795B (el) 2002-02-08
US20030092761A1 (en) 2003-05-15
CA2401374A1 (en) 2001-07-19
FR2805814A1 (fr) 2001-09-07
TR200202096T2 (tr) 2003-01-21
MXPA02008634A (es) 2003-02-24
HUP0300060A3 (en) 2005-02-28
BE1011481A6 (fr) 2001-07-03
EA005491B1 (ru) 2005-02-24
IES20010157A2 (en) 2002-03-06
AR027559A1 (es) 2003-04-02
NO20024180L (no) 2002-09-02
ITMI20010444A1 (it) 2002-09-05
IS6526A (is) 2002-08-27
PL358543A1 (en) 2004-08-09
ZA200206846B (en) 2003-08-27
HUP0300060A2 (en) 2003-05-28
IL151467A0 (en) 2003-04-10
SK14152002A3 (sk) 2003-03-04
CN1411454A (zh) 2003-04-16
WO2001051478A1 (en) 2001-07-19
AU2001240469A1 (en) 2001-07-24
US6768011B2 (en) 2004-07-27
EA200200939A1 (ru) 2003-02-27
HRP20020742A2 (en) 2004-02-29
KR20020080450A (ko) 2002-10-23
JP2003519692A (ja) 2003-06-24
NZ521200A (en) 2004-03-26

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