BG106977A - Нови биарилкарбоксамиди - Google Patents

Info

Publication number

BG106977A

BG106977A BG106977A BG10697702A BG106977A BG 106977 A BG106977 A BG 106977A BG 106977 A BG106977 A BG 106977A BG 10697702 A BG10697702 A BG 10697702A BG 106977 A BG106977 A BG 106977A

Authority

BG

Bulgaria

Prior art keywords

oct

azabicyclo

carboxamide

thiophene

furan

Prior art date

2000-02-18

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims abstract description 353
• 150000003839 salts Chemical class 0.000 claims abstract description 86
• 238000000034 method Methods 0.000 claims abstract description 77
• 125000003118 aryl group Chemical group 0.000 claims abstract description 57
• 229910052760 oxygen Inorganic materials 0.000 claims abstract description 54
• 239000001301 oxygen Substances 0.000 claims abstract description 54
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 52
• 125000001424 substituent group Chemical group 0.000 claims abstract description 46
• 229910052736 halogen Inorganic materials 0.000 claims abstract description 45
• 150000002367 halogens Chemical class 0.000 claims abstract description 45
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims abstract description 40
• 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 34
• 125000004434 sulfur atom Chemical group 0.000 claims abstract description 32
• 229910052717 sulfur Inorganic materials 0.000 claims abstract description 30
• 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 26
• 125000004430 oxygen atom Chemical group O* 0.000 claims abstract description 25
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 22
• 239000011593 sulfur Substances 0.000 claims abstract description 22
• 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 21
• 239000001257 hydrogen Substances 0.000 claims abstract description 21
• 238000011282 treatment Methods 0.000 claims abstract description 18
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 17
• 238000011321 prophylaxis Methods 0.000 claims abstract description 13
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 12
• 125000003226 pyrazolyl group Chemical group 0.000 claims abstract description 9
• 230000006735 deficit Effects 0.000 claims abstract description 7
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
• 208000028017 Psychotic disease Diseases 0.000 claims abstract description 6
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 5
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 4
• 238000002560 therapeutic procedure Methods 0.000 claims abstract description 3
• -1 oct-3-yl Chemical group 0.000 claims description 186
• 238000006243 chemical reaction Methods 0.000 claims description 87
• YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical group C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 63
• 239000002904 solvent Substances 0.000 claims description 57
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 52
• 239000003054 catalyst Substances 0.000 claims description 26
• 150000003857 carboxamides Chemical class 0.000 claims description 25
• 125000002524 organometallic group Chemical group 0.000 claims description 24
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 18
• UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 18
• BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims description 18
• DENPQNAWGQXKCU-UHFFFAOYSA-N thiophene-2-carboxamide Chemical compound NC(=O)C1=CC=CS1 DENPQNAWGQXKCU-UHFFFAOYSA-N 0.000 claims description 18
• 125000000217 alkyl group Chemical group 0.000 claims description 17
• 229910052757 nitrogen Inorganic materials 0.000 claims description 17
• ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims description 16
• KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 14
• TVFIYRKPCACCNL-UHFFFAOYSA-N furan-2-carboxamide Chemical compound NC(=O)C1=CC=CO1 TVFIYRKPCACCNL-UHFFFAOYSA-N 0.000 claims description 14
• ZNMIEYHOIRLLES-UHFFFAOYSA-N 5-phenylfuran-2-carboxamide Chemical compound O1C(C(=O)N)=CC=C1C1=CC=CC=C1 ZNMIEYHOIRLLES-UHFFFAOYSA-N 0.000 claims description 12
• DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 12
• 125000000304 alkynyl group Chemical group 0.000 claims description 11
• 208000035475 disorder Diseases 0.000 claims description 11
• 125000003342 alkenyl group Chemical group 0.000 claims description 9
• 238000002360 preparation method Methods 0.000 claims description 9
• YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 8
• 239000003814 drug Substances 0.000 claims description 8
• 229960002715 nicotine Drugs 0.000 claims description 8
• AVRWEULSKHQETA-UHFFFAOYSA-N Thiophene-2 Chemical compound S1C=2CCCCCC=2C(C(=O)OC)=C1NC(=O)C1=C(F)C(F)=C(F)C(F)=C1F AVRWEULSKHQETA-UHFFFAOYSA-N 0.000 claims description 7
• MVAUXTNBWFARSQ-HNNXBMFYSA-N 5-(3-aminophenyl)-n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]furan-2-carboxamide Chemical compound NC1=CC=CC(C=2OC(=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 MVAUXTNBWFARSQ-HNNXBMFYSA-N 0.000 claims description 6
• 125000005392 carboxamide group Chemical group NC(=O)* 0.000 claims description 6
• CYEBJEDOHLIWNP-UHFFFAOYSA-N methanethioamide Chemical group NC=S CYEBJEDOHLIWNP-UHFFFAOYSA-N 0.000 claims description 6
• CRXXTGJTHQIACI-HNNXBMFYSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(3-chlorophenyl)furan-2-carboxamide Chemical compound ClC1=CC=CC(C=2OC(=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 CRXXTGJTHQIACI-HNNXBMFYSA-N 0.000 claims description 6
• LCGCTFJMVXHREJ-HNNXBMFYSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(3-hydroxyphenyl)thiophene-2-carboxamide Chemical compound OC1=CC=CC(C=2SC(=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 LCGCTFJMVXHREJ-HNNXBMFYSA-N 0.000 claims description 6
• 102000005962 receptors Human genes 0.000 claims description 6
• 108020003175 receptors Proteins 0.000 claims description 6
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 5
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 5
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 5
• 229910052794 bromium Inorganic materials 0.000 claims description 5
• 201000010099 disease Diseases 0.000 claims description 5
• 150000002431 hydrogen Chemical class 0.000 claims description 5
• WAQIEMFSGRAXDS-HNNXBMFYSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(4-fluorophenyl)furan-2-carboxamide Chemical compound C1=CC(F)=CC=C1C1=CC=C(C(=O)N[C@@H]2C3CCN(CC3)C2)O1 WAQIEMFSGRAXDS-HNNXBMFYSA-N 0.000 claims description 5
• ZYVHCJHMRMAHSR-HNNXBMFYSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-[3-(trifluoromethyl)phenyl]furan-2-carboxamide Chemical compound FC(F)(F)C1=CC=CC(C=2OC(=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 ZYVHCJHMRMAHSR-HNNXBMFYSA-N 0.000 claims description 5
• FPIGGZJRNAPCBW-AWEZNQCLSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-pyridin-3-ylthiophene-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(S1)=CC=C1C1=CC=CN=C1 FPIGGZJRNAPCBW-AWEZNQCLSA-N 0.000 claims description 5
• GVYLEUINEJZIHU-HNNXBMFYSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-pyridin-3-ylthiophene-3-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(C=1)=CSC=1C1=CC=CN=C1 GVYLEUINEJZIHU-HNNXBMFYSA-N 0.000 claims description 5
• QDWJHUICASOKIN-AWEZNQCLSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-pyridin-4-ylthiophene-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(S1)=CC=C1C1=CC=NC=C1 QDWJHUICASOKIN-AWEZNQCLSA-N 0.000 claims description 5
• FPIGGZJRNAPCBW-CQSZACIVSA-N n-[(3s)-1-azabicyclo[2.2.2]octan-3-yl]-5-pyridin-3-ylthiophene-2-carboxamide Chemical compound N([C@H]1C2CCN(CC2)C1)C(=O)C(S1)=CC=C1C1=CC=CN=C1 FPIGGZJRNAPCBW-CQSZACIVSA-N 0.000 claims description 5
• SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 4
• HPLGXOSWRUEUNI-HNNXBMFYSA-N 5-(3-aminophenyl)-n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]thiophene-2-carboxamide Chemical compound NC1=CC=CC(C=2SC(=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 HPLGXOSWRUEUNI-HNNXBMFYSA-N 0.000 claims description 4
• 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims description 4
• 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 claims description 4
• 208000002193 Pain Diseases 0.000 claims description 4
• 238000004519 manufacturing process Methods 0.000 claims description 4
• QEIXYTUTAQBVGQ-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-4-phenylthiophene-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(SC=1)=CC=1C1=CC=CC=C1 QEIXYTUTAQBVGQ-UHFFFAOYSA-N 0.000 claims description 4
• YXUZRNBUKKHHJQ-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-bromothiophene-2-carboxamide Chemical compound S1C(Br)=CC=C1C(=O)NC1C(CC2)CCN2C1 YXUZRNBUKKHHJQ-UHFFFAOYSA-N 0.000 claims description 4
• OFMXVWXJUWNVGE-JTQLQIEISA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-4-bromothiophene-2-carboxamide Chemical compound BrC1=CSC(C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 OFMXVWXJUWNVGE-JTQLQIEISA-N 0.000 claims description 4
• XKKZIJRJJSXKPX-ZDUSSCGKSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)furan-2-carboxamide Chemical compound CC1=NOC(C)=C1C1=CC=C(C(=O)N[C@@H]2C3CCN(CC3)C2)O1 XKKZIJRJJSXKPX-ZDUSSCGKSA-N 0.000 claims description 4
• OIEAJUFPEQIZHL-HNNXBMFYSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(3-fluorophenyl)furan-2-carboxamide Chemical compound FC1=CC=CC(C=2OC(=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 OIEAJUFPEQIZHL-HNNXBMFYSA-N 0.000 claims description 4
• HRHDJQHTJTVUMB-HNNXBMFYSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(3-nitrophenyl)furan-2-carboxamide Chemical compound [O-][N+](=O)C1=CC=CC(C=2OC(=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 HRHDJQHTJTVUMB-HNNXBMFYSA-N 0.000 claims description 4
• TYPDWKBLNJSIHR-INIZCTEOSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-[3-(hydroxymethyl)phenyl]thiophene-2-carboxamide Chemical compound OCC1=CC=CC(C=2SC(=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 TYPDWKBLNJSIHR-INIZCTEOSA-N 0.000 claims description 4
• LEUSUHAAYXEGAO-HNNXBMFYSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-phenylthiophene-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(S1)=CC=C1C1=CC=CC=C1 LEUSUHAAYXEGAO-HNNXBMFYSA-N 0.000 claims description 4
• UUSSDOJBSVGPEU-AWEZNQCLSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-pyridin-2-ylthiophene-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(S1)=CC=C1C1=CC=CC=N1 UUSSDOJBSVGPEU-AWEZNQCLSA-N 0.000 claims description 4
• LGYGWEZFGJYJBD-AWEZNQCLSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-pyridin-3-ylfuran-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(O1)=CC=C1C1=CC=CN=C1 LGYGWEZFGJYJBD-AWEZNQCLSA-N 0.000 claims description 4
• ZFFGQNHUUBRDTF-LBPRGKRZSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-thiophen-2-ylfuran-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(O1)=CC=C1C1=CC=CS1 ZFFGQNHUUBRDTF-LBPRGKRZSA-N 0.000 claims description 4
• SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 4
• 150000002902 organometallic compounds Chemical class 0.000 claims description 4
• 201000000980 schizophrenia Diseases 0.000 claims description 4
• 230000005586 smoking cessation Effects 0.000 claims description 4
• XPWHBVLUZBCMJY-UHFFFAOYSA-N 5-(3-fluorophenyl)thiophene-2-carboxamide Chemical compound S1C(C(=O)N)=CC=C1C1=CC=CC(F)=C1 XPWHBVLUZBCMJY-UHFFFAOYSA-N 0.000 claims description 3
• GFHNPIHLDMSUBY-UHFFFAOYSA-N 5-(3-methoxyphenyl)furan-2-carboxamide Chemical compound COC1=CC=CC(C=2OC(=CC=2)C(N)=O)=C1 GFHNPIHLDMSUBY-UHFFFAOYSA-N 0.000 claims description 3
• JZJSJLYCLODZGT-INIZCTEOSA-N 5-[3-(aminomethyl)phenyl]-n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]thiophene-2-carboxamide Chemical compound NCC1=CC=CC(C=2SC(=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 JZJSJLYCLODZGT-INIZCTEOSA-N 0.000 claims description 3
• ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 3
• 208000024827 Alzheimer disease Diseases 0.000 claims description 3
• 208000000044 Amnesia Diseases 0.000 claims description 3
• 208000019901 Anxiety disease Diseases 0.000 claims description 3
• 208000028698 Cognitive impairment Diseases 0.000 claims description 3
• 208000026139 Memory disease Diseases 0.000 claims description 3
• 230000036506 anxiety Effects 0.000 claims description 3
• 230000001713 cholinergic effect Effects 0.000 claims description 3
• 208000010877 cognitive disease Diseases 0.000 claims description 3
• 206010009887 colitis Diseases 0.000 claims description 3
• 230000002757 inflammatory effect Effects 0.000 claims description 3
• 239000011630 iodine Substances 0.000 claims description 3
• 229910052740 iodine Inorganic materials 0.000 claims description 3
• 230000006984 memory degeneration Effects 0.000 claims description 3
• 208000023060 memory loss Diseases 0.000 claims description 3
• UWKVRXHHKRDKTN-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(3-formylphenyl)thiophene-2-carboxamide Chemical compound O=CC1=CC=CC(C=2SC(=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 UWKVRXHHKRDKTN-UHFFFAOYSA-N 0.000 claims description 3
• JEAHJLXHLCBPED-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-bromothiophene-3-carboxamide Chemical compound S1C(Br)=CC(C(=O)NC2C3CCN(CC3)C2)=C1 JEAHJLXHLCBPED-UHFFFAOYSA-N 0.000 claims description 3
• DUMIUMCPYFQUAA-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-naphthalen-2-ylfuran-2-carboxamide Chemical compound C1=CC=CC2=CC(C3=CC=C(O3)C(NC3C4CCN(CC4)C3)=O)=CC=C21 DUMIUMCPYFQUAA-UHFFFAOYSA-N 0.000 claims description 3
• UUSSDOJBSVGPEU-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-pyridin-2-ylthiophene-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(S1)=CC=C1C1=CC=CC=N1 UUSSDOJBSVGPEU-UHFFFAOYSA-N 0.000 claims description 3
• CENIOWYLMHMVTC-KRWDZBQOSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-3-thiophen-3-ylbenzamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(C=1)=CC=CC=1C=1C=CSC=1 CENIOWYLMHMVTC-KRWDZBQOSA-N 0.000 claims description 3
• QEIXYTUTAQBVGQ-INIZCTEOSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-4-phenylthiophene-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(SC=1)=CC=1C1=CC=CC=C1 QEIXYTUTAQBVGQ-INIZCTEOSA-N 0.000 claims description 3
• XGBYUOBPRHUNDX-ZDUSSCGKSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)thiophene-2-carboxamide Chemical compound CC1=NOC(C)=C1C1=CC=C(C(=O)N[C@@H]2C3CCN(CC3)C2)S1 XGBYUOBPRHUNDX-ZDUSSCGKSA-N 0.000 claims description 3
• FZDZHQNLYQWDSJ-INIZCTEOSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(3-cyanophenyl)thiophene-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(S1)=CC=C1C1=CC=CC(C#N)=C1 FZDZHQNLYQWDSJ-INIZCTEOSA-N 0.000 claims description 3
• PJOONCNDVDQBAH-KRWDZBQOSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(3-ethoxyphenyl)thiophene-2-carboxamide Chemical compound CCOC1=CC=CC(C=2SC(=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 PJOONCNDVDQBAH-KRWDZBQOSA-N 0.000 claims description 3
• FEKRXODBAGHYRA-INIZCTEOSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(3-methoxyphenyl)furan-2-carboxamide Chemical compound COC1=CC=CC(C=2OC(=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 FEKRXODBAGHYRA-INIZCTEOSA-N 0.000 claims description 3
• BJVYZNULTKTECP-ZDUSSCGKSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(furan-3-yl)furan-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(O1)=CC=C1C=1C=COC=1 BJVYZNULTKTECP-ZDUSSCGKSA-N 0.000 claims description 3
• DUMIUMCPYFQUAA-IBGZPJMESA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-naphthalen-2-ylfuran-2-carboxamide Chemical compound C1=CC=CC2=CC(C3=CC=C(O3)C(N[C@@H]3C4CCN(CC4)C3)=O)=CC=C21 DUMIUMCPYFQUAA-IBGZPJMESA-N 0.000 claims description 3
• XXXRVCPQJSWEIQ-HNNXBMFYSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-phenylfuran-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(O1)=CC=C1C1=CC=CC=C1 XXXRVCPQJSWEIQ-HNNXBMFYSA-N 0.000 claims description 3
• NKPRIPDEFRADKU-INIZCTEOSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-phenylthiophene-3-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(C=1)=CSC=1C1=CC=CC=C1 NKPRIPDEFRADKU-INIZCTEOSA-N 0.000 claims description 3
• KMILHXLZVLODQX-AWEZNQCLSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-pyridin-2-ylfuran-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(O1)=CC=C1C1=CC=CC=N1 KMILHXLZVLODQX-AWEZNQCLSA-N 0.000 claims description 3
• FMOHTJWWZYDUKQ-AWEZNQCLSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-pyridin-4-ylfuran-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(O1)=CC=C1C1=CC=NC=C1 FMOHTJWWZYDUKQ-AWEZNQCLSA-N 0.000 claims description 3
• YDOOADJCFORQJS-KRWDZBQOSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-quinolin-8-ylthiophene-2-carboxamide Chemical compound C1=CN=C2C(C3=CC=C(S3)C(N[C@@H]3C4CCN(CC4)C3)=O)=CC=CC2=C1 YDOOADJCFORQJS-KRWDZBQOSA-N 0.000 claims description 3
• LEUSUHAAYXEGAO-OAHLLOKOSA-N n-[(3s)-1-azabicyclo[2.2.2]octan-3-yl]-5-phenylthiophene-2-carboxamide Chemical compound N([C@H]1C2CCN(CC2)C1)C(=O)C(S1)=CC=C1C1=CC=CC=C1 LEUSUHAAYXEGAO-OAHLLOKOSA-N 0.000 claims description 3
• UUSSDOJBSVGPEU-CQSZACIVSA-N n-[(3s)-1-azabicyclo[2.2.2]octan-3-yl]-5-pyridin-2-ylthiophene-2-carboxamide Chemical compound N([C@H]1C2CCN(CC2)C1)C(=O)C(S1)=CC=C1C1=CC=CC=N1 UUSSDOJBSVGPEU-CQSZACIVSA-N 0.000 claims description 3
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 3
• 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 2
• 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 2
• ONRPCVPDQHMEQB-KRWDZBQOSA-N 5-(3-acetamidophenyl)-n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]thiophene-2-carboxamide Chemical compound CC(=O)NC1=CC=CC(C=2SC(=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 ONRPCVPDQHMEQB-KRWDZBQOSA-N 0.000 claims description 2
• MVAUXTNBWFARSQ-UHFFFAOYSA-N 5-(3-aminophenyl)-n-(1-azabicyclo[2.2.2]octan-3-yl)furan-2-carboxamide Chemical compound NC1=CC=CC(C=2OC(=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 MVAUXTNBWFARSQ-UHFFFAOYSA-N 0.000 claims description 2
• HPLGXOSWRUEUNI-UHFFFAOYSA-N 5-(3-aminophenyl)-n-(1-azabicyclo[2.2.2]octan-3-yl)thiophene-2-carboxamide Chemical compound NC1=CC=CC(C=2SC(=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 HPLGXOSWRUEUNI-UHFFFAOYSA-N 0.000 claims description 2
• BGMHDSJCHLEOMY-UHFFFAOYSA-N 5-(3-ethoxyphenyl)thiophene-2-carboxamide Chemical compound CCOC1=CC=CC(C=2SC(=CC=2)C(N)=O)=C1 BGMHDSJCHLEOMY-UHFFFAOYSA-N 0.000 claims description 2
• FPASADMLLORPAS-UHFFFAOYSA-N 5-(3-nitrophenyl)furan-2-carboxamide Chemical compound O1C(C(=O)N)=CC=C1C1=CC=CC([N+]([O-])=O)=C1 FPASADMLLORPAS-UHFFFAOYSA-N 0.000 claims description 2
• JZJSJLYCLODZGT-UHFFFAOYSA-N 5-[3-(aminomethyl)phenyl]-n-(1-azabicyclo[2.2.2]octan-3-yl)thiophene-2-carboxamide Chemical compound NCC1=CC=CC(C=2SC(=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 JZJSJLYCLODZGT-UHFFFAOYSA-N 0.000 claims description 2
• SSKSCYLZSWSPFB-UHFFFAOYSA-N 5-phenoxythiophene-2-carboxamide Chemical compound S1C(C(=O)N)=CC=C1OC1=CC=CC=C1 SSKSCYLZSWSPFB-UHFFFAOYSA-N 0.000 claims description 2
• BPSZHKPVINNIBN-UHFFFAOYSA-N 5-pyridin-2-ylthiophene-2-carboxamide Chemical compound S1C(C(=O)N)=CC=C1C1=CC=CC=N1 BPSZHKPVINNIBN-UHFFFAOYSA-N 0.000 claims description 2
• 208000020925 Bipolar disease Diseases 0.000 claims description 2
• 206010012289 Dementia Diseases 0.000 claims description 2
• MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 2
• 208000023105 Huntington disease Diseases 0.000 claims description 2
• 206010026749 Mania Diseases 0.000 claims description 2
• 206010057852 Nicotine dependence Diseases 0.000 claims description 2
• 208000018737 Parkinson disease Diseases 0.000 claims description 2
• 206010037211 Psychomotor hyperactivity Diseases 0.000 claims description 2
• 208000025569 Tobacco Use disease Diseases 0.000 claims description 2
• 208000000323 Tourette Syndrome Diseases 0.000 claims description 2
• 208000016620 Tourette disease Diseases 0.000 claims description 2
• 208000028683 bipolar I disease Diseases 0.000 claims description 2
• KIFFOBXBQBZBPM-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-3-(2-methoxyphenyl)benzamide Chemical compound COC1=CC=CC=C1C1=CC=CC(C(=O)NC2C3CCN(CC3)C2)=C1 KIFFOBXBQBZBPM-UHFFFAOYSA-N 0.000 claims description 2
• BHVNSJHUVOVCMX-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-3-(3-fluorophenyl)benzamide Chemical compound FC1=CC=CC(C=2C=C(C=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 BHVNSJHUVOVCMX-UHFFFAOYSA-N 0.000 claims description 2
• UVLJDZIZYSDTKE-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-3-(3-methoxyphenyl)benzamide Chemical compound COC1=CC=CC(C=2C=C(C=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 UVLJDZIZYSDTKE-UHFFFAOYSA-N 0.000 claims description 2
• VTRZFLGHZHXPNK-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-3-(3-methylphenyl)benzamide Chemical compound CC1=CC=CC(C=2C=C(C=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 VTRZFLGHZHXPNK-UHFFFAOYSA-N 0.000 claims description 2
• CLUDFFGNGQDYJV-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-3-(4-fluorophenyl)benzamide Chemical compound C1=CC(F)=CC=C1C1=CC=CC(C(=O)NC2C3CCN(CC3)C2)=C1 CLUDFFGNGQDYJV-UHFFFAOYSA-N 0.000 claims description 2
• DAWFSECLBKZUHN-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-3-bromobenzamide Chemical compound BrC1=CC=CC(C(=O)NC2C3CCN(CC3)C2)=C1 DAWFSECLBKZUHN-UHFFFAOYSA-N 0.000 claims description 2
• RWRRNEWYRHYZAK-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-3-iodobenzamide Chemical compound IC1=CC=CC(C(=O)NC2C3CCN(CC3)C2)=C1 RWRRNEWYRHYZAK-UHFFFAOYSA-N 0.000 claims description 2
• CAGKKXJJWGYHAV-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-3-naphthalen-2-ylbenzamide Chemical compound C1=CC=CC2=CC(C=3C=CC=C(C=3)C(NC3C4CCN(CC4)C3)=O)=CC=C21 CAGKKXJJWGYHAV-UHFFFAOYSA-N 0.000 claims description 2
• MQDUBMOSAYRTMJ-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-3-phenylbenzamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(C=1)=CC=CC=1C1=CC=CC=C1 MQDUBMOSAYRTMJ-UHFFFAOYSA-N 0.000 claims description 2
• GLNKFTQXNCWCSJ-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-3-pyridin-3-ylbenzamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(C=1)=CC=CC=1C1=CC=CN=C1 GLNKFTQXNCWCSJ-UHFFFAOYSA-N 0.000 claims description 2
• NWJHCFDCWWUKAS-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-3-thiophen-2-ylbenzamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(C=1)=CC=CC=1C1=CC=CS1 NWJHCFDCWWUKAS-UHFFFAOYSA-N 0.000 claims description 2
• CENIOWYLMHMVTC-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-3-thiophen-3-ylbenzamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(C=1)=CC=CC=1C=1C=CSC=1 CENIOWYLMHMVTC-UHFFFAOYSA-N 0.000 claims description 2
• OOGWQHRFIFVTEZ-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-4-iodobenzamide Chemical compound C1=CC(I)=CC=C1C(=O)NC1C(CC2)CCN2C1 OOGWQHRFIFVTEZ-UHFFFAOYSA-N 0.000 claims description 2
• SORHTMNAVSNZNU-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-4-pyridin-2-ylthiophene-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(SC=1)=CC=1C1=CC=CC=N1 SORHTMNAVSNZNU-UHFFFAOYSA-N 0.000 claims description 2
• CCJXUEWABMMONA-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-4-pyridin-3-ylthiophene-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(SC=1)=CC=1C1=CC=CN=C1 CCJXUEWABMMONA-UHFFFAOYSA-N 0.000 claims description 2
• NDEVYBGGPPDEPG-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-4-pyridin-4-ylthiophene-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(SC=1)=CC=1C1=CC=NC=C1 NDEVYBGGPPDEPG-UHFFFAOYSA-N 0.000 claims description 2
• MUAPAJCASHAKDD-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(2-methoxyphenyl)furan-2-carboxamide Chemical compound COC1=CC=CC=C1C1=CC=C(C(=O)NC2C3CCN(CC3)C2)O1 MUAPAJCASHAKDD-UHFFFAOYSA-N 0.000 claims description 2
• XKKZIJRJJSXKPX-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(3,5-dimethyl-1,2-oxazol-4-yl)furan-2-carboxamide Chemical compound CC1=NOC(C)=C1C1=CC=C(C(=O)NC2C3CCN(CC3)C2)O1 XKKZIJRJJSXKPX-UHFFFAOYSA-N 0.000 claims description 2
• CRXXTGJTHQIACI-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(3-chlorophenyl)furan-2-carboxamide Chemical compound ClC1=CC=CC(C=2OC(=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 CRXXTGJTHQIACI-UHFFFAOYSA-N 0.000 claims description 2
• FZDZHQNLYQWDSJ-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(3-cyanophenyl)thiophene-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(S1)=CC=C1C1=CC=CC(C#N)=C1 FZDZHQNLYQWDSJ-UHFFFAOYSA-N 0.000 claims description 2
• PJOONCNDVDQBAH-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(3-ethoxyphenyl)thiophene-2-carboxamide Chemical compound CCOC1=CC=CC(C=2SC(=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 PJOONCNDVDQBAH-UHFFFAOYSA-N 0.000 claims description 2
• FEKRXODBAGHYRA-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(3-methoxyphenyl)furan-2-carboxamide Chemical compound COC1=CC=CC(C=2OC(=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 FEKRXODBAGHYRA-UHFFFAOYSA-N 0.000 claims description 2
• GALYCJSQLYPAQX-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(3-methoxyphenyl)thiophene-2-carboxamide Chemical compound COC1=CC=CC(C=2SC(=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 GALYCJSQLYPAQX-UHFFFAOYSA-N 0.000 claims description 2
• RFMVCNKMEMIOTJ-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(3-methylphenyl)furan-2-carboxamide Chemical compound CC1=CC=CC(C=2OC(=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 RFMVCNKMEMIOTJ-UHFFFAOYSA-N 0.000 claims description 2
• HRHDJQHTJTVUMB-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(3-nitrophenyl)furan-2-carboxamide Chemical compound [O-][N+](=O)C1=CC=CC(C=2OC(=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 HRHDJQHTJTVUMB-UHFFFAOYSA-N 0.000 claims description 2
• SXYCOKGWVCJBTB-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(furan-2-yl)furan-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(O1)=CC=C1C1=CC=CO1 SXYCOKGWVCJBTB-UHFFFAOYSA-N 0.000 claims description 2
• BJVYZNULTKTECP-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(furan-3-yl)furan-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(O1)=CC=C1C=1C=COC=1 BJVYZNULTKTECP-UHFFFAOYSA-N 0.000 claims description 2
• OWGIBYSBTRBKPD-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-[3-(dimethylamino)phenyl]furan-2-carboxamide Chemical compound CN(C)C1=CC=CC(C=2OC(=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 OWGIBYSBTRBKPD-UHFFFAOYSA-N 0.000 claims description 2
• TYPDWKBLNJSIHR-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-[3-(hydroxymethyl)phenyl]thiophene-2-carboxamide Chemical compound OCC1=CC=CC(C=2SC(=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 TYPDWKBLNJSIHR-UHFFFAOYSA-N 0.000 claims description 2
• NRTUMYGDHDVGNW-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-bromofuran-2-carboxamide Chemical compound O1C(Br)=CC=C1C(=O)NC1C(CC2)CCN2C1 NRTUMYGDHDVGNW-UHFFFAOYSA-N 0.000 claims description 2
• LEUSUHAAYXEGAO-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-phenylthiophene-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(S1)=CC=C1C1=CC=CC=C1 LEUSUHAAYXEGAO-UHFFFAOYSA-N 0.000 claims description 2
• NKPRIPDEFRADKU-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-phenylthiophene-3-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(C=1)=CSC=1C1=CC=CC=C1 NKPRIPDEFRADKU-UHFFFAOYSA-N 0.000 claims description 2
• KMILHXLZVLODQX-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-pyridin-2-ylfuran-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(O1)=CC=C1C1=CC=CC=N1 KMILHXLZVLODQX-UHFFFAOYSA-N 0.000 claims description 2
• HXCRNIZEZKEKNY-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-pyridin-3-yl-2h-1,3-thiazole-3-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)N(C=1)CSC=1C1=CC=CN=C1 HXCRNIZEZKEKNY-UHFFFAOYSA-N 0.000 claims description 2
• LGYGWEZFGJYJBD-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-pyridin-3-ylfuran-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(O1)=CC=C1C1=CC=CN=C1 LGYGWEZFGJYJBD-UHFFFAOYSA-N 0.000 claims description 2
• GVYLEUINEJZIHU-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-pyridin-3-ylthiophene-3-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(C=1)=CSC=1C1=CC=CN=C1 GVYLEUINEJZIHU-UHFFFAOYSA-N 0.000 claims description 2
• FMOHTJWWZYDUKQ-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-pyridin-4-ylfuran-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(O1)=CC=C1C1=CC=NC=C1 FMOHTJWWZYDUKQ-UHFFFAOYSA-N 0.000 claims description 2
• YDOOADJCFORQJS-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-quinolin-8-ylthiophene-2-carboxamide Chemical compound C1=CN=C2C(C3=CC=C(S3)C(NC3C4CCN(CC4)C3)=O)=CC=CC2=C1 YDOOADJCFORQJS-UHFFFAOYSA-N 0.000 claims description 2
• ZFFGQNHUUBRDTF-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-thiophen-2-ylfuran-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(O1)=CC=C1C1=CC=CS1 ZFFGQNHUUBRDTF-UHFFFAOYSA-N 0.000 claims description 2
• LFGBLTXCNGFMSZ-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-thiophen-3-ylfuran-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(O1)=CC=C1C=1C=CSC=1 LFGBLTXCNGFMSZ-UHFFFAOYSA-N 0.000 claims description 2
• KIFFOBXBQBZBPM-IBGZPJMESA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-3-(2-methoxyphenyl)benzamide Chemical compound COC1=CC=CC=C1C1=CC=CC(C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 KIFFOBXBQBZBPM-IBGZPJMESA-N 0.000 claims description 2
• BHVNSJHUVOVCMX-IBGZPJMESA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-3-(3-fluorophenyl)benzamide Chemical compound FC1=CC=CC(C=2C=C(C=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 BHVNSJHUVOVCMX-IBGZPJMESA-N 0.000 claims description 2
• UVLJDZIZYSDTKE-FQEVSTJZSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-3-(3-methoxyphenyl)benzamide Chemical compound COC1=CC=CC(C=2C=C(C=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 UVLJDZIZYSDTKE-FQEVSTJZSA-N 0.000 claims description 2
• CLUDFFGNGQDYJV-IBGZPJMESA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-3-(4-fluorophenyl)benzamide Chemical compound C1=CC(F)=CC=C1C1=CC=CC(C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 CLUDFFGNGQDYJV-IBGZPJMESA-N 0.000 claims description 2
• CAGKKXJJWGYHAV-QHCPKHFHSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-3-naphthalen-2-ylbenzamide Chemical compound C1=CC=CC2=CC(C=3C=CC=C(C=3)C(N[C@@H]3C4CCN(CC4)C3)=O)=CC=C21 CAGKKXJJWGYHAV-QHCPKHFHSA-N 0.000 claims description 2
• MQDUBMOSAYRTMJ-IBGZPJMESA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-3-phenylbenzamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(C=1)=CC=CC=1C1=CC=CC=C1 MQDUBMOSAYRTMJ-IBGZPJMESA-N 0.000 claims description 2
• GLNKFTQXNCWCSJ-SFHVURJKSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-3-pyridin-3-ylbenzamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(C=1)=CC=CC=1C1=CC=CN=C1 GLNKFTQXNCWCSJ-SFHVURJKSA-N 0.000 claims description 2
• SORHTMNAVSNZNU-HNNXBMFYSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-4-pyridin-2-ylthiophene-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(SC=1)=CC=1C1=CC=CC=N1 SORHTMNAVSNZNU-HNNXBMFYSA-N 0.000 claims description 2
• CCJXUEWABMMONA-HNNXBMFYSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-4-pyridin-3-ylthiophene-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(SC=1)=CC=1C1=CC=CN=C1 CCJXUEWABMMONA-HNNXBMFYSA-N 0.000 claims description 2
• NDEVYBGGPPDEPG-HNNXBMFYSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-4-pyridin-4-ylthiophene-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(SC=1)=CC=1C1=CC=NC=C1 NDEVYBGGPPDEPG-HNNXBMFYSA-N 0.000 claims description 2
• MUAPAJCASHAKDD-HNNXBMFYSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(2-methoxyphenyl)furan-2-carboxamide Chemical compound COC1=CC=CC=C1C1=CC=C(C(=O)N[C@@H]2C3CCN(CC3)C2)O1 MUAPAJCASHAKDD-HNNXBMFYSA-N 0.000 claims description 2
• QTGLVGGNFKMBPR-HNNXBMFYSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(3-chlorophenyl)thiophene-2-carboxamide Chemical compound ClC1=CC=CC(C=2SC(=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 QTGLVGGNFKMBPR-HNNXBMFYSA-N 0.000 claims description 2
• GALYCJSQLYPAQX-INIZCTEOSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(3-methoxyphenyl)thiophene-2-carboxamide Chemical compound COC1=CC=CC(C=2SC(=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 GALYCJSQLYPAQX-INIZCTEOSA-N 0.000 claims description 2
• IUYIHWNTJKCXNG-IBGZPJMESA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(3-morpholin-4-ylphenyl)thiophene-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(S1)=CC=C1C(C=1)=CC=CC=1N1CCOCC1 IUYIHWNTJKCXNG-IBGZPJMESA-N 0.000 claims description 2
• SXYCOKGWVCJBTB-LBPRGKRZSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(furan-2-yl)furan-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(O1)=CC=C1C1=CC=CO1 SXYCOKGWVCJBTB-LBPRGKRZSA-N 0.000 claims description 2
• QDWJHUICASOKIN-CQSZACIVSA-N n-[(3s)-1-azabicyclo[2.2.2]octan-3-yl]-5-pyridin-4-ylthiophene-2-carboxamide Chemical compound N([C@H]1C2CCN(CC2)C1)C(=O)C(S1)=CC=C1C1=CC=NC=C1 QDWJHUICASOKIN-CQSZACIVSA-N 0.000 claims description 2
• 208000015122 neurodegenerative disease Diseases 0.000 claims description 2
• 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 2
• 125000002541 furyl group Chemical group 0.000 claims 4
• 125000001544 thienyl group Chemical group 0.000 claims 4
• LJGHYPLBDBRCRZ-UHFFFAOYSA-N 3-(3-aminophenyl)sulfonylaniline Chemical group NC1=CC=CC(S(=O)(=O)C=2C=C(N)C=CC=2)=C1 LJGHYPLBDBRCRZ-UHFFFAOYSA-N 0.000 claims 2
• RQJWFHRUPTYLOV-UHFFFAOYSA-N 5-(3-methylphenyl)furan-2-carboxamide Chemical compound CC1=CC=CC(C=2OC(=CC=2)C(N)=O)=C1 RQJWFHRUPTYLOV-UHFFFAOYSA-N 0.000 claims 2
• 241001661355 Synapsis Species 0.000 claims 2
• 230000004913 activation Effects 0.000 claims 2
• 125000004076 pyridyl group Chemical group 0.000 claims 2
• 125000000335 thiazolyl group Chemical group 0.000 claims 2
• QOYCSQBDTFMQSG-UHFFFAOYSA-N 2-(3-chlorophenyl)thiophene Chemical compound ClC1=CC=CC(C=2SC=CC=2)=C1 QOYCSQBDTFMQSG-UHFFFAOYSA-N 0.000 claims 1
• LMXAPFWFOKHBDS-UHFFFAOYSA-N 2-[3-(trifluoromethyl)phenyl]furan Chemical compound FC(F)(F)C1=CC=CC(C=2OC=CC=2)=C1 LMXAPFWFOKHBDS-UHFFFAOYSA-N 0.000 claims 1
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
• 125000004208 3-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C([H])C(*)=C1[H] 0.000 claims 1
• 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
• 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
• ONRPCVPDQHMEQB-UHFFFAOYSA-N 5-(3-acetamidophenyl)-n-(1-azabicyclo[2.2.2]octan-3-yl)thiophene-2-carboxamide Chemical compound CC(=O)NC1=CC=CC(C=2SC(=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 ONRPCVPDQHMEQB-UHFFFAOYSA-N 0.000 claims 1
• VAUBKXFQQWAVRK-UHFFFAOYSA-N 5-(3-methoxyphenyl)thiophene-2-carboxamide Chemical compound COC1=CC=CC(C=2SC(=CC=2)C(N)=O)=C1 VAUBKXFQQWAVRK-UHFFFAOYSA-N 0.000 claims 1
• XTPWJBLYVBMEQX-UHFFFAOYSA-N 5-(4-chlorophenyl)furan-2-carboxamide Chemical compound O1C(C(=O)N)=CC=C1C1=CC=C(Cl)C=C1 XTPWJBLYVBMEQX-UHFFFAOYSA-N 0.000 claims 1
• 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
• 206010012335 Dependence Diseases 0.000 claims 1
• 208000009829 Lewy Body Disease Diseases 0.000 claims 1
• 201000002832 Lewy body dementia Diseases 0.000 claims 1
• 125000003047 N-acetyl group Chemical group 0.000 claims 1
• WTUHRGRJMXKQOM-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-3-(3,5-dichlorophenyl)benzamide Chemical compound ClC1=CC(Cl)=CC(C=2C=C(C=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 WTUHRGRJMXKQOM-UHFFFAOYSA-N 0.000 claims 1
• XGBYUOBPRHUNDX-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(3,5-dimethyl-1,2-oxazol-4-yl)thiophene-2-carboxamide Chemical compound CC1=NOC(C)=C1C1=CC=C(C(=O)NC2C3CCN(CC3)C2)S1 XGBYUOBPRHUNDX-UHFFFAOYSA-N 0.000 claims 1
• OIEAJUFPEQIZHL-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(3-fluorophenyl)furan-2-carboxamide Chemical compound FC1=CC=CC(C=2OC(=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 OIEAJUFPEQIZHL-UHFFFAOYSA-N 0.000 claims 1
• WUKDHJGFJBQDAY-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(3-fluorophenyl)thiophene-2-carboxamide Chemical compound FC1=CC=CC(C=2SC(=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 WUKDHJGFJBQDAY-UHFFFAOYSA-N 0.000 claims 1
• PFKKVUBNDMRQFB-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(4-chlorophenyl)furan-2-carboxamide Chemical compound C1=CC(Cl)=CC=C1C1=CC=C(C(=O)NC2C3CCN(CC3)C2)O1 PFKKVUBNDMRQFB-UHFFFAOYSA-N 0.000 claims 1
• WAQIEMFSGRAXDS-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(4-fluorophenyl)furan-2-carboxamide Chemical compound C1=CC(F)=CC=C1C1=CC=C(C(=O)NC2C3CCN(CC3)C2)O1 WAQIEMFSGRAXDS-UHFFFAOYSA-N 0.000 claims 1
• RIYNGPMSCLNGPX-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-phenoxythiophene-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(S1)=CC=C1OC1=CC=CC=C1 RIYNGPMSCLNGPX-UHFFFAOYSA-N 0.000 claims 1
• XHIBZIFIARCBMN-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-pyridin-4-yl-2h-1,3-thiazole-3-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)N(C=1)CSC=1C1=CC=NC=C1 XHIBZIFIARCBMN-UHFFFAOYSA-N 0.000 claims 1
• VTRZFLGHZHXPNK-FQEVSTJZSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-3-(3-methylphenyl)benzamide Chemical compound CC1=CC=CC(C=2C=C(C=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 VTRZFLGHZHXPNK-FQEVSTJZSA-N 0.000 claims 1
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract description 16
• 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract description 2
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
• 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
• 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
• 101100516563 Caenorhabditis elegans nhr-6 gene Proteins 0.000 abstract 1
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 219
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 198
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 183
• DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 130
• 239000000243 solution Substances 0.000 description 112
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 104
• 239000000203 mixture Substances 0.000 description 104
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 100
• NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 100
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 98
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 96
• 239000003480 eluent Substances 0.000 description 85
• 239000007787 solid Substances 0.000 description 81
• 238000004949 mass spectrometry Methods 0.000 description 80
• XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 78
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 66
• 239000003643 water by type Substances 0.000 description 65
• 238000001704 evaporation Methods 0.000 description 62
• 230000008020 evaporation Effects 0.000 description 61
• ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 56
• 229910000029 sodium carbonate Inorganic materials 0.000 description 49
• 239000002585 base Substances 0.000 description 47
• 238000004007 reversed phase HPLC Methods 0.000 description 46
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 42
• IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 38
• 229910000041 hydrogen chloride Inorganic materials 0.000 description 38
• 239000003446 ligand Substances 0.000 description 32
• KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 30
• JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 28
• VFRSADQPWYCXDG-LEUCUCNGSA-N ethyl (2s,5s)-5-methylpyrrolidine-2-carboxylate;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CCOC(=O)[C@@H]1CC[C@H](C)N1 VFRSADQPWYCXDG-LEUCUCNGSA-N 0.000 description 27
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 25
• XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 24
• 238000001953 recrystallisation Methods 0.000 description 23
• QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 22
• 239000000543 intermediate Substances 0.000 description 22
• 239000002253 acid Substances 0.000 description 21
• MFRIHAYPQRLWNB-UHFFFAOYSA-N sodium tert-butoxide Chemical compound [Na+].CC(C)(C)[O-] MFRIHAYPQRLWNB-UHFFFAOYSA-N 0.000 description 20
• NRTUMYGDHDVGNW-VIFPVBQESA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-bromofuran-2-carboxamide Chemical compound O1C(Br)=CC=C1C(=O)N[C@@H]1C(CC2)CCN2C1 NRTUMYGDHDVGNW-VIFPVBQESA-N 0.000 description 19
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
• YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 18
• 239000012442 inert solvent Substances 0.000 description 18
• 238000004366 reverse phase liquid chromatography Methods 0.000 description 16
• RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 15
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 15
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 15
• YXUZRNBUKKHHJQ-VIFPVBQESA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-bromothiophene-2-carboxamide Chemical compound S1C(Br)=CC=C1C(=O)N[C@@H]1C(CC2)CCN2C1 YXUZRNBUKKHHJQ-VIFPVBQESA-N 0.000 description 15
• FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 description 14
• 229910000024 caesium carbonate Inorganic materials 0.000 description 14
• HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical compound OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 description 14
• 239000000741 silica gel Substances 0.000 description 14
• 229910002027 silica gel Inorganic materials 0.000 description 14
• 239000011230 binding agent Substances 0.000 description 13
• 239000004327 boric acid Substances 0.000 description 13
• 235000010338 boric acid Nutrition 0.000 description 13
• 238000004090 dissolution Methods 0.000 description 13
• 238000003818 flash chromatography Methods 0.000 description 13
• 239000004615 ingredient Substances 0.000 description 13
• 229910052763 palladium Inorganic materials 0.000 description 13
• CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 12
• 230000010933 acylation Effects 0.000 description 12
• 238000005917 acylation reaction Methods 0.000 description 12
• 239000003153 chemical reaction reagent Substances 0.000 description 12
• DAWFSECLBKZUHN-ZDUSSCGKSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-3-bromobenzamide Chemical compound BrC1=CC=CC(C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 DAWFSECLBKZUHN-ZDUSSCGKSA-N 0.000 description 12
• 229910000073 phosphorus hydride Inorganic materials 0.000 description 12
• RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 12
• 150000001408 amides Chemical class 0.000 description 11
• 239000004210 ether based solvent Substances 0.000 description 11
• SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 10
• CBHOOMGKXCMKIR-UHFFFAOYSA-N azane;methanol Chemical compound N.OC CBHOOMGKXCMKIR-UHFFFAOYSA-N 0.000 description 10
• 229920006395 saturated elastomer Polymers 0.000 description 10
• 229960000583 acetic acid Drugs 0.000 description 9
• 239000010410 layer Substances 0.000 description 9
• 239000011541 reaction mixture Substances 0.000 description 9
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
• 238000001035 drying Methods 0.000 description 8
• ZCSHNCUQKCANBX-UHFFFAOYSA-N lithium diisopropylamide Chemical compound [Li+].CC(C)[N-]C(C)C ZCSHNCUQKCANBX-UHFFFAOYSA-N 0.000 description 8
• 238000002414 normal-phase solid-phase extraction Methods 0.000 description 8
• BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 8
• 229910052783 alkali metal Inorganic materials 0.000 description 7
• SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 7
• 238000010438 heat treatment Methods 0.000 description 7
• 238000012360 testing method Methods 0.000 description 7
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
• 239000007983 Tris buffer Substances 0.000 description 6
• 230000029936 alkylation Effects 0.000 description 6
• 238000005804 alkylation reaction Methods 0.000 description 6
• WMKGGPCROCCUDY-PHEQNACWSA-N dibenzylideneacetone Chemical compound C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1 WMKGGPCROCCUDY-PHEQNACWSA-N 0.000 description 6
• 238000001914 filtration Methods 0.000 description 6
• 229910052943 magnesium sulfate Inorganic materials 0.000 description 6
• 235000019341 magnesium sulphate Nutrition 0.000 description 6
• VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
• XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 description 6
• 239000000376 reactant Substances 0.000 description 6
• 238000010992 reflux Methods 0.000 description 6
• PJUPKRYGDFTMTM-UHFFFAOYSA-N 1-hydroxybenzotriazole;hydrate Chemical compound O.C1=CC=C2N(O)N=NC2=C1 PJUPKRYGDFTMTM-UHFFFAOYSA-N 0.000 description 5
• FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 5
• QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 5
• 150000001298 alcohols Chemical class 0.000 description 5
• 230000027455 binding Effects 0.000 description 5
• KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 5
• 125000005619 boric acid group Chemical class 0.000 description 5
• 150000001718 carbodiimides Chemical class 0.000 description 5
• CXQRZKIIGJLWPJ-UHFFFAOYSA-N diphenylphosphane;1-naphthalen-1-ylnaphthalene Chemical group C=1C=CC=CC=1PC1=CC=CC=C1.C1=CC=C2C(C=3C4=CC=CC=C4C=CC=3)=CC=CC2=C1 CXQRZKIIGJLWPJ-UHFFFAOYSA-N 0.000 description 5
• GPAYUJZHTULNBE-UHFFFAOYSA-N diphenylphosphine Chemical compound C=1C=CC=CC=1PC1=CC=CC=C1 GPAYUJZHTULNBE-UHFFFAOYSA-N 0.000 description 5
• 239000000284 extract Substances 0.000 description 5
• 239000012458 free base Substances 0.000 description 5
• NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 5
• 229930182840 (S)-nicotine Natural products 0.000 description 4
• 239000004215 Carbon black (E152) Substances 0.000 description 4
• 150000007513 acids Chemical class 0.000 description 4
• RQPZNWPYLFFXCP-UHFFFAOYSA-L barium dihydroxide Chemical compound [OH-].[OH-].[Ba+2] RQPZNWPYLFFXCP-UHFFFAOYSA-L 0.000 description 4
• 229910001863 barium hydroxide Inorganic materials 0.000 description 4
• 239000003795 chemical substances by application Substances 0.000 description 4
• 238000004587 chromatography analysis Methods 0.000 description 4
• 239000003085 diluting agent Substances 0.000 description 4
• KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 description 4
• 238000004128 high performance liquid chromatography Methods 0.000 description 4
• 229930195733 hydrocarbon Natural products 0.000 description 4
• 150000002430 hydrocarbons Chemical class 0.000 description 4
• 229910052744 lithium Inorganic materials 0.000 description 4
• YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical compound [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 description 4
• 229910000027 potassium carbonate Inorganic materials 0.000 description 4
• LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 4
• ABMYEXAYWZJVOV-UHFFFAOYSA-N pyridin-3-ylboronic acid Chemical compound OB(O)C1=CC=CN=C1 ABMYEXAYWZJVOV-UHFFFAOYSA-N 0.000 description 4
• NLLGFYPSWCMUIV-UHFFFAOYSA-N (3-methoxyphenyl)boronic acid Chemical compound COC1=CC=CC(B(O)O)=C1 NLLGFYPSWCMUIV-UHFFFAOYSA-N 0.000 description 3
• IBXMKLPFLZYRQZ-UHFFFAOYSA-N 1,5-diphenylpenta-1,4-dien-3-one;palladium Chemical compound [Pd].[Pd].C=1C=CC=CC=1C=CC(=O)C=CC1=CC=CC=C1 IBXMKLPFLZYRQZ-UHFFFAOYSA-N 0.000 description 3
• STZHBULOYDCZET-UHFFFAOYSA-N 1-azabicyclo[2.2.2]octan-3-amine;hydron;dichloride Chemical compound Cl.Cl.C1CC2C(N)CN1CC2 STZHBULOYDCZET-UHFFFAOYSA-N 0.000 description 3
• VZXAJUCWNRKHTL-UHFFFAOYSA-N 5-(4-fluorophenyl)furan-2-carboxamide Chemical compound O1C(C(=O)N)=CC=C1C1=CC=C(F)C=C1 VZXAJUCWNRKHTL-UHFFFAOYSA-N 0.000 description 3
• RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
• 229910021595 Copper(I) iodide Inorganic materials 0.000 description 3
• VMQMZMRVKUZKQL-UHFFFAOYSA-N Cu+ Chemical class [Cu+] VMQMZMRVKUZKQL-UHFFFAOYSA-N 0.000 description 3
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
• 239000000556 agonist Substances 0.000 description 3
• 229910000288 alkali metal carbonate Inorganic materials 0.000 description 3
• 150000008041 alkali metal carbonates Chemical class 0.000 description 3
• 150000001412 amines Chemical class 0.000 description 3
• 239000007864 aqueous solution Substances 0.000 description 3
• 229910052802 copper Inorganic materials 0.000 description 3
• 239000010949 copper Substances 0.000 description 3
• LSXDOTMGLUJQCM-UHFFFAOYSA-M copper(i) iodide Chemical compound I[Cu] LSXDOTMGLUJQCM-UHFFFAOYSA-M 0.000 description 3
• 229940079593 drug Drugs 0.000 description 3
• 125000000524 functional group Chemical group 0.000 description 3
• 230000007062 hydrolysis Effects 0.000 description 3
• 238000006460 hydrolysis reaction Methods 0.000 description 3
• 239000012528 membrane Substances 0.000 description 3
• RIYNGPMSCLNGPX-HNNXBMFYSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-phenoxythiophene-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(S1)=CC=C1OC1=CC=CC=C1 RIYNGPMSCLNGPX-HNNXBMFYSA-N 0.000 description 3
• 239000012299 nitrogen atmosphere Substances 0.000 description 3
• 230000008569 process Effects 0.000 description 3
• 239000012279 sodium borohydride Substances 0.000 description 3
• 229910000033 sodium borohydride Inorganic materials 0.000 description 3
• BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 3
• 238000006467 substitution reaction Methods 0.000 description 3
• 238000003786 synthesis reaction Methods 0.000 description 3
• ROEQGIFOWRQYHD-UHFFFAOYSA-N (2-methoxyphenyl)boronic acid Chemical compound COC1=CC=CC=C1B(O)O ROEQGIFOWRQYHD-UHFFFAOYSA-N 0.000 description 2
• SDEAGACSNFSZCU-UHFFFAOYSA-N (3-chlorophenyl)boronic acid Chemical compound OB(O)C1=CC=CC(Cl)=C1 SDEAGACSNFSZCU-UHFFFAOYSA-N 0.000 description 2
• KNXQDJCZSVHEIW-UHFFFAOYSA-N (3-fluorophenyl)boronic acid Chemical compound OB(O)C1=CC=CC(F)=C1 KNXQDJCZSVHEIW-UHFFFAOYSA-N 0.000 description 2
• BJQCPCFFYBKRLM-UHFFFAOYSA-N (3-methylphenyl)boronic acid Chemical compound CC1=CC=CC(B(O)O)=C1 BJQCPCFFYBKRLM-UHFFFAOYSA-N 0.000 description 2
• JOJCFDCFBVAXRD-UHFFFAOYSA-N 3-(3-methylphenyl)benzamide Chemical compound CC1=CC=CC(C=2C=C(C=CC=2)C(N)=O)=C1 JOJCFDCFBVAXRD-UHFFFAOYSA-N 0.000 description 2
• CUYKNJBYIJFRCU-UHFFFAOYSA-N 3-aminopyridine Chemical compound NC1=CC=CN=C1 CUYKNJBYIJFRCU-UHFFFAOYSA-N 0.000 description 2
• HJZFPRVFLBBAMU-UHFFFAOYSA-N 4-bromothiophene-2-carboxylic acid Chemical compound OC(=O)C1=CC(Br)=CS1 HJZFPRVFLBBAMU-UHFFFAOYSA-N 0.000 description 2
• LBUNNMJLXWQQBY-UHFFFAOYSA-N 4-fluorophenylboronic acid Chemical compound OB(O)C1=CC=C(F)C=C1 LBUNNMJLXWQQBY-UHFFFAOYSA-N 0.000 description 2
• COWZPSUDTMGBAT-UHFFFAOYSA-N 5-bromothiophene-2-carboxylic acid Chemical compound OC(=O)C1=CC=C(Br)S1 COWZPSUDTMGBAT-UHFFFAOYSA-N 0.000 description 2
• YCNXGPMGMAKDPM-UHFFFAOYSA-N 5-bromothiophene-3-carboxylic acid Chemical compound OC(=O)C1=CSC(Br)=C1 YCNXGPMGMAKDPM-UHFFFAOYSA-N 0.000 description 2
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
• LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
• YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
• CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
• 229920002873 Polyethylenimine Polymers 0.000 description 2
• VKCLPVFDVVKEKU-UHFFFAOYSA-N S=[P] Chemical class S=[P] VKCLPVFDVVKEKU-UHFFFAOYSA-N 0.000 description 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
• WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 2
• UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 2
• ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 2
• WGLPBDUCMAPZCE-UHFFFAOYSA-N Trioxochromium Chemical compound O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 description 2
• 239000003377 acid catalyst Substances 0.000 description 2
• 125000003277 amino group Chemical group 0.000 description 2
• 125000006615 aromatic heterocyclic group Chemical group 0.000 description 2
• 150000004945 aromatic hydrocarbons Chemical class 0.000 description 2
• 239000003849 aromatic solvent Substances 0.000 description 2
• 238000003556 assay Methods 0.000 description 2
• 239000012298 atmosphere Substances 0.000 description 2
• 230000008901 benefit Effects 0.000 description 2
• 229940098773 bovine serum albumin Drugs 0.000 description 2
• 210000004027 cell Anatomy 0.000 description 2
• 239000003638 chemical reducing agent Substances 0.000 description 2
• 238000007796 conventional method Methods 0.000 description 2
• 239000012954 diazonium Substances 0.000 description 2
• 150000001989 diazonium salts Chemical class 0.000 description 2
• 238000000605 extraction Methods 0.000 description 2
• 239000003365 glass fiber Substances 0.000 description 2
• 230000002140 halogenating effect Effects 0.000 description 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
• 239000008101 lactose Substances 0.000 description 2
• KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 2
• JMZFEHDNIAQMNB-UHFFFAOYSA-N m-aminophenylboronic acid Chemical compound NC1=CC=CC(B(O)O)=C1 JMZFEHDNIAQMNB-UHFFFAOYSA-N 0.000 description 2
• OFMXVWXJUWNVGE-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-4-bromothiophene-2-carboxamide Chemical compound BrC1=CSC(C(=O)NC2C3CCN(CC3)C2)=C1 OFMXVWXJUWNVGE-UHFFFAOYSA-N 0.000 description 2
• LIPAWTBPKLAATH-HNNXBMFYSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(1-benzofuran-2-yl)furan-2-carboxamide Chemical compound C1=CC=C2OC(C3=CC=C(O3)C(N[C@@H]3C4CCN(CC4)C3)=O)=CC2=C1 LIPAWTBPKLAATH-HNNXBMFYSA-N 0.000 description 2
• WUKDHJGFJBQDAY-HNNXBMFYSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(3-fluorophenyl)thiophene-2-carboxamide Chemical compound FC1=CC=CC(C=2SC(=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 WUKDHJGFJBQDAY-HNNXBMFYSA-N 0.000 description 2
• RFMVCNKMEMIOTJ-INIZCTEOSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(3-methylphenyl)furan-2-carboxamide Chemical compound CC1=CC=CC(C=2OC(=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 RFMVCNKMEMIOTJ-INIZCTEOSA-N 0.000 description 2
• YXUZRNBUKKHHJQ-SECBINFHSA-N n-[(3s)-1-azabicyclo[2.2.2]octan-3-yl]-5-bromothiophene-2-carboxamide Chemical compound S1C(Br)=CC=C1C(=O)N[C@H]1C(CC2)CCN2C1 YXUZRNBUKKHHJQ-SECBINFHSA-N 0.000 description 2
• 230000009871 nonspecific binding Effects 0.000 description 2
• 230000000269 nucleophilic effect Effects 0.000 description 2
• 239000012044 organic layer Substances 0.000 description 2
• 230000000144 pharmacologic effect Effects 0.000 description 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
• 125000006239 protecting group Chemical group 0.000 description 2
• 238000000746 purification Methods 0.000 description 2
• 229910052708 sodium Inorganic materials 0.000 description 2
• 239000011734 sodium Substances 0.000 description 2
• 230000009870 specific binding Effects 0.000 description 2
• 238000003756 stirring Methods 0.000 description 2
• 230000001225 therapeutic effect Effects 0.000 description 2
• 150000003568 thioethers Chemical class 0.000 description 2
• 230000009466 transformation Effects 0.000 description 2
• WJKHJLXJJJATHN-UHFFFAOYSA-N triflic anhydride Chemical compound FC(F)(F)S(=O)(=O)OS(=O)(=O)C(F)(F)F WJKHJLXJJJATHN-UHFFFAOYSA-N 0.000 description 2
• 125000005500 uronium group Chemical group 0.000 description 2
• 238000001291 vacuum drying Methods 0.000 description 2
• 239000008096 xylene Substances 0.000 description 2
• JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
• KYLUAQBYONVMCP-UHFFFAOYSA-N (2-methylphenyl)phosphane Chemical compound CC1=CC=CC=C1P KYLUAQBYONVMCP-UHFFFAOYSA-N 0.000 description 1
• DKYRKAIKWFHQHM-UHFFFAOYSA-N (3,5-dichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=CC(Cl)=C1 DKYRKAIKWFHQHM-UHFFFAOYSA-N 0.000 description 1
• XDBHWPLGGBLUHH-UHFFFAOYSA-N (3-cyanophenyl)boronic acid Chemical compound OB(O)C1=CC=CC(C#N)=C1 XDBHWPLGGBLUHH-UHFFFAOYSA-N 0.000 description 1
• HJBGZJMKTOMQRR-UHFFFAOYSA-N (3-formylphenyl)boronic acid Chemical compound OB(O)C1=CC=CC(C=O)=C1 HJBGZJMKTOMQRR-UHFFFAOYSA-N 0.000 description 1
• PZXHYHVAVDOMOR-UHFFFAOYSA-N (3-thiophen-2-ylphenyl)methanamine Chemical compound NCC1=CC=CC(C=2SC=CC=2)=C1 PZXHYHVAVDOMOR-UHFFFAOYSA-N 0.000 description 1
• STZHBULOYDCZET-KLXURFKVSA-N (3r)-1-azabicyclo[2.2.2]octan-3-amine;dihydrochloride Chemical compound Cl.Cl.C1CC2[C@@H](N)CN1CC2 STZHBULOYDCZET-KLXURFKVSA-N 0.000 description 1
• 239000001211 (E)-4-phenylbut-3-en-2-one Substances 0.000 description 1
• NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
• UWKQJZCTQGMHKD-UHFFFAOYSA-N 2,6-di-tert-butylpyridine Chemical compound CC(C)(C)C1=CC=CC(C(C)(C)C)=N1 UWKQJZCTQGMHKD-UHFFFAOYSA-N 0.000 description 1
• UOBYKYZJUGYBDK-UHFFFAOYSA-N 2-naphthoic acid Chemical compound C1=CC=CC2=CC(C(=O)O)=CC=C21 UOBYKYZJUGYBDK-UHFFFAOYSA-N 0.000 description 1
• FOQFGMAZUTUELM-UHFFFAOYSA-N 2-pyridin-3-yl-1,3-thiazole-4-carboxylic acid Chemical compound OC(=O)C1=CSC(C=2C=NC=CC=2)=N1 FOQFGMAZUTUELM-UHFFFAOYSA-N 0.000 description 1
• COOQMBOJAAZEIR-UHFFFAOYSA-N 2-pyridin-4-yl-1,3-thiazole-4-carboxylic acid Chemical compound OC(=O)C1=CSC(C=2C=CN=CC=2)=N1 COOQMBOJAAZEIR-UHFFFAOYSA-N 0.000 description 1
• GEOCTVREWZQICJ-UHFFFAOYSA-N 2h-1,3-thiazole-3-carboxamide Chemical compound NC(=O)N1CSC=C1 GEOCTVREWZQICJ-UHFFFAOYSA-N 0.000 description 1
• VRECCXHVXUPDQT-UHFFFAOYSA-N 3-(2-methoxyphenyl)benzamide Chemical compound COC1=CC=CC=C1C1=CC=CC(C(N)=O)=C1 VRECCXHVXUPDQT-UHFFFAOYSA-N 0.000 description 1
• WPAVZFKFZGIJKZ-UHFFFAOYSA-N 3-(3,5-dichlorophenyl)benzamide Chemical compound NC(=O)C1=CC=CC(C=2C=C(Cl)C=C(Cl)C=2)=C1 WPAVZFKFZGIJKZ-UHFFFAOYSA-N 0.000 description 1
• SNALSZMAYDWAJA-UHFFFAOYSA-N 3-(3-fluorophenyl)benzamide Chemical compound NC(=O)C1=CC=CC(C=2C=C(F)C=CC=2)=C1 SNALSZMAYDWAJA-UHFFFAOYSA-N 0.000 description 1
• XOHZBPMRSYEDHU-UHFFFAOYSA-N 3-(3-methoxyphenyl)benzamide Chemical compound COC1=CC=CC(C=2C=C(C=CC=2)C(N)=O)=C1 XOHZBPMRSYEDHU-UHFFFAOYSA-N 0.000 description 1
• JUVULXADAWDDQO-UHFFFAOYSA-N 3-(4-fluorophenyl)benzamide Chemical compound NC(=O)C1=CC=CC(C=2C=CC(F)=CC=2)=C1 JUVULXADAWDDQO-UHFFFAOYSA-N 0.000 description 1
• BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
• ODJFDWIECLJWSR-UHFFFAOYSA-N 3-bromobenzamide Chemical compound NC(=O)C1=CC=CC(Br)=C1 ODJFDWIECLJWSR-UHFFFAOYSA-N 0.000 description 1
• VOIZNVUXCQLQHS-UHFFFAOYSA-N 3-bromobenzoic acid Chemical compound OC(=O)C1=CC=CC(Br)=C1 VOIZNVUXCQLQHS-UHFFFAOYSA-N 0.000 description 1
• MXNBDFWNYRNIBH-UHFFFAOYSA-N 3-fluorobenzoic acid Chemical compound OC(=O)C1=CC=CC(F)=C1 MXNBDFWNYRNIBH-UHFFFAOYSA-N 0.000 description 1
• HEMYUAPEXJWFCP-UHFFFAOYSA-N 3-iodobenzamide Chemical compound NC(=O)C1=CC=CC(I)=C1 HEMYUAPEXJWFCP-UHFFFAOYSA-N 0.000 description 1
• FXJJAMKDEDZECI-UHFFFAOYSA-N 3-naphthalen-2-ylbenzamide Chemical compound NC(=O)C1=CC=CC(C=2C=C3C=CC=CC3=CC=2)=C1 FXJJAMKDEDZECI-UHFFFAOYSA-N 0.000 description 1
• ZNRGSYUVFVNSAW-UHFFFAOYSA-N 3-nitrophenylboronic acid Chemical compound OB(O)C1=CC=CC([N+]([O-])=O)=C1 ZNRGSYUVFVNSAW-UHFFFAOYSA-N 0.000 description 1
• IYZIARNSXPGYSC-UHFFFAOYSA-N 3-phenylbenzamide Chemical compound NC(=O)C1=CC=CC(C=2C=CC=CC=2)=C1 IYZIARNSXPGYSC-UHFFFAOYSA-N 0.000 description 1
• ZRWNRAJCPNLYAK-UHFFFAOYSA-N 4-bromobenzamide Chemical compound NC(=O)C1=CC=C(Br)C=C1 ZRWNRAJCPNLYAK-UHFFFAOYSA-N 0.000 description 1
• TUXYZHVUPGXXQG-UHFFFAOYSA-N 4-bromobenzoic acid Chemical compound OC(=O)C1=CC=C(Br)C=C1 TUXYZHVUPGXXQG-UHFFFAOYSA-N 0.000 description 1
• PDONIKHDXYHTLS-UHFFFAOYSA-N 4-bromothiophene-2-carbaldehyde Chemical compound BrC1=CSC(C=O)=C1 PDONIKHDXYHTLS-UHFFFAOYSA-N 0.000 description 1
• WPIFYCRDSOUHLT-UHFFFAOYSA-N 4-bromothiophene-2-carboxamide Chemical compound NC(=O)C1=CC(Br)=CS1 WPIFYCRDSOUHLT-UHFFFAOYSA-N 0.000 description 1
• XRNBLQCAFWFFPM-UHFFFAOYSA-N 4-iodobenzamide Chemical compound NC(=O)C1=CC=C(I)C=C1 XRNBLQCAFWFFPM-UHFFFAOYSA-N 0.000 description 1
• WPCSAIACUYFJIQ-UHFFFAOYSA-N 5-(2-methoxyphenyl)furan-2-carboxamide Chemical compound COC1=CC=CC=C1C1=CC=C(C(N)=O)O1 WPCSAIACUYFJIQ-UHFFFAOYSA-N 0.000 description 1
• CUZHIOCSRQUJIM-UHFFFAOYSA-N 5-(3-aminophenyl)furan-2-carboxamide Chemical compound O1C(C(=O)N)=CC=C1C1=CC=CC(N)=C1 CUZHIOCSRQUJIM-UHFFFAOYSA-N 0.000 description 1
• XQIJQYLQZPHQDF-UHFFFAOYSA-N 5-(3-aminophenyl)thiophene-2-carboxamide Chemical compound S1C(C(=O)N)=CC=C1C1=CC=CC(N)=C1 XQIJQYLQZPHQDF-UHFFFAOYSA-N 0.000 description 1
• AQEWVBMTXAOMMP-UHFFFAOYSA-N 5-(3-chlorophenyl)furan-2-carboxamide Chemical compound O1C(C(=O)N)=CC=C1C1=CC=CC(Cl)=C1 AQEWVBMTXAOMMP-UHFFFAOYSA-N 0.000 description 1
• WFHTYWNCRQLNFY-UHFFFAOYSA-N 5-(3-chlorophenyl)thiophene-2-carboxamide Chemical compound S1C(C(=O)N)=CC=C1C1=CC=CC(Cl)=C1 WFHTYWNCRQLNFY-UHFFFAOYSA-N 0.000 description 1
• BZFMDQZSQUUFQS-UHFFFAOYSA-N 5-(3-formylphenyl)thiophene-2-carboxamide Chemical compound C(=O)C=1C=C(C=CC1)C1=CC=C(S1)C(=O)N BZFMDQZSQUUFQS-UHFFFAOYSA-N 0.000 description 1
• LQSYOLVFFWKQRW-UHFFFAOYSA-N 5-(3-hydroxyphenyl)thiophene-2-carboxamide Chemical compound S1C(C(=O)N)=CC=C1C1=CC=CC(O)=C1 LQSYOLVFFWKQRW-UHFFFAOYSA-N 0.000 description 1
• GYDGAXNDWVXCID-UHFFFAOYSA-N 5-[3-(aminomethyl)phenyl]thiophene-2-carboxamide Chemical compound NCC1=CC=CC(C=2SC(=CC=2)C(N)=O)=C1 GYDGAXNDWVXCID-UHFFFAOYSA-N 0.000 description 1
• UZHYAVSDVJYYHA-UHFFFAOYSA-N 5-[3-(hydroxymethyl)phenyl]thiophene-2-carboxamide Chemical compound S1C(C(=O)N)=CC=C1C1=CC=CC(CO)=C1 UZHYAVSDVJYYHA-UHFFFAOYSA-N 0.000 description 1
• VFDAOWISEQYGIF-UHFFFAOYSA-N 5-bromofuran-2-carboxamide Chemical compound NC(=O)C1=CC=C(Br)O1 VFDAOWISEQYGIF-UHFFFAOYSA-N 0.000 description 1
• YVTQHZDUDUCGRD-UHFFFAOYSA-N 5-bromofuran-2-carboxylic acid Chemical compound OC(=O)C1=CC=C(Br)O1 YVTQHZDUDUCGRD-UHFFFAOYSA-N 0.000 description 1
• MTEMDMUNZYLWSQ-UHFFFAOYSA-N 5-bromothiophene-2-carboxamide Chemical compound NC(=O)C1=CC=C(Br)S1 MTEMDMUNZYLWSQ-UHFFFAOYSA-N 0.000 description 1
• ISXKVVQBTQEGSI-UHFFFAOYSA-N 5-bromothiophene-3-carboxamide Chemical compound NC(=O)C1=CSC(Br)=C1 ISXKVVQBTQEGSI-UHFFFAOYSA-N 0.000 description 1
• UBPRKNMUSICIJU-UHFFFAOYSA-N 5-phenylthiophene-3-carboxamide Chemical compound NC(=O)C1=CSC(C=2C=CC=CC=2)=C1 UBPRKNMUSICIJU-UHFFFAOYSA-N 0.000 description 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
• 229930003347 Atropine Natural products 0.000 description 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
• 108010009685 Cholinergic Receptors Proteins 0.000 description 1
• 208000000094 Chronic Pain Diseases 0.000 description 1
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
• VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
• 239000005977 Ethylene Substances 0.000 description 1
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
• BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
• VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical class OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
• 201000004311 Gilles de la Tourette syndrome Diseases 0.000 description 1
• RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 1
• 201000006347 Intellectual Disability Diseases 0.000 description 1
• 241000124008 Mammalia Species 0.000 description 1
• 241001465754 Metazoa Species 0.000 description 1
• BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 1
• 229930040373 Paraformaldehyde Natural products 0.000 description 1
• KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
• KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
• 229920002472 Starch Polymers 0.000 description 1
• 235000021355 Stearic acid Nutrition 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
• DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 1
• WOAORAPRPVIATR-UHFFFAOYSA-N [3-(trifluoromethyl)phenyl]boronic acid Chemical compound OB(O)C1=CC=CC(C(F)(F)F)=C1 WOAORAPRPVIATR-UHFFFAOYSA-N 0.000 description 1
• 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
• 102000034337 acetylcholine receptors Human genes 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 150000001340 alkali metals Chemical class 0.000 description 1
• 150000004703 alkoxides Chemical class 0.000 description 1
• 150000001350 alkyl halides Chemical class 0.000 description 1
• 230000002152 alkylating effect Effects 0.000 description 1
• 229940035676 analgesics Drugs 0.000 description 1
• 238000004458 analytical method Methods 0.000 description 1
• 239000000730 antalgic agent Substances 0.000 description 1
• 238000007080 aromatic substitution reaction Methods 0.000 description 1
• 150000001502 aryl halides Chemical class 0.000 description 1
• RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 1
• 229960000396 atropine Drugs 0.000 description 1
• 125000005605 benzo group Chemical group 0.000 description 1
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
• 229930008407 benzylideneacetone Natural products 0.000 description 1
• 230000015572 biosynthetic process Effects 0.000 description 1
• 230000037396 body weight Effects 0.000 description 1
• 238000009835 boiling Methods 0.000 description 1
• 210000004556 brain Anatomy 0.000 description 1
• 239000000872 buffer Substances 0.000 description 1
• 239000002775 capsule Substances 0.000 description 1
• AIXAANGOTKPUOY-UHFFFAOYSA-N carbachol Chemical compound [Cl-].C[N+](C)(C)CCOC(N)=O AIXAANGOTKPUOY-UHFFFAOYSA-N 0.000 description 1
• 229910052799 carbon Inorganic materials 0.000 description 1
• 125000004432 carbon atom Chemical group C* 0.000 description 1
• 239000000969 carrier Substances 0.000 description 1
• 230000003197 catalytic effect Effects 0.000 description 1
• 238000009903 catalytic hydrogenation reaction Methods 0.000 description 1
• 150000001793 charged compounds Chemical class 0.000 description 1
• 239000007810 chemical reaction solvent Substances 0.000 description 1
• 238000004296 chiral HPLC Methods 0.000 description 1
• 239000000460 chlorine Substances 0.000 description 1
• 229910052801 chlorine Inorganic materials 0.000 description 1
• 230000006949 cholinergic function Effects 0.000 description 1
• 230000001149 cognitive effect Effects 0.000 description 1
• 238000001816 cooling Methods 0.000 description 1
• GBRBMTNGQBKBQE-UHFFFAOYSA-L copper;diiodide Chemical compound I[Cu]I GBRBMTNGQBKBQE-UHFFFAOYSA-L 0.000 description 1
• 125000004122 cyclic group Chemical group 0.000 description 1
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
• 230000007423 decrease Effects 0.000 description 1
• MUCZHBLJLSDCSD-UHFFFAOYSA-N diisopropyl fluorophosphate Chemical compound CC(C)OP(F)(=O)OC(C)C MUCZHBLJLSDCSD-UHFFFAOYSA-N 0.000 description 1
• 239000000539 dimer Substances 0.000 description 1
• 230000003292 diminished effect Effects 0.000 description 1
• 239000008298 dragée Substances 0.000 description 1
• 239000003937 drug carrier Substances 0.000 description 1
• 230000000694 effects Effects 0.000 description 1
• 238000005516 engineering process Methods 0.000 description 1
• 150000002148 esters Chemical class 0.000 description 1
• 235000019441 ethanol Nutrition 0.000 description 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
• DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
• 238000002474 experimental method Methods 0.000 description 1
• 229910052731 fluorine Inorganic materials 0.000 description 1
• 239000011737 fluorine Substances 0.000 description 1
• 229960005051 fluostigmine Drugs 0.000 description 1
• 238000001640 fractional crystallisation Methods 0.000 description 1
• 238000007710 freezing Methods 0.000 description 1
• 230000008014 freezing Effects 0.000 description 1
• 230000006870 function Effects 0.000 description 1
• 238000007306 functionalization reaction Methods 0.000 description 1
• 239000012362 glacial acetic acid Substances 0.000 description 1
• 235000011187 glycerol Nutrition 0.000 description 1
• 229940093915 gynecological organic acid Drugs 0.000 description 1
• 150000004820 halides Chemical class 0.000 description 1
• 150000002366 halogen compounds Chemical class 0.000 description 1
• 125000005843 halogen group Chemical group 0.000 description 1
• 230000026030 halogenation Effects 0.000 description 1
• 238000005658 halogenation reaction Methods 0.000 description 1
• 230000000971 hippocampal effect Effects 0.000 description 1
• 210000001320 hippocampus Anatomy 0.000 description 1
• 239000012456 homogeneous solution Substances 0.000 description 1
• 239000011539 homogenization buffer Substances 0.000 description 1
• 230000001771 impaired effect Effects 0.000 description 1
• 238000002347 injection Methods 0.000 description 1
• 239000007924 injection Substances 0.000 description 1
• 229910052500 inorganic mineral Inorganic materials 0.000 description 1
• 239000003456 ion exchange resin Substances 0.000 description 1
• 229920003303 ion-exchange polymer Polymers 0.000 description 1
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
• 238000000707 layer-by-layer assembly Methods 0.000 description 1
• 231100001231 less toxic Toxicity 0.000 description 1
• 239000007788 liquid Substances 0.000 description 1
• 238000004811 liquid chromatography Methods 0.000 description 1
• VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
• 238000001819 mass spectrum Methods 0.000 description 1
• 230000003923 mental ability Effects 0.000 description 1
• 235000010755 mineral Nutrition 0.000 description 1
• 239000011707 mineral Substances 0.000 description 1
• BXVSCDNQMVRJHW-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-4-bromobenzamide Chemical compound C1=CC(Br)=CC=C1C(=O)NC1C(CC2)CCN2C1 BXVSCDNQMVRJHW-UHFFFAOYSA-N 0.000 description 1
• LIPAWTBPKLAATH-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(1-benzofuran-2-yl)furan-2-carboxamide Chemical compound C1=CC=C2OC(C3=CC=C(O3)C(NC3C4CCN(CC4)C3)=O)=CC2=C1 LIPAWTBPKLAATH-UHFFFAOYSA-N 0.000 description 1
• QTGLVGGNFKMBPR-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(3-chlorophenyl)thiophene-2-carboxamide Chemical compound ClC1=CC=CC(C=2SC(=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 QTGLVGGNFKMBPR-UHFFFAOYSA-N 0.000 description 1
• LCGCTFJMVXHREJ-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide Chemical compound OC1=CC=CC(C=2SC(=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 LCGCTFJMVXHREJ-UHFFFAOYSA-N 0.000 description 1
• ZYVHCJHMRMAHSR-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-[3-(trifluoromethyl)phenyl]furan-2-carboxamide Chemical compound FC(F)(F)C1=CC=CC(C=2OC(=CC=2)C(=O)NC2C3CCN(CC3)C2)=C1 ZYVHCJHMRMAHSR-UHFFFAOYSA-N 0.000 description 1
• XXXRVCPQJSWEIQ-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-phenylfuran-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(O1)=CC=C1C1=CC=CC=C1 XXXRVCPQJSWEIQ-UHFFFAOYSA-N 0.000 description 1
• FPIGGZJRNAPCBW-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-pyridin-3-ylthiophene-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(S1)=CC=C1C1=CC=CN=C1 FPIGGZJRNAPCBW-UHFFFAOYSA-N 0.000 description 1
• QDWJHUICASOKIN-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-pyridin-4-ylthiophene-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(S1)=CC=C1C1=CC=NC=C1 QDWJHUICASOKIN-UHFFFAOYSA-N 0.000 description 1
• KCODCQYYCSDUSC-UHFFFAOYSA-N n-(3-acetamidophenyl)benzamide Chemical compound CC(=O)NC1=CC=CC(NC(=O)C=2C=CC=CC=2)=C1 KCODCQYYCSDUSC-UHFFFAOYSA-N 0.000 description 1
• XGPFTOAIGXUGCR-UHFFFAOYSA-N n-(3-thiophen-2-ylphenyl)acetamide Chemical compound CC(=O)NC1=CC=CC(C=2SC=CC=2)=C1 XGPFTOAIGXUGCR-UHFFFAOYSA-N 0.000 description 1
• WTUHRGRJMXKQOM-IBGZPJMESA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-3-(3,5-dichlorophenyl)benzamide Chemical compound ClC1=CC(Cl)=CC(C=2C=C(C=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 WTUHRGRJMXKQOM-IBGZPJMESA-N 0.000 description 1
• RWRRNEWYRHYZAK-ZDUSSCGKSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-3-iodobenzamide Chemical compound IC1=CC=CC(C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 RWRRNEWYRHYZAK-ZDUSSCGKSA-N 0.000 description 1
• NWJHCFDCWWUKAS-INIZCTEOSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-3-thiophen-2-ylbenzamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(C=1)=CC=CC=1C1=CC=CS1 NWJHCFDCWWUKAS-INIZCTEOSA-N 0.000 description 1
• OOGWQHRFIFVTEZ-ZDUSSCGKSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-4-iodobenzamide Chemical compound C1=CC(I)=CC=C1C(=O)N[C@@H]1C(CC2)CCN2C1 OOGWQHRFIFVTEZ-ZDUSSCGKSA-N 0.000 description 1
• UWKVRXHHKRDKTN-INIZCTEOSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(3-formylphenyl)thiophene-2-carboxamide Chemical compound O=CC1=CC=CC(C=2SC(=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 UWKVRXHHKRDKTN-INIZCTEOSA-N 0.000 description 1
• PFKKVUBNDMRQFB-HNNXBMFYSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-(4-chlorophenyl)furan-2-carboxamide Chemical compound C1=CC(Cl)=CC=C1C1=CC=C(C(=O)N[C@@H]2C3CCN(CC3)C2)O1 PFKKVUBNDMRQFB-HNNXBMFYSA-N 0.000 description 1
• OWGIBYSBTRBKPD-KRWDZBQOSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-[3-(dimethylamino)phenyl]furan-2-carboxamide Chemical compound CN(C)C1=CC=CC(C=2OC(=CC=2)C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 OWGIBYSBTRBKPD-KRWDZBQOSA-N 0.000 description 1
• JEAHJLXHLCBPED-JTQLQIEISA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-bromothiophene-3-carboxamide Chemical compound S1C(Br)=CC(C(=O)N[C@@H]2C3CCN(CC3)C2)=C1 JEAHJLXHLCBPED-JTQLQIEISA-N 0.000 description 1
• HXCRNIZEZKEKNY-AWEZNQCLSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-pyridin-3-yl-2h-1,3-thiazole-3-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)N(C=1)CSC=1C1=CC=CN=C1 HXCRNIZEZKEKNY-AWEZNQCLSA-N 0.000 description 1
• LFGBLTXCNGFMSZ-ZDUSSCGKSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-5-thiophen-3-ylfuran-2-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(O1)=CC=C1C=1C=CSC=1 LFGBLTXCNGFMSZ-ZDUSSCGKSA-N 0.000 description 1
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• JLKFGTFHSHRBGZ-UHFFFAOYSA-N n-pyridin-4-ylfuran-2-carboxamide Chemical compound C=1C=COC=1C(=O)NC1=CC=NC=C1 JLKFGTFHSHRBGZ-UHFFFAOYSA-N 0.000 description 1
• KPTRDYONBVUWPD-UHFFFAOYSA-N naphthalen-2-ylboronic acid Chemical compound C1=CC=CC2=CC(B(O)O)=CC=C21 KPTRDYONBVUWPD-UHFFFAOYSA-N 0.000 description 1
• 230000001537 neural effect Effects 0.000 description 1
• 230000004112 neuroprotection Effects 0.000 description 1
• 239000002858 neurotransmitter agent Substances 0.000 description 1
• 238000006396 nitration reaction Methods 0.000 description 1
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
• 238000010534 nucleophilic substitution reaction Methods 0.000 description 1
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
• 239000003921 oil Substances 0.000 description 1
• 235000019198 oils Nutrition 0.000 description 1
• 230000003287 optical effect Effects 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 235000005985 organic acids Nutrition 0.000 description 1
• 150000002940 palladium Chemical class 0.000 description 1
• 229920002866 paraformaldehyde Polymers 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• 239000008188 pellet Substances 0.000 description 1
• 239000012071 phase Substances 0.000 description 1
• 230000003389 potentiating effect Effects 0.000 description 1
• 238000002203 pretreatment Methods 0.000 description 1
• 230000002265 prevention Effects 0.000 description 1
• 208000020016 psychiatric disease Diseases 0.000 description 1
• 230000006340 racemization Effects 0.000 description 1
• 238000007347 radical substitution reaction Methods 0.000 description 1
• 230000009467 reduction Effects 0.000 description 1
• 238000006722 reduction reaction Methods 0.000 description 1
• 238000005932 reductive alkylation reaction Methods 0.000 description 1
• 230000002441 reversible effect Effects 0.000 description 1
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
• 239000011780 sodium chloride Substances 0.000 description 1
• 239000012312 sodium hydride Substances 0.000 description 1
• 229910000104 sodium hydride Inorganic materials 0.000 description 1
• 239000012453 solvate Substances 0.000 description 1
• 238000010561 standard procedure Methods 0.000 description 1
• 125000005402 stannate group Chemical group 0.000 description 1
• 239000008107 starch Substances 0.000 description 1
• 235000019698 starch Nutrition 0.000 description 1
• 239000008117 stearic acid Substances 0.000 description 1
• 230000006103 sulfonylation Effects 0.000 description 1
• 238000005694 sulfonylation reaction Methods 0.000 description 1
• QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
• 239000000829 suppository Substances 0.000 description 1
• 238000013268 sustained release Methods 0.000 description 1
• 239000012730 sustained-release form Substances 0.000 description 1
• 210000000225 synapse Anatomy 0.000 description 1
• 239000000454 talc Substances 0.000 description 1
• 229910052623 talc Inorganic materials 0.000 description 1
• 235000012222 talc Nutrition 0.000 description 1
• 235000002906 tartaric acid Nutrition 0.000 description 1
• 239000011975 tartaric acid Substances 0.000 description 1
• 239000004149 tartrazine Substances 0.000 description 1
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• DAUYIKBTMNZABP-UHFFFAOYSA-N thiophene-3-carboxamide Chemical compound NC(=O)C=1C=CSC=1 DAUYIKBTMNZABP-UHFFFAOYSA-N 0.000 description 1
• YNVOMSDITJMNET-UHFFFAOYSA-N thiophene-3-carboxylic acid Chemical compound OC(=O)C=1C=CSC=1 YNVOMSDITJMNET-UHFFFAOYSA-N 0.000 description 1
• BWHOZHOGCMHOBV-BQYQJAHWSA-N trans-benzylideneacetone Chemical compound CC(=O)\C=C\C1=CC=CC=C1 BWHOZHOGCMHOBV-BQYQJAHWSA-N 0.000 description 1
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
• 238000000844 transformation Methods 0.000 description 1
• GYUURHMITDQTRU-UHFFFAOYSA-N tributyl(pyridin-2-yl)stannane Chemical compound CCCC[Sn](CCCC)(CCCC)C1=CC=CC=N1 GYUURHMITDQTRU-UHFFFAOYSA-N 0.000 description 1
• AJSTXXYNEIHPMD-UHFFFAOYSA-N triethyl borate Chemical compound CCOB(OCC)OCC AJSTXXYNEIHPMD-UHFFFAOYSA-N 0.000 description 1
• ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
• WRECIMRULFAWHA-UHFFFAOYSA-N trimethyl borate Chemical compound COB(OC)OC WRECIMRULFAWHA-UHFFFAOYSA-N 0.000 description 1
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
• 235000015112 vegetable and seed oil Nutrition 0.000 description 1
• 239000008158 vegetable oil Substances 0.000 description 1
• 239000001993 wax Substances 0.000 description 1
• 239000011592 zinc chloride Substances 0.000 description 1
• 235000005074 zinc chloride Nutrition 0.000 description 1