BG106734A - Pyrazolo[1,5-d][1,2,4]triazines for enhancing cognition - Google Patents

Pyrazolo[1,5-d][1,2,4]triazines for enhancing cognition

Info

Publication number
BG106734A
BG106734A BG106734A BG10673402A BG106734A BG 106734 A BG106734 A BG 106734A BG 106734 A BG106734 A BG 106734A BG 10673402 A BG10673402 A BG 10673402A BG 106734 A BG106734 A BG 106734A
Authority
BG
Bulgaria
Prior art keywords
optionally substituted
heteroaromatic ring
alkyl
compounds
membered heteroaromatic
Prior art date
Application number
BG106734A
Other languages
Bulgarian (bg)
English (en)
Inventor
Helen BRYANT
William Carling
Mark Chambers
Sarah HOBBS
Philip Jones
Angus Macleod
Original Assignee
Merck Sharp & Dohme Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9927874.9A external-priority patent/GB9927874D0/en
Priority claimed from GB0009602A external-priority patent/GB0009602D0/en
Priority claimed from GB0018651A external-priority patent/GB0018651D0/en
Application filed by Merck Sharp & Dohme Limited filed Critical Merck Sharp & Dohme Limited
Publication of BG106734A publication Critical patent/BG106734A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG106734A 1999-11-25 2002-05-22 Pyrazolo[1,5-d][1,2,4]triazines for enhancing cognition BG106734A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9927874.9A GB9927874D0 (en) 1999-11-25 1999-11-25 Therapeutic agents
GB0009602A GB0009602D0 (en) 2000-04-18 2000-04-18 Therapeutic agents
GB0018651A GB0018651D0 (en) 2000-07-28 2000-07-28 Therapeutic agents
PCT/GB2000/004450 WO2001038331A2 (en) 1999-11-25 2000-11-22 Pyrazolo[1,5-d][1,2,4]triazines for enhancing cognition

Publications (1)

Publication Number Publication Date
BG106734A true BG106734A (en) 2003-02-28

Family

ID=27255677

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106734A BG106734A (en) 1999-11-25 2002-05-22 Pyrazolo[1,5-d][1,2,4]triazines for enhancing cognition

Country Status (20)

Country Link
US (1) US6355638B1 (zh)
EP (1) EP1235829A2 (zh)
JP (1) JP2003514909A (zh)
KR (1) KR20020053091A (zh)
CN (1) CN1391574A (zh)
AU (1) AU1533001A (zh)
BG (1) BG106734A (zh)
BR (1) BR0015126A (zh)
CA (1) CA2391103A1 (zh)
CZ (1) CZ20021813A3 (zh)
EA (1) EA200200599A1 (zh)
EE (1) EE200200260A (zh)
HK (1) HK1046406A1 (zh)
HU (1) HUP0203579A3 (zh)
IL (1) IL149051A0 (zh)
MX (1) MXPA02005233A (zh)
NO (1) NO20022456L (zh)
PL (1) PL355637A1 (zh)
SK (1) SK8952002A3 (zh)
WO (1) WO2001038331A2 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0128499D0 (en) * 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
EP2298296A1 (en) * 2009-08-25 2011-03-23 CNRS Centre National De La Recherche Scientifique Composition and method for treating cognitive impairments in down syndrome subjects
EP2576540B1 (en) * 2010-05-26 2019-09-04 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CN107344938B (zh) * 2016-05-06 2022-05-06 上海赛默罗生物科技有限公司 吡唑-三嗪类衍生物、其制备方法、药物组合物和用途
CN107344936B (zh) * 2016-05-06 2022-06-03 上海赛默罗生物科技有限公司 三唑哒嗪类衍生物、其制备方法、药物组合物和用途
MX2021015874A (es) * 2019-06-19 2022-02-03 Biomarin Pharm Inc Inhibidores de glicolato oxidasa para el tratamiento de enfermedades.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE236904T1 (de) * 1996-07-25 2003-04-15 Merck Sharp & Dohme Substituierte triazolo-pyridazin-derivate als liganden von gaba-rezeptoren
GB9715977D0 (en) * 1997-07-29 1997-10-01 Merck Sharp & Dohme Therapeutic agents
US6303597B1 (en) * 1998-01-14 2001-10-16 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
GB9806102D0 (en) * 1998-03-20 1998-05-20 Merck Sharp & Dohme Therapeutic agents
EP1087968A1 (en) * 1998-06-16 2001-04-04 MERCK SHARP & DOHME LTD. Triazolo-pyridine derivatives as ligands for gaba receptors
AU760688B2 (en) * 1998-10-16 2003-05-22 Merck Sharp & Dohme Limited Pyrazolo-triazine derivatives as ligands for GABA receptors

Also Published As

Publication number Publication date
NO20022456D0 (no) 2002-05-24
AU1533001A (en) 2001-06-04
CZ20021813A3 (cs) 2002-08-14
NO20022456L (no) 2002-05-24
KR20020053091A (ko) 2002-07-04
WO2001038331A3 (en) 2001-11-08
JP2003514909A (ja) 2003-04-22
EE200200260A (et) 2003-06-16
SK8952002A3 (en) 2002-10-08
WO2001038331A2 (en) 2001-05-31
PL355637A1 (en) 2004-05-04
HUP0203579A2 (hu) 2003-03-28
IL149051A0 (en) 2002-11-10
EP1235829A2 (en) 2002-09-04
BR0015126A (pt) 2002-07-02
HUP0203579A3 (en) 2003-07-28
MXPA02005233A (es) 2002-11-07
HK1046406A1 (zh) 2003-01-10
CA2391103A1 (en) 2001-05-31
CN1391574A (zh) 2003-01-15
US6355638B1 (en) 2002-03-12
EA200200599A1 (ru) 2002-12-26

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