BG106714A - Метод за лечение на ракови заболявания с аплидин - Google Patents

Метод за лечение на ракови заболявания с аплидин

Info

Publication number
BG106714A
BG106714A BG106714A BG10671402A BG106714A BG 106714 A BG106714 A BG 106714A BG 106714 A BG106714 A BG 106714A BG 10671402 A BG10671402 A BG 10671402A BG 106714 A BG106714 A BG 106714A
Authority
BG
Bulgaria
Prior art keywords
aplidine
cancers
tumors
treatment
aplidine treatment
Prior art date
Application number
BG106714A
Other languages
English (en)
Other versions
BG65381B1 (bg
Inventor
Glynn Faircloth
Chris Twelves
Luis Paz-Ares
Original Assignee
Pharma Mar, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9927006.8A external-priority patent/GB9927006D0/en
Priority claimed from GB0005701A external-priority patent/GB0005701D0/en
Priority claimed from GB0007639A external-priority patent/GB0007639D0/en
Priority claimed from GB0015496A external-priority patent/GB0015496D0/en
Priority claimed from GB0025209A external-priority patent/GB0025209D0/en
Application filed by Pharma Mar, S.A. filed Critical Pharma Mar, S.A.
Publication of BG106714A publication Critical patent/BG106714A/bg
Publication of BG65381B1 publication Critical patent/BG65381B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

Аплидинът е надежден при клинични опити във фаза I на лечение на тумори. Използват се различни дозични режими. При някои тумори като ренален карцином, колоректален рак, белодробен карциноид, мозъчно-тироидни карциноми и меланома, се наблюдава намаляване на тумора. Аплидинът повлиява инхибирането наангиогенеза и проявява антитуморна активност.
BG106714A 1999-11-15 2002-05-18 Приложение на аплидин при получаване на фармацевтичен състав за лечение на рак BG65381B1 (bg)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9927006.8A GB9927006D0 (en) 1999-11-15 1999-11-15 Aplidine treatment of cancers
GB0005701A GB0005701D0 (en) 2000-03-09 2000-03-09 Antitumor utility of aplidine
GB0007639A GB0007639D0 (en) 2000-03-29 2000-03-29 Antitumour and anti-angiogenic compound
GB0015496A GB0015496D0 (en) 2000-06-23 2000-06-23 Antitumour and anti-angiogenic compound
GB0025209A GB0025209D0 (en) 2000-10-13 2000-10-13 Treatment of cancers

Publications (2)

Publication Number Publication Date
BG106714A true BG106714A (bg) 2003-02-28
BG65381B1 BG65381B1 (bg) 2008-05-30

Family

ID=27515929

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106714A BG65381B1 (bg) 1999-11-15 2002-05-18 Приложение на аплидин при получаване на фармацевтичен състав за лечение на рак

Country Status (27)

Country Link
US (1) US20090298752A1 (bg)
EP (1) EP1229922B1 (bg)
JP (1) JP2003514025A (bg)
KR (1) KR100518986B1 (bg)
CN (1) CN1423564A (bg)
AT (1) ATE363910T1 (bg)
AU (1) AU780417B2 (bg)
BG (1) BG65381B1 (bg)
BR (1) BR0015811A (bg)
CA (1) CA2391502A1 (bg)
CY (1) CY1106825T1 (bg)
CZ (1) CZ302498B6 (bg)
DE (1) DE60035120T2 (bg)
DK (1) DK1229922T3 (bg)
ES (1) ES2288486T3 (bg)
HK (1) HK1045648B (bg)
HU (1) HUP0203906A2 (bg)
IL (1) IL149488A0 (bg)
MX (1) MXPA02004862A (bg)
NO (1) NO330719B1 (bg)
NZ (1) NZ518847A (bg)
PL (1) PL200922B1 (bg)
PT (1) PT1229922E (bg)
RU (1) RU2261104C2 (bg)
SI (1) SI1229922T1 (bg)
SK (1) SK287762B6 (bg)
WO (1) WO2001035974A2 (bg)

Families Citing this family (13)

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US20030148933A1 (en) 1990-10-01 2003-08-07 Pharma Mar S.A. Derivatives of dehydrodidemnin B
GB9803448D0 (en) 1998-02-18 1998-04-15 Pharma Mar Sa Pharmaceutical formulation
UA76718C2 (uk) 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
RU2003113210A (ru) 2000-10-12 2004-11-27 Фарма Мар, С.А. (Es) Лечение раковых заболеваний
ATE411036T1 (de) * 2001-10-19 2008-10-15 Pharma Mar Sa Verwendung von aplidine in der behandlung von pankreaskrebs
CN101579520A (zh) * 2003-03-12 2009-11-18 达纳-法伯癌症协会有限公司 用于多发性骨髓瘤的治疗的aplidine
SI1603584T1 (sl) 2003-03-12 2009-02-28 Dana Farber Cancer Inst Inc Aplidin za zdravljenje multiple mieloma
ME02450B (me) 2006-02-28 2016-09-20 Pharma Mar Sa POBOLJŠANO LIJEČENJE MULTlPLOG MIJELOMA
ATE479432T1 (de) * 2006-11-03 2010-09-15 Nerviano Medical Sciences Srl Verfahren zur verabreichung einer antitumoralen verbindung
US20100240595A1 (en) * 2007-10-19 2010-09-23 Pharma Mar ,S.A. Improved Antitumoral Treatments
CN101965191A (zh) * 2008-03-07 2011-02-02 法马马有限公司 改善的抗癌治疗
CN103463020B (zh) * 2013-09-23 2015-11-25 李淑兰 Lycojaponicumin A在制备治疗肾癌药物中的应用
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

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US4342744A (en) * 1979-07-19 1982-08-03 Lever Brothers Company Hair treatment products
DE3161556D1 (en) * 1980-09-12 1984-01-05 Univ Illinois Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them
US4950649A (en) * 1980-09-12 1990-08-21 University Of Illinois Didemnins and nordidemnins
US4493796A (en) * 1980-09-12 1985-01-15 Board Of Trustees, Univ. Of Ill. Didemnins A, B, C, and derivatives thereof, as antiviral agents
IT1153974B (it) * 1982-09-23 1987-01-21 Erba Farmitalia Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
DE3684868D1 (de) * 1985-09-20 1992-05-21 Cernitin Sa Verwendung von pflanzenpollenextrakten zur herstellung von das wachstum von tumorzellen hemmenden pharmazeutischen praeparaten und verfahren zu ihrer herstellung.
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GB8922026D0 (en) * 1989-09-29 1989-11-15 Pharma Mar Sa Novel anti-viral and cytotoxic agent
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FR2698543B1 (fr) * 1992-12-02 1994-12-30 Rhone Poulenc Rorer Sa Nouvelles compositions à base de taxoides.
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JPH09507233A (ja) * 1993-12-29 1997-07-22 マトリクス ファーマスーティカル，インコーポレイティド 細胞増殖性疾患に罹る宿主の治療方法及び治療のための組成物
US5861439A (en) * 1994-11-14 1999-01-19 Alza Corporation Method for enhanced electrotransport agent delivery
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UA76718C2 (uk) * 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
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WO2002032374A2 (en) * 2000-10-18 2002-04-25 Immunex Corporation Methods for treating il-18 mediated disorders
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ATE411036T1 (de) * 2001-10-19 2008-10-15 Pharma Mar Sa Verwendung von aplidine in der behandlung von pankreaskrebs
CN101579520A (zh) * 2003-03-12 2009-11-18 达纳-法伯癌症协会有限公司 用于多发性骨髓瘤的治疗的aplidine
SI1603584T1 (sl) * 2003-03-12 2009-02-28 Dana Farber Cancer Inst Inc Aplidin za zdravljenje multiple mieloma
EP1613338A4 (en) * 2003-03-21 2009-06-24 Madeleine M Joullie TAMANDARIN ANALOGUES, FRAGMENTS THEREOF AND METHODS OF MAKING AND USING THE SAME
US20060019256A1 (en) * 2003-06-09 2006-01-26 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
ME02450B (me) * 2006-02-28 2016-09-20 Pharma Mar Sa POBOLJŠANO LIJEČENJE MULTlPLOG MIJELOMA
US20100240595A1 (en) * 2007-10-19 2010-09-23 Pharma Mar ,S.A. Improved Antitumoral Treatments

Also Published As

Publication number Publication date
DK1229922T3 (da) 2007-10-08
NO20022293L (no) 2002-07-05
HUP0203906A2 (en) 2003-03-28
CN1423564A (zh) 2003-06-11
DE60035120D1 (de) 2007-07-19
CZ20021697A3 (cs) 2003-02-12
NZ518847A (en) 2004-02-27
HK1045648B (zh) 2007-09-21
RU2261104C2 (ru) 2005-09-27
NO20022293D0 (no) 2002-05-14
SI1229922T1 (sl) 2008-04-30
KR20020064313A (ko) 2002-08-07
WO2001035974A3 (en) 2001-11-01
AU780417B2 (en) 2005-03-17
PT1229922E (pt) 2007-09-12
DE60035120T2 (de) 2008-01-31
NO330719B1 (no) 2011-06-20
EP1229922A2 (en) 2002-08-14
PL355335A1 (en) 2004-04-19
JP2003514025A (ja) 2003-04-15
CZ302498B6 (cs) 2011-06-15
ATE363910T1 (de) 2007-06-15
KR100518986B1 (ko) 2005-10-06
CA2391502A1 (en) 2001-05-25
WO2001035974A2 (en) 2001-05-25
BG65381B1 (bg) 2008-05-30
IL149488A0 (en) 2002-11-10
BR0015811A (pt) 2002-08-06
MXPA02004862A (es) 2003-01-28
ES2288486T3 (es) 2008-01-16
CY1106825T1 (el) 2012-05-23
SK6592002A3 (en) 2003-08-05
PL200922B1 (pl) 2009-02-27
HK1045648A1 (en) 2002-12-06
US20090298752A1 (en) 2009-12-03
EP1229922B1 (en) 2007-06-06
RU2002115864A (ru) 2004-01-20
SK287762B6 (sk) 2011-09-05
AU1402301A (en) 2001-05-30

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