RU93051543A - Производные акридина, способ получения, фармацевтическая композиция и способ лечения злокачественных опухолей - Google Patents
Производные акридина, способ получения, фармацевтическая композиция и способ лечения злокачественных опухолейInfo
- Publication number
- RU93051543A RU93051543A RU93051543/14A RU93051543A RU93051543A RU 93051543 A RU93051543 A RU 93051543A RU 93051543/14 A RU93051543/14 A RU 93051543/14A RU 93051543 A RU93051543 A RU 93051543A RU 93051543 A RU93051543 A RU 93051543A
- Authority
- RU
- Russia
- Prior art keywords
- producing
- pharmaceutical composition
- malignant tumors
- acridine derivatives
- treating malignant
- Prior art date
Links
- DZBUGLKDJFMEHC-UHFFFAOYSA-N Acridine Chemical class C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 229940027998 antiseptics and disinfectants Acridine derivatives Drugs 0.000 title 1
- 230000003211 malignant Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Claims (1)
- Новые соединения могут повышать чувствительность мультилекарственно-резистентных раковых клеток к химиотерапевтическим агентам и могут быть сформулированы для использования в терапии, особенно для улучшения или повышения эффективности противоопухолевого лекарства.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9100637.9 | 1991-01-11 | ||
GB919100628A GB9100628D0 (en) | 1991-01-11 | 1991-01-11 | Chemical compounds |
GB9100628.8 | 1991-01-11 | ||
GB919100637A GB9100637D0 (en) | 1991-01-11 | 1991-01-11 | Chemical compounds |
GB9115981.4 | 1991-07-24 | ||
GB919115956A GB9115956D0 (en) | 1991-07-24 | 1991-07-24 | Chemical compounds |
GB919115981A GB9115981D0 (en) | 1991-07-24 | 1991-07-24 | Chemical compounds |
GB9115956.6 | 1991-07-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93051543A true RU93051543A (ru) | 1996-11-10 |
RU2119482C1 RU2119482C1 (ru) | 1998-09-27 |
Family
ID=27450605
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93051543A RU2119482C1 (ru) | 1991-01-11 | 1992-01-07 | Производные акридина, способ получения, фармацевтическая композиция и способ лечения злокачественных опухолей |
Country Status (25)
Country | Link |
---|---|
US (1) | US5604237A (ru) |
EP (2) | EP0569380B1 (ru) |
JP (1) | JP2783680B2 (ru) |
KR (1) | KR100220538B1 (ru) |
AT (1) | ATE153660T1 (ru) |
AU (1) | AU652996B2 (ru) |
CA (1) | CA2100258C (ru) |
CZ (1) | CZ283038B6 (ru) |
DE (1) | DE69220037T2 (ru) |
DK (1) | DK0569380T3 (ru) |
ES (1) | ES2104887T3 (ru) |
FI (1) | FI103888B (ru) |
GE (1) | GEP20002210B (ru) |
GR (1) | GR3024525T3 (ru) |
HU (2) | HUT68856A (ru) |
IE (1) | IE920083A1 (ru) |
IL (1) | IL100631A (ru) |
MX (1) | MX9200109A (ru) |
NO (1) | NO300267B1 (ru) |
NZ (1) | NZ241278A (ru) |
PL (1) | PL168202B1 (ru) |
RU (1) | RU2119482C1 (ru) |
SG (1) | SG45403A1 (ru) |
SK (1) | SK280864B6 (ru) |
WO (1) | WO1992012132A1 (ru) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2100258C (en) * | 1991-01-11 | 1999-12-14 | Bernard Andre Dumaitre | Acridine derivatives |
TR28930A (tr) * | 1992-05-07 | 1997-07-21 | Zeneca Ltd | Alkil sübstitüentli nitrotoluen türevleri |
GB9209872D0 (en) * | 1992-05-07 | 1992-06-24 | Ici Plc | Alkyl substituted nitrotoluene derivatives |
JP2718830B2 (ja) * | 1992-07-10 | 1998-02-25 | ラボラトワール、グラクソ、ソシエテ、アノニム | アニリド誘導体 |
RU2036198C1 (ru) * | 1993-04-01 | 1995-05-27 | Товарищество с ограниченной ответственностью "Полисан" | N-МЕТИЛ-N-( α,D -ГЛЮКОПИРАНОЗИЛ) АММОНИЯ-2-(АКРИДОН-9-ОН-10-ИЛ)АЦЕТАТ(ЦИКЛОФЕРОН), ОБЛАДАЮЩИЙ ИНТЕРФЕРОНОГЕННОЙ, ПРОТИВОВИРУСНОЙ, В ТОМ ЧИСЛЕ АНТИВИЧ, АНТИПАРАЗИТАРНОЙ, АНТИПРОМОТОРНОЙ И РАДИОПРОТЕКТИВНОЙ АКТИВНОСТЬЮ |
US5387685A (en) * | 1993-07-16 | 1995-02-07 | American Cyanamid Co | MDR reversal agents |
DE4422517A1 (de) * | 1994-06-28 | 1996-01-04 | Dresden Arzneimittel | Neue (2-(3,4-Dimethoxy-phenyl)-ethyl)-(2-phenoxy-ethyl)-amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
ATE248802T1 (de) * | 1994-08-04 | 2003-09-15 | C & C Res Labs | Neues amin-derivat, verfahren zur herstellung und dessen verwendung als anti-arrhythmisches mittel |
KR970705997A (ko) * | 1994-10-05 | 1997-11-03 | 그래함 브레레톤 | N-{4-[2-(1, 2, 3, 4-테트라히드로-6, 7-디메톡시-2-이소퀴놀리닐)-에틸]-페닐}-9, 10-디히드로-5-메톡시-9-옥소-4-아크리딘 카르복사미드 화합물(gf120918a)을 포함하는 비경구 제약 조성물(parenteral pharmaceutical compositions containing gf120918a) |
FR2726267B1 (fr) * | 1994-10-26 | 1998-01-02 | Smithkline Beecham Lab | Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer |
WO1998053811A1 (en) * | 1997-05-27 | 1998-12-03 | Baker Norton Pharmaceuticals, Inc. | Method and compositions for administering taxanes orally to human patients |
US6245805B1 (en) | 1995-10-26 | 2001-06-12 | Baker Norton Pharmaceuticals, Inc. | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
US6395770B1 (en) | 1995-10-26 | 2002-05-28 | Baker Norton Pharmaceuticals, Inc. | Method and compositions for administering taxanes orally to human patients |
AU1597197A (en) * | 1996-02-01 | 1997-08-22 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Thienoquinolines |
US6713517B1 (en) | 1996-03-08 | 2004-03-30 | Oxigene, Inc. | Use of aryl N-substituted carboxamides directly and as radio-and chemosensitizers for killing tumor and cancer cells and novel compounds for such use |
RU2118532C1 (ru) * | 1996-04-10 | 1998-09-10 | Олег Викторович Травкин | Противоинфекционное, противовоспалительное и противоопухолевое лекарственное средство |
GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
GB9710612D0 (en) * | 1997-05-23 | 1997-07-16 | Glaxo Group Ltd | Synthesis of acridine derivatives |
GB9718903D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
GB9812189D0 (en) * | 1998-06-05 | 1998-08-05 | Glaxo Group Ltd | Methods and compositions for increasing penetration of HIV protease inhibitors |
WO2000000472A1 (en) * | 1998-06-30 | 2000-01-06 | Du Pont Pharmaceuticals Company | 5-ht7 receptor antagonists |
CZ20011270A3 (cs) | 1998-10-08 | 2001-09-12 | Smithkline Beecham Plc | Tetrahydrobenzazepinové deriváty vhodné jako modulátory dopaminových receptorů D3 |
EP1189637B1 (en) | 1999-05-17 | 2006-08-23 | Cancer Research Ventures Limited | Compositions for improving bioavailability of orally administered drugs |
EP1229934B1 (en) | 1999-10-01 | 2014-03-05 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
US6521635B1 (en) | 2000-01-20 | 2003-02-18 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of MXR transport by acridine derivatives |
WO2001060351A2 (en) | 2000-02-18 | 2001-08-23 | New York Medical College | Nitroacridine/tumor inhibitor compositions |
HU227811B1 (en) * | 2000-03-14 | 2012-03-28 | Actelion Pharmaceuticals Ltd | 1,2,3,4-tetrahydroisquinoline derivatives, pharmaceutical compositions containing them and their preparation processes |
WO2001085693A1 (fr) | 2000-05-11 | 2001-11-15 | Banyu Pharmaceutical Co., Ltd. | Dérivés n-acyltétrahydroisoquinoline |
CN1469735A (zh) * | 2000-10-16 | 2004-01-21 | ����˹��ҩ�﹫˾ | 米托蒽醌的脂质体制剂 |
US7524861B2 (en) * | 2002-05-14 | 2009-04-28 | David Frank Hayman | Process for the preparation of a hydrate of an anthranilic acid derivative |
WO2004039795A2 (en) * | 2002-10-29 | 2004-05-13 | Fujisawa Pharmaceutical Co., Ltd. | Amide compounds for the treatment of hyperlipidemia |
SI1751111T1 (sl) | 2004-03-01 | 2015-04-30 | Actelion Pharmaceuticals Ltd. | Substituirani 1,2,3,4-tetrahidroizokinolinski derivati |
RU2346692C2 (ru) * | 2007-03-29 | 2009-02-20 | Ефаг АО | Применение 9-оксоакридин-10-уксусной кислоты, ее солей и сложных эфиров в комбинированной терапии рака яичников, способ лечения и наборы |
SE531698C2 (sv) * | 2007-07-12 | 2009-07-07 | Respiratorius Ab | Nya bronkdilaterande a,b-omättade amider |
WO2015142670A1 (en) * | 2014-03-15 | 2015-09-24 | Medisyn Technologies, Inc. | Anti-diabetic compounds, pharmaceutical compositions containing them, and method to treat diabetes |
CN104434808A (zh) | 2014-07-03 | 2015-03-25 | 石药集团中奇制药技术(石家庄)有限公司 | 一种治疗性纳米粒子及其制备方法 |
BR112020018669A2 (pt) * | 2018-03-21 | 2020-12-29 | Izumi Technology, Llc | Análogos deuterados de elacridar |
CN115385847B (zh) * | 2021-06-15 | 2023-09-29 | 山东第一医科大学(山东省医学科学院) | 多取代二芳基类化合物及其制备方法和应用 |
CN117414367A (zh) * | 2022-08-09 | 2024-01-19 | 北京清华长庚医院 | 一种逆转仑伐替尼耐药的药物组合物及其用途 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4250182A (en) * | 1972-02-24 | 1981-02-10 | Burroughs Wellcome Co. | Pharmaceutical composition containing acridone compounds and method of using same |
US4021551A (en) * | 1972-06-07 | 1977-05-03 | Boehringer Ingelheim Gmbh | 3,6-Bis-(heterocyclic aminoacyl-amino)-acridines and salts thereof |
US4127573A (en) * | 1972-09-06 | 1978-11-28 | Burroughs Wellcome Co. | Ditetrazole substituted acridone compounds |
EP0048898B1 (en) * | 1980-09-30 | 1985-04-17 | Bayer Ag | Method for the production of an antithrombin-heparin complex and pharmaceutical compositions containing the complex |
NZ198115A (en) * | 1981-08-21 | 1985-05-31 | New Zealand Dev Finance | 9-anilinoacridines;pharmaceutical compositions |
NZ201084A (en) * | 1982-06-25 | 1985-10-11 | New Zealand Dev Finance | 4-carboxamidoacridine derivatives and pharmaceutical compositions containing such |
IN164921B (ru) * | 1986-07-22 | 1989-07-08 | Hoechst India | |
US5104858A (en) * | 1988-09-29 | 1992-04-14 | Yale University | Sensitizing multidrug resistant cells to antitumor agents |
CA1340821C (en) * | 1988-10-06 | 1999-11-16 | Nobuyuki Fukazawa | Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components |
PT94402A (pt) * | 1989-06-19 | 1991-03-20 | Wellcome Found | Processo para a preparacao de compostos azotados que contem sistemas de aneis ciclicos aromaticos e de composicoes farmaceuticas que os contem |
CA2100258C (en) * | 1991-01-11 | 1999-12-14 | Bernard Andre Dumaitre | Acridine derivatives |
US5296602A (en) * | 1991-03-18 | 1994-03-22 | Sloan-Kettering Institute For Cancer Research | Multisubstituted 1-hydroxy-9-acridones with anticancer activity |
US5240936A (en) * | 1992-05-14 | 1993-08-31 | Texas A&M University System | Treating or preventing ocular inflammation or systemic imflammatory disease |
-
1992
- 1992-01-07 CA CA002100258A patent/CA2100258C/en not_active Expired - Lifetime
- 1992-01-07 PL PL92299989A patent/PL168202B1/pl unknown
- 1992-01-07 CZ CS931378A patent/CZ283038B6/cs not_active IP Right Cessation
- 1992-01-07 EP EP92901861A patent/EP0569380B1/en not_active Expired - Lifetime
- 1992-01-07 ES ES92901861T patent/ES2104887T3/es not_active Expired - Lifetime
- 1992-01-07 SG SG1996006197A patent/SG45403A1/en unknown
- 1992-01-07 EP EP92100123A patent/EP0494623A1/en active Pending
- 1992-01-07 KR KR1019930702079A patent/KR100220538B1/ko not_active IP Right Cessation
- 1992-01-07 RU RU93051543A patent/RU2119482C1/ru active
- 1992-01-07 AU AU11543/92A patent/AU652996B2/en not_active Expired
- 1992-01-07 DE DE69220037T patent/DE69220037T2/de not_active Expired - Lifetime
- 1992-01-07 SK SK730-93A patent/SK280864B6/sk not_active IP Right Cessation
- 1992-01-07 WO PCT/EP1992/000020 patent/WO1992012132A1/en active IP Right Grant
- 1992-01-07 GE GEAP19922653A patent/GEP20002210B/en unknown
- 1992-01-07 HU HU9301989A patent/HUT68856A/hu unknown
- 1992-01-07 AT AT92901861T patent/ATE153660T1/de not_active IP Right Cessation
- 1992-01-07 DK DK92901861.2T patent/DK0569380T3/da active
- 1992-01-07 JP JP4501671A patent/JP2783680B2/ja not_active Expired - Lifetime
- 1992-01-10 IE IE008392A patent/IE920083A1/en not_active IP Right Cessation
- 1992-01-10 IL IL10063192A patent/IL100631A/en not_active IP Right Cessation
- 1992-01-10 NZ NZ241278A patent/NZ241278A/en not_active IP Right Cessation
- 1992-01-10 MX MX9200109A patent/MX9200109A/es unknown
-
1993
- 1993-07-09 FI FI933149A patent/FI103888B/fi active
- 1993-07-09 NO NO932512A patent/NO300267B1/no not_active IP Right Cessation
-
1995
- 1995-06-06 US US08/468,620 patent/US5604237A/en not_active Expired - Lifetime
- 1995-06-29 HU HU95P/P00524P patent/HU211623A9/hu unknown
-
1997
- 1997-08-22 GR GR970402168T patent/GR3024525T3/el unknown
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