BG106110A - Метод за лечение на рефракторни тумори при човекас рецепторни антагонисти на епидермалния растеженфактор - Google Patents

Метод за лечение на рефракторни тумори при човекас рецепторни антагонисти на епидермалния растеженфактор Download PDF

Info

Publication number
BG106110A
BG106110A BG106110A BG10611001A BG106110A BG 106110 A BG106110 A BG 106110A BG 106110 A BG106110 A BG 106110A BG 10611001 A BG10611001 A BG 10611001A BG 106110 A BG106110 A BG 106110A
Authority
BG
Bulgaria
Prior art keywords
antagonist
egfr
radiation
tumors
treatment
Prior art date
Application number
BG106110A
Other languages
Bulgarian (bg)
English (en)
Inventor
Harlan WAKSAL
Original Assignee
Imclone Systems Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26978320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG106110(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Imclone Systems Incorporated filed Critical Imclone Systems Incorporated
Publication of BG106110A publication Critical patent/BG106110A/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
BG106110A 1999-05-14 2001-11-14 Метод за лечение на рефракторни тумори при човекас рецепторни антагонисти на епидермалния растеженфактор BG106110A (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31228499A 1999-05-14 1999-05-14
US37402899A 1999-08-13 1999-08-13
PCT/US2000/011756 WO2000069459A1 (fr) 1999-05-14 2000-05-01 Traitement de tumeurs humaines refractaires avec des antagonistes de recepteurs du facteur de croissance epidermique

Publications (1)

Publication Number Publication Date
BG106110A true BG106110A (bg) 2002-04-30

Family

ID=26978320

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106110A BG106110A (bg) 1999-05-14 2001-11-14 Метод за лечение на рефракторни тумори при човекас рецепторни антагонисти на епидермалния растеженфактор

Country Status (20)

Country Link
US (3) US20020012663A1 (fr)
EP (2) EP2042194A3 (fr)
JP (2) JP2003520195A (fr)
KR (1) KR20020000223A (fr)
CN (1) CN1200734C (fr)
AU (1) AU782994C (fr)
BG (1) BG106110A (fr)
BR (1) BR0010524A (fr)
CA (1) CA2373815A1 (fr)
CZ (1) CZ20014083A3 (fr)
EE (1) EE200100603A (fr)
HK (1) HK1047236A1 (fr)
HU (1) HUP0201480A3 (fr)
IL (1) IL146480A0 (fr)
MX (1) MXPA01011632A (fr)
NO (1) NO20015546L (fr)
PL (1) PL365999A1 (fr)
RU (1) RU2294761C2 (fr)
SK (1) SK16522001A3 (fr)
WO (1) WO2000069459A1 (fr)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7060808B1 (en) * 1995-06-07 2006-06-13 Imclone Systems Incorporated Humanized anti-EGF receptor monoclonal antibody
US20030224001A1 (en) * 1998-03-19 2003-12-04 Goldstein Neil I. Antibody and antibody fragments for inhibiting the growth of tumors
ZA200007412B (en) * 1998-05-15 2002-03-12 Imclone Systems Inc Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases.
US20040127470A1 (en) * 1998-12-23 2004-07-01 Pharmacia Corporation Methods and compositions for the prevention or treatment of neoplasia comprising a Cox-2 inhibitor in combination with an epidermal growth factor receptor antagonist
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ES2377847T3 (es) 1999-01-13 2012-04-02 Bayer Healthcare Llc Difenil ureas sustituidas con omega-carboxi arilo como agentes inhibidores de la cinasa p38
EP2042194A3 (fr) * 1999-05-14 2009-04-22 Imclone Systems, Inc. Traitement des tumeurs humaines réfractaires avec des antagonistes de récepteur de facteur de croissance épidermique
US7740841B1 (en) 2000-01-28 2010-06-22 Sunnybrook Health Science Center Therapeutic method for reducing angiogenesis
AU2001295002B2 (en) * 2000-08-09 2007-05-31 Imclone Systems Incorporated Treatment of hyperproliferative diseases with epidermal growth factor receptor antagonists
US20020151508A1 (en) * 2001-02-09 2002-10-17 Schering Corporation Methods for treating proliferative diseases
EP1236474A1 (fr) * 2001-02-26 2002-09-04 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Regulation négative du récepteur de l'EGF par Mig-6
US20080008704A1 (en) * 2001-03-16 2008-01-10 Mark Rubin Methods of treating colorectal cancer with anti-epidermal growth factor antibodies
CA2445898A1 (fr) 2001-05-01 2002-12-19 The General Hospital Corporation Photoimmunotherapies permettant de traiter un cancer a l'aide d'immunoconjugues de photosensibilisant et de therapies de combinaison
CN1507355A (zh) * 2001-05-08 2004-06-23 Ĭ��ר�����޹�˾ 使用抗egfr抗体和抗激素剂的联合疗法
US7589180B2 (en) 2001-05-11 2009-09-15 Abbott Laboratories Inc. Specific binding proteins and uses thereof
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
KR100719624B1 (ko) * 2001-05-18 2007-05-21 석정철 시각장애인을 위한 접착형 점자유도블록 및점자유도블록의 접착방법
US20050271663A1 (en) * 2001-06-28 2005-12-08 Domantis Limited Compositions and methods for treating inflammatory disorders
DK1399484T3 (da) * 2001-06-28 2010-11-08 Domantis Ltd Dobbelt-specifik ligand og anvendelse af denne
SI1478358T1 (sl) 2002-02-11 2013-09-30 Bayer Healthcare Llc Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi
EP2305284A3 (fr) * 2002-03-08 2012-11-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Utilisation de transactivateur de l'EGFR dans le cancer chez l'humain
EP2135879A3 (fr) * 2002-06-28 2010-06-23 Domantis Limited Ligand
US9321832B2 (en) * 2002-06-28 2016-04-26 Domantis Limited Ligand
US7696320B2 (en) 2004-08-24 2010-04-13 Domantis Limited Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
US20040147428A1 (en) * 2002-11-15 2004-07-29 Pluenneke John D. Methods of treatment using an inhibitor of epidermal growth factor receptor
US8505468B2 (en) * 2002-11-19 2013-08-13 Sharp Kabushiki Kaisha Substrate accommodating tray
CA2511910A1 (fr) * 2002-12-27 2004-07-15 Domantis Limited Ligand
JPWO2004060400A1 (ja) * 2003-01-06 2006-05-11 那波　宏之 上皮成長因子受容体を分子標的とする抗精神病薬
EP1599484A2 (fr) * 2003-02-21 2005-11-30 Chugai Seiyaku Kabushiki Kaisha Nouveau procede de preparation de composes hexacycliques
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
DK1626714T3 (da) 2003-05-20 2007-10-15 Bayer Pharmaceuticals Corp Dirarylurinstoffer mod sygdomme medieret af PDGFR
BRPI0411250A (pt) 2003-06-09 2006-08-29 Samuel Waksal método de inibição de receptor tirosina cinase com um antagonista extracelular e um antagonista intracellular
EP1493445A1 (fr) * 2003-07-04 2005-01-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibition de l'activation de l'EGFR, cette activation étant dépendante d'un ligand et étant induite par le stress
RS52625B (en) 2003-07-23 2013-06-28 Bayer Healthcare Llc FLUORO SUBSTITUTED OMEGA-CARBOXYARYL DIPHENYL UREA FOR TREATMENT AND PREVENTION OF DISEASES AND DISEASES
US20060193772A1 (en) * 2003-09-24 2006-08-31 Atsushi Ochiai Drugs for treating cancer
AU2004282219C1 (en) * 2003-10-15 2009-12-17 Osi Pharmaceuticals, Inc. Imidazo [1, 5 - a] pyrazine tyrosine kinase inhibitors
CN103007279B (zh) * 2004-03-19 2017-01-11 英克隆有限责任公司 人抗表皮生长因子受体抗体
PT1740591E (pt) * 2004-04-02 2009-09-24 Osi Pharm Inc Inibidores da proteína quinase heterobicíclicos em substituição de anel bicíclico 6,6
CN1964979B (zh) 2004-04-09 2011-07-27 中外制药株式会社 新颖的水溶性前药
WO2005117916A1 (fr) * 2004-06-03 2005-12-15 F. Hoffmann-La Roche Ag Traitement par la cisplatine et un inhibiteur de l'egfr
BRPI0511800A (pt) * 2004-06-03 2008-01-15 Hoffmann La Roche tratamento com irinotecano (cpt-11) e um inibidor de egfr
EP1755608A1 (fr) * 2004-06-03 2007-02-28 F.Hoffmann-La Roche Ag Traitement a base de gemcitabine et d'un inhibiteur de egfr
MXPA06013997A (es) * 2004-06-03 2007-02-08 Hoffmann La Roche Tratamiento con oxaliplatino y un inhibidor de la quinasa del receptor del factor de crecimiento epidermal (egfr).
US20060084675A1 (en) * 2004-10-18 2006-04-20 Thomas Efferth Combined treatment with artesunate and an epidermal growth factor receptor kinase inhibitor
US20060084666A1 (en) * 2004-10-18 2006-04-20 Harari Paul M Combined treatment with radiation and an epidermal growth factor receptor kinase inhibitor
US20060084691A1 (en) * 2004-10-18 2006-04-20 Bilal Piperdi Combined treatment with bortezomib and an epidermal growth factor receptor kinase inhibitor
US20070099856A1 (en) * 2005-05-13 2007-05-03 Gumerlock Paul H Combined treatment with docetaxel and an epidermal growth factor receptor kinase inhibitor using an intermittent dosing regimen
TW200744603A (en) * 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
CA2626330A1 (fr) * 2005-10-19 2007-04-26 Chugai Seiyaku Kabushiki Kaisha Agents de prevention ou de therapie du cancer du pancreas, des ovaires ou du foie comportant une nouvelle prodrogue soluble dans l'eau
WO2007049361A1 (fr) * 2005-10-27 2007-05-03 Stelic Corp. Inhibiteur de fibrose hepatique
EP1957536A2 (fr) * 2005-12-01 2008-08-20 Domantis Limited Formats d'anticorps a domaine non competitif qui lient le recepteur type 1 d'interleukine 1
US8575164B2 (en) * 2005-12-19 2013-11-05 OSI Pharmaceuticals, LLC Combination cancer therapy
EP2094268A2 (fr) * 2006-05-26 2009-09-02 Bayer HealthCare, LLC Associations de médicaments comportant des urées de diaryle substituées pour le traitement du cancer
KR100723641B1 (ko) * 2006-06-07 2007-06-04 실버레이 주식회사 다중 조리가 가능한 솥
US20070286864A1 (en) * 2006-06-09 2007-12-13 Buck Elizabeth A Combined treatment with an EGFR kinase inhibitor and an agent that sensitizes tumor cells to the effects of EGFR kinase inhibitors
WO2008046107A2 (fr) * 2006-10-13 2008-04-17 The Regents Of The University Of California Nouveaux inhibiteurs de kinase egfr ciblant l'interface de dimère à activation asymétrique
CN104013956B (zh) * 2007-01-25 2018-12-18 达娜-法勃肿瘤研究所公司 抗egfr抗体在治疗egfr突变体介导的疾病中的用途
AU2008227123B2 (en) * 2007-03-15 2014-03-27 Ludwig Institute For Cancer Research Ltd. Treatment method using EGFR antibodies and src inhibitors and related formulations
WO2008149147A2 (fr) * 2007-06-06 2008-12-11 Domantis Limited Polypeptides, domaines variables d'anticorps et antagonistes
CA2696360C (fr) 2007-08-14 2018-11-20 Ludwig Institute For Cancer Research Anticorps monoclonal ciblant le recepteur egfr et ses utilisations
WO2009067548A1 (fr) * 2007-11-19 2009-05-28 The Regents Of The University Of California Nouvelle analyse pour des inhibiteurs d'egfr
EP2250173A1 (fr) * 2008-01-18 2010-11-17 OSI Pharmaceuticals, Inc. Dérivés d'imidazopyrazinol pour le traitement des cancers
AU2009221164B2 (en) * 2008-03-05 2012-07-26 Novartis Ag Use of pyrimidine derivatives for the treatment of EGFR dependent diseases or diseases that have acquired resistance to agents that target EGFR family members
EP2283020B8 (fr) * 2008-05-19 2012-12-12 OSI Pharmaceuticals, LLC Imidazopyrazines et imidazotriazines substituées
US20120064072A1 (en) 2009-03-18 2012-03-15 Maryland Franklin Combination Cancer Therapy Comprising Administration of an EGFR Inhibitor and an IGF-1R Inhibitor
MX2011009729A (es) * 2009-03-20 2011-10-14 Genentech Inc Anticuerpos anti-her.
JP2012524119A (ja) 2009-04-20 2012-10-11 オーエスアイ・ファーマシューティカルズ，エルエルシー Ｃ−ピラジン−メチルアミンの調製
WO2010129740A1 (fr) * 2009-05-07 2010-11-11 Osi Pharmaceuticals, Inc. Utilisation d'osi-906 dans le traitement du carcinome adrénocortical
US20110076232A1 (en) * 2009-09-29 2011-03-31 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
EP2569434B1 (fr) 2010-05-14 2019-09-04 Dana-Farber Cancer Institute, Inc. Compositions et méthodes de traitement de la leucémie et des troubles associés
BR122014024883A2 (pt) 2010-05-14 2019-08-20 Dana-Farber Cancer Institute, Inc. Compostos no tratamento de neoplasia
RU2457546C1 (ru) * 2011-03-09 2012-07-27 Учреждение Российской академии медицинских наук Научный центр реконструктивной и восстановительной хирургии Сибирского отделения РАМН (НЦРВХ СО РАМН) Способ моделирования аденокарциномы толстой кишки человека
WO2012129145A1 (fr) 2011-03-18 2012-09-27 OSI Pharmaceuticals, LLC Polythérapie du cancer du poumon non à petites cellules (nsclc)
WO2012143499A2 (fr) 2011-04-21 2012-10-26 Bayer Intellectual Property Gmbh Nouveaux conjugués liant-principe actif (adc) et leur utilisation
CA2845179A1 (fr) 2011-08-31 2013-03-07 Genentech, Inc. Marqueurs de diagnostic
AU2012321248A1 (en) 2011-09-30 2014-04-24 Genentech, Inc. Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to EGFR kinase inhibitor in tumours or tumour cells
RU2016122654A (ru) 2013-11-08 2017-12-14 Дана-Фарбер Кэнсер Инститьют, Инк. Комбинированная терапия злокачественной опухоли с использованием ингибиторов бромодоменового и экстратерминального (вет) белка
SG11201607108XA (en) 2014-02-28 2016-09-29 Tensha Therapeutics Inc Treatment of conditions associated with hyperinsulinaemia
MA39776A (fr) 2014-03-24 2017-02-01 Hoffmann La Roche Traitement du cancer avec des antagonistes de c-met et corrélation de ces derniers avec l'expression de hgf
CN116333130A (zh) 2016-05-24 2023-06-27 英斯梅德股份有限公司 抗体及其制备方法
AU2018302647A1 (en) * 2017-07-18 2020-02-06 Kyoto University Anti-human CCR1 monoclonal antibody
AR114473A1 (es) * 2018-04-06 2020-09-09 Seattle Genetics Inc Conjugados péptido-camptotecina

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU22545A1 (es) * 1994-11-18 1999-03-31 Centro Inmunologia Molecular Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
FR2388385B1 (fr) * 1977-04-18 1982-01-08 Hitachi Metals Ltd Piece d'ornement fixee par des aimants permanents
US4510924A (en) * 1980-07-10 1985-04-16 Yale-New Haven Hospital, Inc. Brachytherapy devices and methods employing americium-241
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4943533A (en) 1984-03-01 1990-07-24 The Regents Of The University Of California Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
US5866363A (en) * 1985-08-28 1999-02-02 Pieczenik; George Method and means for sorting and identifying biological information
US4816401A (en) * 1985-09-09 1989-03-28 University Of Rochester Serum free cell culture medium
CA1275922C (fr) * 1985-11-28 1990-11-06 Harunobu Amagase Traitement du cancer
US4846782A (en) 1986-03-14 1989-07-11 Schering Corporation Treatment of cancer with interferon and radiotherapy
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4763642A (en) * 1986-04-07 1988-08-16 Horowitz Bruce S Intracavitational brachytherapy
US5260203A (en) * 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
WO1989006692A1 (fr) * 1988-01-12 1989-07-27 Genentech, Inc. Procede de traitement de cellules tumorales par inhibition de la fonction receptrice du facteur de croissance
US5470571A (en) * 1988-01-27 1995-11-28 The Wistar Institute Method of treating human EGF receptor-expressing gliomas using radiolabeled EGF receptor-specific MAB 425
IL89489A0 (en) 1988-03-09 1989-09-10 Hybritech Inc Chimeric antibodies directed against human carcinoembryonic antigen
KR900700134A (ko) 1988-04-15 1990-08-11 원본미기재 Il-2 수용체-특이적 키메릭 항체
WO1989009825A1 (fr) 1988-04-16 1989-10-19 Celltech Limited Procede de production de proteines d'adn recombinant
AU4128089A (en) * 1988-09-15 1990-03-22 Rorer International (Overseas) Inc. Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
CA2063431C (fr) * 1989-07-06 2002-10-29 Lewis T. Williams Recepteurs de facteurs de croisance fibroblastes
US5705157A (en) * 1989-07-27 1998-01-06 The Trustees Of The University Of Pennsylvania Methods of treating cancerous cells with anti-receptor antibodies
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5196446A (en) 1990-04-16 1993-03-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Certain indole compounds which inhibit EGF receptor tyrosine kinase
GB9015198D0 (en) * 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
AU662311B2 (en) 1991-02-05 1995-08-31 Novartis Ag Recombinant antibodies specific for a growth factor receptor
ES2204890T3 (es) * 1991-03-06 2004-05-01 Merck Patent Gmbh Anticuerpos monoclonales humanizados.
US5480883A (en) 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
LU91067I2 (fr) * 1991-06-14 2004-04-02 Genentech Inc Trastuzumab et ses variantes et dérivés immuno chimiques y compris les immotoxines
IE922437A1 (en) 1991-07-25 1993-01-27 Idec Pharma Corp Recombinant antibodies for human therapy
ES2136092T3 (es) * 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5559235A (en) 1991-10-29 1996-09-24 Glaxo Wellcome Inc. Water soluble camptothecin derivatives
ES2313867T3 (es) * 1991-12-02 2009-03-16 Medical Research Council Produccion de anticuerpos anti-auto de repertorios de segmentos de anticuerpo expresados en la superficie de fagos.
GB9300059D0 (en) 1992-01-20 1993-03-03 Zeneca Ltd Quinazoline derivatives
WO1993021319A1 (fr) 1992-04-08 1993-10-28 Cetus Oncology Corporation ANTICORPS HUMANISES SPECIFIES PAR C-erbB-2
US6177401B1 (en) * 1992-11-13 2001-01-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
CA2150262C (fr) * 1992-12-04 2008-07-08 Kaspar-Philipp Holliger Proteines fixatrices multivalentes et multispecifiques, fabrication et utilisation
US5855885A (en) * 1993-01-22 1999-01-05 Smith; Rodger Isolation and production of catalytic antibodies using phage technology
US5550114A (en) * 1993-04-02 1996-08-27 Thomas Jefferson University Epidermal growth factor inhibitor
US5679683A (en) 1994-01-25 1997-10-21 Warner-Lambert Company Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
US6448077B1 (en) * 1994-02-10 2002-09-10 Imclone Systems, Inc. Chimeric and humanized monoclonal antibodies specific to VEGF receptors
US5861499A (en) * 1994-02-10 1999-01-19 Imclone Systems Incorporated Nucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain
US5840301A (en) * 1994-02-10 1998-11-24 Imclone Systems Incorporated Methods of use of chimerized, humanized, and single chain antibodies specific to VEGF receptors
JP2890267B2 (ja) * 1994-02-23 1999-05-10 ファイザー インク． ４−ヘテロサイクリル−置換キナゾリン誘導体、その調製法および抗癌剤としてのその使用法
AU2096895A (en) * 1994-03-07 1995-09-25 Sugen, Incorporated Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
US5656655A (en) 1994-03-17 1997-08-12 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Styryl-substituted heteroaryl compounds which inhibit EGF receptor tyrosine kinase
UA41929C2 (uk) * 1994-03-17 2001-10-15 Мерк Патент Гмбх Анти-ефрр одноланцюжковий fv,молекула днк,яка його кодує, анти-ефрр антитіло,спосіб одержання анти-ефрр одноланцюжкового fv,спосіб одержання повного анти-ефрр антитіла та фармацевтична композиція (варіанти)
US5869465A (en) * 1994-04-08 1999-02-09 Receptagen Corporation Methods of receptor modulation and uses therefor
US5468754A (en) 1994-04-19 1995-11-21 Bionumerik Pharmaceuticals, Inc. 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof
US5604233A (en) 1994-04-28 1997-02-18 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of 7-ethyl camptothecin and methods for uses thereof
US5626862A (en) * 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5663144A (en) * 1995-05-03 1997-09-02 The Trustees Of The University Of Pennsylvania Compounds that bind to p185 and methods of using the same
US5726181A (en) 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
JPH11507535A (ja) * 1995-06-07 1999-07-06 イムクローン システムズ インコーポレイテッド 腫瘍の成長を抑制する抗体および抗体フラグメント類
US7060808B1 (en) * 1995-06-07 2006-06-13 Imclone Systems Incorporated Humanized anti-EGF receptor monoclonal antibody
US6685940B2 (en) * 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
DE69712745T2 (de) * 1996-01-23 2002-10-31 Novartis Ag, Basel Pyrrolopyrimidinen und verfahren zu deren herstellung
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
GB9707800D0 (en) * 1996-05-06 1997-06-04 Zeneca Ltd Chemical compounds
WO1997046684A1 (fr) * 1996-06-06 1997-12-11 University Of Massachusetts Proteines complexes se liant a des recepteurs non actives
US6004967A (en) * 1996-09-13 1999-12-21 Sugen, Inc. Psoriasis treatment with quinazoline compounds
US5942602A (en) * 1997-02-13 1999-08-24 Schering Aktiengessellschaft Growth factor receptor antibodies
US20030105057A1 (en) * 1997-03-19 2003-06-05 Yale University Methods and compositions for stimulating apoptosis and cell death or for inhibiting cell growth and cell attachment
US5914269A (en) * 1997-04-04 1999-06-22 Isis Pharmaceuticals, Inc. Oligonucleotide inhibition of epidermal growth factor receptor expression
US20020173629A1 (en) * 1997-05-05 2002-11-21 Aya Jakobovits Human monoclonal antibodies to epidermal growth factor receptor
US6235883B1 (en) * 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
US6417168B1 (en) * 1998-03-04 2002-07-09 The Trustees Of The University Of Pennsylvania Compositions and methods of treating tumors
ZA200007412B (en) * 1998-05-15 2002-03-12 Imclone Systems Inc Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases.
US7396810B1 (en) * 2000-08-14 2008-07-08 Oregon Health Sciences University Compositions and methods for treating cancer by modulating HER-2 and EGF receptors
EP2042194A3 (fr) * 1999-05-14 2009-04-22 Imclone Systems, Inc. Traitement des tumeurs humaines réfractaires avec des antagonistes de récepteur de facteur de croissance épidermique
PL202369B1 (pl) * 1999-08-27 2009-06-30 Genentech Inc Zastosowanie przeciwciała skierowanego przeciw ErbB2, zastosowanie przeciwciała skierowanego przeciw ErbB oraz zestaw zawierający to przeciwciało
CA2422881A1 (fr) * 2000-10-13 2002-04-18 Uab Research Foundation Anticorps en chaine simple de recepteur de facteur de croissance anti-epidermique humain
WO2002045653A2 (fr) * 2000-12-08 2002-06-13 Uab Research Foundation Radiotherapie et chimiotherapie combinees avec l'administration d'un anticorps du recepteur du facteur de croissance
WO2002087618A1 (fr) * 2001-04-27 2002-11-07 Takeda Chemical Industries, Ltd. Methode de prevention et de traitement du cancer
US7595378B2 (en) * 2001-06-13 2009-09-29 Genmab A/S Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
BRPI0210405B8 (pt) * 2001-06-13 2021-05-25 Genmab As anticorpo monoclonal humano, molécula biespecífica, método in vitro para inibir o crescimento de uma célula expressando egfr, para induzir a citólise de uma célula expressando egfr, e para detectar a presença de antígeno egfr ou uma célula expressando egfr em uma amostra, e, vetor de expressão
DE10163459A1 (de) * 2001-12-21 2003-07-03 Merck Patent Gmbh Lyophilisierte Zubereitung enthaltend Antikörper gegen EGF-Rezeptor
EP2305284A3 (fr) * 2002-03-08 2012-11-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Utilisation de transactivateur de l'EGFR dans le cancer chez l'humain
AU2003222049B2 (en) * 2002-03-21 2007-05-31 Cayman Chemical Company, Incorporated Prostaglandin F2 alpha analogs in combination with antimicrobials for treating glaucoma
WO2003101491A1 (fr) * 2002-06-03 2003-12-11 Mitsubishi Pharma Corporation Moyens preventifs et/ou therapeutiques destines a des sujets presentant l'expression ou l'activation de her2 et/ou egfr
RU2349340C2 (ru) * 2002-10-10 2009-03-20 Мерк Патент Гмбх Биспецифические антитела к erb-b и их применение для лечения опухолей
EP1493445A1 (fr) * 2003-07-04 2005-01-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibition de l'activation de l'EGFR, cette activation étant dépendante d'un ligand et étant induite par le stress
ES2352697T3 (es) * 2003-11-07 2011-02-22 Ablynx N.V. Anticuerpos de dominio único de camelidae vhh dirigidos contra el receptor del factor de crecimiento epidérmico y usos de los mismos.
DE10355904A1 (de) * 2003-11-29 2005-06-30 Merck Patent Gmbh Feste Formen von anti-EGFR-Antikörpern
CN1953768B (zh) * 2004-02-12 2010-10-13 默克专利有限公司 抗-egfr抗体的高浓缩液体制剂
TW200533339A (en) * 2004-03-16 2005-10-16 Bristol Myers Squibb Co Therapeutic synergy of anti-cancer compounds
CN103007279B (zh) * 2004-03-19 2017-01-11 英克隆有限责任公司 人抗表皮生长因子受体抗体
PE20070207A1 (es) * 2005-07-22 2007-03-09 Genentech Inc Tratamiento combinado de los tumores que expresan el her

Also Published As

Publication number Publication date
BR0010524A (pt) 2002-05-28
CZ20014083A3 (cs) 2002-08-14
PL365999A1 (en) 2005-01-24
AU782994B2 (en) 2005-09-15
NO20015546D0 (no) 2001-11-13
IL146480A0 (en) 2002-07-25
EE200100603A (et) 2003-02-17
HK1047236A1 (zh) 2003-02-14
SK16522001A3 (sk) 2002-10-08
US20030157104A1 (en) 2003-08-21
JP2009120583A (ja) 2009-06-04
CA2373815A1 (fr) 2000-11-23
EP2042194A3 (fr) 2009-04-22
MXPA01011632A (es) 2002-11-07
KR20020000223A (ko) 2002-01-05
EP1218032A4 (fr) 2005-05-25
CN1200734C (zh) 2005-05-11
EP2042194A2 (fr) 2009-04-01
JP2003520195A (ja) 2003-07-02
US20050112120A1 (en) 2005-05-26
US20020012663A1 (en) 2002-01-31
AU4687100A (en) 2000-12-05
RU2294761C2 (ru) 2007-03-10
NO20015546L (no) 2002-01-14
HUP0201480A3 (en) 2009-03-30
HUP0201480A2 (en) 2002-08-28
EP1218032A1 (fr) 2002-07-03
WO2000069459A1 (fr) 2000-11-23
AU782994C (en) 2006-08-24
CN1361700A (zh) 2002-07-31

Similar Documents

Publication Publication Date Title
AU782994C (en) Treatment of refractory human tumors with epidermal growth factor receptor antagonists
US9522956B2 (en) Combination therapy using anti-EGFR and anti-HER2 antibodies
CA2436326C (fr) Polytherapie faisant appel a des inhibiteurs de recepteurs tyrosine kinase et a des inhibiteurs d'angiogenese
RU2531758C2 (ru) Моноклональные антитела для лечения опухолей
KR101088661B1 (ko) Ｅｒｂ－ｂ１ 수용체를 표적으로 하는 약학적 조성물
US20090297509A1 (en) Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases
SK17282000A3 (sk) Nerádioaktívne označený inhibítor proteínového tyrozínkynázového receptora
US20030202973A1 (en) Treatment of refractory human tumors with epidermal growth factor receptor and HER1 mitogenic ligand (EGFRML) antagonists
KR20080099290A (ko) 암 치료용 ｉｌ-17 길항 항체
AU2004200705A1 (en) Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases