BG105360A - Модулиране на сложна линия киназни белтъци - Google Patents
Модулиране на сложна линия киназни белтъци Download PDFInfo
- Publication number
- BG105360A BG105360A BG105360A BG10536001A BG105360A BG 105360 A BG105360 A BG 105360A BG 105360 A BG105360 A BG 105360A BG 10536001 A BG10536001 A BG 10536001A BG 105360 A BG105360 A BG 105360A
- Authority
- BG
- Bulgaria
- Prior art keywords
- group
- carbon atoms
- protein
- alkyl
- carbons
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Pain & Pain Management (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Cell Biology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9798098P | 1998-08-26 | 1998-08-26 | |
PCT/US1999/018864 WO2000013015A1 (fr) | 1998-08-26 | 1999-08-18 | Modulation de proteines kinase a lignee multiple |
Publications (1)
Publication Number | Publication Date |
---|---|
BG105360A true BG105360A (bg) | 2001-10-31 |
Family
ID=22266038
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG105360A BG105360A (bg) | 1998-08-26 | 2001-03-19 | Модулиране на сложна линия киназни белтъци |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP1105728B1 (fr) |
JP (1) | JP2002523780A (fr) |
KR (1) | KR100700028B1 (fr) |
CN (3) | CN1206535C (fr) |
AT (1) | ATE293254T1 (fr) |
AU (1) | AU765637B2 (fr) |
BG (1) | BG105360A (fr) |
BR (1) | BR9913190A (fr) |
CA (1) | CA2339539A1 (fr) |
CZ (1) | CZ2001701A3 (fr) |
DE (1) | DE69924738T2 (fr) |
DK (1) | DK1105728T3 (fr) |
EA (2) | EA006648B1 (fr) |
ES (1) | ES2241316T3 (fr) |
HK (1) | HK1037722A1 (fr) |
HU (1) | HUP0103079A3 (fr) |
NO (1) | NO20010389L (fr) |
NZ (1) | NZ509612A (fr) |
PL (1) | PL346246A1 (fr) |
PT (1) | PT1105728E (fr) |
SK (1) | SK2542001A3 (fr) |
TR (2) | TR200400635T2 (fr) |
UA (1) | UA74772C2 (fr) |
WO (1) | WO2000013015A1 (fr) |
ZA (1) | ZA200100835B (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6811992B1 (en) | 1998-05-14 | 2004-11-02 | Ya Fang Liu | Method for identifying MLK inhibitors for the treatment of neurological conditions |
US6841567B1 (en) | 1999-02-12 | 2005-01-11 | Cephalon, Inc. | Cyclic substituted fused pyrrolocarbazoles and isoindolones |
US7122679B2 (en) * | 2000-05-09 | 2006-10-17 | Cephalon, Inc. | Multicyclic compounds and the use thereof |
BR0113266A (pt) * | 2000-08-11 | 2005-01-04 | Cephalon Inc | Métodos para modular proteìnas quinase de linhagem múltipla e compostos protetores que modulam proteìnas quinase de linhagem múltipla |
US7018999B2 (en) | 2001-05-16 | 2006-03-28 | Cephalon, Inc. | Methods for the treatment and prevention of pain |
FR2826653B1 (fr) * | 2001-06-29 | 2005-10-14 | Servier Lab | Nouveaux derives de pyrido-pyrido-pyrrolo[3,2-g]pyrrolo [3,4-e]-indole et pyrido-pyrrolo[2,3-a]pyrrolo[3,4-c] carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
JP2003052395A (ja) * | 2001-08-09 | 2003-02-25 | Japan Tissue Engineering:Kk | 移植適正判定方法 |
AR069501A1 (es) | 2007-11-30 | 2010-01-27 | Genentech Inc | Anticuerpos anti- vegf (factor de crecimiento endotelial vascular) |
EP2240783A2 (fr) * | 2008-02-04 | 2010-10-20 | Galapagos N.V. | Cibles moléculaires et composés, procédés permettant de les identifier, à utiliser dans le traitement des maladies neurodégénératives |
US20100056609A1 (en) * | 2008-08-26 | 2010-03-04 | Washington University | Methods and compositions for inhibition of axonal degeneration by modulation of the dlk/jnk pathway |
AU2015202365B2 (en) * | 2008-10-22 | 2016-11-24 | Genentech, Inc. | Modulation of axon degeneration |
KR20110081862A (ko) * | 2008-10-22 | 2011-07-14 | 제넨테크, 인크. | 축삭 변성의 조절 |
CN102573855A (zh) * | 2009-10-22 | 2012-07-11 | 霍夫曼-拉罗奇有限公司 | 轴突变性的调节 |
ES2385157B1 (es) * | 2010-02-25 | 2013-07-08 | Universidad Del País Vasco | Compuestos para el tratamiento de alzheimer. |
US9539259B2 (en) | 2012-05-23 | 2017-01-10 | The Johns Hopkins University | Compounds and methods of use thereof for treating neurodegenerative disorders |
CN109060472A (zh) * | 2018-07-20 | 2018-12-21 | 上海市农业科学院 | 一种适于荧光染色的草菇菌褶组织切片的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5756494A (en) * | 1992-07-24 | 1998-05-26 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
US5705511A (en) * | 1994-10-14 | 1998-01-06 | Cephalon, Inc. | Fused pyrrolocarbazoles |
US5475110A (en) * | 1994-10-14 | 1995-12-12 | Cephalon, Inc. | Fused Pyrrolocarbazoles |
US6811992B1 (en) * | 1998-05-14 | 2004-11-02 | Ya Fang Liu | Method for identifying MLK inhibitors for the treatment of neurological conditions |
-
1999
- 1999-08-18 AT AT99943759T patent/ATE293254T1/de active
- 1999-08-18 CZ CZ2001701A patent/CZ2001701A3/cs unknown
- 1999-08-18 JP JP2000567949A patent/JP2002523780A/ja active Pending
- 1999-08-18 UA UA2001031963A patent/UA74772C2/uk unknown
- 1999-08-18 CA CA002339539A patent/CA2339539A1/fr not_active Abandoned
- 1999-08-18 CN CNB998101354A patent/CN1206535C/zh not_active Expired - Fee Related
- 1999-08-18 PT PT99943759T patent/PT1105728E/pt unknown
- 1999-08-18 WO PCT/US1999/018864 patent/WO2000013015A1/fr active IP Right Grant
- 1999-08-18 EA EA200100278A patent/EA006648B1/ru not_active IP Right Cessation
- 1999-08-18 DE DE69924738T patent/DE69924738T2/de not_active Expired - Lifetime
- 1999-08-18 BR BR9913190-0A patent/BR9913190A/pt not_active Application Discontinuation
- 1999-08-18 ES ES99943759T patent/ES2241316T3/es not_active Expired - Lifetime
- 1999-08-18 AU AU56793/99A patent/AU765637B2/en not_active Ceased
- 1999-08-18 TR TR2004/00635T patent/TR200400635T2/xx unknown
- 1999-08-18 NZ NZ509612A patent/NZ509612A/en not_active IP Right Cessation
- 1999-08-18 HU HU0103079A patent/HUP0103079A3/hu unknown
- 1999-08-18 PL PL99346246A patent/PL346246A1/xx not_active Application Discontinuation
- 1999-08-18 CN CNA200610099703XA patent/CN1879617A/zh active Pending
- 1999-08-18 CN CNA2004100491086A patent/CN1589788A/zh active Pending
- 1999-08-18 DK DK99943759T patent/DK1105728T3/da active
- 1999-08-18 TR TR2001/00589T patent/TR200100589T2/xx unknown
- 1999-08-18 SK SK254-2001A patent/SK2542001A3/sk unknown
- 1999-08-18 EP EP99943759A patent/EP1105728B1/fr not_active Expired - Lifetime
- 1999-08-18 EA EA200500934A patent/EA200500934A1/ru unknown
- 1999-08-18 KR KR1020017002385A patent/KR100700028B1/ko active IP Right Grant
-
2001
- 2001-01-23 NO NO20010389A patent/NO20010389L/no not_active Application Discontinuation
- 2001-01-30 ZA ZA2001/00835A patent/ZA200100835B/en unknown
- 2001-03-19 BG BG105360A patent/BG105360A/bg unknown
- 2001-11-23 HK HK01108292A patent/HK1037722A1/xx not_active IP Right Cessation
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