DK1105728T3 - Modulering af multiple lineage kinase-proteiner - Google Patents

Modulering af multiple lineage kinase-proteiner

Info

Publication number
DK1105728T3
DK1105728T3 DK99943759T DK99943759T DK1105728T3 DK 1105728 T3 DK1105728 T3 DK 1105728T3 DK 99943759 T DK99943759 T DK 99943759T DK 99943759 T DK99943759 T DK 99943759T DK 1105728 T3 DK1105728 T3 DK 1105728T3
Authority
DK
Denmark
Prior art keywords
lineage kinase
multiple lineage
methods
compound
protein
Prior art date
Application number
DK99943759T
Other languages
Danish (da)
English (en)
Inventor
Nicola Neff
Anna Maroney
Kevin M Walton
Craig A Dionne
Ernest Knight Jr
Marcie A Glicksman
Original Assignee
Cephalon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon Inc filed Critical Cephalon Inc
Application granted granted Critical
Publication of DK1105728T3 publication Critical patent/DK1105728T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
DK99943759T 1998-08-26 1999-08-18 Modulering af multiple lineage kinase-proteiner DK1105728T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9798098P 1998-08-26 1998-08-26
EP99943759A EP1105728B1 (fr) 1998-08-26 1999-08-18 Modulation de proteines kinase a lignee multiple

Publications (1)

Publication Number Publication Date
DK1105728T3 true DK1105728T3 (da) 2005-08-08

Family

ID=22266038

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99943759T DK1105728T3 (da) 1998-08-26 1999-08-18 Modulering af multiple lineage kinase-proteiner

Country Status (25)

Country Link
EP (1) EP1105728B1 (fr)
JP (1) JP2002523780A (fr)
KR (1) KR100700028B1 (fr)
CN (3) CN1879617A (fr)
AT (1) ATE293254T1 (fr)
AU (1) AU765637B2 (fr)
BG (1) BG105360A (fr)
BR (1) BR9913190A (fr)
CA (1) CA2339539A1 (fr)
CZ (1) CZ2001701A3 (fr)
DE (1) DE69924738T2 (fr)
DK (1) DK1105728T3 (fr)
EA (2) EA200500934A1 (fr)
ES (1) ES2241316T3 (fr)
HK (1) HK1037722A1 (fr)
HU (1) HUP0103079A3 (fr)
NO (1) NO20010389L (fr)
NZ (1) NZ509612A (fr)
PL (1) PL346246A1 (fr)
PT (1) PT1105728E (fr)
SK (1) SK2542001A3 (fr)
TR (2) TR200400635T2 (fr)
UA (1) UA74772C2 (fr)
WO (1) WO2000013015A1 (fr)
ZA (1) ZA200100835B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6811992B1 (en) 1998-05-14 2004-11-02 Ya Fang Liu Method for identifying MLK inhibitors for the treatment of neurological conditions
US6841567B1 (en) 1999-02-12 2005-01-11 Cephalon, Inc. Cyclic substituted fused pyrrolocarbazoles and isoindolones
US7122679B2 (en) * 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof
AU2001283179B2 (en) * 2000-08-11 2006-07-13 Cephalon, Inc. Modulating multiple lineage kinase proteins
US7018999B2 (en) 2001-05-16 2006-03-28 Cephalon, Inc. Methods for the treatment and prevention of pain
FR2826653B1 (fr) * 2001-06-29 2005-10-14 Servier Lab Nouveaux derives de pyrido-pyrido-pyrrolo[3,2-g]pyrrolo [3,4-e]-indole et pyrido-pyrrolo[2,3-a]pyrrolo[3,4-c] carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2003052395A (ja) * 2001-08-09 2003-02-25 Japan Tissue Engineering:Kk 移植適正判定方法
AR069501A1 (es) 2007-11-30 2010-01-27 Genentech Inc Anticuerpos anti- vegf (factor de crecimiento endotelial vascular)
US20110077283A1 (en) * 2008-02-04 2011-03-31 David Frederik Fischer Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases
US20100056609A1 (en) * 2008-08-26 2010-03-04 Washington University Methods and compositions for inhibition of axonal degeneration by modulation of the dlk/jnk pathway
AU2015202365B2 (en) * 2008-10-22 2016-11-24 Genentech, Inc. Modulation of axon degeneration
MX2011004306A (es) * 2008-10-22 2011-07-28 Genentech Inc Modulacion de degeneracion de axones.
AU2010310589A1 (en) * 2009-10-22 2012-05-10 Genentech, Inc. Modulation of axon degeneration
ES2385157B1 (es) * 2010-02-25 2013-07-08 Universidad Del País Vasco Compuestos para el tratamiento de alzheimer.
WO2013177367A2 (fr) 2012-05-23 2013-11-28 The Johns Hopkins University Composés et méthodes d'utilisation de ceux-ci pour traiter des troubles neurodégénératifs
CN109060472A (zh) * 2018-07-20 2018-12-21 上海市农业科学院 一种适于荧光染色的草菇菌褶组织切片的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756494A (en) * 1992-07-24 1998-05-26 Cephalon, Inc. Protein kinase inhibitors for treatment of neurological disorders
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
US5475110A (en) * 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
US6811992B1 (en) * 1998-05-14 2004-11-02 Ya Fang Liu Method for identifying MLK inhibitors for the treatment of neurological conditions

Also Published As

Publication number Publication date
DE69924738T2 (de) 2006-03-02
EP1105728B1 (fr) 2005-04-13
EA200500934A1 (ru) 2006-04-28
DE69924738D1 (de) 2005-05-19
CN1206535C (zh) 2005-06-15
CN1589788A (zh) 2005-03-09
BG105360A (bg) 2001-10-31
JP2002523780A (ja) 2002-07-30
HUP0103079A2 (hu) 2001-12-28
WO2000013015A8 (fr) 2000-05-11
EA200100278A1 (ru) 2002-06-27
HUP0103079A3 (en) 2004-03-01
ATE293254T1 (de) 2005-04-15
WO2000013015A1 (fr) 2000-03-09
TR200100589T2 (tr) 2001-07-23
HK1037722A1 (en) 2002-02-15
NO20010389L (no) 2001-04-02
NZ509612A (en) 2003-10-31
EA006648B1 (ru) 2006-02-24
NO20010389D0 (no) 2001-01-23
KR100700028B1 (ko) 2007-03-27
ZA200100835B (en) 2002-06-26
ES2241316T3 (es) 2005-10-16
AU765637B2 (en) 2003-09-25
BR9913190A (pt) 2001-12-11
CA2339539A1 (fr) 2000-03-09
SK2542001A3 (en) 2002-06-04
CN1879617A (zh) 2006-12-20
TR200400635T2 (tr) 2005-10-21
AU5679399A (en) 2000-03-21
KR20010103573A (ko) 2001-11-23
CZ2001701A3 (cs) 2002-04-17
EP1105728A1 (fr) 2001-06-13
CN1314999A (zh) 2001-09-26
PT1105728E (pt) 2005-07-29
UA74772C2 (en) 2006-02-15
PL346246A1 (en) 2002-01-28

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