ATE293254T1 - Modulierung von mlk- (multiple lineage kinase) proteinen - Google Patents

Modulierung von mlk- (multiple lineage kinase) proteinen

Info

Publication number
ATE293254T1
ATE293254T1 AT99943759T AT99943759T ATE293254T1 AT E293254 T1 ATE293254 T1 AT E293254T1 AT 99943759 T AT99943759 T AT 99943759T AT 99943759 T AT99943759 T AT 99943759T AT E293254 T1 ATE293254 T1 AT E293254T1
Authority
AT
Austria
Prior art keywords
lineage kinase
multiple lineage
methods
compound
protein
Prior art date
Application number
AT99943759T
Other languages
English (en)
Inventor
Anna Maroney
Kevin M Walton
Craig A Dionne
Nicola Neff
Ernest Knight Jr
Marcie A Glicksman
Original Assignee
Cephalon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon Inc filed Critical Cephalon Inc
Application granted granted Critical
Publication of ATE293254T1 publication Critical patent/ATE293254T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Psychiatry (AREA)
  • Pathology (AREA)
AT99943759T 1998-08-26 1999-08-18 Modulierung von mlk- (multiple lineage kinase) proteinen ATE293254T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9798098P 1998-08-26 1998-08-26
PCT/US1999/018864 WO2000013015A1 (en) 1998-08-26 1999-08-18 Modulating multiple lineage kinase proteins

Publications (1)

Publication Number Publication Date
ATE293254T1 true ATE293254T1 (de) 2005-04-15

Family

ID=22266038

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99943759T ATE293254T1 (de) 1998-08-26 1999-08-18 Modulierung von mlk- (multiple lineage kinase) proteinen

Country Status (24)

Country Link
EP (1) EP1105728B1 (de)
JP (1) JP2002523780A (de)
KR (1) KR100700028B1 (de)
CN (3) CN1589788A (de)
AT (1) ATE293254T1 (de)
AU (1) AU765637B2 (de)
BG (1) BG105360A (de)
BR (1) BR9913190A (de)
CA (1) CA2339539A1 (de)
CZ (1) CZ2001701A3 (de)
DE (1) DE69924738T2 (de)
DK (1) DK1105728T3 (de)
EA (2) EA006648B1 (de)
ES (1) ES2241316T3 (de)
HU (1) HUP0103079A3 (de)
NO (1) NO20010389L (de)
NZ (1) NZ509612A (de)
PL (1) PL346246A1 (de)
PT (1) PT1105728E (de)
SK (1) SK2542001A3 (de)
TR (2) TR200400635T2 (de)
UA (1) UA74772C2 (de)
WO (1) WO2000013015A1 (de)
ZA (1) ZA200100835B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6811992B1 (en) 1998-05-14 2004-11-02 Ya Fang Liu Method for identifying MLK inhibitors for the treatment of neurological conditions
US6841567B1 (en) 1999-02-12 2005-01-11 Cephalon, Inc. Cyclic substituted fused pyrrolocarbazoles and isoindolones
US7122679B2 (en) * 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof
CN1458979A (zh) * 2000-08-11 2003-11-26 赛福伦公司 调节多谱系激酶蛋白
US7018999B2 (en) 2001-05-16 2006-03-28 Cephalon, Inc. Methods for the treatment and prevention of pain
FR2826653B1 (fr) * 2001-06-29 2005-10-14 Servier Lab Nouveaux derives de pyrido-pyrido-pyrrolo[3,2-g]pyrrolo [3,4-e]-indole et pyrido-pyrrolo[2,3-a]pyrrolo[3,4-c] carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2003052395A (ja) * 2001-08-09 2003-02-25 Japan Tissue Engineering:Kk 移植適正判定方法
TWI468417B (zh) 2007-11-30 2015-01-11 Genentech Inc 抗－ｖｅｇｆ抗體
JP2011517339A (ja) * 2008-02-04 2011-06-02 ガラパゴス・ナムローゼ・フェンノートシャップ 神経変性疾患の治療に有用な分子標的及び化合物並びにこれらの同定方法
US20100056609A1 (en) * 2008-08-26 2010-03-04 Washington University Methods and compositions for inhibition of axonal degeneration by modulation of the dlk/jnk pathway
CN102307593B (zh) 2008-10-22 2016-04-13 弗·哈夫曼-拉罗切有限公司 轴突变性的调节
AU2015202365B2 (en) * 2008-10-22 2016-11-24 Genentech, Inc. Modulation of axon degeneration
AU2010310589A1 (en) * 2009-10-22 2012-05-10 Genentech, Inc. Modulation of axon degeneration
ES2385157B1 (es) * 2010-02-25 2013-07-08 Universidad Del País Vasco Compuestos para el tratamiento de alzheimer.
WO2013177367A2 (en) 2012-05-23 2013-11-28 The Johns Hopkins University Compounds and methods of use thereof for treating neurodegenerative disorders
CN109060472A (zh) * 2018-07-20 2018-12-21 上海市农业科学院 一种适于荧光染色的草菇菌褶组织切片的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756494A (en) * 1992-07-24 1998-05-26 Cephalon, Inc. Protein kinase inhibitors for treatment of neurological disorders
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
US5475110A (en) * 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
US6811992B1 (en) * 1998-05-14 2004-11-02 Ya Fang Liu Method for identifying MLK inhibitors for the treatment of neurological conditions

Also Published As

Publication number Publication date
CN1314999A (zh) 2001-09-26
ZA200100835B (en) 2002-06-26
NO20010389L (no) 2001-04-02
ES2241316T3 (es) 2005-10-16
NO20010389D0 (no) 2001-01-23
DE69924738D1 (de) 2005-05-19
CZ2001701A3 (cs) 2002-04-17
NZ509612A (en) 2003-10-31
HUP0103079A2 (hu) 2001-12-28
BG105360A (bg) 2001-10-31
DE69924738T2 (de) 2006-03-02
CN1206535C (zh) 2005-06-15
PL346246A1 (en) 2002-01-28
TR200100589T2 (tr) 2001-07-23
CA2339539A1 (en) 2000-03-09
HK1037722A1 (en) 2002-02-15
PT1105728E (pt) 2005-07-29
WO2000013015A1 (en) 2000-03-09
CN1589788A (zh) 2005-03-09
EP1105728A1 (de) 2001-06-13
AU765637B2 (en) 2003-09-25
EA006648B1 (ru) 2006-02-24
JP2002523780A (ja) 2002-07-30
EA200100278A1 (ru) 2002-06-27
UA74772C2 (en) 2006-02-15
EA200500934A1 (ru) 2006-04-28
AU5679399A (en) 2000-03-21
HUP0103079A3 (en) 2004-03-01
KR20010103573A (ko) 2001-11-23
BR9913190A (pt) 2001-12-11
WO2000013015A8 (en) 2000-05-11
SK2542001A3 (en) 2002-06-04
DK1105728T3 (da) 2005-08-08
TR200400635T2 (tr) 2005-10-21
EP1105728B1 (de) 2005-04-13
CN1879617A (zh) 2006-12-20
KR100700028B1 (ko) 2007-03-27

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