BG105310A - Метод за получаване на некристална анхидратна форма на пароксетин хидрохлорид - Google Patents

Метод за получаване на некристална анхидратна форма на пароксетин хидрохлорид

Info

Publication number
BG105310A
BG105310A BG105310A BG10531001A BG105310A BG 105310 A BG105310 A BG 105310A BG 105310 A BG105310 A BG 105310A BG 10531001 A BG10531001 A BG 10531001A BG 105310 A BG105310 A BG 105310A
Authority
BG
Bulgaria
Prior art keywords
paroxetine hydrochloride
preparation
crystalline anhydrate
propan
solvate
Prior art date
Application number
BG105310A
Other languages
English (en)
Inventor
Victor JACEWICZ
Neal Ward
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9817196.0A external-priority patent/GB9817196D0/en
Priority claimed from GBGB9828777.4A external-priority patent/GB9828777D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of BG105310A publication Critical patent/BG105310A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретението се отнася до метод, по който пропан-2-олов солват на пароксетин хидрохлорид се десолватизира за отстраняване на пропан-2-ола. Получава се пароксетин хидрохлорид анхидрид чрез загряване на солватната маса при повишаване на температурата, така че да се понижи количеството на пропан-2-ола в нея.
BG105310A 1998-08-07 2001-03-06 Метод за получаване на некристална анхидратна форма на пароксетин хидрохлорид BG105310A (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9817196.0A GB9817196D0 (en) 1998-08-07 1998-08-07 Novel process
GBGB9828777.4A GB9828777D0 (en) 1998-12-29 1998-12-29 Novel compounds
PCT/GB1999/002592 WO2000008017A1 (en) 1998-08-07 1999-08-06 Process for the preparation of a non-crystalline anhydrate form of paroxetine hydrochloride

Publications (1)

Publication Number Publication Date
BG105310A true BG105310A (bg) 2001-12-29

Family

ID=26314179

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105310A BG105310A (bg) 1998-08-07 2001-03-06 Метод за получаване на некристална анхидратна форма на пароксетин хидрохлорид

Country Status (24)

Country Link
EP (2) EP1321465A3 (bg)
JP (1) JP2002522434A (bg)
KR (1) KR20010072323A (bg)
CN (1) CN1321155A (bg)
AP (2) AP0102072A0 (bg)
AT (1) ATE239016T1 (bg)
AU (1) AU5428999A (bg)
BG (1) BG105310A (bg)
BR (1) BR9912858A (bg)
CA (1) CA2339857A1 (bg)
DE (1) DE69907467T2 (bg)
DK (1) DK1100796T3 (bg)
EA (1) EA200100221A1 (bg)
ES (1) ES2198940T3 (bg)
HK (1) HK1038230A1 (bg)
HU (1) HUP0105466A3 (bg)
ID (1) ID27914A (bg)
IL (1) IL141286A0 (bg)
NO (1) NO20010629L (bg)
PL (1) PL345885A1 (bg)
PT (1) PT1100796E (bg)
SK (1) SK1972001A3 (bg)
TR (1) TR200100444T2 (bg)
WO (1) WO2000008017A1 (bg)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0812827B1 (en) 1996-06-13 2009-09-02 Sumitomo Chemical Company, Limited Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation
JP3796351B2 (ja) 1998-04-13 2006-07-12 住友化学株式会社 パロキセチン塩酸塩無水和物の乾燥方法
GB9923446D0 (en) * 1999-10-04 1999-12-08 Smithkline Beecham Plc Novel process
CA2425558C (en) * 2000-11-17 2012-01-03 Eli Lilly And Company Lactam compound
US8697094B2 (en) * 2002-10-16 2014-04-15 Takeda Pharmaceutical Company Limited Stable solid preparations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
EP0223403B1 (en) * 1985-10-25 1993-08-04 Beecham Group Plc Piperidine derivative, its preparation, and its use as medicament
AR001982A1 (es) * 1995-02-06 1998-01-07 Smithkline Beecham Plc Clorhidrato de paroxetina anhidratado, y procedimiento para su preparacion
TR199901622T2 (xx) * 1997-01-15 1999-09-21 Smithkline Beecham Plc Paroksetin terkipleri.
JP3796351B2 (ja) * 1998-04-13 2006-07-12 住友化学株式会社 パロキセチン塩酸塩無水和物の乾燥方法

Also Published As

Publication number Publication date
BR9912858A (pt) 2001-11-20
HUP0105466A2 (hu) 2002-05-29
HUP0105466A3 (en) 2002-11-28
CA2339857A1 (en) 2000-02-17
IL141286A0 (en) 2002-03-10
TR200100444T2 (tr) 2001-07-23
NO20010629D0 (no) 2001-02-06
KR20010072323A (ko) 2001-07-31
DE69907467D1 (de) 2003-06-05
AP0102072A0 (en) 2001-02-06
WO2000008017A1 (en) 2000-02-17
DK1100796T3 (da) 2003-08-25
EP1100796B1 (en) 2003-05-02
PL345885A1 (en) 2002-01-14
EP1321465A3 (en) 2003-09-03
AP2001002072A0 (en) 2001-03-31
ES2198940T3 (es) 2004-02-01
AU5428999A (en) 2000-02-28
ID27914A (id) 2001-05-03
DE69907467T2 (de) 2004-03-11
EA200100221A1 (ru) 2001-08-27
EP1321465A2 (en) 2003-06-25
CN1321155A (zh) 2001-11-07
SK1972001A3 (en) 2001-08-06
ATE239016T1 (de) 2003-05-15
JP2002522434A (ja) 2002-07-23
HK1038230A1 (en) 2002-03-08
EP1100796A1 (en) 2001-05-23
NO20010629L (no) 2001-03-20
PT1100796E (pt) 2003-09-30

Similar Documents

Publication Publication Date Title
PL319384A1 (en) Steroic compositions from soap mass
ES2114471A1 (es) Nuevos compuestos de paroxetina y procedimiento para su preparacion.
MY119800A (en) Pyridine derivatives
CZ258896A3 (en) Morpholine derivatives, process of their preparation and pharmaceutical compositions containing thereof
MY124151A (en) Epothilone derivatives
HUP0101511A3 (en) 1-[(1-substituted-4-piperidinyl)methyl]-4-piperidine derivatives, process for producing the same, medicinal compositions containing the same and intermediates of these compounds
ATE211732T1 (de) N-benzylpiperidin- und tetrahydropyridin-derivate
HUP0100760A3 (en) 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives, process for producing them and pharmaceutical compositions containing them
IL127929A0 (en) Use of novel glass compositions in preparing dental glass pillars and support pillars and method for producing the glass pillars
BG105310A (bg) Метод за получаване на некристална анхидратна форма на пароксетин хидрохлорид
MY125975A (en) Crystalline form vii of cabergoline
BG105204A (bg) Соли на пароксетина
ZA200005110B (en) Process for preparing intermediates.
BG104604A (bg) Метод за получаване на пароксетин хидрохлорид
TW344650B (en) Fungicidal compositions and the process for the preparation thereof
MXPA02006965A (es) Solvato de etanol de (-) -cis-2 -(2-clorofenil) -5, 7-dihidroxi -8[4r-(3s -hidroxi -1-metil] piperidinil] -4h-1 -benzopiran-4 -ona.
DE69728271D1 (en) Kristallines (-)-3r,4r-trans-7-methoxy-2,2-dimethyl-3-phenyl-4[4-(2-pyrrolidin-1-yl)ethoxy] phenyl-chroman-wasserstoffumarate
NO20012028D0 (no) Fremgangsmåte for fremstilling av 4-((2',5'-diamino-6'- halogenpyrimidin-4'-yl)amino)-cyclopent-2-enyl-metanoler
PL318280A1 (en) Novel polymorphous modifications of lesopitrone dihydrochloride and theirhydrogenated forms, methods of obtaining them and compositions containing them
TW374764B (en) Antitumor and antileukaemic compounds, their preparation and pharmaceutical composition containing them
AU7025800A (en) Process for the preparation of 1-methyl-3-carbomethoxy-4-(4'-fluorophenyl)-piperidine