HUP0105466A2 - Eljárás paroxetin-hidroklorid nemkristályos anhidrát forma előállítására és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

Eljárás paroxetin-hidroklorid nemkristályos anhidrát forma előállítására és a vegyületeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0105466A2
HUP0105466A2 HU0105466A HUP0105466A HUP0105466A2 HU P0105466 A2 HUP0105466 A2 HU P0105466A2 HU 0105466 A HU0105466 A HU 0105466A HU P0105466 A HUP0105466 A HU P0105466A HU P0105466 A2 HUP0105466 A2 HU P0105466A2
Authority
HU
Hungary
Prior art keywords
paroxetine hydrochloride
preparation
pharmaceutical compositions
compositions containing
anhydrate form
Prior art date
Application number
HU0105466A
Other languages
English (en)
Inventor
Victor Witold Jacewicz
Neal Ward
Original Assignee
Smithkline Beecham P.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9817196.0A external-priority patent/GB9817196D0/en
Priority claimed from GBGB9828777.4A external-priority patent/GB9828777D0/en
Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.
Publication of HUP0105466A2 publication Critical patent/HUP0105466A2/hu
Publication of HUP0105466A3 publication Critical patent/HUP0105466A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány paroxetin-hidroklorid anhidrát előállítási eljárásáravonatkozik, amelynek során egy paroxetin-hidroklorid szolvátot aszolvatáló oldószer eltávolítása érdekében csökkentett nyomás alattmelegítenek, és miközben a szolvátban visszamaradó oldószer mennyiségecsökken, a melegítés hőmérsékletét emelik. Ugyancsak a találmánytárgyát képezi egy eljárás paroxetin-hidroklorid szolvátok szárításáraés deszolvatálására, amelynek során a szolvátokat mikrohullámúszárításnak vetik alá. A találmány kiterjed a találmány szerintieljárásokkal előállított termékekre, valamint ezek felhasználására ésa termékeket tartalmazó gyógyszerkészítményekre is. Ó
HU0105466A 1998-08-07 1999-08-06 Process for the preparation of a non-crystalline anhydrate form of paroxetine hydrochloride and pharmaceutical compositions containing them HUP0105466A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9817196.0A GB9817196D0 (en) 1998-08-07 1998-08-07 Novel process
GBGB9828777.4A GB9828777D0 (en) 1998-12-29 1998-12-29 Novel compounds

Publications (2)

Publication Number Publication Date
HUP0105466A2 true HUP0105466A2 (hu) 2002-05-29
HUP0105466A3 HUP0105466A3 (en) 2002-11-28

Family

ID=26314179

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0105466A HUP0105466A3 (en) 1998-08-07 1999-08-06 Process for the preparation of a non-crystalline anhydrate form of paroxetine hydrochloride and pharmaceutical compositions containing them

Country Status (24)

Country Link
EP (2) EP1100796B1 (hu)
JP (1) JP2002522434A (hu)
KR (1) KR20010072323A (hu)
CN (1) CN1321155A (hu)
AP (2) AP2001002072A0 (hu)
AT (1) ATE239016T1 (hu)
AU (1) AU5428999A (hu)
BG (1) BG105310A (hu)
BR (1) BR9912858A (hu)
CA (1) CA2339857A1 (hu)
DE (1) DE69907467T2 (hu)
DK (1) DK1100796T3 (hu)
EA (1) EA200100221A1 (hu)
ES (1) ES2198940T3 (hu)
HK (1) HK1038230A1 (hu)
HU (1) HUP0105466A3 (hu)
ID (1) ID27914A (hu)
IL (1) IL141286A0 (hu)
NO (1) NO20010629L (hu)
PL (1) PL345885A1 (hu)
PT (1) PT1100796E (hu)
SK (1) SK1972001A3 (hu)
TR (1) TR200100444T2 (hu)
WO (1) WO2000008017A1 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1384711A1 (en) * 1996-06-13 2004-01-28 SUMIKA FINE CHEMICALS Co., Ltd. Optical resolution of a piperidine derivative
JP3796351B2 (ja) * 1998-04-13 2006-07-12 住友化学株式会社 パロキセチン塩酸塩無水和物の乾燥方法
GB9923446D0 (en) * 1999-10-04 1999-12-08 Smithkline Beecham Plc Novel process
ATE405577T1 (de) * 2000-11-17 2008-09-15 Lilly Co Eli Lactam dipeptid und dessen verwendung zur inhibierung der beta-amyloid peptid frisetzung
CA2502219C (en) 2002-10-16 2012-05-29 Takeda Pharmaceutical Company Limited A process for producing an amorphous isomer of lansoprazole

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
EP0223403B1 (en) * 1985-10-25 1993-08-04 Beecham Group Plc Piperidine derivative, its preparation, and its use as medicament
AR001982A1 (es) * 1995-02-06 1998-01-07 Smithkline Beecham Plc Clorhidrato de paroxetina anhidratado, y procedimiento para su preparacion
AP9901604A0 (en) * 1997-01-15 1999-09-30 Smithkline Beecham Plc Paroxetine compositions.
JP3796351B2 (ja) * 1998-04-13 2006-07-12 住友化学株式会社 パロキセチン塩酸塩無水和物の乾燥方法

Also Published As

Publication number Publication date
BG105310A (en) 2001-12-29
EA200100221A1 (ru) 2001-08-27
EP1321465A2 (en) 2003-06-25
BR9912858A (pt) 2001-11-20
ES2198940T3 (es) 2004-02-01
PL345885A1 (en) 2002-01-14
DK1100796T3 (da) 2003-08-25
PT1100796E (pt) 2003-09-30
EP1100796B1 (en) 2003-05-02
HUP0105466A3 (en) 2002-11-28
IL141286A0 (en) 2002-03-10
ID27914A (id) 2001-05-03
CN1321155A (zh) 2001-11-07
AP0102072A0 (en) 2001-02-06
TR200100444T2 (tr) 2001-07-23
DE69907467T2 (de) 2004-03-11
JP2002522434A (ja) 2002-07-23
ATE239016T1 (de) 2003-05-15
DE69907467D1 (de) 2003-06-05
WO2000008017A1 (en) 2000-02-17
SK1972001A3 (en) 2001-08-06
HK1038230A1 (en) 2002-03-08
AU5428999A (en) 2000-02-28
NO20010629L (no) 2001-03-20
CA2339857A1 (en) 2000-02-17
KR20010072323A (ko) 2001-07-31
AP2001002072A0 (en) 2001-03-31
EP1321465A3 (en) 2003-09-03
EP1100796A1 (en) 2001-05-23
NO20010629D0 (no) 2001-02-06

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