BG104713A - Е-2-[4-(4-хлоро-1,2-дифенил-бут-1-енил) фенокси]-етанол и негови фармацевтични състави - Google Patents
Е-2-[4-(4-хлоро-1,2-дифенил-бут-1-енил) фенокси]-етанол и негови фармацевтични съставиInfo
- Publication number
- BG104713A BG104713A BG104713A BG10471300A BG104713A BG 104713 A BG104713 A BG 104713A BG 104713 A BG104713 A BG 104713A BG 10471300 A BG10471300 A BG 10471300A BG 104713 A BG104713 A BG 104713A
- Authority
- BG
- Bulgaria
- Prior art keywords
- enyl
- phenoxy
- diphenyl
- chloro
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- LUMKNAVTFCDUIE-WCWDXBQESA-N 2-[4-[(e)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]ethanol Chemical compound C1=CC(OCCO)=CC=C1C(\C=1C=CC=CC=1)=C(/CCCl)C1=CC=CC=C1 LUMKNAVTFCDUIE-WCWDXBQESA-N 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Изобретението се отнася до Е-2-[4-(4-хлоро-1,2-дифенил-бут-1-енил)фенокси]етанол, който се използваза понижаване на серумен холестерол, и до фармацевтични състави, които го съдържат както и до методза понижаване на серумен холестерол и до метод запрофилактика или лечение на атеросклероза.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9803521.5A GB9803521D0 (en) | 1998-02-19 | 1998-02-19 | New compounds and pharmaceutical compositions thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
BG104713A true BG104713A (bg) | 2001-03-30 |
BG64471B1 BG64471B1 (bg) | 2005-04-30 |
Family
ID=10827263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG104713A BG64471B1 (bg) | 1998-02-19 | 2000-08-28 | Е-2-[4-(4-хлоро-1,2-дифенил-бут-1-енил) фенокси]-етанол и негови фармацевтични състави |
Country Status (33)
Country | Link |
---|---|
US (1) | US6395785B1 (bg) |
EP (1) | EP1056701B1 (bg) |
JP (1) | JP2002503713A (bg) |
KR (1) | KR100755918B1 (bg) |
CN (1) | CN1161314C (bg) |
AR (1) | AR014961A1 (bg) |
AT (1) | ATE252531T1 (bg) |
AU (1) | AU755798B2 (bg) |
BG (1) | BG64471B1 (bg) |
BR (1) | BR9907688A (bg) |
CA (1) | CA2321122C (bg) |
CZ (1) | CZ294315B6 (bg) |
DE (1) | DE69912247T2 (bg) |
DK (1) | DK1056701T3 (bg) |
EA (1) | EA002919B1 (bg) |
EE (1) | EE04233B1 (bg) |
ES (1) | ES2211038T3 (bg) |
GB (1) | GB9803521D0 (bg) |
GE (1) | GEP20022794B (bg) |
HR (1) | HRP20000545A2 (bg) |
HU (1) | HUP0101354A3 (bg) |
ID (1) | ID26857A (bg) |
IL (1) | IL137214A (bg) |
NO (1) | NO325595B1 (bg) |
NZ (1) | NZ505637A (bg) |
PL (1) | PL193315B1 (bg) |
PT (1) | PT1056701E (bg) |
RS (1) | RS49660B (bg) |
SK (1) | SK285940B6 (bg) |
TR (1) | TR200002037T2 (bg) |
UA (1) | UA57132C2 (bg) |
WO (1) | WO1999042427A1 (bg) |
ZA (1) | ZA991232B (bg) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW593256B (en) * | 1999-11-16 | 2004-06-21 | Hormos Medical Oy Ltd | Triphenylalkene derivatives and their use as selective estrogen receptor modulators |
SI1235776T1 (sl) * | 1999-11-16 | 2006-06-30 | Hormos Medical Corp | Trifenilalkenski derivati in njihova uporaba kot selektivni estrogenski receptorski modulatorji |
US20040248989A1 (en) | 2003-06-05 | 2004-12-09 | Risto Santti | Method for the treatment or prevention of lower urinary tract symptoms |
CN101448490A (zh) | 2006-05-22 | 2009-06-03 | 霍尔莫斯医疗有限公司 | 治疗慢性非细菌性前列腺炎的选择性雌激素受体调节剂或者芳香酶抑制剂 |
EP2121553B1 (en) | 2007-02-14 | 2012-06-27 | Hormos Medical Ltd. | Method for the preparation of therapeutically valuable triphenylbutene derivatives |
US7504530B2 (en) | 2007-02-14 | 2009-03-17 | Hormos Medical Ltd. | Methods for the preparation of fispemifene from ospemifene |
CN102770402B (zh) | 2010-01-19 | 2016-01-20 | 坎布雷卡尔斯库加公司 | 制造二苯甲酮衍生物的新方法 |
JP6174156B2 (ja) | 2012-10-19 | 2017-08-02 | フェルミオン オサケ ユキチュア | オスペミフェンの製造方法 |
US20150321983A1 (en) * | 2012-10-19 | 2015-11-12 | Fermion Oy | A process for the preparation of ospemifene |
CN104030896A (zh) * | 2013-03-07 | 2014-09-10 | 天津药物研究院 | 一种简易去除欧司哌米芬特异杂质的方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2126576B (en) | 1982-06-25 | 1985-06-19 | Farmos Group Limited | Alkane and alkene derivatives |
GB9418067D0 (en) | 1994-09-07 | 1994-10-26 | Orion Yhtymae Oy | Triphenylethylenes for the prevention and treatment of osteoporosis |
GB9604577D0 (en) * | 1996-03-04 | 1996-05-01 | Orion Yhtymae Oy | Serum cholesterol lowering agent |
-
1998
- 1998-02-19 GB GBGB9803521.5A patent/GB9803521D0/en not_active Ceased
-
1999
- 1999-02-16 ZA ZA9901232A patent/ZA991232B/xx unknown
- 1999-02-16 AR ARP990100642A patent/AR014961A1/es active IP Right Grant
- 1999-02-19 TR TR2000/02037T patent/TR200002037T2/xx unknown
- 1999-02-19 PT PT99904899T patent/PT1056701E/pt unknown
- 1999-02-19 WO PCT/FI1999/000137 patent/WO1999042427A1/en active IP Right Grant
- 1999-02-19 AT AT99904899T patent/ATE252531T1/de not_active IP Right Cessation
- 1999-02-19 DE DE69912247T patent/DE69912247T2/de not_active Expired - Fee Related
- 1999-02-19 GE GEAP19995553A patent/GEP20022794B/en unknown
- 1999-02-19 US US09/601,612 patent/US6395785B1/en not_active Expired - Fee Related
- 1999-02-19 CA CA002321122A patent/CA2321122C/en not_active Expired - Fee Related
- 1999-02-19 RS YUP-510/00A patent/RS49660B/sr unknown
- 1999-02-19 AU AU25244/99A patent/AU755798B2/en not_active Ceased
- 1999-02-19 KR KR1020007008982A patent/KR100755918B1/ko not_active IP Right Cessation
- 1999-02-19 ES ES99904899T patent/ES2211038T3/es not_active Expired - Lifetime
- 1999-02-19 BR BR9907688-8A patent/BR9907688A/pt not_active Application Discontinuation
- 1999-02-19 SK SK1205-2000A patent/SK285940B6/sk unknown
- 1999-02-19 HU HU0101354A patent/HUP0101354A3/hu unknown
- 1999-02-19 JP JP2000532381A patent/JP2002503713A/ja active Pending
- 1999-02-19 NZ NZ505637A patent/NZ505637A/xx unknown
- 1999-02-19 CN CNB998030139A patent/CN1161314C/zh not_active Expired - Fee Related
- 1999-02-19 IL IL13721499A patent/IL137214A/xx unknown
- 1999-02-19 EA EA200000851A patent/EA002919B1/ru not_active IP Right Cessation
- 1999-02-19 PL PL342445A patent/PL193315B1/pl unknown
- 1999-02-19 ID IDW20001841A patent/ID26857A/id unknown
- 1999-02-19 CZ CZ20002927A patent/CZ294315B6/cs not_active IP Right Cessation
- 1999-02-19 DK DK99904899T patent/DK1056701T3/da active
- 1999-02-19 EE EEP200000473A patent/EE04233B1/xx not_active IP Right Cessation
- 1999-02-19 EP EP99904899A patent/EP1056701B1/en not_active Expired - Lifetime
- 1999-02-19 UA UA2000095331A patent/UA57132C2/uk unknown
-
2000
- 2000-08-07 NO NO20003987A patent/NO325595B1/no unknown
- 2000-08-18 HR HR20000545A patent/HRP20000545A2/xx not_active Application Discontinuation
- 2000-08-28 BG BG104713A patent/BG64471B1/bg unknown
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