EA200000851A1 - Е - 2 - [4 - (4 - хлор - 1, 2 - дифенил - бут - 1 - енил) фенокси] этанол и фармацевтические композиции на его основе - Google Patents

Е - 2 - [4 - (4 - хлор - 1, 2 - дифенил - бут - 1 - енил) фенокси] этанол и фармацевтические композиции на его основе

Info

Publication number
EA200000851A1
EA200000851A1 EA200000851A EA200000851A EA200000851A1 EA 200000851 A1 EA200000851 A1 EA 200000851A1 EA 200000851 A EA200000851 A EA 200000851A EA 200000851 A EA200000851 A EA 200000851A EA 200000851 A1 EA200000851 A1 EA 200000851A1
Authority
EA
Eurasian Patent Office
Prior art keywords
phenoxy
diphenyl
ethanol
pharmaceutical compositions
enil
Prior art date
Application number
EA200000851A
Other languages
English (en)
Other versions
EA002919B1 (ru
Inventor
Марья-Лииса Седервалл
Арья Калапудас
Антти Виитанен
Эро Мянтюля
Original Assignee
Орион Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Орион Корпорейшн filed Critical Орион Корпорейшн
Publication of EA200000851A1 publication Critical patent/EA200000851A1/ru
Publication of EA002919B1 publication Critical patent/EA002919B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение относится к Е-2-[4-(4-хлор-1,2-дифенил-бут-1-енил)фенокси]этанолу, полезному для снижения уровня холестерина в сыворотке крови, а также к фармацевтическим композициям на его основе. Описывается также способ снижения уровня холестерина в сыворотке крови и способ предотвращения или лечения атеросклероза.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000851A 1998-02-19 1999-02-19 Е-2-[4(4-хлор-1,2-дифенил-бут-1-енил) фенокси]этанол и фармацевтические композиции на его основе EA002919B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9803521.5A GB9803521D0 (en) 1998-02-19 1998-02-19 New compounds and pharmaceutical compositions thereof
PCT/FI1999/000137 WO1999042427A1 (en) 1998-02-19 1999-02-19 E-2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol and pharmaceutical compositions thereof

Publications (2)

Publication Number Publication Date
EA200000851A1 true EA200000851A1 (ru) 2001-02-26
EA002919B1 EA002919B1 (ru) 2002-10-31

Family

ID=10827263

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000851A EA002919B1 (ru) 1998-02-19 1999-02-19 Е-2-[4(4-хлор-1,2-дифенил-бут-1-енил) фенокси]этанол и фармацевтические композиции на его основе

Country Status (33)

Country Link
US (1) US6395785B1 (ru)
EP (1) EP1056701B1 (ru)
JP (1) JP2002503713A (ru)
KR (1) KR100755918B1 (ru)
CN (1) CN1161314C (ru)
AR (1) AR014961A1 (ru)
AT (1) ATE252531T1 (ru)
AU (1) AU755798B2 (ru)
BG (1) BG64471B1 (ru)
BR (1) BR9907688A (ru)
CA (1) CA2321122C (ru)
CZ (1) CZ294315B6 (ru)
DE (1) DE69912247T2 (ru)
DK (1) DK1056701T3 (ru)
EA (1) EA002919B1 (ru)
EE (1) EE04233B1 (ru)
ES (1) ES2211038T3 (ru)
GB (1) GB9803521D0 (ru)
GE (1) GEP20022794B (ru)
HR (1) HRP20000545A2 (ru)
HU (1) HUP0101354A3 (ru)
ID (1) ID26857A (ru)
IL (1) IL137214A (ru)
NO (1) NO325595B1 (ru)
NZ (1) NZ505637A (ru)
PL (1) PL193315B1 (ru)
PT (1) PT1056701E (ru)
RS (1) RS49660B (ru)
SK (1) SK285940B6 (ru)
TR (1) TR200002037T2 (ru)
UA (1) UA57132C2 (ru)
WO (1) WO1999042427A1 (ru)
ZA (1) ZA991232B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW593256B (en) 1999-11-16 2004-06-21 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
SI1235776T1 (sl) * 1999-11-16 2006-06-30 Hormos Medical Corp Trifenilalkenski derivati in njihova uporaba kot selektivni estrogenski receptorski modulatorji
US20040248989A1 (en) 2003-06-05 2004-12-09 Risto Santti Method for the treatment or prevention of lower urinary tract symptoms
EP2029128B1 (en) 2006-05-22 2015-08-05 Hormos Medical Ltd. Method of treatment of chronic nonbacterial prostatitis with selective estrogen receptor modulators or aromatase inhibitors
WO2008099060A2 (en) 2007-02-14 2008-08-21 Hormos Medical Ltd Methods for the preparation of fispemifene from ospemifene
MX2009008660A (es) 2007-02-14 2009-10-13 Hormos Medical Ltd Metodo para la preparacion de derivados de trifenilbuteno terapeuticamente valiosos.
DK2526080T3 (da) 2010-01-19 2014-04-28 Cambrex Karlskoga Ab Nye fremgangsmåder til fremstilling af benzophenonderivater
US20150321983A1 (en) * 2012-10-19 2015-11-12 Fermion Oy A process for the preparation of ospemifene
WO2014060639A1 (en) 2012-10-19 2014-04-24 Fermion Oy A process for the preparation of ospemifene
CN104030896A (zh) * 2013-03-07 2014-09-10 天津药物研究院 一种简易去除欧司哌米芬特异杂质的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2126576B (en) 1982-06-25 1985-06-19 Farmos Group Limited Alkane and alkene derivatives
GB9418067D0 (en) 1994-09-07 1994-10-26 Orion Yhtymae Oy Triphenylethylenes for the prevention and treatment of osteoporosis
GB9604577D0 (en) * 1996-03-04 1996-05-01 Orion Yhtymae Oy Serum cholesterol lowering agent

Also Published As

Publication number Publication date
UA57132C2 (ru) 2003-06-16
EA002919B1 (ru) 2002-10-31
GB9803521D0 (en) 1998-04-15
EE200000473A (et) 2001-12-17
HRP20000545A2 (en) 2001-02-28
BG64471B1 (bg) 2005-04-30
NO20003987L (no) 2000-08-07
PL342445A1 (en) 2001-06-04
DE69912247T2 (de) 2004-07-29
SK285940B6 (sk) 2007-11-02
AU755798B2 (en) 2002-12-19
HUP0101354A3 (en) 2002-05-28
YU51000A (sh) 2002-11-15
CA2321122A1 (en) 1999-08-26
ID26857A (id) 2001-02-15
SK12052000A3 (sk) 2001-01-18
IL137214A (en) 2005-05-17
WO1999042427A1 (en) 1999-08-26
KR20010040985A (ko) 2001-05-15
EE04233B1 (et) 2004-02-16
CA2321122C (en) 2008-02-12
TR200002037T2 (tr) 2001-02-21
AR014961A1 (es) 2001-04-11
KR100755918B1 (ko) 2007-09-06
CZ294315B6 (cs) 2004-11-10
CN1291178A (zh) 2001-04-11
IL137214A0 (en) 2001-07-24
AU2524499A (en) 1999-09-06
BR9907688A (pt) 2000-11-14
EP1056701A1 (en) 2000-12-06
RS49660B (sr) 2007-09-21
DK1056701T3 (da) 2004-02-02
NO20003987D0 (no) 2000-08-07
PL193315B1 (pl) 2007-01-31
CZ20002927A3 (cs) 2000-12-13
DE69912247D1 (de) 2003-11-27
PT1056701E (pt) 2004-03-31
NO325595B1 (no) 2008-06-23
ZA991232B (en) 1999-09-17
CN1161314C (zh) 2004-08-11
JP2002503713A (ja) 2002-02-05
GEP20022794B (en) 2002-09-25
US6395785B1 (en) 2002-05-28
NZ505637A (en) 2002-10-25
EP1056701B1 (en) 2003-10-22
BG104713A (en) 2001-03-30
HUP0101354A2 (hu) 2002-03-28
ES2211038T3 (es) 2004-07-01
ATE252531T1 (de) 2003-11-15

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU