YU51000A - E-2-(4-(4-hlor-1,2-difenil-but-1-enil)fenoksi)etanol i njegove farmaceutske kompozicije - Google Patents

E-2-(4-(4-hlor-1,2-difenil-but-1-enil)fenoksi)etanol i njegove farmaceutske kompozicije

Info

Publication number
YU51000A
YU51000A YU51000A YU51000A YU51000A YU 51000 A YU51000 A YU 51000A YU 51000 A YU51000 A YU 51000A YU 51000 A YU51000 A YU 51000A YU 51000 A YU51000 A YU 51000A
Authority
YU
Yugoslavia
Prior art keywords
enyl
phenoxy
diphenyl
chloro
pharmaceutical compositions
Prior art date
Application number
YU51000A
Other languages
English (en)
Inventor
Marja-Liisa Sodervall
Arja Kalapudas
Antti Viitanen
Eero Mantyla
Original Assignee
Orion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corporation filed Critical Orion Corporation
Publication of YU51000A publication Critical patent/YU51000A/sh
Publication of RS49660B publication Critical patent/RS49660B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Ovaj pronalazak se odnosi na E-2-[4-(4-hlor-1,2-difenil-but-1-enil)fenoksi]etanol koristan u snižavanju holesterola u serumu i na njegove farmaceutske kompozicije. Takodje su opisani postupak za snižavanje holesterola u serumu i postupak za sprečavanje ili tretiranje ateroskleroze.[The present invention relates to E-2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol useful in lowering serum cholesterol and to pharmaceutical compositions thereof. A method of lowering serum cholesterol and a method for the prevention or treatment of atherosclerosis is also disclosed.
YUP-510/00A 1998-02-19 1999-02-19 E-2-(4-(4-hlor-1,2-difenil-but-1- enil)fenoksi)etanol i njegove farmaceutske kompozicije RS49660B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9803521.5A GB9803521D0 (en) 1998-02-19 1998-02-19 New compounds and pharmaceutical compositions thereof

Publications (2)

Publication Number Publication Date
YU51000A true YU51000A (sh) 2002-11-15
RS49660B RS49660B (sr) 2007-09-21

Family

ID=10827263

Country Status (33)

Country Link
US (1) US6395785B1 (sh)
EP (1) EP1056701B1 (sh)
JP (1) JP2002503713A (sh)
KR (1) KR100755918B1 (sh)
CN (1) CN1161314C (sh)
AR (1) AR014961A1 (sh)
AT (1) ATE252531T1 (sh)
AU (1) AU755798B2 (sh)
BG (1) BG64471B1 (sh)
BR (1) BR9907688A (sh)
CA (1) CA2321122C (sh)
CZ (1) CZ294315B6 (sh)
DE (1) DE69912247T2 (sh)
DK (1) DK1056701T3 (sh)
EA (1) EA002919B1 (sh)
EE (1) EE04233B1 (sh)
ES (1) ES2211038T3 (sh)
GB (1) GB9803521D0 (sh)
GE (1) GEP20022794B (sh)
HR (1) HRP20000545A2 (sh)
HU (1) HUP0101354A3 (sh)
ID (1) ID26857A (sh)
IL (1) IL137214A (sh)
NO (1) NO325595B1 (sh)
NZ (1) NZ505637A (sh)
PL (1) PL193315B1 (sh)
PT (1) PT1056701E (sh)
RS (1) RS49660B (sh)
SK (1) SK285940B6 (sh)
TR (1) TR200002037T2 (sh)
UA (1) UA57132C2 (sh)
WO (1) WO1999042427A1 (sh)
ZA (1) ZA991232B (sh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1705169A3 (en) * 1999-11-16 2006-11-15 Hormos Medical Ltd. Triphenylalkene derivatives and their use as selective estrogen receptor modulators
TW593256B (en) * 1999-11-16 2004-06-21 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
US20040248989A1 (en) 2003-06-05 2004-12-09 Risto Santti Method for the treatment or prevention of lower urinary tract symptoms
KR101505884B1 (ko) 2006-05-22 2015-03-25 호르모스 메디칼 리미티드 만성 비세균성 전립선염 치료용 선택적 에스트로겐 수용체 조절제 또는 아로마타아제 저해제
CN101636372B (zh) 2007-02-14 2013-03-27 霍尔莫斯医疗有限公司 有治疗价值的三苯基丁烯衍生物的制备方法
WO2008099060A2 (en) 2007-02-14 2008-08-21 Hormos Medical Ltd Methods for the preparation of fispemifene from ospemifene
DK2526080T3 (da) 2010-01-19 2014-04-28 Cambrex Karlskoga Ab Nye fremgangsmåder til fremstilling af benzophenonderivater
US20150321983A1 (en) * 2012-10-19 2015-11-12 Fermion Oy A process for the preparation of ospemifene
WO2014060639A1 (en) 2012-10-19 2014-04-24 Fermion Oy A process for the preparation of ospemifene
CN104030896A (zh) * 2013-03-07 2014-09-10 天津药物研究院 一种简易去除欧司哌米芬特异杂质的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2126576B (en) 1982-06-25 1985-06-19 Farmos Group Limited Alkane and alkene derivatives
GB9418067D0 (en) 1994-09-07 1994-10-26 Orion Yhtymae Oy Triphenylethylenes for the prevention and treatment of osteoporosis
GB9604577D0 (en) * 1996-03-04 1996-05-01 Orion Yhtymae Oy Serum cholesterol lowering agent

Also Published As

Publication number Publication date
GEP20022794B (en) 2002-09-25
US6395785B1 (en) 2002-05-28
EP1056701B1 (en) 2003-10-22
CN1161314C (zh) 2004-08-11
KR20010040985A (ko) 2001-05-15
ATE252531T1 (de) 2003-11-15
CZ294315B6 (cs) 2004-11-10
SK285940B6 (sk) 2007-11-02
TR200002037T2 (tr) 2001-02-21
HRP20000545A2 (en) 2001-02-28
DE69912247D1 (de) 2003-11-27
ES2211038T3 (es) 2004-07-01
NZ505637A (en) 2002-10-25
DE69912247T2 (de) 2004-07-29
RS49660B (sr) 2007-09-21
NO325595B1 (no) 2008-06-23
IL137214A (en) 2005-05-17
EE04233B1 (et) 2004-02-16
PT1056701E (pt) 2004-03-31
CA2321122C (en) 2008-02-12
BG64471B1 (bg) 2005-04-30
PL342445A1 (en) 2001-06-04
AU755798B2 (en) 2002-12-19
NO20003987D0 (no) 2000-08-07
BR9907688A (pt) 2000-11-14
WO1999042427A1 (en) 1999-08-26
GB9803521D0 (en) 1998-04-15
CA2321122A1 (en) 1999-08-26
DK1056701T3 (da) 2004-02-02
SK12052000A3 (sk) 2001-01-18
CZ20002927A3 (cs) 2000-12-13
JP2002503713A (ja) 2002-02-05
ID26857A (id) 2001-02-15
PL193315B1 (pl) 2007-01-31
EA002919B1 (ru) 2002-10-31
IL137214A0 (en) 2001-07-24
HUP0101354A2 (hu) 2002-03-28
BG104713A (en) 2001-03-30
ZA991232B (en) 1999-09-17
AR014961A1 (es) 2001-04-11
NO20003987L (no) 2000-08-07
EE200000473A (et) 2001-12-17
AU2524499A (en) 1999-09-06
EA200000851A1 (ru) 2001-02-26
UA57132C2 (uk) 2003-06-16
KR100755918B1 (ko) 2007-09-06
HUP0101354A3 (en) 2002-05-28
EP1056701A1 (en) 2000-12-06
CN1291178A (zh) 2001-04-11

Similar Documents

Publication Publication Date Title
BG103190A (en) Substituted pyrimidine derivatives and their pharmaceutical application
YU51000A (sh) E-2-(4-(4-hlor-1,2-difenil-but-1-enil)fenoksi)etanol i njegove farmaceutske kompozicije
WO1996009827A3 (en) Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor
CA2248032A1 (en) Serum cholesterol lowering agent
BG101354A (en) Sterol compositions of sapinofication pulp
AU2001241941A1 (en) System and method for dynamic, multivariable comparison of financial products
BG101209A (en) Hypolipidemic compounds
CA2356158A1 (en) Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
AU1296099A (en) Methods and compositions for treating dermatoses
MY114803A (en) Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
BG105432A (en) METHOD FOR TREATING ATHEROSCLEROSIS EMPLOYING AN aP2 INHIBITOR AND COMBINATION
CA2347117A1 (en) Methods for inhibiting diabetic complications
AU3074099A (en) Method and composition for lowering low density lipoprotein cholesterol
AU9465298A (en) Process for reducing the content of cholesterol in dairy products
AU1156301A (en) Composition and process for oil extraction
PL343722A1 (en) Stabile compositions comprising levosimendan and alginic acid
AU3601700A (en) System and method for performing internet based purchase transactions
SI1056701T1 (en) E-2- 4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol and pharmaceutical compositions thereof