YU51000A - E-2-(4-(4-hlor-1,2-difenil-but-1-enil)fenoksi)etanol i njegove farmaceutske kompozicije - Google Patents

E-2-(4-(4-hlor-1,2-difenil-but-1-enil)fenoksi)etanol i njegove farmaceutske kompozicije

Info

Publication number
YU51000A
YU51000A YU51000A YU51000A YU51000A YU 51000 A YU51000 A YU 51000A YU 51000 A YU51000 A YU 51000A YU 51000 A YU51000 A YU 51000A YU 51000 A YU51000 A YU 51000A
Authority
YU
Yugoslavia
Prior art keywords
enyl
phenoxy
diphenyl
chloro
pharmaceutical compositions
Prior art date
Application number
YU51000A
Other languages
English (en)
Inventor
Marja-Liisa Sodervall
Arja Kalapudas
Antti Viitanen
Eero Mantyla
Original Assignee
Orion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corporation filed Critical Orion Corporation
Publication of YU51000A publication Critical patent/YU51000A/sh
Publication of RS49660B publication Critical patent/RS49660B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Ovaj pronalazak se odnosi na E-2-[4-(4-hlor-1,2-difenil-but-1-enil)fenoksi]etanol koristan u snižavanju holesterola u serumu i na njegove farmaceutske kompozicije. Takodje su opisani postupak za snižavanje holesterola u serumu i postupak za sprečavanje ili tretiranje ateroskleroze.[The present invention relates to E-2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol useful in lowering serum cholesterol and to pharmaceutical compositions thereof. A method of lowering serum cholesterol and a method for the prevention or treatment of atherosclerosis is also disclosed.
YUP-510/00A 1998-02-19 1999-02-19 E-2-(4-(4-hlor-1,2-difenil-but-1- enil)fenoksi)etanol i njegove farmaceutske kompozicije RS49660B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9803521.5A GB9803521D0 (en) 1998-02-19 1998-02-19 New compounds and pharmaceutical compositions thereof

Publications (2)

Publication Number Publication Date
YU51000A true YU51000A (sh) 2002-11-15
RS49660B RS49660B (sr) 2007-09-21

Family

ID=10827263

Country Status (33)

Country Link
US (1) US6395785B1 (sh)
EP (1) EP1056701B1 (sh)
JP (1) JP2002503713A (sh)
KR (1) KR100755918B1 (sh)
CN (1) CN1161314C (sh)
AR (1) AR014961A1 (sh)
AT (1) ATE252531T1 (sh)
AU (1) AU755798B2 (sh)
BG (1) BG64471B1 (sh)
BR (1) BR9907688A (sh)
CA (1) CA2321122C (sh)
CZ (1) CZ294315B6 (sh)
DE (1) DE69912247T2 (sh)
DK (1) DK1056701T3 (sh)
EA (1) EA002919B1 (sh)
EE (1) EE04233B1 (sh)
ES (1) ES2211038T3 (sh)
GB (1) GB9803521D0 (sh)
GE (1) GEP20022794B (sh)
HR (1) HRP20000545A2 (sh)
HU (1) HUP0101354A3 (sh)
ID (1) ID26857A (sh)
IL (1) IL137214A (sh)
NO (1) NO325595B1 (sh)
NZ (1) NZ505637A (sh)
PL (1) PL193315B1 (sh)
PT (1) PT1056701E (sh)
RS (1) RS49660B (sh)
SK (1) SK285940B6 (sh)
TR (1) TR200002037T2 (sh)
UA (1) UA57132C2 (sh)
WO (1) WO1999042427A1 (sh)
ZA (1) ZA991232B (sh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW593256B (en) * 1999-11-16 2004-06-21 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
SI1235776T1 (sl) * 1999-11-16 2006-06-30 Hormos Medical Corp Trifenilalkenski derivati in njihova uporaba kot selektivni estrogenski receptorski modulatorji
US20040248989A1 (en) 2003-06-05 2004-12-09 Risto Santti Method for the treatment or prevention of lower urinary tract symptoms
CN101448490A (zh) 2006-05-22 2009-06-03 霍尔莫斯医疗有限公司 治疗慢性非细菌性前列腺炎的选择性雌激素受体调节剂或者芳香酶抑制剂
EP2121553B1 (en) 2007-02-14 2012-06-27 Hormos Medical Ltd. Method for the preparation of therapeutically valuable triphenylbutene derivatives
US7504530B2 (en) 2007-02-14 2009-03-17 Hormos Medical Ltd. Methods for the preparation of fispemifene from ospemifene
CN102770402B (zh) 2010-01-19 2016-01-20 坎布雷卡尔斯库加公司 制造二苯甲酮衍生物的新方法
JP6174156B2 (ja) 2012-10-19 2017-08-02 フェルミオン オサケ ユキチュア オスペミフェンの製造方法
US20150321983A1 (en) * 2012-10-19 2015-11-12 Fermion Oy A process for the preparation of ospemifene
CN104030896A (zh) * 2013-03-07 2014-09-10 天津药物研究院 一种简易去除欧司哌米芬特异杂质的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2126576B (en) 1982-06-25 1985-06-19 Farmos Group Limited Alkane and alkene derivatives
GB9418067D0 (en) 1994-09-07 1994-10-26 Orion Yhtymae Oy Triphenylethylenes for the prevention and treatment of osteoporosis
GB9604577D0 (en) * 1996-03-04 1996-05-01 Orion Yhtymae Oy Serum cholesterol lowering agent

Also Published As

Publication number Publication date
SK285940B6 (sk) 2007-11-02
BG104713A (en) 2001-03-30
HRP20000545A2 (en) 2001-02-28
PL193315B1 (pl) 2007-01-31
IL137214A0 (en) 2001-07-24
US6395785B1 (en) 2002-05-28
CA2321122A1 (en) 1999-08-26
DE69912247T2 (de) 2004-07-29
CZ294315B6 (cs) 2004-11-10
EP1056701A1 (en) 2000-12-06
EE04233B1 (et) 2004-02-16
BG64471B1 (bg) 2005-04-30
ZA991232B (en) 1999-09-17
JP2002503713A (ja) 2002-02-05
UA57132C2 (uk) 2003-06-16
HUP0101354A3 (en) 2002-05-28
PL342445A1 (en) 2001-06-04
ATE252531T1 (de) 2003-11-15
KR20010040985A (ko) 2001-05-15
TR200002037T2 (tr) 2001-02-21
EP1056701B1 (en) 2003-10-22
NZ505637A (en) 2002-10-25
NO20003987D0 (no) 2000-08-07
CN1161314C (zh) 2004-08-11
AR014961A1 (es) 2001-04-11
ES2211038T3 (es) 2004-07-01
PT1056701E (pt) 2004-03-31
GB9803521D0 (en) 1998-04-15
WO1999042427A1 (en) 1999-08-26
KR100755918B1 (ko) 2007-09-06
GEP20022794B (en) 2002-09-25
CZ20002927A3 (cs) 2000-12-13
DE69912247D1 (de) 2003-11-27
CA2321122C (en) 2008-02-12
IL137214A (en) 2005-05-17
NO325595B1 (no) 2008-06-23
EA200000851A1 (ru) 2001-02-26
SK12052000A3 (sk) 2001-01-18
BR9907688A (pt) 2000-11-14
AU2524499A (en) 1999-09-06
HUP0101354A2 (hu) 2002-03-28
EA002919B1 (ru) 2002-10-31
RS49660B (sr) 2007-09-21
AU755798B2 (en) 2002-12-19
CN1291178A (zh) 2001-04-11
EE200000473A (et) 2001-12-17
ID26857A (id) 2001-02-15
DK1056701T3 (da) 2004-02-02
NO20003987L (no) 2000-08-07

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