BG103673A - 3'-n-оксидни, 3'-n-диметиламинови, 9-оксимни производни на еритромицин а - Google Patents

3'-n-оксидни, 3'-n-диметиламинови, 9-оксимни производни на еритромицин а

Info

Publication number
BG103673A
BG103673A BG103673A BG10367399A BG103673A BG 103673 A BG103673 A BG 103673A BG 103673 A BG103673 A BG 103673A BG 10367399 A BG10367399 A BG 10367399A BG 103673 A BG103673 A BG 103673A
Authority
BG
Bulgaria
Prior art keywords
oxide
erythromycin
dimethylamine
oxime derivatives
alkylerythromycin
Prior art date
Application number
BG103673A
Other languages
English (en)
Other versions
BG64099B1 (bg
Inventor
Yi-Yin Ku
David Riley
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of BG103673A publication Critical patent/BG103673A/bg
Publication of BG64099B1 publication Critical patent/BG64099B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретението се отнася до нови 3'-N-O-, 9-O-оксим защитени производни на 6-О-алкилеритромицин с формула (I), разкрита в описанието, и до метод за тяхното получаване. Изобретението се отнася също така и до метод за получаване на 6-О-алкилеритромицинА чрез отстраняване на 3'-N-оксидната група и на 9-О-оксимзащитните групи и евентуално деблокиране на хидроксилните групи на 2'-ра и 4''-та позиция при подходящи условия на реакцията.
BG103673A 1997-02-13 1999-08-20 3'-n-оксидни, 3'-n-диметиламинови, 9-оксимни производни на еритромицин а BG64099B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/800,009 US5864023A (en) 1997-02-13 1997-02-13 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
PCT/US1998/001929 WO1998035976A1 (en) 1997-02-13 1998-02-03 3'-n-oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives

Publications (2)

Publication Number Publication Date
BG103673A true BG103673A (bg) 2000-02-29
BG64099B1 BG64099B1 (bg) 2003-12-31

Family

ID=25177295

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103673A BG64099B1 (bg) 1997-02-13 1999-08-20 3'-n-оксидни, 3'-n-диметиламинови, 9-оксимни производни на еритромицин а

Country Status (25)

Country Link
US (1) US5864023A (bg)
EP (1) EP0966477B1 (bg)
JP (1) JP2001512456A (bg)
KR (1) KR100561326B1 (bg)
CN (1) CN1326865C (bg)
AR (1) AR012032A1 (bg)
AT (1) ATE252108T1 (bg)
AU (1) AU725274B2 (bg)
BG (1) BG64099B1 (bg)
BR (1) BR9807349A (bg)
CA (1) CA2279932C (bg)
CZ (1) CZ294481B6 (bg)
DE (1) DE69818977T2 (bg)
DK (1) DK0966477T3 (bg)
ES (1) ES2212266T3 (bg)
HU (1) HUP0001330A3 (bg)
IL (1) IL130697A0 (bg)
NO (1) NO993876D0 (bg)
NZ (1) NZ336482A (bg)
PL (1) PL187357B1 (bg)
PT (1) PT966477E (bg)
SK (1) SK284157B6 (bg)
TR (1) TR199901874T2 (bg)
WO (1) WO1998035976A1 (bg)
ZA (1) ZA98986B (bg)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100317907B1 (ko) * 1998-11-24 2001-12-24 김 완 주 신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
KR20010008496A (ko) * 1999-07-01 2001-02-05 유충식 6-오-메틸 에리트로마이신의 제조방법
KR100336447B1 (ko) * 1999-11-24 2002-05-15 민경윤 클라리스로마이신의 개선된 제조방법
AU783055B2 (en) * 1999-12-16 2005-09-22 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin polymorphs and novel polymorph IV
CA2397092A1 (en) * 2000-01-11 2001-07-19 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin polymorphs
US6544555B2 (en) * 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
IL151496A0 (en) * 2000-02-29 2003-04-10 Teva Pharma Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
CN1193036C (zh) * 2000-03-15 2005-03-16 韩美药品工业株式会社 制备甲红霉素－克拉霉素ⅱ型晶体的方法
KR20000037126A (ko) * 2000-04-08 2000-07-05 김용규 6-메틸 에리스로마이신 ａ의 제조방법
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
US8313776B2 (en) * 2003-07-21 2012-11-20 Shionogi Inc. Antibiotic product, use and formulation thereof
EP1648418A4 (en) * 2003-07-21 2011-11-16 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
US8313775B2 (en) * 2003-07-21 2012-11-20 Shionogi Inc. Antibiotic product, use and formulation thereof
AU2004264939A1 (en) * 2003-08-11 2005-02-24 Middlebrook Pharmaceuticals, Inc. Robust pellet
EP1653924A4 (en) * 2003-08-12 2009-09-09 Middlebrook Pharmaceuticals In ANTIBIOTICS, USE AND FORMULATION ASSOCIATED
AU2004270170B2 (en) * 2003-08-29 2011-01-27 Shionogi, Inc. Antibiotic product, use and formulation thereof
JP2007513869A (ja) * 2003-09-15 2007-05-31 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
AU2004308419B2 (en) * 2003-12-24 2011-06-02 Victory Pharma, Inc. Enhanced absorption of modified release dosage forms
EP1771158A4 (en) * 2004-07-02 2008-03-12 Advancis Pharmaceutical Corp TABLET FOR PULSE DISTRIBUTION
US7694523B2 (en) * 2004-07-19 2010-04-13 Earthrenew, Inc. Control system for gas turbine in material treatment unit
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
WO2009023191A2 (en) * 2007-08-09 2009-02-19 Teva Pharmaceutical Industries Ltd. An improved process for the preparation of clarithromycin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
JPS60214796A (ja) * 1984-04-06 1985-10-28 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシン類の製法
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
US4670549A (en) * 1985-03-18 1987-06-02 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin a derivatives
JPS61229895A (ja) * 1985-04-03 1986-10-14 Nippon Zeon Co Ltd 保護化デス−ｎ−メチルエリスロマイシン誘導体
EP0254534A3 (en) * 1986-07-24 1991-04-17 William S. Robinson Erythromycin derivatives and compositions and use for inhibiting virus replication and disease
EP0260938B1 (en) * 1986-09-18 1992-12-09 Taisho Pharmaceutical Co. Ltd Erythromycin a derivatives and method for preparing the same
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
JP2751385B2 (ja) * 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法

Also Published As

Publication number Publication date
WO1998035976A1 (en) 1998-08-20
CA2279932C (en) 2008-04-22
CN1326865C (zh) 2007-07-18
NO993876L (no) 1999-08-11
AU6260898A (en) 1998-09-08
TR199901874T2 (xx) 2000-04-21
EP0966477A1 (en) 1999-12-29
CN1246864A (zh) 2000-03-08
SK284157B6 (sk) 2004-10-05
HUP0001330A2 (hu) 2000-08-28
BG64099B1 (bg) 2003-12-31
KR100561326B1 (ko) 2006-03-16
NZ336482A (en) 2001-02-23
IL130697A0 (en) 2000-06-01
CZ294481B6 (cs) 2005-01-12
AU725274B2 (en) 2000-10-12
PL335301A1 (en) 2000-04-10
ZA98986B (en) 1998-08-05
AR012032A1 (es) 2000-09-27
KR20000070985A (ko) 2000-11-25
EP0966477B1 (en) 2003-10-15
DK0966477T3 (da) 2004-02-23
CZ270499A3 (cs) 1999-11-17
ATE252108T1 (de) 2003-11-15
BR9807349A (pt) 2000-04-25
HUP0001330A3 (en) 2000-09-28
DE69818977D1 (en) 2003-11-20
SK97499A3 (en) 2000-01-18
PT966477E (pt) 2004-03-31
PL187357B1 (pl) 2004-06-30
US5864023A (en) 1999-01-26
JP2001512456A (ja) 2001-08-21
NO993876D0 (no) 1999-08-11
CA2279932A1 (en) 1998-08-20
ES2212266T3 (es) 2004-07-16
DE69818977T2 (de) 2004-08-12

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