BG102616A - Заместени аза- и диазациклохептанови и циклооктанови производни и използването им - Google Patents

Заместени аза- и диазациклохептанови и циклооктанови производни и използването им

Info

Publication number
BG102616A
BG102616A BG102616A BG10261698A BG102616A BG 102616 A BG102616 A BG 102616A BG 102616 A BG102616 A BG 102616A BG 10261698 A BG10261698 A BG 10261698A BG 102616 A BG102616 A BG 102616A
Authority
BG
Bulgaria
Prior art keywords
diazacycloheptane
cyclooctane
derivatives
application
substituted aza
Prior art date
Application number
BG102616A
Other languages
English (en)
Other versions
BG64098B1 (bg
Inventor
Hans-Joerg Treiber
Stefan Blank
Dorothea Starck
Liliane Unger
Hans-Juergen Teschedorf
Karsten Wicke
Original Assignee
Abbott Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co. Kg filed Critical Abbott Gmbh & Co. Kg
Publication of BG102616A publication Critical patent/BG102616A/bg
Publication of BG64098B1 publication Critical patent/BG64098B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Luminescent Compositions (AREA)

Abstract

Съединенията имат висок афинитет спрямо допамин-D3-рецепторите и могат да се използват за лечение на заболявания, обусловени от допамин-D3-лиганди. Те имат формула@Ar1 - A - B - Ar2,@в която Ar1, A, B и Ar2 имат значенията, посочени в описанието.
BG102616A 1996-01-12 1998-07-09 Заместени аза- и диазациклохептанови и циклооктанови производни и използването им BG64098B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19600934A DE19600934A1 (de) 1996-01-12 1996-01-12 Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung
PCT/EP1997/000106 WO1997025324A1 (de) 1996-01-12 1997-01-10 Substituierte aza- und diazacycloheptan- und -cyclooctanverbindungen und deren verwendung

Publications (2)

Publication Number Publication Date
BG102616A true BG102616A (bg) 1999-04-30
BG64098B1 BG64098B1 (bg) 2003-12-31

Family

ID=7782613

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102616A BG64098B1 (bg) 1996-01-12 1998-07-09 Заместени аза- и диазациклохептанови и циклооктанови производни и използването им

Country Status (26)

Country Link
US (2) US6214822B1 (bg)
EP (1) EP0877744B1 (bg)
JP (1) JP4349657B2 (bg)
KR (1) KR100441073B1 (bg)
CN (2) CN1075070C (bg)
AR (1) AR005868A1 (bg)
AT (1) ATE273301T1 (bg)
AU (1) AU717726B2 (bg)
BG (1) BG64098B1 (bg)
CA (1) CA2241787C (bg)
CO (1) CO4790173A1 (bg)
CZ (1) CZ297981B6 (bg)
DE (2) DE19600934A1 (bg)
ES (1) ES2225947T3 (bg)
HR (1) HRP970021A2 (bg)
HU (1) HU228457B1 (bg)
IL (1) IL125076A (bg)
MX (1) MX9805499A (bg)
NO (1) NO316753B1 (bg)
NZ (1) NZ326332A (bg)
PL (1) PL327692A1 (bg)
SK (1) SK284987B6 (bg)
TR (1) TR199801302T2 (bg)
TW (1) TW475929B (bg)
WO (1) WO1997025324A1 (bg)
ZA (1) ZA97209B (bg)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19728996A1 (de) * 1997-07-07 1999-01-14 Basf Ag Triazolverbindungen und deren Verwendung
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
CO5140073A1 (es) 1998-10-08 2002-03-22 Smithkline Beecham Plc Derivados de 2,3,4,5-tetrahidro-1h-3-benzapina
TWI274750B (en) * 1999-01-12 2007-03-01 Abbott Gmbh & Co Kg Triazole compounds showing high affinity to dopamine D3 receptor and pharmaceutical composition comprising the same
DE19922443A1 (de) * 1999-05-07 2000-11-09 Basf Ag Verwendung von Dopamin-D3-Rezeptorliganden zur Herstellung von Arzneimittel für die Behandlung von Nierenfunktionsstörungen
US7037916B2 (en) 1999-07-15 2006-05-02 Pharmacopeia Drug Discovery, Inc. Pyrimidine derivatives as IL-8 receptor antagonists
ES2311012T3 (es) * 2000-03-27 2009-02-01 ABBOTT GMBH & CO. KG Ligandos del receptor d3 de la dopamina para el tratamiento de la adiccion.
EP1362039B1 (en) 2001-02-16 2005-12-21 Aventis Pharmaceuticals Inc. Heterocyclic substituted carbonyl derivatives and their use as dopamine d3 receptor ligands
DE10109866A1 (de) * 2001-03-01 2002-09-05 Abbott Gmbh & Co Kg Triazolverbindungen und deren Verwendung zur Prophylaxe und Therapie neurodegenerativer Erkrankungen, Hirntrauma und zerebraler Ischämie
DE10131543A1 (de) * 2001-06-29 2003-01-16 Abbott Lab Pyrimidinoxyalkylpiperazine und ihre therapeutische Verwendung
ES2330927T3 (es) * 2001-11-28 2009-12-17 Ipsen Pharma Derivados de 5-sulfanil-4h-1,2,4-triazoles para tratar trastornos asociados a la somatostatina.
AU2003214110A1 (en) * 2002-03-15 2003-09-29 Ciba Specialty Chemicals Holding Inc. 4-aminopyrimidines and their use for the antimicrobial treatment of surfaces
DE10304870A1 (de) * 2003-02-06 2004-08-19 Abbott Gmbh & Co. Kg Triazolverbindungen und ihre therapeutische Verwendung
TW200507841A (en) * 2003-03-27 2005-03-01 Glaxo Group Ltd Antibacterial agents
DE10358004A1 (de) * 2003-12-11 2005-07-14 Abbott Gmbh & Co. Kg Ketolactam-Verbindungen und ihre Verwendung
DE102004027358A1 (de) 2004-06-04 2005-12-29 Abbott Gmbh & Co. Kg Pyrimidinverbindungen und ihre Verwendung
FR2877005A1 (fr) * 2004-10-22 2006-04-28 Bioprojet Soc Civ Ile Nouveaux derives d'arylpiperazine
JP2008528604A (ja) * 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
JP2007106746A (ja) * 2005-09-13 2007-04-26 Tosoh Corp 新規アリールホモピペラジン類、またはその塩と製造方法
US7935706B2 (en) * 2006-02-23 2011-05-03 Shionogi & Co., Ltd. Nitrogen-containing heterocycle derivatives substituted with cyclic group
EP2004166A2 (en) * 2006-03-31 2008-12-24 La Jolla Pharmaceutical Company Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment and prevention of diseases
EP1882688A1 (en) 2006-07-25 2008-01-30 EPFL Ecole Polytechnique Fédérale de Lausanne Labelling of fusion proteins with synthetic probes
JP4840440B2 (ja) * 2008-12-24 2011-12-21 ソニー株式会社 画像処理装置およびその方法、並びにプログラム
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
US8883785B2 (en) * 2010-01-25 2014-11-11 Chdi Foundation, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US9156822B2 (en) * 2010-07-02 2015-10-13 The University Of North Carolina At Chapel Hill Functionally selective ligands of dopamine D2 receptors
CA2817165A1 (en) 2010-11-15 2012-05-24 Patrick Chaltin Novel antiviral compounds
EA027451B1 (ru) 2011-08-30 2017-07-31 Схди Фаундейшн, Инк. Ингибиторы кинуренин-3-монооксигеназы, фармацевтические композиции и их применение
BR112014004845A2 (pt) 2011-08-30 2017-04-04 Chdi Foundation Inc pelo menos uma entidade química; pelo menos um composto; composição farmacêutica; uso de uma quantidade terapeuticamente eficaz de pelo menos uma entidade química; composição farmacêutica embalada
CN110016015B (zh) 2013-12-24 2021-06-25 昂康塔睿迪斯股份有限公司 苯甲酰胺和烟酰胺化合物及其使用方法
US10258621B2 (en) 2014-07-17 2019-04-16 Chdi Foundation, Inc. Methods and compositions for treating HIV-related disorders

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE628766A (bg) 1962-12-26
BE792206A (bg) 1971-12-02 1973-06-01 Byk Gulden Lomberg Chem Fab
US5139998A (en) 1988-08-31 1992-08-18 Superconductor Technologies, Inc. Controlled thallous oxide evaporation for thallium superconductor films and reactor design
SE8803429D0 (sv) 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
US5008267A (en) 1988-10-29 1991-04-16 Mitsui Toatsu Chemicals, Incorporated Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same
JP2815218B2 (ja) 1990-04-13 1998-10-27 三井化学株式会社 ピリミジンジオン誘導体、およびそれを含有する抗不整脈剤
FR2663638B2 (fr) 1990-04-06 1995-02-10 Institut Nal Sante Recherc Medic Polypeptides ayant une activite de recepteur dopaminergique, acides nucleiques codant pour ces polypeptides et utilisation de ces polypeptides pour le criblage de substances actives sur ces polypeptides.
JP2518965B2 (ja) 1990-09-21 1996-07-31 三井東圧化学株式会社 新規ピリジン誘導体及びそれを有効成分として含有する制癌剤効果増強剤
FR2668771B1 (fr) 1990-11-06 1995-03-17 Inst Nat Sante Rech Med Acides nucleiques codant pour des polypeptides ayant une activite de recepteur dopaminergique humain et utilisation de ces polypeptides pour le criblage de substances actives sur ces polypeptides.
DE4425144A1 (de) 1994-07-15 1996-01-18 Basf Ag Triazolverbindungen und deren Verwendung
DE4425143A1 (de) 1994-07-15 1996-01-18 Basf Ag Substituierte Pyrimidinverbindungen und deren Verwendung
DE4425145A1 (de) 1994-07-15 1996-01-18 Basf Ag Verwendung von Thiazol- und Thiadiazolverbindungen
DE4425146A1 (de) 1994-07-15 1996-01-18 Basf Ag Verwendung heterocyclischer Verbindungen
US5635503A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Company Dihydropyridine npy antagonists: piperazine derivatives
FR2742149B1 (fr) 1995-12-11 1998-02-13 Inst Nat Sante Rech Med Nouveaux derives de 2-naphtamides et leurs applications therapeutiques

Also Published As

Publication number Publication date
TR199801302T2 (xx) 1998-11-23
NO316753B1 (no) 2004-04-26
NO983187L (no) 1998-09-09
CN1212692A (zh) 1999-03-31
NZ326332A (en) 1999-04-29
SK94198A3 (en) 1999-03-12
SK284987B6 (sk) 2006-04-06
KR100441073B1 (ko) 2004-11-16
CN1075070C (zh) 2001-11-21
CA2241787C (en) 2006-04-04
TW475929B (en) 2002-02-11
WO1997025324A1 (de) 1997-07-17
DE19600934A1 (de) 1997-07-17
CN1348956A (zh) 2002-05-15
ES2225947T3 (es) 2005-03-16
HRP970021A2 (en) 1998-04-30
BG64098B1 (bg) 2003-12-31
AU717726B2 (en) 2000-03-30
HU228457B1 (en) 2013-03-28
CZ297981B6 (cs) 2007-05-16
JP4349657B2 (ja) 2009-10-21
AU1440797A (en) 1997-08-01
ZA97209B (en) 1998-07-10
CZ215998A3 (cs) 1999-05-12
US6214822B1 (en) 2001-04-10
EP0877744B1 (de) 2004-08-11
JP2000505072A (ja) 2000-04-25
AR005868A1 (es) 1999-07-21
CN1146551C (zh) 2004-04-21
MX9805499A (es) 1998-11-30
US6352981B1 (en) 2002-03-05
EP0877744A1 (de) 1998-11-18
PL327692A1 (en) 1998-12-21
IL125076A (en) 2001-05-20
ATE273301T1 (de) 2004-08-15
HUP9901590A3 (en) 2002-01-28
IL125076A0 (en) 1999-01-26
KR19990077127A (ko) 1999-10-25
CA2241787A1 (en) 1997-07-17
DE59711847D1 (de) 2004-09-16
CO4790173A1 (es) 1999-05-31
HUP9901590A2 (hu) 1999-08-30

Similar Documents

Publication Publication Date Title
BG102616A (bg) Заместени аза- и диазациклохептанови и циклооктанови производни и използването им
BG104056A (bg) Триазолови съединения и използването им като допамин-d3-лиганди
MX9700430A (es) El uso de compuestos heterociclicos.
MX9700885A (es) Nuevas heteroariloxazolidinonas.
NO931635D0 (no) Fremgangsmaate for fremstilling av kinazolin-derivater
ZA9710796B (en) Oxyiminopregnanecarbolactones.
DE69807074D1 (de) Substituierte 1,2,4-triazolo[3,4,-a]phthalazin-derivate als gaba-alpha 5-liganden
AU5624699A (en) Use of 5ht-6 antagonists
NO20075066L (no) Farmasoytisk sammensetning som inneholder isoflavoner
BG101110A (bg) Заместени пиримидинови съединения и тяхното използване
CY1108610T1 (el) Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες
IL130260A0 (en) 3-thiocarbamoylpyrazole derivatives as pesticides
BG102125A (bg) Нови доластатинови производни, тяхното получаванеи приложение
BG103399A (bg) Нови заместени с хетероцикъл бензамиди и тяхното използване за лечение на болести
IL114294A0 (en) Sterol derivatives
BG103310A (bg) Бензонафтиридини като бронхиални лечебни средства
MX9704050A (es) P-amidinobencilamidas de dipeptido novedosas con radicales sulfonilo o aminosulfonilo en terminal n.
TR200001102T2 (tr) İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
ES2174113T3 (es) Nuevos derivados de ((3-alcoxi-fenoxi)-etil)-dialquilamina y su utilizacion como anestesicos locales.
BG102707A (bg) Нови триазолопурини, метод за тяхното получаване и тяхното приложение като лекарствени средства
MX9700813A (es) Nuevos derivados 3-substituidos de 3h-2,3-benzodiazepina, su preparacion y su uso como medicamentos.
DE3572489D1 (en) Indolophenanthridines, their preparation and use
MX9700854A (es) Derivados de azabicicloheptano n-substituidos utiles como neurolepticos.
BG102771A (bg) Нови диарилметилиденфуранови производни, метод за тяхното получаване и използването им като лекарствени средства
DE59510131D1 (de) Imidazopyridin-azolidinone