BG102476A - Полиморфни форми за усилване секрецията на хормона на растежа - Google Patents
Полиморфни форми за усилване секрецията на хормона на растежаInfo
- Publication number
- BG102476A BG102476A BG102476A BG10247698A BG102476A BG 102476 A BG102476 A BG 102476A BG 102476 A BG102476 A BG 102476A BG 10247698 A BG10247698 A BG 10247698A BG 102476 A BG102476 A BG 102476A
- Authority
- BG
- Bulgaria
- Prior art keywords
- forms
- polymorphous forms
- secretagogue
- phenylmethoxy
- propanamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
- Fodder In General (AREA)
Abstract
Изобретението се отнася до полиморфни форми на съединението N-[1(R)-[(1,2-дихидро-1-метансулфонилспиро[3Н-индол-3,4'-пипердин]-1'-ил)карбонил]-2-(фенилметилокси)етил]-2-амино-2-метил-пропанамид метансулфонат. То е секретагог на растежен хормон и е полезно при хранене на животни за ускоряване на растежа им, като по този начин се повишава ефективността при производството на хранителни месни продукти. При хора се използва за третиране на физиологични или медицински състояния, характеризиращи се с намалена секреция на растежен хормон, и на медицински състояния, които се подобряват от анаболни ефекти на растежен хормон. Моментните полиморфни форми имат предимство пред други познати форми на N-[1(R)-[(1,2-дихидро-1-метансулфонилспиро [3Н-индол-3,4'-пипердин]-1'-ил)карбонил]-2-(фенилметокси)етил]-2-амино-2-метил-пропанамид метансулфонат по отношение на термодинамична стабилност и с това, че саподходящи за включване във фармацевтични формулировки. Изобретението се отнася също и до процесите на получаване на тези полиморфни форми, до фармацевтични формулировки, които ги включват като активни съставки, и до използването на полиморфните форми на съединението и техни формулировки за третиране на някои отклонения.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US590095P | 1995-10-27 | 1995-10-27 | |
| GBGB9603361.8A GB9603361D0 (en) | 1996-02-16 | 1996-02-16 | Polymorphic forms of a growth hormone secretagogue |
| PCT/US1996/016955 WO1997015574A1 (en) | 1995-10-27 | 1996-10-23 | Polymorphic forms of a growth hormone secretagogue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG102476A true BG102476A (bg) | 1999-04-30 |
Family
ID=26308741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG102476A BG102476A (bg) | 1995-10-27 | 1998-05-21 | Полиморфни форми за усилване секрецията на хормона на растежа |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1019402A1 (bg) |
| JP (1) | JP3204266B2 (bg) |
| KR (1) | KR19990067098A (bg) |
| CN (1) | CN1067687C (bg) |
| AU (1) | AU707946B2 (bg) |
| BG (1) | BG102476A (bg) |
| BR (1) | BR9611229A (bg) |
| CA (1) | CA2235371A1 (bg) |
| CO (1) | CO4770956A1 (bg) |
| CZ (1) | CZ128098A3 (bg) |
| EA (1) | EA000528B1 (bg) |
| EE (1) | EE9800147A (bg) |
| HK (1) | HK1017894A1 (bg) |
| HU (1) | HUP9902208A3 (bg) |
| IS (1) | IS4721A (bg) |
| NO (1) | NO310556B1 (bg) |
| NZ (1) | NZ321370A (bg) |
| PL (1) | PL327511A1 (bg) |
| SK (1) | SK51398A3 (bg) |
| TR (1) | TR199800726T2 (bg) |
| WO (1) | WO1997015574A1 (bg) |
| YU (1) | YU56696A (bg) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6046333A (en) * | 1996-10-25 | 2000-04-04 | Merck & Co., Inc. | Convergent process for the preparation of a growth hormone secretagogue |
| US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
| WO2017075535A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RO115804B1 (ro) * | 1992-12-11 | 2000-06-30 | Merck & Co Inc | Derivati de spiropiperidine, procedee de preparare si compozitii farmaceutice ale acestora |
-
1996
- 1996-10-23 WO PCT/US1996/016955 patent/WO1997015574A1/en not_active Application Discontinuation
- 1996-10-23 BR BR9611229A patent/BR9611229A/pt not_active IP Right Cessation
- 1996-10-23 HU HU9902208A patent/HUP9902208A3/hu unknown
- 1996-10-23 JP JP51673797A patent/JP3204266B2/ja not_active Expired - Lifetime
- 1996-10-23 NZ NZ321370A patent/NZ321370A/xx not_active IP Right Cessation
- 1996-10-23 KR KR1019980703038A patent/KR19990067098A/ko not_active Application Discontinuation
- 1996-10-23 EA EA199800335A patent/EA000528B1/ru not_active IP Right Cessation
- 1996-10-23 AU AU74686/96A patent/AU707946B2/en not_active Expired
- 1996-10-23 EE EE9800147A patent/EE9800147A/xx unknown
- 1996-10-23 SK SK513-98A patent/SK51398A3/sk unknown
- 1996-10-23 CN CN96199328A patent/CN1067687C/zh not_active Expired - Lifetime
- 1996-10-23 CZ CZ981280A patent/CZ128098A3/cs unknown
- 1996-10-23 CA CA002235371A patent/CA2235371A1/en not_active Abandoned
- 1996-10-23 EP EP96936869A patent/EP1019402A1/en not_active Withdrawn
- 1996-10-23 PL PL96327511A patent/PL327511A1/xx unknown
- 1996-10-23 TR TR1998/00726T patent/TR199800726T2/xx unknown
- 1996-10-25 CO CO96056663A patent/CO4770956A1/es unknown
- 1996-10-25 YU YU56696A patent/YU56696A/sh unknown
-
1998
- 1998-04-21 IS IS4721A patent/IS4721A/is unknown
- 1998-04-24 NO NO19981867A patent/NO310556B1/no not_active IP Right Cessation
- 1998-05-21 BG BG102476A patent/BG102476A/bg unknown
-
1999
- 1999-07-12 HK HK99102961A patent/HK1017894A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1017894A1 (en) | 1999-12-03 |
| CN1067687C (zh) | 2001-06-27 |
| PL327511A1 (en) | 1998-12-21 |
| BR9611229A (pt) | 1999-05-25 |
| NZ321370A (en) | 1999-11-29 |
| AU7468696A (en) | 1997-05-15 |
| KR19990067098A (ko) | 1999-08-16 |
| CN1205703A (zh) | 1999-01-20 |
| JPH10512295A (ja) | 1998-11-24 |
| NO981867L (no) | 1998-06-29 |
| NO310556B1 (no) | 2001-07-23 |
| EA199800335A1 (ru) | 1998-12-24 |
| EA000528B1 (ru) | 1999-10-28 |
| HUP9902208A2 (hu) | 1999-10-28 |
| CZ128098A3 (cs) | 1998-09-16 |
| AU707946B2 (en) | 1999-07-22 |
| HUP9902208A3 (en) | 2001-05-28 |
| SK51398A3 (en) | 1998-12-02 |
| NO981867D0 (no) | 1998-04-24 |
| WO1997015574A1 (en) | 1997-05-01 |
| IS4721A (is) | 1998-04-21 |
| TR199800726T2 (xx) | 1998-08-21 |
| CO4770956A1 (es) | 1999-04-30 |
| CA2235371A1 (en) | 1997-05-01 |
| EE9800147A (et) | 1998-12-15 |
| EP1019402A1 (en) | 2000-07-19 |
| YU56696A (sh) | 1999-09-27 |
| JP3204266B2 (ja) | 2001-09-04 |
| MX9803351A (es) | 1998-09-30 |
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