BG101130A - Инхибитори на интерлевкин 1 бета-конвертиращ ензим - Google Patents
Инхибитори на интерлевкин 1 бета-конвертиращ ензимInfo
- Publication number
- BG101130A BG101130A BG101130A BG10113097A BG101130A BG 101130 A BG101130 A BG 101130A BG 101130 A BG101130 A BG 101130A BG 10113097 A BG10113097 A BG 10113097A BG 101130 A BG101130 A BG 101130A
- Authority
- BG
- Bulgaria
- Prior art keywords
- interleukin
- inhibitors
- converting enzyme
- compounds
- relates
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Paper (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Изобретението се отнася до нов клас съединения, които са инхибитори на интерлевкин-1 -конвертиращ ензим. Те се характеризират със структурни и физико-химични особености. Изобретението се отнася и до фармацевтични състави, съдържащисъединенията, които са особено подходящи за инхибиране на ICE активността и могат да се използват като средства срещу заболявания, при които медиатор е интерлевкин-1, включително възпалителни, автоимунни и невродегенеративни заболявания. Изобретението се отнася и до методи за инхибиране на ICE активността и за лечение на заболявания, при които медиатор е интерлевкин-1, като се използват посочените съединения и състави.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/261,452 US5756466A (en) | 1994-06-17 | 1994-06-17 | Inhibitors of interleukin-1β converting enzyme |
US08/405,581 US5656627A (en) | 1994-06-17 | 1995-03-17 | Inhibitors of interleukin-1β converting enzyme |
US08/440,898 US5847135A (en) | 1994-06-17 | 1995-05-25 | Inhibitors of interleukin-1β converting enzyme |
PCT/US1995/007617 WO1995035308A1 (en) | 1994-06-17 | 1995-06-16 | INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME |
Publications (2)
Publication Number | Publication Date |
---|---|
BG101130A true BG101130A (bg) | 1997-08-29 |
BG63634B1 BG63634B1 (bg) | 2002-07-31 |
Family
ID=27401408
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG101130A BG63634B1 (bg) | 1994-06-17 | 1997-01-14 | Инхибитори на интерлевкин 1 бета-конвертиращ ензим |
Country Status (22)
Country | Link |
---|---|
US (2) | US5716929A (bg) |
EP (1) | EP0784628A1 (bg) |
JP (1) | JP4190029B2 (bg) |
CN (1) | CN1192035C (bg) |
AP (1) | AP797A (bg) |
AU (1) | AU709114B2 (bg) |
BG (1) | BG63634B1 (bg) |
BR (1) | BR9508051A (bg) |
CA (1) | CA2192089C (bg) |
CZ (1) | CZ298625B6 (bg) |
FI (1) | FI965036A (bg) |
GE (1) | GEP20012446B (bg) |
HU (1) | HUT76622A (bg) |
IL (1) | IL114015A0 (bg) |
IS (1) | IS4399A (bg) |
MA (1) | MA24511A1 (bg) |
MX (1) | MX9606546A (bg) |
NZ (1) | NZ289560A (bg) |
PL (1) | PL185693B1 (bg) |
SK (1) | SK287422B6 (bg) |
TW (1) | TW509698B (bg) |
WO (1) | WO1995035308A1 (bg) |
Families Citing this family (138)
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- 1995-06-05 US US08/464,964 patent/US5716929A/en not_active Expired - Lifetime
- 1995-06-06 IL IL11401595A patent/IL114015A0/xx not_active IP Right Cessation
- 1995-06-09 TW TW084105903A patent/TW509698B/zh not_active IP Right Cessation
- 1995-06-16 HU HU9603475A patent/HUT76622A/hu not_active Application Discontinuation
- 1995-06-16 AU AU29446/95A patent/AU709114B2/en not_active Ceased
- 1995-06-16 EP EP95925257A patent/EP0784628A1/en not_active Withdrawn
- 1995-06-16 NZ NZ289560A patent/NZ289560A/en not_active IP Right Cessation
- 1995-06-16 MA MA23932A patent/MA24511A1/fr unknown
- 1995-06-16 BR BR9508051A patent/BR9508051A/pt not_active Application Discontinuation
- 1995-06-16 PL PL95318220A patent/PL185693B1/pl not_active IP Right Cessation
- 1995-06-16 WO PCT/US1995/007617 patent/WO1995035308A1/en active IP Right Grant
- 1995-06-16 SK SK1609-96A patent/SK287422B6/sk not_active IP Right Cessation
- 1995-06-16 CN CNB951943812A patent/CN1192035C/zh not_active Expired - Fee Related
- 1995-06-16 CA CA002192089A patent/CA2192089C/en not_active Expired - Fee Related
- 1995-06-16 GE GEAP19953528A patent/GEP20012446B/en unknown
- 1995-06-16 MX MX9606546A patent/MX9606546A/es not_active IP Right Cessation
- 1995-06-16 AP APAP/P/1997/000960A patent/AP797A/en active
- 1995-06-16 CZ CZ0369896A patent/CZ298625B6/cs not_active IP Right Cessation
- 1995-06-16 JP JP50247896A patent/JP4190029B2/ja not_active Expired - Lifetime
-
1996
- 1996-12-16 FI FI965036A patent/FI965036A/fi not_active Application Discontinuation
- 1996-12-17 IS IS4399A patent/IS4399A/is unknown
-
1997
- 1997-01-14 BG BG101130A patent/BG63634B1/bg unknown
- 1997-03-28 US US08/828,941 patent/US5973111A/en not_active Expired - Lifetime
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NZ289560A (en) | 1999-09-29 |
AP9700960A0 (en) | 1997-04-30 |
PL185693B1 (pl) | 2003-07-31 |
IS4399A (is) | 1996-12-17 |
BR9508051A (pt) | 1997-10-21 |
US5716929A (en) | 1998-02-10 |
AU2944695A (en) | 1996-01-15 |
CN1192035C (zh) | 2005-03-09 |
BG63634B1 (bg) | 2002-07-31 |
IL114015A0 (en) | 1995-10-31 |
FI965036A0 (fi) | 1996-12-16 |
SK160996A3 (en) | 1997-09-10 |
PL318220A1 (en) | 1997-05-26 |
HUT76622A (en) | 1997-10-28 |
MA24511A1 (fr) | 1998-12-31 |
SK287422B6 (sk) | 2010-09-07 |
CZ369896A3 (en) | 1997-06-11 |
CZ298625B6 (cs) | 2007-11-28 |
JP4190029B2 (ja) | 2008-12-03 |
FI965036A (fi) | 1997-02-14 |
WO1995035308A1 (en) | 1995-12-28 |
CA2192089C (en) | 2010-01-12 |
MX9606546A (es) | 1997-03-29 |
US5973111A (en) | 1999-10-26 |
CA2192089A1 (en) | 1995-12-28 |
GEP20012446B (en) | 2001-05-25 |
TW509698B (en) | 2002-11-11 |
CN1159196A (zh) | 1997-09-10 |
JPH10504285A (ja) | 1998-04-28 |
EP0784628A1 (en) | 1997-07-23 |
HU9603475D0 (en) | 1997-02-28 |
AP797A (en) | 2000-01-07 |
AU709114B2 (en) | 1999-08-19 |
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