BE894651A - "n-(3-aminopropyl) aminobutyl)-2-(-guanidino(acido gras) amido) - thanamides substitues en position 2 et leur sels, procede pour leur preparation et leur application therapeutique - Google Patents

"n-(3-aminopropyl) aminobutyl)-2-(-guanidino(acido gras) amido) - thanamides substitues en position 2 et leur sels, procede pour leur preparation et leur application therapeutique

Info

Publication number
BE894651A
BE894651A BE0/209206A BE209206A BE894651A BE 894651 A BE894651 A BE 894651A BE 0/209206 A BE0/209206 A BE 0/209206A BE 209206 A BE209206 A BE 209206A BE 894651 A BE894651 A BE 894651A
Authority
BE
Belgium
Prior art keywords
thanamides
acido
aminobutyl
gras
guanidino
Prior art date
Application number
BE0/209206A
Other languages
English (en)
French (fr)
Original Assignee
Zaidan Hojin Biseibutsu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zaidan Hojin Biseibutsu filed Critical Zaidan Hojin Biseibutsu
Publication of BE894651A publication Critical patent/BE894651A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BE0/209206A 1981-10-08 1982-10-08 "n-(3-aminopropyl) aminobutyl)-2-(-guanidino(acido gras) amido) - thanamides substitues en position 2 et leur sels, procede pour leur preparation et leur application therapeutique BE894651A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56159503A JPS5862152A (ja) 1981-10-08 1981-10-08 Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法

Publications (1)

Publication Number Publication Date
BE894651A true BE894651A (fr) 1983-01-31

Family

ID=15695187

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/209206A BE894651A (fr) 1981-10-08 1982-10-08 "n-(3-aminopropyl) aminobutyl)-2-(-guanidino(acido gras) amido) - thanamides substitues en position 2 et leur sels, procede pour leur preparation et leur application therapeutique

Country Status (19)

Country Link
US (3) US4518532A (OSRAM)
JP (1) JPS5862152A (OSRAM)
KR (1) KR870000656B1 (OSRAM)
AT (1) AT393680B (OSRAM)
AU (1) AU554489B2 (OSRAM)
BE (1) BE894651A (OSRAM)
CA (1) CA1187513A (OSRAM)
CH (1) CH653015A5 (OSRAM)
CS (1) CS268654B2 (OSRAM)
DE (1) DE3236725A1 (OSRAM)
DK (1) DK166080C (OSRAM)
ES (2) ES516258A0 (OSRAM)
FR (1) FR2514350B1 (OSRAM)
GB (1) GB2111480B (OSRAM)
HU (1) HU187417B (OSRAM)
IT (1) IT1189373B (OSRAM)
NL (1) NL193107C (OSRAM)
SE (1) SE452006B (OSRAM)
YU (1) YU44678B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3506330A1 (de) * 1984-02-29 1985-08-29 Nippon Kayaku K.K., Tokio/Tokyo Verfahren zur herstellung von glyoxylylspermidin und seine verwendung fuer verwandte verbindungen des 15-deoxyspergualins

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS60185758A (ja) * 1984-03-02 1985-09-21 Microbial Chem Res Found フエニレン基を有するスパガリン関連化合物およびその製造法
JPS61129119A (ja) * 1984-11-13 1986-06-17 Microbial Chem Res Found 新規免疫抑制剤
JPS61165322A (ja) * 1985-01-14 1986-07-26 Microbial Chem Res Found スパガリン類の注射用凍結乾燥製剤
JPH0742268B2 (ja) * 1985-08-27 1995-05-10 財団法人微生物化学研究会 フエニレン基を有するスパガリン類縁化合物及びその製造法
DE3770680D1 (de) * 1986-04-04 1991-07-18 Microbial Chem Res Found Spergualinaehnliche verbindungen und ihr herstellungsverfahren.
JP2605762B2 (ja) * 1986-12-10 1997-04-30 武田薬品工業株式会社 δ−ハイドロキシ−β−リジン誘導体およびその製造法
US5061787A (en) * 1988-06-24 1991-10-29 Nippon Kayaku Kabushiki Kaisha Novel spergualin-related compounds and compositions
JPH0776204B2 (ja) * 1988-07-01 1995-08-16 寳酒造株式会社 スパガリン類の精製法
US4990536A (en) * 1989-04-03 1991-02-05 Nippon Kayaku Kabushiki Kaisha Immunopotentiator and spergualin-related compound therefor
US5162581A (en) * 1989-05-29 1992-11-10 Takaru Shuzo Co., Ltd. Crystalline deoxyspergualin, process for its preparation and suppository containing the same
YU48230B (sh) * 1989-05-29 1997-08-22 Takara Shuzo Co.Ltd. Kristalni deoksispergvalin i postupak za njegovo pripremanje
RU2171811C2 (ru) * 1989-05-29 2001-08-10 Такара Сузо Ко., Лтд., (Jp), Ниппон Каяку Кабусики Кайся КРИСТАЛЛИЧЕСКИЙ ТРИГИДРОХЛОРИД ДЕОКСИСПЕРГУАЛИНА В β-ФОРМЕ, ОБЛАДАЮЩИЙ ПРОТИВООПУХОЛЕВОЙ АКТИВНОСТЬЮ И СПОСОБ ЕГО ПОЛУЧЕНИЯ
US5196453A (en) * 1989-05-29 1993-03-23 Takara Shuzo Co., Ltd. Crystalline deoxyspergualin, process for its preparation and suppository containing the same
EP0467280B1 (en) * 1990-07-20 1994-09-28 Nippon Kayaku Kabushiki Kaisha Novel spergualin-related compound and use thereof
WO1994004140A1 (fr) * 1992-08-19 1994-03-03 Nippon Kayaku Kabushiki Kaisha Medicament anti-protozoose
CA2183917A1 (en) * 1995-09-26 1997-03-27 Xuebao Wang Preparation of optically active (s)-(-) and (r)-(+)- deoxyspergualin and novel intermediates thereof
CN1203846C (zh) 1998-03-19 2005-06-01 布里斯托尔-迈尔斯斯奎布公司 高溶解性药物的双相控释递送系统和方法
US20020142000A1 (en) * 1999-01-15 2002-10-03 Digan Mary Ellen Anti-CD3 immunotoxins and therapeutic uses therefor
US8716558B2 (en) 1999-06-30 2014-05-06 Marker Gene Technologies, Inc. Method of altering glycosylation of proteins in response to nojirimycin glucuronide in a plant cell expressing glucuronidase
US6656917B1 (en) * 1999-06-30 2003-12-02 Marker Gene Technologies, Inc. Compositions and methods for targeted enzymatic release of cell regulatory compounds
JP2005531391A (ja) * 2002-06-27 2005-10-20 微創医療器械（上海）有限公司 薬剤放出ステント
US7635773B2 (en) 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
ES2575860T3 (es) 2010-07-09 2016-07-01 Bhv Pharma, Inc. Sistema de administración de liberación inmediata/retardada de combinación para productos farmacéuticos de semivida corta que incluyen remogliflozina
PT3702374T (pt) 2012-02-15 2022-06-23 Cydex Pharmaceuticals Inc Processo de fabrico para derivados de ciclodextrina
CN110066351B (zh) 2012-02-28 2022-06-14 锡德克斯药物公司 烷基化环糊精组合物及其制备和使用方法
JP6557144B2 (ja) 2012-10-22 2019-08-07 サイデックス・ファーマシューティカルズ・インコーポレイテッド アルキル化シクロデキストリン組成物ならびにその調製方法および使用方法
FI3183295T3 (fi) 2014-08-22 2023-09-25 Cydex Pharmaceuticals Inc Fraktioidut alkyloidut syklodekstriinikoostumukset ja menetelmät niiden valmistamiseksi ja käyttämiseksi

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2015651A1 (de) * 1969-04-02 1970-10-15 Taiho Pharmaceutical Company Ltd., Tokio omega-Guanidinosäurediamid-Derivate und deren Oniumsalze
JPS5748957A (en) * 1980-09-08 1982-03-20 Microbial Chem Res Found Novel antibiotic bmg 162-af2, its preparation and carcinostatic agent comprising it as active ingredient
JPS57185254A (en) * 1981-05-11 1982-11-15 Microbial Chem Res Found Novel carcinostatic substances and their preparation
JPS57192347A (en) * 1981-05-18 1982-11-26 Microbial Chem Res Found N-(4-(3-aminopropyl)aminobutyl)-2,2-dihydroxyethanamide and its synthesis
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
US4525299A (en) * 1983-05-10 1985-06-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai (-)-15-Deoxyspergualin, process for the preparation thereof, and intermediate of the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3506330A1 (de) * 1984-02-29 1985-08-29 Nippon Kayaku K.K., Tokio/Tokyo Verfahren zur herstellung von glyoxylylspermidin und seine verwendung fuer verwandte verbindungen des 15-deoxyspergualins

Also Published As

Publication number Publication date
AU554489B2 (en) 1986-08-21
KR870000656B1 (ko) 1987-04-04
HU187417B (en) 1986-01-28
DE3236725C2 (OSRAM) 1991-01-24
GB2111480A (en) 1983-07-06
CS268654B2 (en) 1990-04-11
DK166080C (da) 1993-08-02
ES8504690A1 (es) 1985-04-16
AT393680B (de) 1991-11-25
DE3236725A1 (de) 1983-04-28
SE8205698D0 (sv) 1982-10-06
KR840001952A (ko) 1984-06-07
FR2514350A1 (fr) 1983-04-15
US4658058A (en) 1987-04-14
GB2111480B (en) 1985-03-13
JPS6123183B2 (OSRAM) 1986-06-04
US4983328A (en) 1991-01-08
ES8402558A1 (es) 1984-02-01
CH653015A5 (de) 1985-12-13
SE8205698L (sv) 1983-04-09
AU8912182A (en) 1983-04-14
CS717982A2 (en) 1989-08-14
SE452006B (sv) 1987-11-09
JPS5862152A (ja) 1983-04-13
NL193107B (nl) 1998-07-01
FR2514350B1 (fr) 1985-10-25
US4518532A (en) 1985-05-21
IT8249228A0 (it) 1982-10-07
YU227682A (en) 1985-06-30
CA1187513A (en) 1985-05-21
YU44678B (en) 1990-12-31
DK166080B (da) 1993-03-08
DK445182A (da) 1983-04-09
NL193107C (nl) 1998-11-03
ES526501A0 (es) 1985-04-16
ES516258A0 (es) 1984-02-01
IT1189373B (it) 1988-02-04
NL8203874A (nl) 1983-05-02
ATA369682A (de) 1991-05-15

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