BE794669A - Derives de 3,4-dihydrocarbostyryle et leur procede de preparation - Google Patents

Derives de 3,4-dihydrocarbostyryle et leur procede de preparation

Info

Publication number
BE794669A
BE794669A BE794669DA BE794669A BE 794669 A BE794669 A BE 794669A BE 794669D A BE794669D A BE 794669DA BE 794669 A BE794669 A BE 794669A
Authority
BE
Belgium
Prior art keywords
dihydrocarbostyryl
derivatives
preparation process
preparation
dihydrocarbostyryl derivatives
Prior art date
Application number
Other languages
English (en)
French (fr)
Inventor
K Nakagawa
N Murakami
S Yoshizaki
H Mori
M Tominaga
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP47092558A external-priority patent/JPS5241268B2/ja
Priority claimed from JP47092560A external-priority patent/JPS5246231B2/ja
Priority claimed from JP9255772A external-priority patent/JPS5324431B2/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of BE794669A publication Critical patent/BE794669A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE794669D 1972-04-13 1973-01-29 Derives de 3,4-dihydrocarbostyryle et leur procede de preparation BE794669A (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP47037181A JPS517672B2 (pt) 1972-04-13 1972-04-13
JP47037182A JPS48103590A (pt) 1972-04-13 1972-04-13
JP47092558A JPS5241268B2 (pt) 1972-09-14 1972-09-14
JP47092560A JPS5246231B2 (pt) 1972-09-14 1972-09-14
JP9255772A JPS5324431B2 (pt) 1972-09-14 1972-09-14
JP47120953A JPS5229745B2 (pt) 1972-04-13 1972-12-02
JP47125858A JPS5239036B2 (pt) 1972-04-13 1972-12-14
JP47128972A JPS5241269B2 (pt) 1972-04-13 1972-12-21

Publications (1)

Publication Number Publication Date
BE794669A true BE794669A (fr) 1973-05-16

Family

ID=27572212

Family Applications (1)

Application Number Title Priority Date Filing Date
BE794669D BE794669A (fr) 1972-04-13 1973-01-29 Derives de 3,4-dihydrocarbostyryle et leur procede de preparation

Country Status (17)

Country Link
JP (5) JPS48103590A (pt)
AR (1) AR209575A1 (pt)
AU (1) AU475964B2 (pt)
BE (1) BE794669A (pt)
CA (1) CA1025447A (pt)
CH (1) CH575929A5 (pt)
DD (2) DD112446A5 (pt)
DE (1) DE2302027C2 (pt)
DK (1) DK141603B (pt)
FI (1) FI53703C (pt)
FR (1) FR2179715B1 (pt)
GB (2) GB1424572A (pt)
HK (1) HK19481A (pt)
NL (1) NL158176B (pt)
NO (1) NO140589C (pt)
SE (1) SE380018B (pt)
YU (1) YU41187B (pt)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2453113A1 (de) * 1973-11-10 1975-05-15 Otsuka Pharma Co Ltd 5-(hydroxy-3-tert.-butylamino)-propoxy-3,4-dihydro-2-hydroxychinolin enthaltende arzneipraeparate
US4137331A (en) 1974-06-19 1979-01-30 Sandoz Ltd. 3-Piperidino-2-hydroxypropoxy substituted-2-indolinones

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
JPS516971A (en) * 1974-07-08 1976-01-20 Otsuka Pharma Co Ltd Nitoro 3*44 jihidorokarubosuchirirujudotaino seizoho
JPS5129486A (en) * 1974-09-02 1976-03-12 Otsuka Pharma Co Ltd * 33 arukiruamino 22 hidorokishi * purohokishi 3 44 jihidorokarubosuchirirujudotai no seizoho
JPS5148674A (en) * 1974-10-17 1976-04-26 Otsuka Pharma Co Ltd 3 44 jihidorokarubosuchirirujudotaino seizoho
JPS5152179A (ja) * 1974-10-31 1976-05-08 Otsuka Pharma Co Ltd Karubosuchirirujudotaino seizoho
JPS5152180A (ja) * 1974-10-31 1976-05-08 Otsuka Pharma Co Ltd Karubosuchirirujudotaino seizoho
JPS5152178A (ja) * 1974-10-31 1976-05-08 Otsuka Pharma Co Ltd Karubosuchirirujudotaino seizoho
FI58329C (fi) * 1974-11-08 1981-01-12 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av i 8-staellning substituerade 5-(3'-alkylamino-2'-hydroxi)propoxi-3,4-dihydrokarbostyrilderivat
US4081447A (en) * 1975-04-09 1978-03-28 Abbott Laboratories 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
CH619453A5 (pt) * 1976-03-17 1980-09-30 Otsuka Pharma Co Ltd
DE2719562C2 (de) * 1976-05-08 1986-05-07 Otsuka Pharmaceutical Co. Ltd., Tokio/Tokyo 3, 4-Dihydrocarbostyrilderivate, Verfahren zu deren Herstellung und Arzneimittel, welche diese enthalten
US4146630A (en) * 1976-11-12 1979-03-27 Boehringer Mannheim Gmbh Blood pressure lowering and adrenergic β-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
DE2960178D1 (en) * 1978-06-06 1981-04-09 Hoechst Ag New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation
DE2827566A1 (de) * 1978-06-23 1980-01-10 Boehringer Mannheim Gmbh 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung
AU518814B2 (en) * 1979-01-30 1981-10-22 Otsuka Pharamaceutical Co. Glaucoma treatment
DE3034237A1 (de) * 1979-09-18 1981-04-16 Otsuka Pharmaceutical Co. Ltd., Tokyo Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel
JPS56122356A (en) * 1980-02-29 1981-09-25 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS58103343A (ja) * 1981-12-15 1983-06-20 Ota Seiyaku Kk プロパノ−ルアミン化合物の製造法
JPS597186A (ja) * 1982-07-02 1984-01-14 Ota Seiyaku Kk １，３，２−ジオキサチオラン２−オキシド誘導体
JPS63193086U (pt) * 1987-05-30 1988-12-13
DE3808136A1 (de) * 1988-03-11 1989-09-21 Thomae Gmbh Dr K Arzneimittel, enthaltend chinolin-2,5-dione, neue chinolin-2,5-dione und verfahren zu ihrer herstellung
US5053514A (en) * 1988-08-10 1991-10-01 Otsuka Pharmaceutical Company, Limited Cardiotonics
US5266577A (en) * 1988-08-10 1993-11-30 Otsuka Pharmaceutical Company Ltd. Method of treating congestive heart failure using carbostyril derivatives
WO1993004042A1 (fr) * 1991-08-23 1993-03-04 Otsuka Pharmaceutical Co., Ltd. Derive de carbostyrile et antiagregant plaquettaire
ES2048108B1 (es) * 1992-07-17 1994-10-01 Lusochimica Spa Procedimiento para la preparacion de 5-(3-terc-butilamino-2-hidroxipropoxi)-3,4-dihidrocarboestirilo.
IT1264816B1 (it) * 1993-07-28 1996-10-10 Pergam Srl Procedimento per la preparazione di derivati del procedimento per la preparazione di derivati del 3,4-diidrocarbostirile 3,4-diidrocarbostirile
CZ300351B6 (cs) * 2005-05-26 2009-04-29 Zentiva, A. S. Zpusob prípravy 7-hydroxy-3,4-dihydrokarbostyrilu

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1058822A (en) * 1963-07-30 1967-02-15 Ici Ltd 3-amino-2-hydroxypropoxy heterocyclic derivatives
CH523899A (de) * 1968-07-05 1972-06-15 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von Derivaten des 2-Oxo-1,2-dihydro-chinolins

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2453113A1 (de) * 1973-11-10 1975-05-15 Otsuka Pharma Co Ltd 5-(hydroxy-3-tert.-butylamino)-propoxy-3,4-dihydro-2-hydroxychinolin enthaltende arzneipraeparate
US4137331A (en) 1974-06-19 1979-01-30 Sandoz Ltd. 3-Piperidino-2-hydroxypropoxy substituted-2-indolinones

Also Published As

Publication number Publication date
JPS5229745B2 (pt) 1977-08-03
YU41187B (en) 1986-12-31
CA1025447A (en) 1978-01-31
DE2302027A1 (de) 1973-12-06
JPS5239036B2 (pt) 1977-10-03
NL7302353A (pt) 1973-10-16
AU475964B2 (en) 1976-09-09
JPS48103589A (pt) 1973-12-25
FR2179715A1 (pt) 1973-11-23
DK141603B (da) 1980-05-05
DE2302027C2 (de) 1983-03-17
DK141603C (pt) 1980-10-06
HK19481A (en) 1981-05-22
JPS4981373A (pt) 1974-08-06
JPS517672B2 (pt) 1976-03-10
DD108293A5 (pt) 1974-09-12
FR2179715B1 (pt) 1976-12-03
CH575929A5 (pt) 1976-05-31
GB1424572A (en) 1976-02-11
AU5438673A (en) 1974-10-17
NO140589C (no) 1979-10-03
SE380018B (pt) 1975-10-27
JPS4976878A (pt) 1974-07-24
NL158176B (nl) 1978-10-16
FI53703C (fi) 1978-07-10
YU254979A (en) 1982-10-31
GB1424571A (en) 1976-02-11
JPS5241269B2 (pt) 1977-10-17
JPS48103590A (pt) 1973-12-25
NO140589B (no) 1979-06-25
JPS4982673A (pt) 1974-08-08
AR209575A1 (es) 1977-05-13
FI53703B (pt) 1978-03-31
DD112446A5 (pt) 1975-04-12

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: OTSUKA PHARMACEUTICAL CO. LTD

Effective date: 19930129

CCPA Application for a supplementary protection certificate

Free format text: 093C0005

CCPV Grant of a supplementary protection certificate

Free format text: 093C0005, EXPIRES 19970503