FR2179715B1 - - Google Patents

Info

Publication number
FR2179715B1
FR2179715B1 FR7300739A FR7300739A FR2179715B1 FR 2179715 B1 FR2179715 B1 FR 2179715B1 FR 7300739 A FR7300739 A FR 7300739A FR 7300739 A FR7300739 A FR 7300739A FR 2179715 B1 FR2179715 B1 FR 2179715B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7300739A
Other versions
FR2179715A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP47092560A external-priority patent/JPS5246231B2/ja
Priority claimed from JP47092558A external-priority patent/JPS5241268B2/ja
Priority claimed from JP9255772A external-priority patent/JPS5324431B2/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of FR2179715A1 publication Critical patent/FR2179715A1/fr
Application granted granted Critical
Publication of FR2179715B1 publication Critical patent/FR2179715B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR7300739A 1972-04-13 1973-01-10 Expired FR2179715B1 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP47037181A JPS517672B2 (fr) 1972-04-13 1972-04-13
JP47037182A JPS48103590A (fr) 1972-04-13 1972-04-13
JP47092560A JPS5246231B2 (fr) 1972-09-14 1972-09-14
JP47092558A JPS5241268B2 (fr) 1972-09-14 1972-09-14
JP9255772A JPS5324431B2 (fr) 1972-09-14 1972-09-14
JP47120953A JPS5229745B2 (fr) 1972-04-13 1972-12-02
JP47125858A JPS5239036B2 (fr) 1972-04-13 1972-12-14
JP47128972A JPS5241269B2 (fr) 1972-04-13 1972-12-21

Publications (2)

Publication Number Publication Date
FR2179715A1 FR2179715A1 (fr) 1973-11-23
FR2179715B1 true FR2179715B1 (fr) 1976-12-03

Family

ID=27572212

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7300739A Expired FR2179715B1 (fr) 1972-04-13 1973-01-10

Country Status (17)

Country Link
JP (5) JPS517672B2 (fr)
AR (1) AR209575A1 (fr)
AU (1) AU475964B2 (fr)
BE (1) BE794669A (fr)
CA (1) CA1025447A (fr)
CH (1) CH575929A5 (fr)
DD (2) DD108293A5 (fr)
DE (1) DE2302027C2 (fr)
DK (1) DK141603B (fr)
FI (1) FI53703C (fr)
FR (1) FR2179715B1 (fr)
GB (2) GB1424572A (fr)
HK (1) HK19481A (fr)
NL (1) NL158176B (fr)
NO (1) NO140589C (fr)
SE (1) SE380018B (fr)
YU (1) YU41187B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5082218A (fr) * 1973-11-10 1975-07-03
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
US4137331A (en) 1974-06-19 1979-01-30 Sandoz Ltd. 3-Piperidino-2-hydroxypropoxy substituted-2-indolinones
JPS516971A (en) * 1974-07-08 1976-01-20 Otsuka Pharma Co Ltd Nitoro 3*44 jihidorokarubosuchirirujudotaino seizoho
JPS5129486A (en) * 1974-09-02 1976-03-12 Otsuka Pharma Co Ltd * 33 arukiruamino 22 hidorokishi * purohokishi 3 44 jihidorokarubosuchirirujudotai no seizoho
JPS5148674A (en) * 1974-10-17 1976-04-26 Otsuka Pharma Co Ltd 3 44 jihidorokarubosuchirirujudotaino seizoho
JPS5152180A (ja) * 1974-10-31 1976-05-08 Otsuka Pharma Co Ltd Karubosuchirirujudotaino seizoho
JPS5152178A (ja) * 1974-10-31 1976-05-08 Otsuka Pharma Co Ltd Karubosuchirirujudotaino seizoho
JPS5152179A (ja) * 1974-10-31 1976-05-08 Otsuka Pharma Co Ltd Karubosuchirirujudotaino seizoho
FI58329C (fi) * 1974-11-08 1981-01-12 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av i 8-staellning substituerade 5-(3'-alkylamino-2'-hydroxi)propoxi-3,4-dihydrokarbostyrilderivat
US4081447A (en) * 1975-04-09 1978-03-28 Abbott Laboratories 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
CH619453A5 (fr) * 1976-03-17 1980-09-30 Otsuka Pharma Co Ltd
DE2719562C2 (de) * 1976-05-08 1986-05-07 Otsuka Pharmaceutical Co. Ltd., Tokio/Tokyo 3, 4-Dihydrocarbostyrilderivate, Verfahren zu deren Herstellung und Arzneimittel, welche diese enthalten
US4146630A (en) * 1976-11-12 1979-03-27 Boehringer Mannheim Gmbh Blood pressure lowering and adrenergic β-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
EP0005828B1 (fr) * 1978-06-06 1981-03-11 Hoechst Aktiengesellschaft Nouvelles dérivés de la phénylpipérazine substitués, médicaments les contenant et procédés pour leur préparation
DE2827566A1 (de) * 1978-06-23 1980-01-10 Boehringer Mannheim Gmbh 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung
AU518814B2 (en) * 1979-01-30 1981-10-22 Otsuka Pharamaceutical Co. Glaucoma treatment
DE3034237A1 (de) * 1979-09-18 1981-04-16 Otsuka Pharmaceutical Co. Ltd., Tokyo Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel
JPS56122356A (en) * 1980-02-29 1981-09-25 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS58103343A (ja) * 1981-12-15 1983-06-20 Ota Seiyaku Kk プロパノ−ルアミン化合物の製造法
JPS597186A (ja) * 1982-07-02 1984-01-14 Ota Seiyaku Kk １，３，２−ジオキサチオラン２−オキシド誘導体
JPS63193086U (fr) * 1987-05-30 1988-12-13
DE3808136A1 (de) * 1988-03-11 1989-09-21 Thomae Gmbh Dr K Arzneimittel, enthaltend chinolin-2,5-dione, neue chinolin-2,5-dione und verfahren zu ihrer herstellung
US5266577A (en) * 1988-08-10 1993-11-30 Otsuka Pharmaceutical Company Ltd. Method of treating congestive heart failure using carbostyril derivatives
EP0355583B1 (fr) * 1988-08-10 1995-01-25 Otsuka Pharmaceutical Co., Ltd. Agents cardiotoniques
EP0569592A4 (fr) * 1991-08-23 1994-12-07 Otsuka Pharma Co Ltd Derive de carbostyrile et antiagregant plaquettaire.
ES2048108B1 (es) * 1992-07-17 1994-10-01 Lusochimica Spa Procedimiento para la preparacion de 5-(3-terc-butilamino-2-hidroxipropoxi)-3,4-dihidrocarboestirilo.
IT1264816B1 (it) * 1993-07-28 1996-10-10 Pergam Srl Procedimento per la preparazione di derivati del procedimento per la preparazione di derivati del 3,4-diidrocarbostirile 3,4-diidrocarbostirile
CZ300351B6 (cs) * 2005-05-26 2009-04-29 Zentiva, A. S. Zpusob prípravy 7-hydroxy-3,4-dihydrokarbostyrilu

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1058822A (en) * 1963-07-30 1967-02-15 Ici Ltd 3-amino-2-hydroxypropoxy heterocyclic derivatives
CH514611A (de) * 1968-07-05 1971-10-31 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von Derivaten des 2-Oxo-1,2-dihydro-chinolins

Also Published As

Publication number Publication date
DE2302027C2 (de) 1983-03-17
JPS517672B2 (fr) 1976-03-10
DD112446A5 (fr) 1975-04-12
JPS5229745B2 (fr) 1977-08-03
DD108293A5 (fr) 1974-09-12
JPS48103589A (fr) 1973-12-25
BE794669A (fr) 1973-05-16
AR209575A1 (es) 1977-05-13
CA1025447A (fr) 1978-01-31
FI53703C (fi) 1978-07-10
NO140589C (no) 1979-10-03
NO140589B (no) 1979-06-25
JPS4976878A (fr) 1974-07-24
AU475964B2 (en) 1976-09-09
YU254979A (en) 1982-10-31
GB1424572A (en) 1976-02-11
AU5438673A (en) 1974-10-17
FI53703B (fr) 1978-03-31
JPS4982673A (fr) 1974-08-08
NL158176B (nl) 1978-10-16
SE380018B (fr) 1975-10-27
JPS48103590A (fr) 1973-12-25
DK141603B (da) 1980-05-05
JPS4981373A (fr) 1974-08-06
YU41187B (en) 1986-12-31
JPS5239036B2 (fr) 1977-10-03
FR2179715A1 (fr) 1973-11-23
GB1424571A (en) 1976-02-11
NL7302353A (fr) 1973-10-16
JPS5241269B2 (fr) 1977-10-17
CH575929A5 (fr) 1976-05-31
DE2302027A1 (de) 1973-12-06
DK141603C (fr) 1980-10-06
HK19481A (en) 1981-05-22

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Legal Events

Date Code Title Description
CP Supplementary protection certificate (spc) filed

Free format text: PRODUCT NAME: CARTEOLOL HYDROCHLORIDE; NAT. REGISTRATION NO/DATE: NL 13776 19850220; FIRST REGISTRATION:

Spc suppl protection certif: 93C0031

Filing date: 19930628

Free format text: PRODUCT NAME: CARTEOLOL HYDROCHLORIDE; NAT. REGISTRATION NO/DATE: NL 13775 19850220; FIRST REGISTRATION:

Spc suppl protection certif: 93C0032

Filing date: 19930628

CP Supplementary protection certificate (spc) filed
CP Supplementary protection certificate (spc) filed
RN Application for restoration
CX Request for supplementary protection certificate (spc) rejected

Free format text: 93C0032, 19930628

CP Supplementary protection certificate (spc) filed