AU5438673A - Process for preparing 3,4-dihydrocarbostyril derivatives - Google Patents

Process for preparing 3,4-dihydrocarbostyril derivatives

Info

Publication number
AU5438673A
AU5438673A AU54386/73A AU5438673A AU5438673A AU 5438673 A AU5438673 A AU 5438673A AU 54386/73 A AU54386/73 A AU 54386/73A AU 5438673 A AU5438673 A AU 5438673A AU 5438673 A AU5438673 A AU 5438673A
Authority
AU
Australia
Prior art keywords
preparing
dihydrocarbostyril derivatives
dihydrocarbostyril
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU54386/73A
Other versions
AU475964B2 (en
Inventor
NANAMI MURAKAMI SHIRO YOSHIZAKI HIDEO MORI MICHIAKI TOMINAGA and YASUMITSU TAMURA KAZUYUKI NAKAGAWA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP47092558A external-priority patent/JPS5241268B2/ja
Priority claimed from JP9255772A external-priority patent/JPS5324431B2/ja
Priority claimed from JP47092560A external-priority patent/JPS5246231B2/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of AU5438673A publication Critical patent/AU5438673A/en
Application granted granted Critical
Publication of AU475964B2 publication Critical patent/AU475964B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU54386/73A 1972-04-13 1973-04-11 Process for preparing 3,4-dihydrocarbostyril derivatives Expired AU475964B2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP47037182A JPS48103590A (en) 1972-04-13 1972-04-13
JP47037181A JPS517672B2 (en) 1972-04-13 1972-04-13
JP47092558A JPS5241268B2 (en) 1972-09-14 1972-09-14
JP9255772A JPS5324431B2 (en) 1972-09-14 1972-09-14
JP47092560A JPS5246231B2 (en) 1972-09-14 1972-09-14
JP47120953A JPS5229745B2 (en) 1972-04-13 1972-12-02
JP47125858A JPS5239036B2 (en) 1972-04-13 1972-12-14
JP47128972A JPS5241269B2 (en) 1972-04-13 1972-12-21

Publications (2)

Publication Number Publication Date
AU5438673A true AU5438673A (en) 1974-10-17
AU475964B2 AU475964B2 (en) 1976-09-09

Family

ID=27572212

Family Applications (1)

Application Number Title Priority Date Filing Date
AU54386/73A Expired AU475964B2 (en) 1972-04-13 1973-04-11 Process for preparing 3,4-dihydrocarbostyril derivatives

Country Status (17)

Country Link
JP (5) JPS48103590A (en)
AR (1) AR209575A1 (en)
AU (1) AU475964B2 (en)
BE (1) BE794669A (en)
CA (1) CA1025447A (en)
CH (1) CH575929A5 (en)
DD (2) DD108293A5 (en)
DE (1) DE2302027C2 (en)
DK (1) DK141603B (en)
FI (1) FI53703C (en)
FR (1) FR2179715B1 (en)
GB (2) GB1424572A (en)
HK (1) HK19481A (en)
NL (1) NL158176B (en)
NO (1) NO140589C (en)
SE (1) SE380018B (en)
YU (1) YU41187B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5082218A (en) * 1973-11-10 1975-07-03
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
US4137331A (en) 1974-06-19 1979-01-30 Sandoz Ltd. 3-Piperidino-2-hydroxypropoxy substituted-2-indolinones
JPS516971A (en) * 1974-07-08 1976-01-20 Otsuka Pharma Co Ltd Nitoro 3*44 jihidorokarubosuchirirujudotaino seizoho
JPS5129486A (en) * 1974-09-02 1976-03-12 Otsuka Pharma Co Ltd * 33 arukiruamino 22 hidorokishi * purohokishi 3 44 jihidorokarubosuchirirujudotai no seizoho
JPS5148674A (en) * 1974-10-17 1976-04-26 Otsuka Pharma Co Ltd 3 44 jihidorokarubosuchirirujudotaino seizoho
JPS5152180A (en) * 1974-10-31 1976-05-08 Otsuka Pharma Co Ltd KARUBOSUCHIRIRU JUDOTAINO SEIZOHO
JPS5152179A (en) * 1974-10-31 1976-05-08 Otsuka Pharma Co Ltd KARUBOSUCHIRIRU JUDOTAINO SEIZOHO
JPS5152178A (en) * 1974-10-31 1976-05-08 Otsuka Pharma Co Ltd KARUBOSUCHIRIRU JUDOTAINO SEIZOHO
FI58329C (en) * 1974-11-08 1981-01-12 Otsuka Pharma Co Ltd PROCEDURE FOR FRAMSTATION OF I 8-STATIONARY SUBSTITUTES 5- (3'-ALKYLAMINO-2'-HYDROXY) PROPOXI-3,4-DIHYDROCARBOSTYRILDER
US4081447A (en) * 1975-04-09 1978-03-28 Abbott Laboratories 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
CH619453A5 (en) * 1976-03-17 1980-09-30 Otsuka Pharma Co Ltd
GB1574665A (en) * 1976-05-08 1980-09-10 Otsuka Pharma Co Ltd 3,4-dihydrocarbostyril derivatives and process for preparing the same
US4146630A (en) * 1976-11-12 1979-03-27 Boehringer Mannheim Gmbh Blood pressure lowering and adrenergic β-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
DE2960178D1 (en) * 1978-06-06 1981-04-09 Hoechst Ag New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation
DE2827566A1 (en) * 1978-06-23 1980-01-10 Boehringer Mannheim Gmbh 1,2-DIHYDRO-CHINOLIN-2-ON DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
AU518814B2 (en) * 1979-01-30 1981-10-22 Otsuka Pharamaceutical Co. Glaucoma treatment
DE3034237A1 (en) * 1979-09-18 1981-04-16 Otsuka Pharmaceutical Co. Ltd., Tokyo CARBOSTYRIL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND ANTIHISTAMINICALLY ACTIVE AGENTS CONTAINING THESE COMPOUNDS
JPS56122356A (en) * 1980-02-29 1981-09-25 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS58103343A (en) * 1981-12-15 1983-06-20 Ota Seiyaku Kk Preparation of propanolamine compound
JPS597186A (en) * 1982-07-02 1984-01-14 Ota Seiyaku Kk 1,3,2-dioxathiolane 2-oxide derivative
JPS63193086U (en) * 1987-05-30 1988-12-13
DE3808136A1 (en) * 1988-03-11 1989-09-21 Thomae Gmbh Dr K DRUGS CONTAINING CHINOLINE-2,5-DIONE, NEW CHINOLINE-2,5-DIONE AND METHOD OF PREPARING THEM
US5053514A (en) * 1988-08-10 1991-10-01 Otsuka Pharmaceutical Company, Limited Cardiotonics
US5266577A (en) * 1988-08-10 1993-11-30 Otsuka Pharmaceutical Company Ltd. Method of treating congestive heart failure using carbostyril derivatives
EP0569592A4 (en) * 1991-08-23 1994-12-07 Otsuka Pharma Co Ltd Carbostyril derivative and platelet agglutination inhibitor.
ES2048108B1 (en) * 1992-07-17 1994-10-01 Lusochimica Spa PROCEDURE FOR THE PREPARATION OF 5- (3-TERC-BUTILAMINO-2-HIDROXIPROPOXI) -3,4-DIHIDROCARBOESTIRILO.
IT1264816B1 (en) * 1993-07-28 1996-10-10 Pergam Srl Process for the preparation of 3,4-dihydrocarbostyryl derivatives
CZ300351B6 (en) * 2005-05-26 2009-04-29 Zentiva, A. S. Process for preparing 7-hydroxy-3,4-dihydrocarbostyril

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1058822A (en) * 1963-07-30 1967-02-15 Ici Ltd 3-amino-2-hydroxypropoxy heterocyclic derivatives
CH514611A (en) * 1968-07-05 1971-10-31 Cassella Farbwerke Mainkur Ag Process for the preparation of derivatives of 2-oxo-1,2-dihydro-quinoline

Also Published As

Publication number Publication date
NO140589C (en) 1979-10-03
GB1424572A (en) 1976-02-11
DE2302027A1 (en) 1973-12-06
HK19481A (en) 1981-05-22
SE380018B (en) 1975-10-27
NL7302353A (en) 1973-10-16
JPS48103590A (en) 1973-12-25
NL158176B (en) 1978-10-16
FR2179715A1 (en) 1973-11-23
JPS517672B2 (en) 1976-03-10
JPS5229745B2 (en) 1977-08-03
JPS4982673A (en) 1974-08-08
DE2302027C2 (en) 1983-03-17
YU41187B (en) 1986-12-31
NO140589B (en) 1979-06-25
AU475964B2 (en) 1976-09-09
JPS5239036B2 (en) 1977-10-03
BE794669A (en) 1973-05-16
JPS5241269B2 (en) 1977-10-17
FR2179715B1 (en) 1976-12-03
GB1424571A (en) 1976-02-11
DK141603C (en) 1980-10-06
JPS4976878A (en) 1974-07-24
FI53703B (en) 1978-03-31
CA1025447A (en) 1978-01-31
DD112446A5 (en) 1975-04-12
DK141603B (en) 1980-05-05
YU254979A (en) 1982-10-31
CH575929A5 (en) 1976-05-31
AR209575A1 (en) 1977-05-13
DD108293A5 (en) 1974-09-12
JPS4981373A (en) 1974-08-06
FI53703C (en) 1978-07-10
JPS48103589A (en) 1973-12-25

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