BE794669A - 3,4-DIHYDROCARBOSTYRYL DERIVATIVES AND THEIR PREPARATION PROCESS - Google Patents

3,4-DIHYDROCARBOSTYRYL DERIVATIVES AND THEIR PREPARATION PROCESS

Info

Publication number
BE794669A
BE794669A BE794669DA BE794669A BE 794669 A BE794669 A BE 794669A BE 794669D A BE794669D A BE 794669DA BE 794669 A BE794669 A BE 794669A
Authority
BE
Belgium
Prior art keywords
dihydrocarbostyryl
derivatives
preparation process
preparation
dihydrocarbostyryl derivatives
Prior art date
Application number
Other languages
French (fr)
Inventor
K Nakagawa
N Murakami
S Yoshizaki
H Mori
M Tominaga
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP47092558A external-priority patent/JPS5241268B2/ja
Priority claimed from JP47092560A external-priority patent/JPS5246231B2/ja
Priority claimed from JP9255772A external-priority patent/JPS5324431B2/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of BE794669A publication Critical patent/BE794669A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE794669D 1972-04-13 1973-01-29 3,4-DIHYDROCARBOSTYRYL DERIVATIVES AND THEIR PREPARATION PROCESS BE794669A (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP47037181A JPS517672B2 (en) 1972-04-13 1972-04-13
JP47037182A JPS48103590A (en) 1972-04-13 1972-04-13
JP47092558A JPS5241268B2 (en) 1972-09-14 1972-09-14
JP47092560A JPS5246231B2 (en) 1972-09-14 1972-09-14
JP9255772A JPS5324431B2 (en) 1972-09-14 1972-09-14
JP47120953A JPS5229745B2 (en) 1972-04-13 1972-12-02
JP47125858A JPS5239036B2 (en) 1972-04-13 1972-12-14
JP47128972A JPS5241269B2 (en) 1972-04-13 1972-12-21

Publications (1)

Publication Number Publication Date
BE794669A true BE794669A (en) 1973-05-16

Family

ID=27572212

Family Applications (1)

Application Number Title Priority Date Filing Date
BE794669D BE794669A (en) 1972-04-13 1973-01-29 3,4-DIHYDROCARBOSTYRYL DERIVATIVES AND THEIR PREPARATION PROCESS

Country Status (17)

Country Link
JP (5) JPS517672B2 (en)
AR (1) AR209575A1 (en)
AU (1) AU475964B2 (en)
BE (1) BE794669A (en)
CA (1) CA1025447A (en)
CH (1) CH575929A5 (en)
DD (2) DD108293A5 (en)
DE (1) DE2302027C2 (en)
DK (1) DK141603B (en)
FI (1) FI53703C (en)
FR (1) FR2179715B1 (en)
GB (2) GB1424572A (en)
HK (1) HK19481A (en)
NL (1) NL158176B (en)
NO (1) NO140589C (en)
SE (1) SE380018B (en)
YU (1) YU41187B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2453113A1 (en) * 1973-11-10 1975-05-15 Otsuka Pharma Co Ltd 5- (HYDROXY-3-TERT.-BUTYLAMINO) -PROPOXY-3,4-DIHYDRO-2-HYDROXYCHINOLIN CONTAINING MEDICINAL PREPARATIONS
US4137331A (en) 1974-06-19 1979-01-30 Sandoz Ltd. 3-Piperidino-2-hydroxypropoxy substituted-2-indolinones

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
JPS516971A (en) * 1974-07-08 1976-01-20 Otsuka Pharma Co Ltd Nitoro 3*44 jihidorokarubosuchirirujudotaino seizoho
JPS5129486A (en) * 1974-09-02 1976-03-12 Otsuka Pharma Co Ltd * 33 arukiruamino 22 hidorokishi * purohokishi 3 44 jihidorokarubosuchirirujudotai no seizoho
JPS5148674A (en) * 1974-10-17 1976-04-26 Otsuka Pharma Co Ltd 3 44 jihidorokarubosuchirirujudotaino seizoho
JPS5152179A (en) * 1974-10-31 1976-05-08 Otsuka Pharma Co Ltd KARUBOSUCHIRIRU JUDOTAINO SEIZOHO
JPS5152180A (en) * 1974-10-31 1976-05-08 Otsuka Pharma Co Ltd KARUBOSUCHIRIRU JUDOTAINO SEIZOHO
JPS5152178A (en) * 1974-10-31 1976-05-08 Otsuka Pharma Co Ltd KARUBOSUCHIRIRU JUDOTAINO SEIZOHO
FI58329C (en) * 1974-11-08 1981-01-12 Otsuka Pharma Co Ltd PROCEDURE FOR FRAMSTATION OF I 8-STATIONARY SUBSTITUTES 5- (3'-ALKYLAMINO-2'-HYDROXY) PROPOXI-3,4-DIHYDROCARBOSTYRILDER
US4081447A (en) * 1975-04-09 1978-03-28 Abbott Laboratories 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
CH619453A5 (en) * 1976-03-17 1980-09-30 Otsuka Pharma Co Ltd
GB1574665A (en) * 1976-05-08 1980-09-10 Otsuka Pharma Co Ltd 3,4-dihydrocarbostyril derivatives and process for preparing the same
US4146630A (en) * 1976-11-12 1979-03-27 Boehringer Mannheim Gmbh Blood pressure lowering and adrenergic β-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
DE2960178D1 (en) * 1978-06-06 1981-04-09 Hoechst Ag New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation
DE2827566A1 (en) * 1978-06-23 1980-01-10 Boehringer Mannheim Gmbh 1,2-DIHYDRO-CHINOLIN-2-ON DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
AU518814B2 (en) * 1979-01-30 1981-10-22 Otsuka Pharamaceutical Co. Glaucoma treatment
DE3034237A1 (en) * 1979-09-18 1981-04-16 Otsuka Pharmaceutical Co. Ltd., Tokyo CARBOSTYRIL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND ANTIHISTAMINICALLY ACTIVE AGENTS CONTAINING THESE COMPOUNDS
JPS56122356A (en) * 1980-02-29 1981-09-25 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS58103343A (en) * 1981-12-15 1983-06-20 Ota Seiyaku Kk Preparation of propanolamine compound
JPS597186A (en) * 1982-07-02 1984-01-14 Ota Seiyaku Kk 1,3,2-dioxathiolane 2-oxide derivative
JPS63193086U (en) * 1987-05-30 1988-12-13
DE3808136A1 (en) * 1988-03-11 1989-09-21 Thomae Gmbh Dr K DRUGS CONTAINING CHINOLINE-2,5-DIONE, NEW CHINOLINE-2,5-DIONE AND METHOD OF PREPARING THEM
US5266577A (en) * 1988-08-10 1993-11-30 Otsuka Pharmaceutical Company Ltd. Method of treating congestive heart failure using carbostyril derivatives
EP0355583B1 (en) * 1988-08-10 1995-01-25 Otsuka Pharmaceutical Co., Ltd. Cardiotonics
AU653060B2 (en) * 1991-08-23 1994-09-15 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelet agglutination inhibitor
ES2048108B1 (en) * 1992-07-17 1994-10-01 Lusochimica Spa PROCEDURE FOR THE PREPARATION OF 5- (3-TERC-BUTILAMINO-2-HIDROXIPROPOXI) -3,4-DIHIDROCARBOESTIRILO.
IT1264816B1 (en) * 1993-07-28 1996-10-10 Pergam Srl Process for the preparation of 3,4-dihydrocarbostyryl derivatives
CZ300351B6 (en) * 2005-05-26 2009-04-29 Zentiva, A. S. Process for preparing 7-hydroxy-3,4-dihydrocarbostyril

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1058822A (en) * 1963-07-30 1967-02-15 Ici Ltd 3-amino-2-hydroxypropoxy heterocyclic derivatives
CH514611A (en) * 1968-07-05 1971-10-31 Cassella Farbwerke Mainkur Ag Process for the preparation of derivatives of 2-oxo-1,2-dihydro-quinoline

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2453113A1 (en) * 1973-11-10 1975-05-15 Otsuka Pharma Co Ltd 5- (HYDROXY-3-TERT.-BUTYLAMINO) -PROPOXY-3,4-DIHYDRO-2-HYDROXYCHINOLIN CONTAINING MEDICINAL PREPARATIONS
US4137331A (en) 1974-06-19 1979-01-30 Sandoz Ltd. 3-Piperidino-2-hydroxypropoxy substituted-2-indolinones

Also Published As

Publication number Publication date
JPS517672B2 (en) 1976-03-10
NO140589B (en) 1979-06-25
AU5438673A (en) 1974-10-17
DD108293A5 (en) 1974-09-12
GB1424571A (en) 1976-02-11
NL158176B (en) 1978-10-16
JPS48103589A (en) 1973-12-25
DE2302027A1 (en) 1973-12-06
FI53703B (en) 1978-03-31
NL7302353A (en) 1973-10-16
YU254979A (en) 1982-10-31
JPS5241269B2 (en) 1977-10-17
JPS48103590A (en) 1973-12-25
CH575929A5 (en) 1976-05-31
AR209575A1 (en) 1977-05-13
AU475964B2 (en) 1976-09-09
CA1025447A (en) 1978-01-31
DD112446A5 (en) 1975-04-12
JPS4982673A (en) 1974-08-08
DK141603C (en) 1980-10-06
HK19481A (en) 1981-05-22
JPS4976878A (en) 1974-07-24
DE2302027C2 (en) 1983-03-17
YU41187B (en) 1986-12-31
JPS5239036B2 (en) 1977-10-03
SE380018B (en) 1975-10-27
FR2179715B1 (en) 1976-12-03
NO140589C (en) 1979-10-03
DK141603B (en) 1980-05-05
JPS4981373A (en) 1974-08-06
FI53703C (en) 1978-07-10
FR2179715A1 (en) 1973-11-23
GB1424572A (en) 1976-02-11
JPS5229745B2 (en) 1977-08-03

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: OTSUKA PHARMACEUTICAL CO. LTD

Effective date: 19930129

CCPA Application for a supplementary protection certificate

Free format text: 093C0005

CCPV Grant of a supplementary protection certificate

Free format text: 093C0005, EXPIRES 19970503