ES2048108B1 - Procedimiento para la preparacion de 5-(3-terc-butilamino-2-hidroxipropoxi)-3,4-dihidrocarboestirilo. - Google Patents

Procedimiento para la preparacion de 5-(3-terc-butilamino-2-hidroxipropoxi)-3,4-dihidrocarboestirilo.

Info

Publication number
ES2048108B1
ES2048108B1 ES09201501A ES9201501A ES2048108B1 ES 2048108 B1 ES2048108 B1 ES 2048108B1 ES 09201501 A ES09201501 A ES 09201501A ES 9201501 A ES9201501 A ES 9201501A ES 2048108 B1 ES2048108 B1 ES 2048108B1
Authority
ES
Spain
Prior art keywords
preparation
hidroxipropoxi
dihidrocarboestirilo
butilamino
terc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09201501A
Other languages
English (en)
Other versions
ES2048108A1 (es
Inventor
Elso Manghisi
Bruno Perego
Aldo Salimbeni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lusochimica SpA
Original Assignee
Lusochimica SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lusochimica SpA filed Critical Lusochimica SpA
Priority to ES09201501A priority Critical patent/ES2048108B1/es
Priority to EP93110843A priority patent/EP0579096B1/en
Priority to AT93110843T priority patent/ATE180473T1/de
Priority to DE69325054T priority patent/DE69325054T2/de
Publication of ES2048108A1 publication Critical patent/ES2048108A1/es
Application granted granted Critical
Publication of ES2048108B1 publication Critical patent/ES2048108B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

METODO PARA LA PREPARACION DEL COMPUESTO HIDROCLORURO DE 5-(3-TERC-BUTILAMINO-2-HIDROXIPROPOXI)-3,4-DIHIDRO-CARBOESTIRILO DE FORMULA (I) HACIENDO REACCIONAR 5-HIDROXI-3,4-DIHIDROCARBOESTIRILO CON EPICLORHIDRINA EN UNA MEZCLA DE DISOLVENTE APROTICO, SELECCIONADO ENTRE DIMETILSULFOXIDO, DIMETILFORMAMIDA Y METILPIRROLIDONA, CON AGUA A TEMPERATURA AMBIENTE EN PRESENCIA DE HIDROXIDOS ALCALINOS, HACIENDO REACCIONAR EL COMPUESTO ASI OBTENIDO CON TERC-BUTILAMINA EN PRESENCIA DE DIMETIL-SULFOXIDO Y SALIFICANDO EL PRODUCTO FINAL.
ES09201501A 1992-07-17 1992-07-17 Procedimiento para la preparacion de 5-(3-terc-butilamino-2-hidroxipropoxi)-3,4-dihidrocarboestirilo. Expired - Fee Related ES2048108B1 (es)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES09201501A ES2048108B1 (es) 1992-07-17 1992-07-17 Procedimiento para la preparacion de 5-(3-terc-butilamino-2-hidroxipropoxi)-3,4-dihidrocarboestirilo.
EP93110843A EP0579096B1 (en) 1992-07-17 1993-07-07 A process for the preparation of 5-(3-tert.-butylamino-2-hydroxypropoxy)-3,4-dihydro- carbostyryl.
AT93110843T ATE180473T1 (de) 1992-07-17 1993-07-07 Verfahren zur herstellung von 5-(3-tert.- butylamino-2-hydroxypropoxy)-3,4- dihydrocarbostyryl
DE69325054T DE69325054T2 (de) 1992-07-17 1993-07-07 Verfahren zur Herstellung von 5-(3-tert.-butylamino-2-hydroxypropoxy)-3,4-dihydrocarbostyryl

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09201501A ES2048108B1 (es) 1992-07-17 1992-07-17 Procedimiento para la preparacion de 5-(3-terc-butilamino-2-hidroxipropoxi)-3,4-dihidrocarboestirilo.

Publications (2)

Publication Number Publication Date
ES2048108A1 ES2048108A1 (es) 1994-03-01
ES2048108B1 true ES2048108B1 (es) 1994-10-01

Family

ID=8277697

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09201501A Expired - Fee Related ES2048108B1 (es) 1992-07-17 1992-07-17 Procedimiento para la preparacion de 5-(3-terc-butilamino-2-hidroxipropoxi)-3,4-dihidrocarboestirilo.

Country Status (4)

Country Link
EP (1) EP0579096B1 (es)
AT (1) ATE180473T1 (es)
DE (1) DE69325054T2 (es)
ES (1) ES2048108B1 (es)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES412484A1 (es) * 1972-04-13 1977-04-01 Otsuka Pharma Co Ltd Procedimiento para la preparacion de derivados carbostirili-cos.
JPS48103590A (es) * 1972-04-13 1973-12-25
JPS5239035B2 (es) * 1972-12-14 1977-10-03
JPS5239829B2 (es) * 1973-01-22 1977-10-07
JPS5148674A (en) * 1974-10-17 1976-04-26 Otsuka Pharma Co Ltd 3 44 jihidorokarubosuchirirujudotaino seizoho
JPS5148676A (en) * 1974-10-21 1976-04-26 Otsuka Pharma Co Ltd 55 * 33 arukiruamino 22 hidorokishi * purohokishi 3*44 jihidorokarubosuchirirujudotaino seizoho
JPS5239830A (en) * 1975-09-23 1977-03-28 Tlv Co Ltd Air vent
JPS5936617B2 (ja) * 1976-03-05 1984-09-05 大塚製薬株式会社 カルボスチリル誘導体
JPH0377870A (ja) * 1989-08-18 1991-04-03 Sakai Yakuhin Kk ３，４―ジヒドロカルボスチリル誘導体の製造方法
FR2719715B1 (fr) * 1994-05-04 1996-07-26 Magneti Marelli France Contacteur électrique tournant comprenant des moyens de réglage point milieu perfectionnés.

Also Published As

Publication number Publication date
DE69325054D1 (de) 1999-07-01
EP0579096A3 (es) 1994-04-27
DE69325054T2 (de) 1999-10-21
ATE180473T1 (de) 1999-06-15
EP0579096B1 (en) 1999-05-26
EP0579096A2 (en) 1994-01-19
ES2048108A1 (es) 1994-03-01

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Effective date: 20141120