BE2015C070I2 - - Google Patents
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- Publication number
- BE2015C070I2 BE2015C070I2 BE2015C070C BE2015C070C BE2015C070I2 BE 2015C070 I2 BE2015C070 I2 BE 2015C070I2 BE 2015C070 C BE2015C070 C BE 2015C070C BE 2015C070 C BE2015C070 C BE 2015C070C BE 2015C070 I2 BE2015C070 I2 BE 2015C070I2
- Authority
- BE
- Belgium
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51921103P | 2003-11-12 | 2003-11-12 | |
| EP04810619A EP1687329B8 (en) | 2003-11-12 | 2004-11-10 | Optimized expression of hpv 58 l1 in yeast |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE2015C070I2 true BE2015C070I2 (https=) | 2023-12-18 |
Family
ID=34590374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE2015C070C BE2015C070I2 (https=) | 2003-11-12 | 2015-12-09 |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US7498036B2 (https=) |
| EP (1) | EP1687329B8 (https=) |
| JP (2) | JP4912885B2 (https=) |
| KR (1) | KR101170654B1 (https=) |
| CN (1) | CN1942583B (https=) |
| AR (1) | AR046835A1 (https=) |
| AT (1) | ATE452977T1 (https=) |
| AU (1) | AU2004290032B2 (https=) |
| BE (1) | BE2015C070I2 (https=) |
| BR (1) | BRPI0416393B1 (https=) |
| CA (1) | CA2543928C (https=) |
| CY (2) | CY1113875T1 (https=) |
| DE (1) | DE602004024821D1 (https=) |
| DK (1) | DK1687329T3 (https=) |
| ES (1) | ES2340287T3 (https=) |
| FR (1) | FR15C0081I2 (https=) |
| HU (1) | HUS1500064I1 (https=) |
| IL (1) | IL175353A (https=) |
| IS (1) | IS2741B (https=) |
| LT (1) | LTC1687329I2 (https=) |
| LU (1) | LU92901I2 (https=) |
| MY (1) | MY139500A (https=) |
| NL (1) | NL300775I2 (https=) |
| NO (3) | NO340633B1 (https=) |
| NZ (1) | NZ546697A (https=) |
| PL (1) | PL1687329T3 (https=) |
| PT (1) | PT1687329E (https=) |
| RU (1) | RU2370538C2 (https=) |
| SI (1) | SI1687329T1 (https=) |
| TW (1) | TWI332988B (https=) |
| WO (1) | WO2005047315A2 (https=) |
| ZA (1) | ZA200603106B (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7858098B2 (en) * | 2002-12-20 | 2010-12-28 | Glaxosmithkline Biologicals, S.A. | Vaccine |
| US8206950B2 (en) | 2003-06-09 | 2012-06-26 | Animal Technology Institute Taiwan | Fusion antigen used as vaccine and method of making them |
| MY148656A (en) * | 2004-03-24 | 2013-05-15 | Merck Sharp & Dohme | Optimized expression of hpv 52 l1 in yeast. |
| US20070243587A1 (en) * | 2006-04-14 | 2007-10-18 | Healthbanks Biotech Co., Ltd. | Using a reverse genetic engineering platform to produce protein vaccines and protein vaccine of avian influenza virus |
| CN101148661B (zh) * | 2006-09-18 | 2013-01-02 | 中国医学科学院基础医学研究所 | 人乳头瘤病毒16型外壳蛋白病毒样颗粒及其制备方法和用途 |
| CA2679720A1 (en) * | 2007-03-09 | 2008-09-18 | Merck & Co., Inc. | Papillomavirus vaccine compositions |
| US9428555B2 (en) | 2007-04-29 | 2016-08-30 | Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. | Truncated L1 protein of Human Papillomavirus type 16 |
| WO2008134935A1 (en) | 2007-04-29 | 2008-11-13 | Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. | Truncated human papillomavirus type 18 l1 proteins |
| DK2154149T3 (da) * | 2007-05-29 | 2019-10-14 | Univ Xiamen | En trunkeret l1-protein af human papillomavirus 6 |
| CN101113417B (zh) * | 2007-06-22 | 2011-04-27 | 山东大学 | Hpv基因酵母体外翻译系统的建立 |
| CN101200696B (zh) * | 2007-11-14 | 2011-07-20 | 山东大学 | 人乳头瘤病毒的酵母增殖模型及建立方法与应用 |
| EP2479187A1 (en) | 2007-11-23 | 2012-07-25 | Shanghai Zerun Biotechnology Co., Ltd. | Genes encoding major capsid protein L1 of human papilloma viruses |
| KR20090073987A (ko) * | 2007-12-31 | 2009-07-03 | 정운원 | 인간유두종바이러스 유전자형 검사를 위한 프라이머, 프로브 및 이를 포함하는 ｄｎａ칩, 이의 검사 방법 및 검사 키트 |
| US9623098B2 (en) * | 2008-05-26 | 2017-04-18 | Cadila Healthcare Limited | Combined measles-human papilloma vaccine |
| US9335868B2 (en) * | 2008-07-31 | 2016-05-10 | Apple Inc. | Capacitive sensor behind black mask |
| JP6153866B2 (ja) | 2010-05-25 | 2017-06-28 | キアゲン ガイサーズバーグ アイエヌシー． | 迅速なハイブリッド捕捉アッセイ、及び関連する戦略的に切断されたプローブ |
| CN101857870B (zh) * | 2010-06-12 | 2012-09-05 | 上海泽润生物科技有限公司 | Hpv58 l1基因及载体、菌株和表达方法 |
| CN102336822B (zh) * | 2010-07-16 | 2015-10-14 | 厦门大学 | 截短的人乳头瘤病毒58型l1蛋白 |
| CN102154325B (zh) * | 2011-01-01 | 2013-08-21 | 上海生物制品研究所有限责任公司 | 针对人乳头瘤状病毒的疫苗及其制法和用途 |
| EP2722389B1 (en) * | 2011-06-15 | 2018-03-07 | Hong Jin Kim | Method for enhancing the production yield of human papillomavirus l1 protein |
| CN103361280B (zh) * | 2012-03-28 | 2018-07-24 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv11 l1蛋白的方法 |
| KR102092981B1 (ko) * | 2012-06-07 | 2020-03-24 | 더 칠드런스 호스피탈 오브 필라델피아 | 조절된 유전자 발현 방법 |
| CN103992395B (zh) * | 2013-02-18 | 2018-07-27 | 北京康乐卫士生物技术股份有限公司 | 重组hpv-58型l1的vlp疫苗及其制备方法 |
| CN104120088B (zh) * | 2013-04-26 | 2019-09-24 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv58 l1蛋白的方法 |
| CN104164373B (zh) * | 2013-05-17 | 2019-04-02 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv68l1蛋白的方法 |
| CN110592133A (zh) * | 2013-05-17 | 2019-12-20 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv31 l1蛋白的方法 |
| EP3057612B1 (en) | 2013-10-16 | 2020-05-06 | Merck Sharp & Dohme Corp. | Method of obtaining thermostable dried vaccine formulations |
| CN107002085A (zh) * | 2014-09-11 | 2017-08-01 | 卡迪拉保健有限公司 | 具有优异免疫学特性的优异的人乳头瘤病毒抗原和含有其的疫苗 |
| CN117187263A (zh) * | 2015-03-30 | 2023-12-08 | 上海泽润生物科技有限公司 | 重组人乳头瘤病毒33亚型蛋白表达 |
| CN104878022A (zh) * | 2015-04-27 | 2015-09-02 | 段青姣 | 编码hpv58l1、hpv52l1蛋白的核苷酸序列及其应用 |
| EP3385273A4 (en) * | 2015-12-04 | 2019-08-07 | Xiamen University | MUTANT OF HUMAN PAPILLOMAIRUS TYPE 58 L1 PROTEIN |
| JP2023516904A (ja) | 2020-02-14 | 2023-04-21 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｈｐｖワクチン |
| CN113073105B (zh) * | 2021-03-23 | 2023-06-13 | 重庆博唯佰泰生物制药有限公司 | 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用 |
| CN113549634B (zh) * | 2021-06-07 | 2023-03-31 | 郑州大学 | 编码可溶性hpv58 l1蛋白的基因及其重组质粒的构建与应用 |
| AR126708A1 (es) | 2021-08-06 | 2023-11-08 | Merck Sharp & Dohme Llc | Vacuna para el vph |
| JP2024532127A (ja) | 2021-08-19 | 2024-09-05 | メルク・シャープ・アンド・ドーム・エルエルシー | 熱安定性脂質ナノ粒子およびその使用方法 |
| TW202513091A (zh) | 2023-06-09 | 2025-04-01 | 美商默沙東有限責任公司 | 用於人類乳突病毒疫苗之奈米乳液佐劑組合物 |
| CN117054647A (zh) * | 2023-07-17 | 2023-11-14 | 广东省一鼎生物技术有限公司 | 一种检测HPV IgG抗体试剂盒及其制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5821087A (en) | 1995-03-30 | 1998-10-13 | Merck & Co., Inc. | Production of recombinant human papillomavirus type II protein utilizing papillomavirus 6/11 hybrid DNA |
| IL117591A0 (en) | 1995-03-30 | 1996-07-23 | Merck & Co Inc | Synthetic DNA encoding human papillomavirus type 11 L1 protein |
| EE9900343A (et) | 1997-02-07 | 2000-02-15 | Merck & Co., Inc. | Sünteetiline polünukleotiid, immuunvastuste tekitamise meetod, immunogeenne kompositsioon, anti-HIV immuunvastuste indutseerimise meetod, meetod antigeeni tekitava raku indutseerimiseks ja farmatseutiline kompositsioon |
| EP1002091B1 (en) | 1997-07-09 | 2012-02-29 | Coridon Pty Limited | Nucleic acid sequence and method for selectively expressing a protein in a target cell or tissue |
| HUP0103091A3 (en) * | 1998-08-14 | 2002-03-28 | Merck & Co Inc | Process for purifying human papillomavirus virus-like particles |
| EP1105157B1 (en) | 1998-08-14 | 2006-11-02 | Merck & Co., Inc. | Protein delivery system using human papillomavirus virus-like particles |
| SE514982C2 (sv) * | 1999-09-30 | 2001-05-28 | Active Biotech Ab | Bärare innehållande ett huvudkapsidprotein L1 från humant papillomavirus samt dess användning |
| EP1212358B1 (en) * | 1999-08-25 | 2004-12-15 | Merck & Co., Inc. | Synthetic papillomavirus genes optimized for expression in human cells |
| US6436402B1 (en) | 1999-10-15 | 2002-08-20 | Merck & Co., Inc. | Process for making human papillomavirus virus-like particles with improved properties |
| US7026443B1 (en) * | 1999-12-10 | 2006-04-11 | Epimmune Inc. | Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions |
| HK1056195B (en) | 2000-07-21 | 2007-06-22 | Glaxo Group Limited | Codon-optimized papilloma virus sequences |
| US20040121465A1 (en) * | 2002-02-14 | 2004-06-24 | Novavax, Inc. | Optimization of gene sequences of virus-like particles for expression in insect cells |
| KR101080628B1 (ko) * | 2003-03-24 | 2011-11-08 | 머크 샤프 앤드 돔 코포레이션 | 효모에서 ｈｐｖ 31 ｌ1의 최적 발현 |
| MY140664A (en) | 2003-09-29 | 2010-01-15 | Merck Sharp & Dohme | Optimized expression of hpv 45 l1 in yeast |
-
2004
- 2004-11-09 MY MYPI20044678A patent/MY139500A/en unknown
- 2004-11-10 EP EP04810619A patent/EP1687329B8/en not_active Expired - Lifetime
- 2004-11-10 US US10/579,111 patent/US7498036B2/en not_active Expired - Lifetime
- 2004-11-10 AU AU2004290032A patent/AU2004290032B2/en active Active
- 2004-11-10 WO PCT/US2004/037372 patent/WO2005047315A2/en not_active Ceased
- 2004-11-10 AT AT04810619T patent/ATE452977T1/de active
- 2004-11-10 NZ NZ546697A patent/NZ546697A/en not_active IP Right Cessation
- 2004-11-10 SI SI200431328T patent/SI1687329T1/sl unknown
- 2004-11-10 KR KR1020067009199A patent/KR101170654B1/ko not_active Expired - Lifetime
- 2004-11-10 DK DK04810619.9T patent/DK1687329T3/da active
- 2004-11-10 PL PL04810619T patent/PL1687329T3/pl unknown
- 2004-11-10 ES ES04810619T patent/ES2340287T3/es not_active Expired - Lifetime
- 2004-11-10 BR BRPI0416393-1A patent/BRPI0416393B1/pt not_active IP Right Cessation
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2006
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2009
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2010
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2011
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2015
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2017
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2022
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