BE2015C026I2 - 2-phenyl-1-[-(2-aminoethoxy)-benzyl -indole in combination with estrogens - Google Patents

2-phenyl-1-[-(2-aminoethoxy)-benzyl -indole in combination with estrogens

Info

Publication number
BE2015C026I2
BE2015C026I2 BE2015C026C BE2015C026C BE2015C026I2 BE 2015C026 I2 BE2015C026 I2 BE 2015C026I2 BE 2015C026 C BE2015C026 C BE 2015C026C BE 2015C026 C BE2015C026 C BE 2015C026C BE 2015C026 I2 BE2015C026 I2 BE 2015C026I2
Authority
BE
Belgium
Prior art keywords
aminoethoxy
estrogens
benzyl
phenyl
indole
Prior art date
Application number
BE2015C026C
Other languages
English (en)
French (fr)
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22151320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2015C026(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of BE2015C026I2 publication Critical patent/BE2015C026I2/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE2015C026C 1998-05-15 2015-04-28 2-phenyl-1-[-(2-aminoethoxy)-benzyl -indole in combination with estrogens BE2015C026I2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7956198A 1998-05-15 1998-05-15
EP99921834A EP1076558B1 (en) 1998-05-15 1999-05-11 2-phenyl-1-[-(2-aminoethoxy)-benzyl -indole in combination with estrogens
PCT/US1999/010217 WO1999059581A1 (en) 1998-05-15 1999-05-11 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens

Publications (1)

Publication Number Publication Date
BE2015C026I2 true BE2015C026I2 (en) 2018-08-24

Family

ID=22151320

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2015C026C BE2015C026I2 (en) 1998-05-15 2015-04-28 2-phenyl-1-[-(2-aminoethoxy)-benzyl -indole in combination with estrogens

Country Status (41)

Country Link
EP (1) EP1076558B1 (oth)
JP (3) JP2002515431A (oth)
KR (1) KR100620772B1 (oth)
CN (1) CN1230163C (oth)
AP (1) AP1424A (oth)
AR (1) AR020074A1 (oth)
AT (1) ATE245026T1 (oth)
AU (1) AU760378B2 (oth)
BE (1) BE2015C026I2 (oth)
BG (1) BG64783B1 (oth)
BR (1) BR9911040A (oth)
CA (1) CA2329530A1 (oth)
CU (1) CU23241B7 (oth)
CY (1) CY2015020I1 (oth)
CZ (1) CZ299334B6 (oth)
DE (1) DE69909616T2 (oth)
DK (1) DK1076558T3 (oth)
EA (1) EA005932B1 (oth)
EE (1) EE04262B1 (oth)
ES (1) ES2203131T3 (oth)
FR (1) FR15C0035I2 (oth)
GE (1) GEP20033079B (oth)
HR (1) HRP20000778B1 (oth)
HU (2) HU226587B1 (oth)
ID (1) ID26890A (oth)
IL (1) IL139130A (oth)
IN (1) IN192220B (oth)
LT (1) LTC1076558I2 (oth)
LU (1) LU92699I2 (oth)
NO (2) NO328129B1 (oth)
NZ (1) NZ508200A (oth)
OA (1) OA11552A (oth)
PL (1) PL194750B1 (oth)
PT (1) PT1076558E (oth)
SI (1) SI1076558T1 (oth)
SK (1) SK284666B6 (oth)
TR (1) TR200003377T2 (oth)
TW (1) TW565554B (oth)
UA (1) UA66861C2 (oth)
WO (1) WO1999059581A1 (oth)
ZA (1) ZA200006959B (oth)

Families Citing this family (26)

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Publication number Priority date Publication date Assignee Title
JP2002515431A (ja) * 1998-05-15 2002-05-28 アメリカン・ホーム・プロダクツ・コーポレイション エストロゲンと組み合わせる２−フェニル−１−［４−（２−アミノエトキシ）ベンジルオキシ］インドール
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
TR200403328T2 (tr) 1999-07-06 2005-03-21 Endorecherche, Inc. Kilo alımını tedavi ve/veya önleme metotları.
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
AU2001273125A1 (en) * 2000-07-06 2002-01-21 American Home Products Corporation Combinations of bisphosphonates, estrogenic agents and optionally estrogens
AU2001271781A1 (en) * 2000-07-06 2002-01-21 Wyeth Use of substituted indole compounds for treating sphincter incontinence
CA2414060A1 (en) * 2000-07-06 2002-01-17 Wyeth Combinations of statins, estrogenic agents and optionally estrogens
WO2002003992A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating prosthesis-related bone degeneration
DE10117441A1 (de) * 2001-04-03 2002-10-10 Schering Ag 1-Indolylderivate, deren Verwendung zur Herstellung von Arzneimitteln, ein Verfahren zur Herstellung der 1-Indolylderivate sowie 1-Indolylderivate enthaltende pharmzeutische Präparate
WO2003011282A1 (en) 2001-07-31 2003-02-13 Pfizer Products Inc. Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins
KR100470274B1 (ko) 2002-11-08 2005-02-05 진 장 덮개층을 이용한 비정질 물질의 상 변화 방법
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
FR2880625B1 (fr) * 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
HUE025471T2 (hu) 2008-04-16 2016-03-29 Karobio Ab Új ösztrogén receptor ligandumok
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN102690225B (zh) * 2012-04-11 2014-12-24 南京友杰医药科技有限公司 巴多昔芬的合成方法
CN103709090A (zh) * 2014-01-16 2014-04-09 江苏万特制药有限公司 醋酸巴多昔芬的制备方法及其关键中间体
CN103739540B (zh) * 2014-01-20 2016-05-04 华润赛科药业有限责任公司 一种醋酸巴多昔芬中间体的制备方法
CN105669518B (zh) * 2014-12-04 2019-06-04 上海医药集团股份有限公司 醋酸巴多昔芬及其a晶型的制备方法
JP7287964B2 (ja) * 2017-12-15 2023-06-06 ブリストル－マイヤーズ スクイブ カンパニー 置換インドールエーテル化合物
IT201800006562A1 (it) * 2018-06-21 2019-12-21 Procedimento e intermedi utili per la preparazione di indoli
CN115380026B (zh) * 2020-03-17 2023-11-07 南京明德新药研发有限公司 蛋白降解调节剂与其使用方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
WO1993023374A1 (fr) * 1992-05-08 1993-11-25 Otsuka Pharmaceutical Factory, Inc. Derive d'indole
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
GB9326332D0 (en) * 1993-12-23 1994-02-23 Karo Bio Indole derivatives
DE4426625A1 (de) * 1994-07-27 1996-03-14 Schering Ag 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
ATE206701T1 (de) * 1996-04-19 2001-10-15 American Home Prod Östrogene verbindungen
TW397821B (en) * 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
TR199900138T2 (xx) * 1996-07-09 1999-04-21 Smithkline Beecham S.P.A. Osteoporozun tedavisi i�in indolin t�revleri.
US5672609A (en) * 1996-07-18 1997-09-30 Eli Lilly And Company Pyridine compounds, intermediates compositions and methods of use
AR015183A1 (es) * 1997-10-15 2001-04-18 Wyeth Corp Ariloxi-alquil-dialquilaminas y procesos para su produccion
AU1197299A (en) * 1997-10-28 1999-05-17 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
UA68365C2 (en) * 1997-11-06 2004-08-16 Wyeth Corp Peroral contraception by combination of anti-estrogen and progestin
JP2002515431A (ja) * 1998-05-15 2002-05-28 アメリカン・ホーム・プロダクツ・コーポレイション エストロゲンと組み合わせる２−フェニル−１−［４−（２−アミノエトキシ）ベンジルオキシ］インドール

Also Published As

Publication number Publication date
AP1424A (en) 2005-06-06
DK1076558T3 (da) 2003-11-03
TW565554B (en) 2003-12-11
TR200003377T2 (tr) 2001-03-21
BG64783B1 (bg) 2006-04-28
LTC1076558I2 (lt) 2016-11-10
CN1230163C (zh) 2005-12-07
GEP20033079B (en) 2003-10-27
NO328129B1 (no) 2009-12-14
JP2014159472A (ja) 2014-09-04
CY2015020I1 (el) 2020-05-29
HUP0103096A2 (hu) 2002-05-29
DE69909616D1 (de) 2003-08-21
SI1076558T1 (en) 2003-10-31
CZ20004254A3 (cs) 2001-12-12
EE200000652A (et) 2002-04-15
HK1031691A1 (en) 2001-06-22
HRP20000778A2 (en) 2001-06-30
NZ508200A (en) 2003-09-26
KR100620772B1 (ko) 2006-09-13
AU760378B2 (en) 2003-05-15
SK284666B6 (sk) 2005-08-04
EP1076558A1 (en) 2001-02-21
BG104930A (en) 2001-07-31
AR020074A1 (es) 2002-04-10
CN1326347A (zh) 2001-12-12
EA005932B1 (ru) 2005-08-25
NO2015015I1 (no) 2015-06-02
EE04262B1 (et) 2004-04-15
NO20005770L (no) 2001-01-12
IN192220B (oth) 2004-03-20
IL139130A (en) 2005-11-20
HU226587B1 (en) 2009-04-28
JP2002515431A (ja) 2002-05-28
SK17202000A3 (sk) 2001-07-10
OA11552A (en) 2004-06-07
HRP20000778B1 (en) 2004-10-31
JP5872624B2 (ja) 2016-03-01
JP5607871B2 (ja) 2014-10-15
DE69909616T2 (de) 2004-06-17
CA2329530A1 (en) 1999-11-25
LU92699I2 (fr) 2015-06-24
HUS1500023I1 (hu) 2017-03-28
PL345268A1 (en) 2001-12-03
EA200001193A1 (ru) 2001-12-24
ID26890A (id) 2001-02-15
BR9911040A (pt) 2001-02-13
FR15C0035I1 (oth) 2015-06-26
IL139130A0 (en) 2001-11-25
ES2203131T3 (es) 2004-04-01
FR15C0035I2 (fr) 2015-08-28
WO1999059581A1 (en) 1999-11-25
CU23241B7 (es) 2007-10-17
ATE245026T1 (de) 2003-08-15
NO20005770D0 (no) 2000-11-14
JP2009019042A (ja) 2009-01-29
UA66861C2 (uk) 2004-06-15
PT1076558E (pt) 2003-11-28
NO2015015I2 (no) 2015-06-02
HUP0103096A3 (en) 2002-11-28
CZ299334B6 (cs) 2008-06-25
PL194750B1 (pl) 2007-06-29
ZA200006959B (en) 2001-11-27
EP1076558B1 (en) 2003-07-16
AU3894499A (en) 1999-12-06
KR20010043641A (ko) 2001-05-25
AP2000001970A0 (en) 2000-12-31

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