BE2015C017I2 - - Google Patents
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- Publication number
- BE2015C017I2 BE2015C017I2 BE2015C017C BE2015C017C BE2015C017I2 BE 2015C017 I2 BE2015C017 I2 BE 2015C017I2 BE 2015C017 C BE2015C017 C BE 2015C017C BE 2015C017 C BE2015C017 C BE 2015C017C BE 2015C017 I2 BE2015C017 I2 BE 2015C017I2
- Authority
- BE
- Belgium
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39995602P | 2002-07-29 | 2002-07-29 | |
| PCT/US2003/021977 WO2004014295A2 (en) | 2002-07-29 | 2003-07-15 | Tiacumicin production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE2015C017I2 true BE2015C017I2 (enrdf_load_stackoverflow) | 2022-09-22 |
Family
ID=31715689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE2015C017C BE2015C017I2 (enrdf_load_stackoverflow) | 2002-07-29 | 2015-03-26 |
Country Status (18)
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2527052T3 (es) * | 2002-07-29 | 2015-01-20 | Optimer Pharmaceuticals, Inc. | Producción de tiacumicina |
| US20070105791A1 (en) * | 2002-07-29 | 2007-05-10 | Optimer Pharmaceuticals, Inc. | Method of treating clostridium difficile-associated diarrhea |
| US7906489B2 (en) * | 2004-05-14 | 2011-03-15 | Optimer Pharmaceuticals, Inc. | 18-membered macrocycles and analogs thereof |
| CA2566687C (en) * | 2004-05-14 | 2012-07-24 | Optimer Pharmaceuticals, Inc. | The use of tiacumicin b in the treatment of antibiotic resistant staphylococcus or vancomycin-resistant enterococci infections |
| AU2012200784B2 (en) * | 2005-01-31 | 2013-07-11 | Merck Sharp & Dohme Llc | 18-membered macrocycles and analogs thereof |
| US7378508B2 (en) | 2007-01-22 | 2008-05-27 | Optimer Pharmaceuticals, Inc. | Polymorphic crystalline forms of tiacumicin B |
| CN102614207B (zh) * | 2005-01-31 | 2016-01-13 | 默克夏普&多梅有限公司 | 18元环大环化合物及其类似物 |
| CN102503994A (zh) * | 2005-10-21 | 2012-06-20 | 奥普蒂姆药物公司 | 治疗艰难梭菌相关的腹泻的方法 |
| US20080176927A1 (en) * | 2007-01-19 | 2008-07-24 | Optimer Pharmaceuticals, Inc. | Compositions of stable tiacumicins |
| KR100891313B1 (ko) * | 2007-08-17 | 2009-03-31 | (주) 제노텍 | 담체로 작용하는 흡착성 수지의 제공에 의한 트리사이클로화합물의 생산 및 추출 방법 |
| TWI326284B (en) * | 2007-10-26 | 2010-06-21 | Echem Hightech Co Ltd | Derivatives of tiacumicin b as anti-cancer agents |
| TWI523654B (zh) | 2007-11-27 | 2016-03-01 | 默沙東藥廠 | 抗生素巨環化合物以及其製造及使用之方法 |
| JP2013519380A (ja) * | 2010-02-15 | 2013-05-30 | アッヴィ・インコーポレイテッド | ｓｃｙｌｌｏ−イノシトールを調製するための方法 |
| JP2013543513A (ja) | 2010-10-13 | 2013-12-05 | エラン ファーマシューティカルズ，インコーポレイテッド | シリトールおよび関連化合物の合成方法 |
| CN102115757B (zh) * | 2010-12-14 | 2015-10-28 | 中国科学院南海海洋研究所 | 台勾霉素的生物合成基因簇及其应用 |
| ITMI20120560A1 (it) | 2012-04-05 | 2013-10-06 | Olon Spa | Procedimento per la purificazione della tiacumicina b |
| ITMI20120559A1 (it) | 2012-04-05 | 2013-10-06 | Olon Spa | Procedimento migliorato per la produzione di tiacumicina b |
| EP2855499A1 (en) * | 2012-05-10 | 2015-04-08 | Teva Pharmaceutical Works Ltd. | Solid state forms of fidaxomycin and processes for preparation thereof |
| ITMI20130856A1 (it) * | 2013-05-27 | 2014-11-28 | Olon Spa | Procedimento per la produzione di tiacumicina b |
| ITMI20121406A1 (it) * | 2012-08-07 | 2014-02-08 | Olon Spa | Procedimento per la produzione di tiacumicina b |
| EP2882860B1 (en) | 2012-08-07 | 2016-05-04 | OLON S.p.A. | Enzymatic production of tiacumicin b (fidaxomicin) |
| CN102993251B (zh) * | 2012-12-17 | 2016-03-16 | 苏州纳微科技有限公司 | 一种用高效液相色谱纯化台勾霉素b的方法 |
| JO3464B1 (ar) | 2013-01-15 | 2020-07-05 | Astellas Pharma Europe Ltd | التركيبات الخاصة بمركبات التياكوميسين |
| US10119158B2 (en) * | 2013-04-23 | 2018-11-06 | Concord Biotech Limited | Process for the preparation of fidaxomicin |
| CN103275152B (zh) * | 2013-05-29 | 2015-11-18 | 华北制药集团新药研究开发有限责任公司 | 一种高纯度非达霉素的制备方法 |
| CN103275153B (zh) * | 2013-06-27 | 2016-03-23 | 华北制药集团新药研究开发有限责任公司 | 一种非达霉素晶体的制备方法 |
| CN104418925B (zh) * | 2013-09-05 | 2018-09-28 | 重庆乾泰生物医药有限公司 | 一种制备高纯度非达霉素的方法 |
| CN104513286B (zh) * | 2013-09-27 | 2018-08-17 | 博瑞生物医药（苏州）股份有限公司 | 一种分离纯化非达米星的方法 |
| CN104560766B (zh) | 2013-10-16 | 2017-07-28 | 浙江海正药业股份有限公司 | 一种游动放线菌菌株及其应用 |
| CN104561198B (zh) * | 2013-10-18 | 2019-04-12 | 重庆乾泰生物医药有限公司 | 一种发酵生产非达霉素的方法 |
| RU2016128553A (ru) * | 2013-12-20 | 2018-01-25 | Кселлия Фармасьютикалз Апс | Способ получения тиакумицина |
| CN104846044B (zh) * | 2014-02-17 | 2019-02-01 | 上海医药工业研究院 | 一种提高非达霉素产量的发酵培养基 |
| WO2015127955A1 (en) | 2014-02-25 | 2015-09-03 | Olon S.P.A. | A new polymorph of tiacumicin b and process for preparation thereof |
| PT3119793T (pt) | 2014-03-18 | 2018-05-10 | Xellia Pharmaceuticals Aps | Polimorfos inovadores e estados sólidos inovadores de tiacumicina b |
| CN104946708B (zh) * | 2014-03-28 | 2018-06-12 | 上海医药工业研究院 | 一种生产非达霉素的发酵培养基以及发酵方法 |
| CN103880904B (zh) * | 2014-03-28 | 2016-08-24 | 华北制药集团新药研究开发有限责任公司 | 非达霉素晶型i及其制备方法 |
| AU2015258130B2 (en) | 2014-05-09 | 2019-10-31 | Astellas Pharma Europe Ltd | Treatment regimen tiacumicin compound |
| CN104098637B (zh) | 2014-07-09 | 2017-01-04 | 浙江海正药业股份有限公司 | 一种纯化非达霉素的方法 |
| US10548912B2 (en) | 2015-07-03 | 2020-02-04 | Astellas Pharma Europe Ltd. | Dosage regimen for a tiacumicin compound |
| IL251499B (en) * | 2017-04-02 | 2019-02-28 | Efraty Avi | Reverse osmosis installation in a closed circuit with a hydraulic arm for desalination with low energy consumption and a high recovery ratio |
| CN107236686B (zh) * | 2017-06-21 | 2019-10-15 | 杭州华东医药集团新药研究院有限公司 | 一种桔橙指孢囊菌及其在调控微生物代谢物非达霉素中的应用 |
| CN114084964B (zh) * | 2020-08-24 | 2023-02-24 | 中国石油化工股份有限公司 | 一种芳香有机化合物废水生物处理促进剂及制备方法和应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3000792A (en) | 1957-05-21 | 1961-09-19 | Merck & Co Inc | Antibiotic adsorption process |
| GB1458512A (en) * | 1973-11-22 | 1976-12-15 | Lepetit Spa | Antibiotic substance |
| US4632902A (en) * | 1981-08-20 | 1986-12-30 | Becton, Dickinson And Company | Method for detecting biological activity in a body fluid |
| US4843008A (en) * | 1984-12-24 | 1989-06-27 | Yamanouchi Pharmaceutical Co., Ltd. | Novel microorganisms and a novel process for producing antibiotics |
| US4918174A (en) * | 1986-09-26 | 1990-04-17 | Abbott Laboratories | Tiacumicin compounds |
| US5242815A (en) * | 1990-01-24 | 1993-09-07 | Shin-Etsu Chemical Co., Ltd. | Process for preparation of streptovaricin |
| CA2384529C (en) * | 1991-03-04 | 2007-01-02 | Bayer Corporation | Automated analyzer |
| US5767096A (en) * | 1996-07-12 | 1998-06-16 | Abbott Laboratories | Bromotiacumicin compounds |
| DK0941227T5 (da) * | 1996-11-18 | 2009-10-05 | Biotechnolog Forschung Gmbh | Epothilon D, dens fremstilling samt dens anvendelse som cytostatisk middel og som plantebeskyttelsesmiddel |
| JP2000072760A (ja) * | 1998-06-19 | 2000-03-07 | Ajinomoto Co Inc | 新規シストチアゾール類縁体 |
| JP2000053514A (ja) * | 1998-08-06 | 2000-02-22 | Aquas Corp | レジオネラ属細菌が生産する殺菌性物質、これを用いた殺菌剤、水処理剤、スライム抑制剤、及びこれらの製造方法 |
| JP2000239266A (ja) * | 1999-02-17 | 2000-09-05 | Ajinomoto Co Inc | 新規ポリエン系抗生物質 |
| ATE309369T1 (de) * | 2000-04-28 | 2005-11-15 | Kosan Biosciences Inc | Heterologe herstellung von polyketiden |
| ES2527052T3 (es) * | 2002-07-29 | 2015-01-20 | Optimer Pharmaceuticals, Inc. | Producción de tiacumicina |
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2003
- 2003-07-15 ES ES03784766.2T patent/ES2527052T3/es not_active Expired - Lifetime
- 2003-07-15 SI SI200332404T patent/SI1539977T1/sl unknown
- 2003-07-15 AU AU2003251902A patent/AU2003251902B2/en not_active Expired
- 2003-07-15 JP JP2004527605A patent/JP2005534332A/ja active Pending
- 2003-07-15 DK DK03784766.2T patent/DK1539977T3/en active
- 2003-07-15 PT PT37847662T patent/PT1539977E/pt unknown
- 2003-07-15 US US10/520,863 patent/US7507564B2/en not_active Expired - Lifetime
- 2003-07-15 CA CA2494742A patent/CA2494742C/en not_active Expired - Lifetime
- 2003-07-15 WO PCT/US2003/021977 patent/WO2004014295A2/en active Application Filing
- 2003-07-15 EP EP03784766.2A patent/EP1539977B1/en not_active Expired - Lifetime
- 2003-07-15 EP EP20140187987 patent/EP2860241A1/en not_active Withdrawn
- 2003-07-15 KR KR1020057001613A patent/KR100972542B1/ko not_active Expired - Fee Related
- 2003-07-15 CN CNB038180162A patent/CN100519757C/zh not_active Expired - Lifetime
-
2009
- 2009-02-04 US US12/365,230 patent/US20100028970A1/en not_active Abandoned
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2010
- 2010-05-10 JP JP2010108270A patent/JP5729919B2/ja not_active Expired - Lifetime
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2012
- 2012-06-12 US US13/494,887 patent/US8728796B2/en not_active Expired - Lifetime
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2013
- 2013-06-14 JP JP2013125445A patent/JP5907931B2/ja not_active Expired - Lifetime
-
2014
- 2014-05-19 US US14/281,496 patent/US20140296498A1/en not_active Abandoned
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2015
- 2015-03-25 NL NL300727C patent/NL300727I2/nl unknown
- 2015-03-26 LU LU92684C patent/LU92684I2/xx unknown
- 2015-03-26 BE BE2015C017C patent/BE2015C017I2/fr unknown
- 2015-03-27 HU HUS1500016C patent/HUS1500016I1/hu unknown
- 2015-03-27 FR FR15C0028C patent/FR15C0028I2/fr active Active
- 2015-04-03 CY CY2015015C patent/CY2015015I1/el unknown