BE2015C017I2 - - Google Patents

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Publication number
BE2015C017I2
BE2015C017I2 BE2015C017C BE2015C017C BE2015C017I2 BE 2015C017 I2 BE2015C017 I2 BE 2015C017I2 BE 2015C017 C BE2015C017 C BE 2015C017C BE 2015C017 C BE2015C017 C BE 2015C017C BE 2015C017 I2 BE2015C017 I2 BE 2015C017I2
Authority
BE
Belgium
Application number
BE2015C017C
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of BE2015C017I2 publication Critical patent/BE2015C017I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
BE2015C017C 2002-07-29 2015-03-26 BE2015C017I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39995602P 2002-07-29 2002-07-29
PCT/US2003/021977 WO2004014295A2 (fr) 2002-07-29 2003-07-15 Fabrication de tiacumicine

Publications (1)

Publication Number Publication Date
BE2015C017I2 true BE2015C017I2 (fr) 2022-09-22

Family

ID=31715689

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2015C017C BE2015C017I2 (fr) 2002-07-29 2015-03-26

Country Status (18)

Country Link
US (4) US7507564B2 (fr)
EP (2) EP1539977B1 (fr)
JP (3) JP2005534332A (fr)
KR (1) KR100972542B1 (fr)
CN (1) CN100519757C (fr)
AU (1) AU2003251902B2 (fr)
BE (1) BE2015C017I2 (fr)
CA (1) CA2494742C (fr)
CY (1) CY2015015I1 (fr)
DK (1) DK1539977T3 (fr)
ES (1) ES2527052T3 (fr)
FR (1) FR15C0028I2 (fr)
HU (1) HUS1500016I1 (fr)
LU (1) LU92684I2 (fr)
NL (1) NL300727I2 (fr)
PT (1) PT1539977E (fr)
SI (1) SI1539977T1 (fr)
WO (1) WO2004014295A2 (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
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US20070105791A1 (en) * 2002-07-29 2007-05-10 Optimer Pharmaceuticals, Inc. Method of treating clostridium difficile-associated diarrhea
US7507564B2 (en) * 2002-07-29 2009-03-24 Optimer Pharmaceuticals, Inc. Tiacumicin production
US7906489B2 (en) * 2004-05-14 2011-03-15 Optimer Pharmaceuticals, Inc. 18-membered macrocycles and analogs thereof
JP5734545B2 (ja) * 2004-05-14 2015-06-17 オプティマー ファーマシューティカルズ、インコーポレイテッド 抗生物質の使用に関連する疾患の治療
AU2012200784B2 (en) * 2005-01-31 2013-07-11 Merck Sharp & Dohme Llc 18-membered macrocycles and analogs thereof
US7378508B2 (en) * 2007-01-22 2008-05-27 Optimer Pharmaceuticals, Inc. Polymorphic crystalline forms of tiacumicin B
BRPI0519890A2 (pt) * 2005-01-31 2009-03-31 Optimer Pharmaceuticals Inc macrociclos de 18 elementos e seus análogos
CN102503994A (zh) * 2005-10-21 2012-06-20 奥普蒂姆药物公司 治疗艰难梭菌相关的腹泻的方法
US20080176927A1 (en) * 2007-01-19 2008-07-24 Optimer Pharmaceuticals, Inc. Compositions of stable tiacumicins
KR100891313B1 (ko) * 2007-08-17 2009-03-31 (주) 제노텍 담체로 작용하는 흡착성 수지의 제공에 의한 트리사이클로화합물의 생산 및 추출 방법
TWI326284B (en) * 2007-10-26 2010-06-21 Echem Hightech Co Ltd Derivatives of tiacumicin b as anti-cancer agents
TWI523654B (zh) 2007-11-27 2016-03-01 默沙東藥廠 抗生素巨環化合物以及其製造及使用之方法
AU2011215616A1 (en) * 2010-02-15 2012-09-06 Transition Therapeutics Ireland Limited Process for the preparation of scyllo-Inositol
WO2012051395A1 (fr) 2010-10-13 2012-04-19 Elan Pharmaceuticals, Inc. Procédés de synthèse de scyllitol et de composés connexes
CN102115757B (zh) * 2010-12-14 2015-10-28 中国科学院南海海洋研究所 台勾霉素的生物合成基因簇及其应用
ITMI20120559A1 (it) * 2012-04-05 2013-10-06 Olon Spa Procedimento migliorato per la produzione di tiacumicina b
ITMI20120560A1 (it) 2012-04-05 2013-10-06 Olon Spa Procedimento per la purificazione della tiacumicina b
EP2855499A1 (fr) * 2012-05-10 2015-04-08 Teva Pharmaceutical Works Ltd. Formes à l'état solide de fidaxomycine et procédés pour la préparation de celles-ci
ITMI20130856A1 (it) * 2013-05-27 2014-11-28 Olon Spa Procedimento per la produzione di tiacumicina b
CA2881302C (fr) * 2012-08-07 2020-12-15 Olon S.P.A. Procedure pour la production de tiacumicine b
ITMI20121406A1 (it) * 2012-08-07 2014-02-08 Olon Spa Procedimento per la produzione di tiacumicina b
CN102993251B (zh) * 2012-12-17 2016-03-16 苏州纳微科技有限公司 一种用高效液相色谱纯化台勾霉素b的方法
JO3464B1 (ar) 2013-01-15 2020-07-05 Astellas Pharma Europe Ltd التركيبات الخاصة بمركبات التياكوميسين
US10119158B2 (en) * 2013-04-23 2018-11-06 Concord Biotech Limited Process for the preparation of fidaxomicin
CN103275152B (zh) * 2013-05-29 2015-11-18 华北制药集团新药研究开发有限责任公司 一种高纯度非达霉素的制备方法
CN103275153B (zh) * 2013-06-27 2016-03-23 华北制药集团新药研究开发有限责任公司 一种非达霉素晶体的制备方法
CN104418925B (zh) * 2013-09-05 2018-09-28 重庆乾泰生物医药有限公司 一种制备高纯度非达霉素的方法
CN104513286B (zh) * 2013-09-27 2018-08-17 博瑞生物医药（苏州）股份有限公司 一种分离纯化非达米星的方法
CN104560766B (zh) * 2013-10-16 2017-07-28 浙江海正药业股份有限公司 一种游动放线菌菌株及其应用
CN104561198B (zh) * 2013-10-18 2019-04-12 重庆乾泰生物医药有限公司 一种发酵生产非达霉素的方法
CA2931596C (fr) * 2013-12-20 2023-03-28 Xellia Pharmaceuticals Aps Procede pour la preparation de tiacumicine
CN104846044B (zh) * 2014-02-17 2019-02-01 上海医药工业研究院 一种提高非达霉素产量的发酵培养基
WO2015127955A1 (fr) 2014-02-25 2015-09-03 Olon S.P.A. Nouvelle forme polymorphe de tiacumicine b et son procede de preparation
HUE038426T2 (hu) 2014-03-18 2018-10-29 Xellia Pharmaceuticals Aps Tiacumicin B új polimorfjai és új szilárd állapotai
CN103880904B (zh) * 2014-03-28 2016-08-24 华北制药集团新药研究开发有限责任公司 非达霉素晶型i及其制备方法
CN104946708B (zh) * 2014-03-28 2018-06-12 上海医药工业研究院 一种生产非达霉素的发酵培养基以及发酵方法
JP6579662B2 (ja) 2014-05-09 2019-09-25 アステラス ファーマ ユーロープ リミテッド チアクマイシン化合物の治療レジメン
CN104098637B (zh) * 2014-07-09 2017-01-04 浙江海正药业股份有限公司 一种纯化非达霉素的方法
AU2016289307A1 (en) 2015-07-03 2018-01-18 Astellas Pharma Europe Ltd. Novel dosage regimen tiacumicin compound
IL251499B (en) * 2017-04-02 2019-02-28 Efraty Avi Reverse osmosis installation in a closed circuit with a hydraulic arm for desalination with low energy consumption and a high recovery ratio
CN107236686B (zh) * 2017-06-21 2019-10-15 杭州华东医药集团新药研究院有限公司 一种桔橙指孢囊菌及其在调控微生物代谢物非达霉素中的应用
CN114084964B (zh) * 2020-08-24 2023-02-24 中国石油化工股份有限公司 一种芳香有机化合物废水生物处理促进剂及制备方法和应用

Family Cites Families (14)

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US3000792A (en) 1957-05-21 1961-09-19 Merck & Co Inc Antibiotic adsorption process
GB1458512A (en) * 1973-11-22 1976-12-15 Lepetit Spa Antibiotic substance
US4632902A (en) * 1981-08-20 1986-12-30 Becton, Dickinson And Company Method for detecting biological activity in a body fluid
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US4918174A (en) * 1986-09-26 1990-04-17 Abbott Laboratories Tiacumicin compounds
US5242815A (en) * 1990-01-24 1993-09-07 Shin-Etsu Chemical Co., Ltd. Process for preparation of streptovaricin
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US5767096A (en) * 1996-07-12 1998-06-16 Abbott Laboratories Bromotiacumicin compounds
EP0941227B2 (fr) * 1996-11-18 2009-10-14 Gesellschaft für biotechnologische Forschung mbH (GBF) Epothilone d, mode de preparation et application comme agent cytostatique et phytosanitaire
JP2000072760A (ja) * 1998-06-19 2000-03-07 Ajinomoto Co Inc 新規シストチアゾール類縁体
JP2000053514A (ja) * 1998-08-06 2000-02-22 Aquas Corp レジオネラ属細菌が生産する殺菌性物質、これを用いた殺菌剤、水処理剤、スライム抑制剤、及びこれらの製造方法
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Also Published As

Publication number Publication date
DK1539977T3 (en) 2014-11-17
CN100519757C (zh) 2009-07-29
CN1688707A (zh) 2005-10-26
FR15C0028I1 (fr) 2015-05-15
US20100028970A1 (en) 2010-02-04
JP5729919B2 (ja) 2015-06-03
SI1539977T1 (sl) 2015-01-30
KR20050053598A (ko) 2005-06-08
AU2003251902B2 (en) 2008-03-06
US20060257981A1 (en) 2006-11-16
JP2013208131A (ja) 2013-10-10
CY2015015I1 (el) 2020-05-29
EP1539977B1 (fr) 2014-10-08
JP2005534332A (ja) 2005-11-17
EP1539977A4 (fr) 2006-10-11
EP1539977A2 (fr) 2005-06-15
WO2004014295A3 (fr) 2005-04-14
JP2010178760A (ja) 2010-08-19
NL300727I2 (fr) 2016-05-17
US7507564B2 (en) 2009-03-24
WO2004014295A2 (fr) 2004-02-19
ES2527052T3 (es) 2015-01-20
AU2003251902A1 (en) 2004-02-25
US20130123477A1 (en) 2013-05-16
FR15C0028I2 (fr) 2015-11-13
CA2494742A1 (fr) 2004-02-19
KR100972542B1 (ko) 2010-07-28
US20140296498A1 (en) 2014-10-02
HUS1500016I1 (hu) 2017-10-30
EP2860241A1 (fr) 2015-04-15
PT1539977E (pt) 2015-01-14
LU92684I2 (fr) 2015-11-02
CA2494742C (fr) 2015-05-12
US8728796B2 (en) 2014-05-20
JP5907931B2 (ja) 2016-04-26

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