BA98299A - Postupak za pripremanje azabiciklo hinolon karboksilne kiseline - Google Patents

Postupak za pripremanje azabiciklo hinolon karboksilne kiseline

Info

Publication number
BA98299A
BA98299A BA980299A BA980299A BA98299A BA 98299 A BA98299 A BA 98299A BA 980299 A BA980299 A BA 980299A BA 980299 A BA980299 A BA 980299A BA 98299 A BA98299 A BA 98299A
Authority
BA
Bosnia and Herzegovina
Prior art keywords
azabicycloquinolone
preparation
carboxylic acid
alkyl
methyl
Prior art date
Application number
BA980299A
Other languages
Bosnian (bs)
English (en)
Inventor
Katherine Elizabeth Brighty
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from YU156890A external-priority patent/YU47935B/sh
Application filed by Pfizer filed Critical Pfizer
Publication of BA98299A publication Critical patent/BA98299A/bs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Quinoline Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BA980299A 1989-08-16 1998-03-30 Postupak za pripremanje azabiciklo hinolon karboksilne kiseline BA98299A (bs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1989/003489 WO1991002526A1 (en) 1989-08-16 1989-08-16 Azabicyclo quinolone carboxylic acids
YU156890A YU47935B (sh) 1989-08-16 1990-08-15 Azabiciklo hinolon karboksilne kiseline

Publications (1)

Publication Number Publication Date
BA98299A true BA98299A (bs) 2001-09-14

Family

ID=22215165

Family Applications (1)

Application Number Title Priority Date Filing Date
BA980299A BA98299A (bs) 1989-08-16 1998-03-30 Postupak za pripremanje azabiciklo hinolon karboksilne kiseline

Country Status (30)

Country Link
EP (1) EP0413455B1 (de)
JP (2) JPH072734B2 (de)
KR (1) KR930004844B1 (de)
CN (1) CN1025192C (de)
AT (1) ATE124040T1 (de)
AU (1) AU623801B2 (de)
BA (1) BA98299A (de)
CA (2) CA2127561C (de)
CY (2) CY1969A (de)
CZ (1) CZ281127B6 (de)
DD (1) DD298399A5 (de)
DE (3) DE19875052I2 (de)
DK (1) DK0413455T3 (de)
EG (1) EG19251A (de)
ES (1) ES2074131T4 (de)
FI (2) FI108228B (de)
GR (1) GR3017072T3 (de)
HK (1) HK1000207A1 (de)
HU (2) HU219403B (de)
IE (1) IE66202B1 (de)
IL (1) IL95331A (de)
LU (2) LU90310I2 (de)
NL (2) NL980033I2 (de)
NO (1) NO300214B1 (de)
NZ (1) NZ234920A (de)
PL (1) PL166381B1 (de)
PT (1) PT94998B (de)
RU (1) RU2049777C1 (de)
WO (1) WO1991002526A1 (de)
ZA (1) ZA906450B (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
FR2675144B1 (fr) * 1991-04-10 1995-06-16 Bouchara Sa Nouvelles quinolones difluorees - leur procede de preparation et les compositions pharmaceutiques en renfermant.
DK0641339T3 (da) * 1991-06-19 1999-12-20 Pfizer Antibakterielle midler med azaspiroquinolon
US5256791A (en) * 1992-03-02 1993-10-26 Pfizer Inc. Preparation of intermediates in the synthesis of quinoline antibiotics
EG20543A (en) * 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones
US5527910A (en) * 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
US5591766A (en) * 1993-12-03 1997-01-07 Cheil Foods & Chemicals, Inc. Solid oral formulations of pyridone carboxylic acids
PT812838E (pt) * 1994-02-04 2002-10-31 Dainippon Pharmaceutical Co Derivado de acido piridonacarboxilico substituido com o grupo amino biciclico seu ester seu sal e amina biciclica como seu intermediario
DE69627985T2 (de) * 1995-02-02 2004-02-19 Daiichi Pharmaceutical Co., Ltd. Heterozyklische verbindungen
JPH08213881A (ja) * 1995-02-02 1996-08-20 Fujitsu Ltd 周波数制御回路
DE69628158T2 (de) * 1995-02-07 2004-03-25 Daiichi Pharmaceutical Co., Ltd. Heterocyclische spiroderivate
DK0789697T3 (da) * 1995-06-06 1998-10-19 Pfizer Krystalform af vandfrit 7-([1alfa, 5alfa, 6alfa,]-6-amino-3-azabicyclo[3.1.0]hex-3-yl)-6-fluor-1-(2,4-difluorphenyl)-1,4-d
JP3029293B2 (ja) * 1995-06-15 2000-04-04 ファイザー・インコーポレーテッド ジペプチドを含む、アザビシクロナフチリジンカルボン酸の誘導体を調製するための方法
PT882725E (pt) * 1996-02-09 2003-04-30 Toyama Chemical Co Ltd Derivados do acido quinolonacarboxilico ou os seus sais
AP788A (en) * 1996-08-26 1999-12-03 Pfizer Novel crystal form of anhydrous 7-(1a, 5a, 6a)-6-Amino-3-Azabicyclo(3.1.0) hex-3-YI)-6-Fluoro-1-(2,4- Difluorophenyl)-1,4-Dihydro-4-Oxo-1, 8-Naphthyridine-3-Carboxylic Acid, Methanesulfonic acid salt.
TW519542B (en) * 1996-09-27 2003-02-01 Daiichi Seiyaku Co Bicyclic amine derivative
EP0947513B1 (de) 1996-10-25 2004-05-19 Daiichi Pharmaceutical Co., Ltd. Tricyclische aminderivate
US20020032216A1 (en) 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
MA24500A1 (fr) 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
DE19733439A1 (de) * 1997-08-02 1999-02-04 Bayer Ag Neue 6-endo-Amino-3-azabicyclo(3.1.0)hexande, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung von Chinolon- und Naphthyridincarbonsäure-Derviaten mit verbesserten Eigenschaften
SK286420B6 (sk) 1997-09-15 2008-09-05 The Procter & Gamble Company Zlúčenina so štruktúrou chinolónu, farmaceutický prostriedok s jej obsahom a jej použitie
US6184380B1 (en) * 1999-01-25 2001-02-06 Pfizer Inc. Process for preparing naphthyridones and intermediates
PA8464701A1 (es) * 1998-01-16 2000-09-29 Pfizer Prod Inc Procedimiento e intermedios para preparar naftiridonas
US7019142B2 (en) 1998-01-16 2006-03-28 Pfizer Inc. Process for preparing naphthyridones and intermediates
GB9820405D0 (en) * 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
KR100768034B1 (ko) 1999-03-17 2007-10-17 다이이찌 세이야꾸 가부시기가이샤 의약 조성물
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
WO2002048143A2 (en) 2000-12-14 2002-06-20 The Procter & Gamble Company Antimicrobial 2-pyridones, their compositions and uses
AU3089102A (en) 2000-12-14 2002-06-24 Procter & Gamble Antimicrobial quinolones
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
AU2002345266B2 (en) 2002-07-08 2009-07-02 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
US7288562B2 (en) 2002-08-23 2007-10-30 Ranbaxy Laboratories Limited Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists
WO2004089898A1 (en) 2003-04-09 2004-10-21 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
ATE362364T1 (de) 2003-04-10 2007-06-15 Ranbaxy Lab Ltd Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten
US20070021487A1 (en) 2003-04-11 2007-01-25 Mohammad Salman Azabicyclo derivatives as muscarinic receptor antagonists
EP1670759A1 (de) * 2003-09-18 2006-06-21 Ranbaxy Laboratories Limited Verfahren zur herstellung von (1a, 5a, 6a)-6-aminomethyl-3-benzyl-3-azabicyclo[3.1.0]hexan
AU2007230630B2 (en) 2006-03-28 2012-12-20 Taigen Biotechnology Co., Ltd Malate salts, and polymorphs of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
US7456279B2 (en) 2006-03-28 2008-11-25 The Procter & Gamble Company Coupling process for preparing quinolone intermediates
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
EP2621902B1 (de) 2010-09-28 2017-04-12 Panacea Biotec Ltd 3-azabicyclo[3.1.0]hexanverbindungen zur behandlung von zns-erkrankungen
US20210395222A1 (en) * 2018-10-05 2021-12-23 New York University Fused Bicyclic Heterocycles as Therapeutic Agents
CN112442084B (zh) * 2020-12-03 2022-09-09 国药集团致君（深圳）制药有限公司 一种抗菌药中间体的制备方法
CN113307768B (zh) * 2021-04-29 2023-12-12 中国农业科学院兰州畜牧与兽药研究所 喹诺酮类衍生物及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0676400B2 (ja) * 1987-08-25 1994-09-28 大日本製薬株式会社 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
US4973091A (en) * 1989-09-20 1990-11-27 Truth Incorporated Sliding patio door dual point latch and lock

Also Published As

Publication number Publication date
CY99010I2 (en) 2010-07-28
PL166381B1 (pl) 1995-05-31
NL980032I1 (nl) 1999-02-01
FI920632A0 (fi) 1992-02-14
DE19875050I2 (de) 2009-05-28
HU219403B (hu) 2001-04-28
CN1049501A (zh) 1991-02-27
KR930004844B1 (ko) 1993-06-09
DK0413455T3 (da) 1995-08-14
PT94998A (pt) 1991-04-18
IL95331A0 (en) 1991-06-30
FI108228B (fi) 2001-12-14
KR910004572A (ko) 1991-03-28
PT94998B (pt) 1997-05-28
JPH0819099B2 (ja) 1996-02-28
JPH0386875A (ja) 1991-04-11
CN1025192C (zh) 1994-06-29
NO920599D0 (no) 1992-02-14
IL95331A (en) 1995-07-31
JPH072734B2 (ja) 1995-01-18
ES2074131T3 (es) 1995-09-01
NO300214B1 (no) 1997-04-28
JPH07149758A (ja) 1995-06-13
PL286484A1 (en) 1991-05-20
AU6104290A (en) 1991-02-21
LU90311I2 (fr) 1999-01-25
NL980032I2 (nl) 1999-05-03
CA2023217A1 (en) 1991-02-17
EP0413455A3 (en) 1991-10-09
RU2049777C1 (ru) 1995-12-10
GR3017072T3 (en) 1995-11-30
NO920599L (no) 1992-04-14
IE902950A1 (en) 1991-02-27
NL980033I2 (nl) 1999-05-03
EP0413455B1 (de) 1995-06-21
FI103879B (fi) 1999-10-15
CA2127561A1 (en) 1991-02-17
CZ402790A3 (en) 1996-04-17
EG19251A (en) 1994-09-29
ES2074131T4 (es) 1996-05-01
DE69020262T2 (de) 1995-10-26
FI964520A0 (fi) 1996-11-11
HK1000207A1 (en) 1998-02-06
ATE124040T1 (de) 1995-07-15
NL980033I1 (nl) 1999-02-01
CY1969A (en) 1997-09-05
NZ234920A (en) 1992-06-25
LU90310I2 (fr) 1999-01-25
CA2127561C (en) 1998-07-28
CZ281127B6 (cs) 1996-06-12
DE69020262D1 (de) 1995-07-27
IE66202B1 (en) 1995-12-13
ZA906450B (en) 1992-03-25
AU623801B2 (en) 1992-05-21
EP0413455A2 (de) 1991-02-20
HU211681A9 (en) 1995-12-28
FI103879B1 (fi) 1999-10-15
DD298399A5 (de) 1992-02-20
DE19875052I2 (de) 2009-05-28
WO1991002526A1 (en) 1991-03-07
FI964520A (fi) 1996-11-11
CA2023217C (en) 1996-12-10

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