AU758571B2 - Confocal microscopy imaging system - Google Patents
Confocal microscopy imaging system Download PDFInfo
- Publication number
- AU758571B2 AU758571B2 AU33547/99A AU3354799A AU758571B2 AU 758571 B2 AU758571 B2 AU 758571B2 AU 33547/99 A AU33547/99 A AU 33547/99A AU 3354799 A AU3354799 A AU 3354799A AU 758571 B2 AU758571 B2 AU 758571B2
- Authority
- AU
- Australia
- Prior art keywords
- objective lens
- electromagnetic radiation
- substrate
- discontinuous surface
- focusing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/008—Details of detection or image processing, including general computer control
- G02B21/0084—Details of detection or image processing, including general computer control time-scale detection, e.g. strobed, ultra-fast, heterodyne detection
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0028—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders specially adapted for specific applications, e.g. for endoscopes, ophthalmoscopes, attachments to conventional microscopes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5002—Partitioning blood components
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/006—Optical details of the image generation focusing arrangements; selection of the plane to be imaged
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0064—Optical details of the image generation multi-spectral or wavelength-selective arrangements, e.g. wavelength fan-out, chromatic profiling
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0072—Optical details of the image generation details concerning resolution or correction, including general design of CSOM objectives
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003204937A AU2003204937B2 (en) | 1998-03-16 | 2003-06-25 | Confocal microscopy imaging system |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4252798A | 1998-03-16 | 1998-03-16 | |
US09/042527 | 1998-03-16 | ||
PCT/US1999/005589 WO1999047963A1 (fr) | 1998-03-16 | 1999-03-16 | Systeme d'imagerie confocal pour microscopie |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2003204937A Division AU2003204937B2 (en) | 1998-03-16 | 2003-06-25 | Confocal microscopy imaging system |
Publications (2)
Publication Number | Publication Date |
---|---|
AU3354799A AU3354799A (en) | 1999-10-11 |
AU758571B2 true AU758571B2 (en) | 2003-03-27 |
Family
ID=21922413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU33547/99A Ceased AU758571B2 (en) | 1998-03-16 | 1999-03-16 | Confocal microscopy imaging system |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1064579A4 (fr) |
JP (1) | JP4812937B2 (fr) |
KR (2) | KR100560588B1 (fr) |
CN (1) | CN100380160C (fr) |
AU (1) | AU758571B2 (fr) |
BR (1) | BR9908767B1 (fr) |
CA (1) | CA2324262C (fr) |
IL (2) | IL138496A0 (fr) |
NO (1) | NO20004601L (fr) |
WO (1) | WO1999047963A1 (fr) |
Families Citing this family (89)
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US6690463B2 (en) * | 2000-02-10 | 2004-02-10 | Evotec Biosystems Ag | Fluorescence intensity and lifetime distribution analysis |
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FR2820828B1 (fr) * | 2001-02-09 | 2003-05-02 | Commissariat Energie Atomique | Dispositif d'observation d'echantillons par fluorescence, notamment de facon sequentielle |
DE10117723A1 (de) * | 2001-04-09 | 2002-10-17 | Evotec Ag | Probenträger, insbesondere für biochemische Reaktionen |
US7219016B2 (en) | 2001-04-20 | 2007-05-15 | Yale University | Systems and methods for automated analysis of cells and tissues |
DE10122607B4 (de) * | 2001-05-10 | 2006-11-30 | Leica Microsystems Cms Gmbh | Verfahren und Anordnung zur direkten Fourierabbildung von Proben |
DE10157511A1 (de) | 2001-11-23 | 2003-06-12 | Evotec Ag | Verfahren und Vorrichtung zur Korrektur der Größe und/oder Form eines Messvolumens in einer chemischen und/oder biologischen Probe |
JP2003177131A (ja) * | 2001-12-11 | 2003-06-27 | Olympus Optical Co Ltd | 生物学的な結合親和性を検出する方法 |
GB0211068D0 (en) * | 2002-05-14 | 2002-06-26 | Amersham Biosciences Uk Ltd | Method for assessing biofilms |
GB0211072D0 (en) * | 2002-05-15 | 2002-06-26 | Amersham Biosciences Uk Ltd | Reagent and method for the determination of changes in a cellular morphological parameter |
US6982166B2 (en) | 2002-05-16 | 2006-01-03 | Applera Corporation | Lens assembly for biological testing |
US9157860B2 (en) | 2002-05-16 | 2015-10-13 | Applied Biosystems, Llc | Achromatic lens array |
DE102004014048B4 (de) * | 2004-03-19 | 2008-10-30 | Sirona Dental Systems Gmbh | Vermessungseinrichtung und Verfahren nach dem Grundprinzip der konfokalen Mikroskopie |
US7170675B2 (en) | 2004-05-19 | 2007-01-30 | Celloptic, Inc. | Method and system for wide-field multi-photon microscopy having a confocal excitation plane |
DE102004034970A1 (de) * | 2004-07-16 | 2006-02-02 | Carl Zeiss Jena Gmbh | Lichtrastermikroskop und Verwendung |
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CN1310023C (zh) * | 2004-11-10 | 2007-04-11 | 哈尔滨工业大学 | 三差动共焦显微三维超分辨成像方法 |
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CN105403545B (zh) | 2007-12-21 | 2019-05-28 | 哈佛大学 | 三维中的亚衍射极限图像分辨率 |
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US5915048A (en) * | 1996-06-05 | 1999-06-22 | Zetetic Institute | Method and apparatus for discriminating in-focus images from out-of-focus light signals from background and foreground light sources |
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1999
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- 1999-03-16 IL IL13849699A patent/IL138496A0/xx not_active IP Right Cessation
- 1999-03-16 JP JP2000537103A patent/JP4812937B2/ja not_active Expired - Fee Related
- 1999-03-16 AU AU33547/99A patent/AU758571B2/en not_active Ceased
- 1999-03-16 KR KR1020057015316A patent/KR100618502B1/ko not_active IP Right Cessation
- 1999-03-16 CA CA2324262A patent/CA2324262C/fr not_active Expired - Fee Related
- 1999-03-16 CN CNB998062219A patent/CN100380160C/zh not_active Expired - Fee Related
- 1999-03-16 WO PCT/US1999/005589 patent/WO1999047963A1/fr active IP Right Grant
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US5915048A (en) * | 1996-06-05 | 1999-06-22 | Zetetic Institute | Method and apparatus for discriminating in-focus images from out-of-focus light signals from background and foreground light sources |
US5760901A (en) * | 1997-01-28 | 1998-06-02 | Zetetic Institute | Method and apparatus for confocal interference microscopy with background amplitude reduction and compensation |
Also Published As
Publication number | Publication date |
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CN1301357A (zh) | 2001-06-27 |
WO1999047963A9 (fr) | 1999-12-23 |
KR100618502B1 (ko) | 2006-09-01 |
CN100380160C (zh) | 2008-04-09 |
AU3354799A (en) | 1999-10-11 |
EP1064579A1 (fr) | 2001-01-03 |
NO20004601D0 (no) | 2000-09-15 |
WO1999047963A1 (fr) | 1999-09-23 |
WO1999047963A8 (fr) | 1999-11-18 |
IL138496A0 (en) | 2001-10-31 |
KR20010041945A (ko) | 2001-05-25 |
BR9908767B1 (pt) | 2011-09-06 |
BR9908767A (pt) | 2001-10-16 |
KR100560588B1 (ko) | 2006-03-16 |
JP4812937B2 (ja) | 2011-11-09 |
CA2324262C (fr) | 2010-05-25 |
EP1064579A4 (fr) | 2007-11-07 |
CA2324262A1 (fr) | 1999-09-23 |
JP2002507762A (ja) | 2002-03-12 |
IL164319A0 (en) | 2005-12-18 |
KR20050088500A (ko) | 2005-09-06 |
NO20004601L (no) | 2000-11-10 |
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