AU744264B2 - Integrated microfluidic devices - Google Patents

Integrated microfluidic devices Download PDF

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Publication number
AU744264B2
AU744264B2 AU39680/97A AU3968097A AU744264B2 AU 744264 B2 AU744264 B2 AU 744264B2 AU 39680/97 A AU39680/97 A AU 39680/97A AU 3968097 A AU3968097 A AU 3968097A AU 744264 B2 AU744264 B2 AU 744264B2
Authority
AU
Australia
Prior art keywords
microchannel
electrophoretic
enrichment
analyte
enrichment channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU39680/97A
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English (en)
Other versions
AU3968097A (en
Inventor
Alan K. Hauser
Alexander P. Sassi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monogram Biosciences Inc
Original Assignee
Aclara Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aclara Biosciences Inc filed Critical Aclara Biosciences Inc
Publication of AU3968097A publication Critical patent/AU3968097A/en
Application granted granted Critical
Publication of AU744264B2 publication Critical patent/AU744264B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44756Apparatus specially adapted therefor
    • G01N27/44791Microapparatus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44704Details; Accessories
    • G01N27/44743Introducing samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30Micromixers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Materials For Photolithography (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
AU39680/97A 1996-07-30 1997-07-30 Integrated microfluidic devices Ceased AU744264B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/690307 1996-07-30
US08/690,307 US5770029A (en) 1996-07-30 1996-07-30 Integrated electrophoretic microdevices
PCT/US1997/013503 WO1998004909A1 (en) 1996-07-30 1997-07-30 Integrated microfluidic devices

Publications (2)

Publication Number Publication Date
AU3968097A AU3968097A (en) 1998-02-20
AU744264B2 true AU744264B2 (en) 2002-02-21

Family

ID=24771959

Family Applications (1)

Application Number Title Priority Date Filing Date
AU39680/97A Ceased AU744264B2 (en) 1996-07-30 1997-07-30 Integrated microfluidic devices

Country Status (8)

Country Link
US (2) US5770029A (Direct)
EP (1) EP1007953B1 (Direct)
JP (1) JP3989964B2 (Direct)
AT (1) ATE347692T1 (Direct)
AU (1) AU744264B2 (Direct)
CA (1) CA2261869C (Direct)
DE (1) DE69737071T2 (Direct)
WO (1) WO1998004909A1 (Direct)

Families Citing this family (394)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225059B1 (en) 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US6309602B1 (en) * 1993-11-01 2001-10-30 Nanogen, Inc. Stacked, reconfigurable system for electrophoretic transport of charged materials
US6638482B1 (en) 1993-11-01 2003-10-28 Nanogen, Inc. Reconfigurable detection and analysis apparatus and method
US6331274B1 (en) 1993-11-01 2001-12-18 Nanogen, Inc. Advanced active circuits and devices for molecular biological analysis and diagnostics
US6319472B1 (en) * 1993-11-01 2001-11-20 Nanogen, Inc. System including functionally separated regions in electrophoretic system
US7857957B2 (en) 1994-07-07 2010-12-28 Gamida For Life B.V. Integrated portable biological detection system
US6403367B1 (en) 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US20060000722A1 (en) * 1996-06-28 2006-01-05 Caliper Life Sciences, Inc. High throughput screening assay systems in microscale fluidic devices
NZ333346A (en) * 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
US6074827A (en) * 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US6447727B1 (en) * 1996-11-19 2002-09-10 Caliper Technologies Corp. Microfluidic systems
WO1998049344A1 (en) * 1997-04-28 1998-11-05 Lockheed Martin Energy Research Corporation Method and apparatus for analyzing nucleic acids
WO1998052691A1 (en) * 1997-05-16 1998-11-26 Alberta Research Council Microfluidic system and methods of use
US6632619B1 (en) 1997-05-16 2003-10-14 The Governors Of The University Of Alberta Microfluidic system and methods of use
US6090251A (en) * 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
WO1999014368A2 (en) * 1997-09-15 1999-03-25 Whitehead Institute For Biomedical Research Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device
US6833242B2 (en) 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US6106779A (en) * 1997-10-02 2000-08-22 Biosite Diagnostics, Inc. Lysis chamber for use in an assay device
ES2309022T3 (es) * 1997-12-24 2008-12-16 Cepheid Dispositivo y procedimiento para lisis.
US6830729B1 (en) 1998-05-18 2004-12-14 University Of Washington Sample analysis instrument
CA2320296A1 (en) 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
US6274089B1 (en) * 1998-06-08 2001-08-14 Caliper Technologies Corp. Microfluidic devices, systems and methods for performing integrated reactions and separations
EP1084391A4 (en) * 1998-06-08 2006-06-14 Caliper Life Sciences Inc MICROFLUIDIC DEVICES, SYSTEMS AND METHODS FOR REALIZING INTEGRATED REACTIONS AND SEPARATIONS
US6306590B1 (en) * 1998-06-08 2001-10-23 Caliper Technologies Corp. Microfluidic matrix localization apparatus and methods
DE19826020C2 (de) * 1998-06-10 2000-11-02 Max Planck Gesellschaft Vorrichtung und Verfahren zur miniaturisierten, hochparallelen elektrophoretischen Trennung
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6761816B1 (en) * 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US20050244954A1 (en) * 1998-06-23 2005-11-03 Blackburn Gary F Binding acceleration techniques for the detection of analytes
EP2045334A1 (en) 1998-06-24 2009-04-08 Illumina, Inc. Decoding of array sensors with microspheres
WO1999067639A1 (en) * 1998-06-25 1999-12-29 Caliper Technologies Corporation High throughput methods, systems and apparatus for performing cell based screening assays
US6375901B1 (en) 1998-06-29 2002-04-23 Agilent Technologies, Inc. Chemico-mechanical microvalve and devices comprising the same
US6716394B2 (en) 1998-08-11 2004-04-06 Caliper Technologies Corp. DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
US6447724B1 (en) 1998-08-11 2002-09-10 Caliper Technologies Corp. DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
JP2002523741A (ja) * 1998-08-19 2002-07-30 イェーノプティク アクチエンゲゼルシャフト 極少量の液体を搬送する装置およびその製造方法
DE19846958C2 (de) * 1998-08-19 2001-06-13 Fraunhofer Ges Forschung Verfahren zur Herstellung einer Einrichtung zum Transport von kleinsten Flüssigkeitsmengen
EP1124939B1 (en) 1998-10-08 2003-04-23 AstraZeneca AB Microfabricated cell injector
US6887693B2 (en) 1998-12-24 2005-05-03 Cepheid Device and method for lysing cells, spores, or microorganisms
US7914994B2 (en) * 1998-12-24 2011-03-29 Cepheid Method for separating an analyte from a sample
JP2002536640A (ja) * 1999-02-03 2002-10-29 アクララ バイオサイエンシーズ, インコーポレイテッド 微小流体導入の際のマルチチャネル制御
ATE556149T1 (de) 1999-02-23 2012-05-15 Caliper Life Sciences Inc Manipulation von mikropartikeln in mikrofluidischen systemen
US6296702B1 (en) * 1999-03-15 2001-10-02 Pe Corporation (Ny) Apparatus and method for spotting a substrate
US6605475B1 (en) * 1999-04-16 2003-08-12 Perspective Biosystems, Inc. Apparatus and method for sample delivery
CA2370749A1 (en) 1999-04-20 2000-10-26 Target Discovery, Inc. Polypeptide fingerprinting methods, metabolic profiling, and bioinformatics database
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US7312087B2 (en) * 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8080380B2 (en) * 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8815521B2 (en) * 2000-05-30 2014-08-26 Cepheid Apparatus and method for cell disruption
JP4022069B2 (ja) * 1999-05-28 2007-12-12 シーフィード 細胞破壊装置および方法
US9073053B2 (en) * 1999-05-28 2015-07-07 Cepheid Apparatus and method for cell disruption
US6818185B1 (en) 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
DE19927535B4 (de) * 1999-06-16 2004-06-17 Merck Patent Gmbh Miniaturisiertes Analysensystem mit Vorrichtung zum Ausschleusen von Substanzen
AU6068300A (en) * 1999-07-06 2001-01-22 Caliper Technologies Corporation Microfluidic systems and methods for determining modulator kinetics
US6381025B1 (en) 1999-08-19 2002-04-30 Texas Tech University Interferometric detection system and method
US6613581B1 (en) * 1999-08-26 2003-09-02 Caliper Technologies Corp. Microfluidic analytic detection assays, devices, and integrated systems
US6676819B1 (en) * 1999-09-14 2004-01-13 Yaoqing Diana Liu Methods and apparatus for automatic on-line multi-dimensional electrophoresis
US6210986B1 (en) * 1999-09-23 2001-04-03 Sandia Corporation Microfluidic channel fabrication method
US6406604B1 (en) * 1999-11-08 2002-06-18 Norberto A. Guzman Multi-dimensional electrophoresis apparatus
US7329388B2 (en) * 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
US20060128006A1 (en) * 1999-11-10 2006-06-15 Gerhardt Antimony L Hydrodynamic capture and release mechanisms for particle manipulation
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
CA2290731A1 (en) * 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
DE10004853C1 (de) * 2000-02-03 2001-04-26 Fraunhofer Ges Forschung Verfahren zum dauerhaften Verbinden von Polymerbauteilen mit Bauteilen aus gleichartigem oder andersartigem Material
US6728429B1 (en) 2000-02-16 2004-04-27 Biotell, Inc. Optical detection
US6824669B1 (en) * 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
CA2401118A1 (en) 2000-02-23 2001-08-30 Zyomyx, Inc. Microfluidic devices and methods
JP2001242137A (ja) * 2000-02-29 2001-09-07 Hitachi Chem Co Ltd マイクロチップ電気泳動装置
WO2001069226A1 (en) * 2000-03-10 2001-09-20 Dna Sciences, Inc. Cross channel device for serial sample injection
US6537433B1 (en) * 2000-03-10 2003-03-25 Applera Corporation Methods and apparatus for the location and concentration of polar analytes using an alternating electric field
US20020012971A1 (en) * 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
US6561208B1 (en) 2000-04-14 2003-05-13 Nanostream, Inc. Fluidic impedances in microfluidic system
US7435579B2 (en) * 2000-04-17 2008-10-14 Purdue Research Foundation Biosensor and related method
US7306924B2 (en) * 2000-04-17 2007-12-11 Purdue Research Foundation Biosensor and related method
US6716620B2 (en) * 2000-04-17 2004-04-06 Purdue Research Foundation Biosensor and related method
DE10023423B4 (de) * 2000-05-12 2009-03-05 Gnothis Holding Sa Direkter Nachweis von Einzelmolekülen
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
CA2314398A1 (en) 2000-08-10 2002-02-10 Edward Shipwash Microarrays and microsystems for amino acid analysis and protein sequencing
US6860980B2 (en) * 2000-09-15 2005-03-01 The United States Of America As Represented By The Secretary Of Commerce Polyelectrolyte derivatization of microfluidic devices
EP2381116A1 (en) 2000-11-16 2011-10-26 California Institute of Technology Apparatus and methods for conducting assays and high throughput screening
US6459581B1 (en) 2000-12-19 2002-10-01 Harris Corporation Electronic device using evaporative micro-cooling and associated methods
US6783992B2 (en) 2001-01-03 2004-08-31 Agilent Technologies, Inc. Methods and using chemico-mechanical microvalve devices for the selective separation of components from multi-component fluid samples
WO2002059579A1 (en) 2001-01-25 2002-08-01 Texas Tech University Universal detector for biological and chemical separations or assays using plastic microfluidic devices
WO2002059589A2 (en) * 2001-01-26 2002-08-01 Biocal Technology, Inc. Multi-channel bio-separation cartridge
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
JP4809983B2 (ja) * 2001-02-14 2011-11-09 明彦 谷岡 生体高分子とリガンドとの相互作用を検出する装置及びその方法
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US20040121309A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
WO2004060278A2 (en) 2002-12-06 2004-07-22 Isis Pharmaceuticals, Inc. Methods for rapid identification of pathogens in humans and animals
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US7718354B2 (en) 2001-03-02 2010-05-18 Ibis Biosciences, Inc. Methods for rapid identification of pathogens in humans and animals
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US20020127740A1 (en) * 2001-03-06 2002-09-12 Ho Winston Z. Quantitative microfluidic biochip and method of use
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7270786B2 (en) 2001-03-28 2007-09-18 Handylab, Inc. Methods and systems for processing microfluidic samples of particle containing fluids
US6575188B2 (en) 2001-07-26 2003-06-10 Handylab, Inc. Methods and systems for fluid control in microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7192557B2 (en) * 2001-03-28 2007-03-20 Handylab, Inc. Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
EP1384022A4 (en) 2001-04-06 2004-08-04 California Inst Of Techn NUCLEIC ACID AMPLIFICATION USING MICROFLUID DEVICES
US6418968B1 (en) 2001-04-20 2002-07-16 Nanostream, Inc. Porous microfluidic valves
ATE367205T1 (de) * 2001-05-02 2007-08-15 Applera Corp Konzentration und reinigung von analyten mit elektrischen feldern
US6802489B2 (en) * 2001-05-03 2004-10-12 Colorado School Of Mines Micro-fluidic valve with a colloidal particle element
US20050009101A1 (en) * 2001-05-17 2005-01-13 Motorola, Inc. Microfluidic devices comprising biochannels
US7214300B2 (en) * 2001-06-04 2007-05-08 Epocal Inc. Integrated electrokinetic devices and methods of manufacture
US6811695B2 (en) 2001-06-07 2004-11-02 Nanostream, Inc. Microfluidic filter
US20020187557A1 (en) * 2001-06-07 2002-12-12 Hobbs Steven E. Systems and methods for introducing samples into microfluidic devices
US20030077570A1 (en) * 2001-09-20 2003-04-24 Coventor, Inc. Small molecule substrate based enzyme activity assays
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US8073627B2 (en) 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
EP1418997B1 (en) * 2001-08-13 2010-04-28 The Board Of Trustees Of The Leland Stanford Junior University Bonded phase photopolymerized sol-gel column and associated methods
US20030108664A1 (en) * 2001-10-05 2003-06-12 Kodas Toivo T. Methods and compositions for the formation of recessed electrical features on a substrate
AU2002360282A1 (en) * 2001-10-19 2003-06-10 West Virginia University Research Corporation Microflludic system for proteome analysis
AU2002343573A1 (en) * 2001-10-24 2003-05-06 Singulex, Inc. Methods for detecting genetic haplotypes by interaction with probes
US20030175947A1 (en) * 2001-11-05 2003-09-18 Liu Robin Hui Enhanced mixing in microfluidic devices
WO2003044481A2 (en) * 2001-11-20 2003-05-30 Burstein Technologies, Inc. Optical bio-discs and microfluidic devices for analysis of cells
WO2003045556A2 (en) * 2001-11-26 2003-06-05 Keck Graduate Institute Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like
US20040231987A1 (en) * 2001-11-26 2004-11-25 Keck Graduate Institute Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like
US20030098661A1 (en) * 2001-11-29 2003-05-29 Ken Stewart-Smith Control system for vehicle seats
JP4355210B2 (ja) 2001-11-30 2009-10-28 フルイディグム コーポレイション 微小流体デバイスおよび微小流体デバイスの使用方法
US7192560B2 (en) * 2001-12-20 2007-03-20 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using anion exchange
KR100408871B1 (ko) * 2001-12-20 2003-12-11 삼성전자주식회사 바이오칩 상에서 탄소나노튜브를 이용한 시료의 분리 또는여과 방법
US7347976B2 (en) 2001-12-20 2008-03-25 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using a hydrophilic solid support in a hydrophobic matrix
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
US7018849B2 (en) * 2002-01-15 2006-03-28 Piasio Roger N Process for (A) separating biological/ligands from dilute solutions and (B) conducting an immunochromatographic assay thereof employing superparamagnetic particles throughtout
WO2003066191A1 (en) * 2002-02-04 2003-08-14 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
EP1474236B1 (en) 2002-02-13 2006-01-04 Nanostream, Inc. Microfluidic separation column devices and fabrication methods
US7261812B1 (en) 2002-02-13 2007-08-28 Nanostream, Inc. Multi-column separation devices and methods
CA2480728A1 (en) 2002-04-01 2003-10-16 Fluidigm Corporation Microfluidic particle-analysis systems
US20050277195A1 (en) * 2002-04-30 2005-12-15 Gyros Ab Integrated microfluidic device (ea)
US20030217923A1 (en) * 2002-05-24 2003-11-27 Harrison D. Jed Apparatus and method for trapping bead based reagents within microfluidic analysis systems
US7338459B2 (en) * 2002-05-31 2008-03-04 Swidler Steven A Impact table system and method
WO2003103925A1 (en) * 2002-06-06 2003-12-18 Rutgers, The State University Co-continuous phase composite polymer blends for in-vivo and in-vitro biomedical applications
US20050238506A1 (en) * 2002-06-21 2005-10-27 The Charles Stark Draper Laboratory, Inc. Electromagnetically-actuated microfluidic flow regulators and related applications
US7235164B2 (en) * 2002-10-18 2007-06-26 Eksigent Technologies, Llc Electrokinetic pump having capacitive electrodes
US7364647B2 (en) * 2002-07-17 2008-04-29 Eksigent Technologies Llc Laminated flow device
US7517440B2 (en) 2002-07-17 2009-04-14 Eksigent Technologies Llc Electrokinetic delivery systems, devices and methods
US20040011650A1 (en) * 2002-07-22 2004-01-22 Frederic Zenhausern Method and apparatus for manipulating polarizable analytes via dielectrophoresis
AU2003269954A1 (en) * 2002-08-07 2004-02-25 National Institutes Of Health Measurement systems and methods
US7094345B2 (en) * 2002-09-09 2006-08-22 Cytonome, Inc. Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system
WO2004028955A2 (en) 2002-09-25 2004-04-08 California Institute Of Technology Microfluidic large scale integration
US20040115830A1 (en) * 2002-09-25 2004-06-17 Igor Touzov Components for nano-scale Reactor
TW590982B (en) * 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
ES2375724T3 (es) 2002-09-27 2012-03-05 The General Hospital Corporation Dispositivo microflu�?dico para seperación de células y sus usos.
WO2004040001A2 (en) 2002-10-02 2004-05-13 California Institute Of Technology Microfluidic nucleic acid analysis
GB0223984D0 (en) * 2002-10-15 2002-11-20 Novartis Forschungsstiftung Methods for detecting teneurin signalling and related screening methods
US7010964B2 (en) 2002-10-31 2006-03-14 Nanostream, Inc. Pressurized microfluidic devices with optical detection regions
US20060211055A1 (en) * 2002-11-12 2006-09-21 Caliper Life Sciences, Inc. Capture and release assay system and method
EP1594694A4 (en) 2002-12-30 2010-01-20 Univ California METHOD AND DEVICE FOR DETECTING AND ANALYZING DISEASES OF DISEASE
CA2513985C (en) * 2003-01-21 2012-05-29 Illumina Inc. Chemical reaction monitor
WO2004077017A2 (en) * 2003-02-21 2004-09-10 West Virginia University Research Corporation Apparatus and method for on-chip concentration using a microfluidic device with an integrated ultrafiltration membrane structure
US7655477B1 (en) * 2003-02-26 2010-02-02 Science Applications International Corporation System and method for the separation of analytes
US7147764B2 (en) * 2003-03-28 2006-12-12 Applera Corporation Dual electrode injection of analyte into a capillary electrophoretic device
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US20040195099A1 (en) * 2003-04-04 2004-10-07 Jacobson Stephen C. Sample filtration, concentration and separation on microfluidic devices
US7981600B2 (en) * 2003-04-17 2011-07-19 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using an anion exchange material that includes a polyoxyalkylene
US8046171B2 (en) 2003-04-18 2011-10-25 Ibis Biosciences, Inc. Methods and apparatus for genetic evaluation
US8057993B2 (en) 2003-04-26 2011-11-15 Ibis Biosciences, Inc. Methods for identification of coronaviruses
WO2004101151A1 (en) 2003-05-08 2004-11-25 Nanostream, Inc. Sample preparation for parallel chromatography
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
DE602004002888T2 (de) * 2003-05-13 2007-05-31 Becton Dickinson And Co. Vorrichtung und Verfahren zum Sanieren und Entsalzen von biologischen Proben
US7402398B2 (en) 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
WO2005019419A2 (en) * 2003-07-31 2005-03-03 Singulex, Inc. Co-detection of single polypeptide and polynucleotide molecules
EP2407243B1 (en) 2003-07-31 2020-04-22 Handylab, Inc. Multilayered microfluidic device
US7028536B2 (en) 2004-06-29 2006-04-18 Nanostream, Inc. Sealing interface for microfluidic device
NZ545873A (en) 2003-08-11 2009-05-31 Monogram Biosciences Inc Detecting and profiling molecular complexes
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US20120122102A1 (en) 2003-09-11 2012-05-17 Rangarajan Sampath Compositions for use in identification of bacteria
US7235163B2 (en) * 2003-09-12 2007-06-26 Applera Corporation Loading features for channel array
US20080021674A1 (en) * 2003-09-30 2008-01-24 Robert Puskas Methods for Enhancing the Analysis of Particle Detection
US20050082168A1 (en) * 2003-10-17 2005-04-21 Kang Jing X. Apparatus of electrophoresis
JP2007512509A (ja) * 2003-11-05 2007-05-17 エグザクト サイエンシーズ コーポレイション 反復的親和性分離およびその使用
EP1706735B1 (en) * 2003-11-07 2017-01-04 Princeton Biochemicals, Inc. Multi-dimensional electrophoresis apparatus
US8007724B2 (en) * 2003-11-07 2011-08-30 Princeton Biochemicals, Inc. Electrophoresis apparatus having at least one auxiliary buffer passage
US8163895B2 (en) 2003-12-05 2012-04-24 Ibis Biosciences, Inc. Compositions for use in identification of orthopoxviruses
US20050130177A1 (en) 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US7322254B2 (en) 2003-12-12 2008-01-29 3M Innovative Properties Company Variable valve apparatus and methods
US7727710B2 (en) 2003-12-24 2010-06-01 3M Innovative Properties Company Materials, methods, and kits for reducing nonspecific binding of molecules to a surface
US7939249B2 (en) 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
US20050148064A1 (en) * 2003-12-29 2005-07-07 Intel Corporation Microfluid molecular-flow fractionator and bioreactor with integrated active/passive diffusion barrier
US7867194B2 (en) 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
WO2005072793A1 (en) * 2004-01-29 2005-08-11 The Charles Stark Draper Laboratory, Inc. Implantable drug delivery apparatus
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
CN101354392A (zh) * 2004-03-01 2009-01-28 松下电器产业株式会社 生物传感器、生物传感芯片以及生物传感装置
US8119336B2 (en) * 2004-03-03 2012-02-21 Ibis Biosciences, Inc. Compositions for use in identification of alphaviruses
US7559356B2 (en) * 2004-04-19 2009-07-14 Eksident Technologies, Inc. Electrokinetic pump driven heat transfer system
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
CA3198754A1 (en) 2004-05-03 2005-11-17 Handylab, Inc. A microfluidic device and methods for processing polynucleotide-containing samples
WO2005114166A1 (en) 2004-05-21 2005-12-01 Atonomics A/S Surface acoustic wave sensor comprising a hydrogel
JP4810533B2 (ja) 2004-05-24 2011-11-09 アイビス バイオサイエンシズ インコーポレイティッド ディジタルスレショルド化による選択的イオン濾過作用を用いた質量分光測定法
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7799553B2 (en) * 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
US7211184B2 (en) * 2004-08-04 2007-05-01 Ast Management Inc. Capillary electrophoresis devices
JP4735119B2 (ja) * 2004-08-09 2011-07-27 日本精工株式会社 反応器及びその製造方法
CN102759466A (zh) 2004-09-15 2012-10-31 英特基因有限公司 微流体装置
US7745207B2 (en) 2006-02-03 2010-06-29 IntegenX, Inc. Microfluidic devices
US7572640B2 (en) * 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
US20060078998A1 (en) * 2004-09-28 2006-04-13 Singulex, Inc. System and methods for sample analysis
US8685711B2 (en) 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
US9040305B2 (en) * 2004-09-28 2015-05-26 Singulex, Inc. Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry
CN101039751B (zh) * 2004-10-15 2010-05-05 西门子公司 用于在一次性卡盒中进行集成式自动dna或蛋白质分析的布置、所述卡盒的制备方法和使用所述卡盒进行dna或蛋白质分析的操作方法
CN101048490A (zh) * 2004-10-27 2007-10-03 柯尼卡美能达医疗印刷器材株式会社 基因检查用微反应器
US20060205061A1 (en) * 2004-11-24 2006-09-14 California Institute Of Technology Biosensors based upon actuated desorption
CN101031802B (zh) * 2005-01-07 2012-11-07 积水化学工业株式会社 使用盒的检测装置
US20060171846A1 (en) * 2005-01-10 2006-08-03 Marr David W M Microfluidic systems incorporating integrated optical waveguides
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
US8182992B2 (en) 2005-03-03 2012-05-22 Ibis Biosciences, Inc. Compositions for use in identification of adventitious viruses
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US8206974B2 (en) 2005-05-19 2012-06-26 Netbio, Inc. Ruggedized apparatus for analysis of nucleic acid and proteins
US20070017808A1 (en) * 2005-05-27 2007-01-25 Intel Corporation Linear valve-coupled two-dimensional separation device and separation matrix and method
US20070014699A1 (en) * 2005-06-23 2007-01-18 Beckman Coulter, Inc, Methods and apparatus for improving the sensitivity of capillary zone electrophoresis
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
CA2616281C (en) 2005-07-21 2014-04-22 Isis Pharmaceuticals, Inc. Methods for rapid identification and quantitation of mitochondrial dna variants
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
EP1922364A4 (en) 2005-08-09 2010-04-21 Univ North Carolina METHOD AND MATERIALS FOR PRODUCING MICROFLUIDIC DEVICES
US20070059716A1 (en) * 2005-09-15 2007-03-15 Ulysses Balis Methods for detecting fetal abnormality
CN101317086B (zh) * 2005-10-04 2013-08-14 海德威技术公司 分析物的微观流体检测
US7828948B1 (en) * 2005-10-06 2010-11-09 Sandia Corporation Preconcentration and separation of analytes in microchannels
US20070178133A1 (en) * 2005-11-09 2007-08-02 Liquidia Technologies, Inc. Medical device, materials, and methods
US8794929B2 (en) 2005-11-23 2014-08-05 Eksigent Technologies Llc Electrokinetic pump designs and drug delivery systems
US20070140918A1 (en) * 2005-12-19 2007-06-21 Hongfeng Yin Fluidic separation devices and methods with reduced sample broadening
US9487812B2 (en) 2012-02-17 2016-11-08 Colorado School Of Mines Optical alignment deformation spectroscopy
US9885644B2 (en) 2006-01-10 2018-02-06 Colorado School Of Mines Dynamic viscoelasticity as a rapid single-cell biomarker
US9878326B2 (en) * 2007-09-26 2018-01-30 Colorado School Of Mines Fiber-focused diode-bar optical trapping for microfluidic manipulation
US8119976B2 (en) * 2007-07-03 2012-02-21 Colorado School Of Mines Optical-based cell deformability
US7749365B2 (en) 2006-02-01 2010-07-06 IntegenX, Inc. Optimized sample injection structures in microfluidic separations
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US8492098B2 (en) 2006-02-21 2013-07-23 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of reaction components that affect a reaction
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US7766033B2 (en) * 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
ES2692380T3 (es) 2006-03-24 2018-12-03 Handylab, Inc. Método para realizar PCR con un cartucho con varias pistas
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
CN101438146B (zh) 2006-04-04 2014-12-10 神谷来克斯公司 高灵敏标志物分析和分子检测的方法和组合物
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
EP3156799B1 (en) 2006-04-04 2024-01-24 Novilux, LLC Analyzer and method for highly sensitive detection of analytes
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
WO2007147074A2 (en) 2006-06-14 2007-12-21 Living Microsystems, Inc. Use of highly parallel snp genotyping for fetal diagnosis
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US20070292889A1 (en) * 2006-06-16 2007-12-20 The Regents Of The University Of California Immunoassay magnetic trapping device
US20080007838A1 (en) * 2006-07-07 2008-01-10 Omnitech Partners, Inc. Field-of-view indicator, and optical system and associated method employing the same
WO2008094198A2 (en) * 2006-07-28 2008-08-07 Biosite Incorporated Devices and methods for performing receptor binding assays using magnetic particles
EP2064332B1 (en) 2006-09-14 2012-07-18 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
US7807454B2 (en) 2006-10-18 2010-10-05 The Regents Of The University Of California Microfluidic magnetophoretic device and methods for using the same
WO2008052138A2 (en) * 2006-10-25 2008-05-02 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated dna analysis system using same
US8765076B2 (en) 2006-11-14 2014-07-01 Handylab, Inc. Microfluidic valve and method of making same
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
EP1944078B1 (de) * 2007-01-10 2011-03-02 F. Hoffmann-La Roche AG Vorrichtung zum Bestimmen eines Analyts in einer Flüssigkeit und Verfahren
US20080245740A1 (en) * 2007-01-29 2008-10-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
US7867592B2 (en) 2007-01-30 2011-01-11 Eksigent Technologies, Inc. Methods, compositions and devices, including electroosmotic pumps, comprising coated porous surfaces
WO2008094672A2 (en) * 2007-01-31 2008-08-07 Charles Stark Draper Laboratory, Inc. Membrane-based fluid control in microfluidic devices
CN101715483A (zh) 2007-02-05 2010-05-26 微芯片生物工艺学股份有限公司 微流体和纳米流体装置、系统和应用
JP5680304B2 (ja) 2007-02-23 2015-03-04 アイビス バイオサイエンシズ インコーポレイティッド 迅速な法医学的dna分析法
EP3032251B1 (en) 2007-04-04 2018-05-23 Ande Corporation Plastic microfluidic separation and detection platforms
US20080302732A1 (en) * 2007-05-24 2008-12-11 Hyongsok Soh Integrated fluidics devices with magnetic sorting
US20080296158A1 (en) * 2007-05-31 2008-12-04 Sharp Kabushiki Kaisha Device for electrophoresis, device for transfer, device for electrophoresis and transfer, chip for electrophoresis and transfer, and method for electrophoresis, method for transfer, and method for electrophoresis and transfer
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
WO2009012185A1 (en) 2007-07-13 2009-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
WO2009015296A1 (en) 2007-07-24 2009-01-29 The Regents Of The University Of California Microfabricated dropley generator
EP2178646A1 (en) * 2007-08-23 2010-04-28 Cynvenio Biosystems, LLC Trapping magnetic sorting system for target species
US20090087860A1 (en) * 2007-08-24 2009-04-02 Todd John A Highly sensitive system and methods for analysis of prostate specific antigen (psa)
US20110195852A1 (en) 2007-08-30 2011-08-11 Trustees Of Tufts College Methods for determining the concentration of an analyte in solution
US20090062828A1 (en) * 2007-09-04 2009-03-05 Colorado School Of Mines Magnetic field-based colloidal atherectomy
US10722250B2 (en) 2007-09-04 2020-07-28 Colorado School Of Mines Magnetic-field driven colloidal microbots, methods for forming and using the same
US8445217B2 (en) 2007-09-20 2013-05-21 Vanderbilt University Free solution measurement of molecular interactions by backscattering interferometry
US8381169B2 (en) * 2007-10-30 2013-02-19 International Business Machines Corporation Extending unified process and method content to include dynamic and collaborative content
US8251672B2 (en) 2007-12-11 2012-08-28 Eksigent Technologies, Llc Electrokinetic pump with fixed stroke volume
WO2009117033A2 (en) 2007-12-19 2009-09-24 Singulex, Inc. Scanning analyzer for single molecule detection and methods of use
US20090253181A1 (en) 2008-01-22 2009-10-08 Microchip Biotechnologies, Inc. Universal sample preparation system and use in an integrated analysis system
CA2716522A1 (en) * 2008-03-05 2009-10-15 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
US20110127222A1 (en) * 2008-03-19 2011-06-02 Cynvenio Biosystems, Inc. Trapping magnetic cell sorting system
WO2009129415A1 (en) * 2008-04-16 2009-10-22 Cynvenio Biosystems, Llc Magnetic separation system with pre and post processing modules
FR2931141B1 (fr) * 2008-05-13 2011-07-01 Commissariat Energie Atomique Systeme microfluidique et procede pour le tri d'amas de cellules et de preference pour leur encapsulation en continu suite a leur tri
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US8753868B2 (en) * 2008-08-04 2014-06-17 General Electric Company Method and system for selective isolation of target biological molecules in a general purpose system
EP2163305A1 (en) * 2008-09-05 2010-03-17 INSTITUT FÜR MIKROTECHNIK MAINZ GmbH Device and process for rapid isolation of a compound in a sample
US8550694B2 (en) 2008-09-16 2013-10-08 Ibis Biosciences, Inc. Mixing cartridges, mixing stations, and related kits, systems, and methods
US8534447B2 (en) 2008-09-16 2013-09-17 Ibis Biosciences, Inc. Microplate handling systems and related computer program products and methods
WO2010033627A2 (en) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
GB2464183A (en) * 2008-09-19 2010-04-14 Singulex Inc Sandwich assay
SI2562268T1 (sl) 2008-09-20 2017-05-31 The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Building 170 Neinvazivna diagnoza fetalne anevploidije s sekvenciranjem
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US8053239B2 (en) * 2008-10-08 2011-11-08 The Governing Council Of The University Of Toronto Digital microfluidic method for protein extraction by precipitation from heterogeneous mixtures
WO2010040227A1 (en) 2008-10-10 2010-04-15 The Governing Council Of The University Of Toronto Hybrid digital and channel microfluidic devices and methods of use thereof
GB0818609D0 (en) 2008-10-10 2008-11-19 Univ Hull apparatus and method
KR20110111449A (ko) 2008-12-31 2011-10-11 인터젠엑스 인크. 미세유체 칩을 갖는 기구
KR101786506B1 (ko) 2009-02-03 2017-10-18 네트바이오, 인코포레이티드 핵산 정제
EP2393943A2 (en) * 2009-02-09 2011-12-14 Forensic Science Service Ltd Improvements in and relating to performance
WO2010093943A1 (en) 2009-02-12 2010-08-19 Ibis Biosciences, Inc. Ionization probe assemblies
KR20120017038A (ko) 2009-04-14 2012-02-27 비오까르띠 에스아 감소된 파워 임계치를 갖는 hifu 유도 캐비테이션
AU2010237533B2 (en) 2009-04-15 2014-09-25 Biocartis Nv Protection of bioanalytical sample chambers
EP2419743B1 (en) 2009-04-15 2020-08-05 Biocartis NV OPTICAL DETECTION SYSTEM FOR MONITORING rtPCR REACTION
EP2427270B1 (en) 2009-05-06 2015-04-01 Biocartis NV Device for cutting a sample carrier
US8388908B2 (en) 2009-06-02 2013-03-05 Integenx Inc. Fluidic devices with diaphragm valves
WO2010141131A1 (en) 2009-06-04 2010-12-09 Lockheed Martin Corporation Multiple-sample microfluidic chip for dna analysis
WO2010141921A1 (en) 2009-06-05 2010-12-09 Integenx Inc. Universal sample preparation system and use in an integrated analysis system
JP5678045B2 (ja) 2009-06-08 2015-02-25 シンギュレックス・インコーポレイテッド 高感度バイオマーカーパネル
JP5337912B2 (ja) * 2009-06-10 2013-11-06 シンベニオ・バイオシステムズ・インコーポレーテッド シース流装置及び方法
JP2012529908A (ja) 2009-06-15 2012-11-29 ネットバイオ・インコーポレーテッド 法医学的dnaの定量化のための改善された方法
WO2011008971A1 (en) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Lift and mount apparatus
EP2454000A4 (en) 2009-07-17 2016-08-10 Ibis Biosciences Inc SYSTEMS FOR IDENTIFYING BIOLOGICAL SUBSTANCES
EP2488656B1 (en) 2009-10-15 2015-06-03 Ibis Biosciences, Inc. Multiple displacement amplification
USD638951S1 (en) 2009-11-13 2011-05-31 3M Innovative Properties Company Sample processing disk cover
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
USD638550S1 (en) 2009-11-13 2011-05-24 3M Innovative Properties Company Sample processing disk cover
USD667561S1 (en) 2009-11-13 2012-09-18 3M Innovative Properties Company Sample processing disk cover
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8236574B2 (en) * 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8415171B2 (en) * 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
CA2791655C (en) 2010-03-01 2014-11-04 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
WO2011137533A1 (en) 2010-05-05 2011-11-10 The Governing Council Of The University Of Toronto Method of processing dried samples using digital microfluidic device
JP2013525820A (ja) 2010-05-06 2013-06-20 シングレクス、インコーポレイテッド 関節リウマチの発症に関するリスクを診断し、病期分類し、予測し、治療レスポンダーを同定するための方法
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
WO2011156713A1 (en) 2010-06-11 2011-12-15 Vanderbilt University Multiplexed interferometric detection system and method
US9188593B2 (en) 2010-07-16 2015-11-17 The University Of British Columbia Methods for assaying cellular binding interactions
EP2606154B1 (en) 2010-08-20 2019-09-25 Integenx Inc. Integrated analysis system
WO2012024657A1 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Microfluidic devices with mechanically-sealed diaphragm valves
AU2011315951B2 (en) 2010-10-15 2015-03-19 Lockheed Martin Corporation Micro fluidic optic design
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
EP2670456B1 (en) 2011-02-02 2019-12-18 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
CN106190806B (zh) 2011-04-15 2018-11-06 贝克顿·迪金森公司 扫描实时微流体热循环仪和用于同步的热循环和扫描光学检测的方法
JP2014519570A (ja) 2011-05-05 2014-08-14 エクシジェント テクノロジーズ, エルエルシー 動電学的送出システム用のゲル結合部
EP2709762B1 (en) 2011-05-18 2021-03-31 DiaSorin S.p.A. Systems and methods for detecting the presence of a selected volume of material in a sample processing device
EP2709760B1 (en) 2011-05-18 2019-06-05 DiaSorin S.p.A. Systems and methods for valving on a sample processing device
EP2709761B1 (en) 2011-05-18 2019-08-14 DiaSorin S.p.A. Systems and methods for volumetric metering on a sample processing device
EP2742347B1 (en) * 2011-08-12 2020-03-04 Life Technologies Corporation Apparatuses, methods, computer program products, and kits for hi-throughput glycan analysis
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
EP3273253B1 (en) 2011-09-30 2020-08-26 Becton, Dickinson and Company Unitized reagent strip
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
BR112014018995B1 (pt) 2012-02-03 2021-01-19 Becton, Dickson And Company sistemas para executar ensaio automatizado
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
JP6100472B2 (ja) * 2012-03-30 2017-03-22 シャープ株式会社 測定装置、透析終了条件判定装置、および透析経過提示装置
US9273949B2 (en) 2012-05-11 2016-03-01 Vanderbilt University Backscattering interferometric methods
NL2009517C2 (en) * 2012-09-25 2014-03-27 Micronit Microfluidics Bv Device and method for activating a capillary-stop valve of a device.
WO2014100686A1 (en) * 2012-12-20 2014-06-26 University Of Notre Dame Du Lac Non-aqueous microchip electrophoresis for characterization of lipid biomarkers
EP2939018B1 (en) * 2012-12-31 2022-04-20 Eprep Pty Ltd. Syringe assembly
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
WO2014113598A2 (en) 2013-01-16 2014-07-24 The Regents Of The University Of California Microfluidic devices to extract, concentrate and isolate molecules
US9862987B2 (en) * 2013-01-16 2018-01-09 The Regents Of The University Of California Label free molecular detection methods, systems and devices
US10191071B2 (en) 2013-11-18 2019-01-29 IntegenX, Inc. Cartridges and instruments for sample analysis
US10151753B2 (en) * 2013-12-17 2018-12-11 The General Hospital Corporation Microfluidic devices for isolating particles
WO2015109126A1 (en) * 2014-01-15 2015-07-23 Caliper Life Sciences, Inc. Method and system of microfluidic immunoassay using magnetic beads
WO2015179098A1 (en) 2014-05-21 2015-11-26 Integenx Inc. Fluidic cartridge with valve mechanism
US10690627B2 (en) 2014-10-22 2020-06-23 IntegenX, Inc. Systems and methods for sample preparation, processing and analysis
US10591401B2 (en) * 2014-10-27 2020-03-17 Universidade De Aveiro Equipment for the chromatic discrimination and counting of organisms
WO2016118812A1 (en) 2015-01-23 2016-07-28 Vanderbilt University A robust interferometer and methods of using same
US10734216B2 (en) 2015-05-11 2020-08-04 The University Of North Carolina At Chapel Hill Pressure driven fluidic injection for chemical separations by electrophoresis
US9606082B2 (en) 2015-05-11 2017-03-28 The University Of North Carolina At Chapel Hill Pressure driven microfluidic injection for chemical separations
CN108026494A (zh) 2015-06-05 2018-05-11 米罗库鲁斯公司 限制蒸发和表面结垢的空气基质数字微流控装置和方法
US10695762B2 (en) 2015-06-05 2020-06-30 Miroculus Inc. Evaporation management in digital microfluidic devices
US9728387B2 (en) 2015-10-20 2017-08-08 The University Of North Carolina At Chapel Hill Solid phase extraction with capillary electrophoresis
US10627396B2 (en) 2016-01-29 2020-04-21 Vanderbilt University Free-solution response function interferometry
JP2020501107A (ja) 2016-08-22 2020-01-16 ミロキュラス インコーポレイテッド デジタルマイクロ流体デバイスにおける並行小滴制御のためのフィードバックシステム
CA3049416A1 (en) 2016-12-28 2018-07-05 Miroculus Inc. Digital microfluidic devices and methods
US11623219B2 (en) 2017-04-04 2023-04-11 Miroculus Inc. Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets
CN107225006B (zh) * 2017-07-03 2018-04-03 南京岚煜生物科技有限公司 基于主动控制液体流动的多通量微流控芯片
CN110892258A (zh) 2017-07-24 2020-03-17 米罗库鲁斯公司 具有集成的血浆收集设备的数字微流控系统和方法
CN115582155B (zh) 2017-09-01 2025-08-26 因特格拉生物科学股份公司 数字微流控设备及其使用方法
CA3096855A1 (en) 2018-05-23 2019-11-28 Miroculus Inc. Control of evaporation in digital microfluidics
EP3859324B1 (en) * 2018-10-26 2024-06-12 TERUMO Kabushiki Kaisha Target substance separation and quantification method
CN113543883A (zh) 2019-01-31 2021-10-22 米罗库鲁斯公司 非结垢组合物以及用于操控和处理包封的微滴的方法
EP3953041A4 (en) 2019-04-08 2023-01-25 Miroculus Inc. MULTI-CARTRIDGE DIGITAL MICROFLUID DEVICES AND METHODS OF USE
US11524298B2 (en) 2019-07-25 2022-12-13 Miroculus Inc. Digital microfluidics devices and methods of use thereof
US20210263025A1 (en) * 2020-02-20 2021-08-26 FemtoDx Micro-separation for multiplexing
US11857961B2 (en) 2022-01-12 2024-01-02 Miroculus Inc. Sequencing by synthesis using mechanical compression
US12318779B2 (en) * 2023-06-13 2025-06-03 Guangzhou Hybribio Medicine Technology Ltd. Microfluidic chip for sorting living cells

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05164737A (ja) * 1991-12-18 1993-06-29 Shimadzu Corp オンライン前処理可能なキャピラリ電気泳動方法及び装置
WO1993022053A1 (en) * 1992-05-01 1993-11-11 Trustees Of The University Of Pennsylvania Microfabricated detection structures
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4714680B1 (en) * 1984-02-06 1995-06-27 Univ Johns Hopkins Human stem cells
US5202010A (en) * 1987-11-25 1993-04-13 Princeton Biochemicals, Inc. Automated capillary electrophoresis apparatus
US4931328A (en) * 1988-08-19 1990-06-05 Hewlett-Packard Company Capillary tube with reduced protein interactions and controllable electroosmotic flow
US5114768A (en) * 1988-06-02 1992-05-19 Hewlett-Packard Company Surfaces with reduced protein interactions
US5006313A (en) * 1988-06-02 1991-04-09 Hewlett-Packard Company Halogenated surface with reduced protein interaction
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5132012A (en) * 1988-06-24 1992-07-21 Hitachi, Ltd. Liquid chromatograph
EP0356160A3 (en) * 1988-08-24 1991-09-11 The Board Of Trustees Of The Leland Stanford Junior University Capillary device
US5081030A (en) * 1989-04-25 1992-01-14 The Johns Hopkins University Release of cells from affinity matrices
US5110514A (en) * 1989-05-01 1992-05-05 Soane Technologies, Inc. Controlled casting of a shrinkable material
US5110745A (en) * 1989-06-01 1992-05-05 The Trustees Of The University Of Pennsylvania Methods of detecting glycated proteins
US5126022A (en) * 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US5246577A (en) * 1990-05-29 1993-09-21 Millipore Corporation Apparatus for effecting capillary electrophoresis
US5085756A (en) * 1990-08-21 1992-02-04 Hewlett-Packard Company Column separation system for electrophoresis with sample pretreatment
EP0497077B1 (de) * 1991-01-28 1996-07-17 Ciba-Geigy Ag Vorrichtung zur Vorbereitung von Proben insbesondere für Analysezwecke
US5340452A (en) * 1991-02-01 1994-08-23 Beckman Instruments, Inc. On-column preconcentration of samples in capillary electrophoresis
US5646001A (en) * 1991-03-25 1997-07-08 Immunivest Corporation Affinity-binding separation and release of one or more selected subset of biological entities from a mixed population thereof
US5294534A (en) * 1991-08-13 1994-03-15 Miles, Inc. Amplification method for polynucleotide assays
EP0544969B1 (de) * 1991-12-06 1997-03-05 Ciba-Geigy Ag Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren
US5486335A (en) * 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5296375A (en) * 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5744366A (en) * 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5650274A (en) * 1993-06-25 1997-07-22 Hitachi, Ltd. DNA analyzing method
DE59410283D1 (de) * 1993-11-11 2003-06-18 Aclara Biosciences Inc Vorrichtung und Verfahren zur elektrophoretischen Trennung von fluiden Substanzgemischen
US5514340A (en) * 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
US5423966A (en) * 1994-01-25 1995-06-13 Perkin-Elmer Corporation On line ion contaminant removal apparatus and method for capillary electrophoresis
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5641400A (en) * 1994-10-19 1997-06-24 Hewlett-Packard Company Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems
US5500071A (en) * 1994-10-19 1996-03-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5658413A (en) * 1994-10-19 1997-08-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5645702A (en) * 1995-06-07 1997-07-08 Hewlett-Packard Company Low voltage miniaturized column analytical apparatus and method
US5571410A (en) * 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5985119A (en) * 1994-11-10 1999-11-16 Sarnoff Corporation Electrokinetic pumping
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
CA2204912C (en) * 1994-11-10 2005-01-04 David Sarnoff Research Center, Inc. Liquid distribution system
US5632876A (en) * 1995-06-06 1997-05-27 David Sarnoff Research Center, Inc. Apparatus and methods for controlling fluid flow in microchannels
US5603351A (en) * 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5705059A (en) * 1995-02-27 1998-01-06 Miltenyi; Stefan Magnetic separation apparatus
DE69636564T2 (de) * 1995-04-06 2007-06-06 Miltenyi Biotec Inc., Auburn Verfahren zur freisetzung von magnetischen teilchen, die an zelloberflächen gebunden sind
JPH11506412A (ja) * 1995-06-06 1999-06-08 デイヴィッド サーノフ リサーチ センター,インコーポレイテッド 超小型電気管路の製造方法
US5646048A (en) * 1995-07-24 1997-07-08 Hewlett-Packard Company Microcolumnar analytical apparatus with microcolumnar flow gating interface and method of using the apparatus
JP2000500331A (ja) * 1995-11-03 2000-01-18 サーノフ コーポレイション アッセイシステムおよびアッセイを実施する方法
KR19990067263A (ko) * 1995-11-03 1999-08-16 윌리암 제이. 버크 마그네트
CA2236788A1 (en) * 1995-11-09 1997-05-15 David Sarnoff Research Center, Inc. Field-assisted sealing
US5863502A (en) * 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
AU2609997A (en) * 1996-04-09 1997-10-29 David Sarnoff Research Center, Inc. Plate for reaction system
EP0909385B1 (en) * 1996-06-28 2008-09-10 Caliper Life Sciences, Inc. Method of transporting fluid samples within a microfluidic channel
NZ333346A (en) * 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
US5800690A (en) * 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US5699157A (en) * 1996-07-16 1997-12-16 Caliper Technologies Corp. Fourier detection of species migrating in a microchannel
AU4607197A (en) * 1996-09-26 1998-04-17 Sarnoff Corporation Massively parallel detection

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05164737A (ja) * 1991-12-18 1993-06-29 Shimadzu Corp オンライン前処理可能なキャピラリ電気泳動方法及び装置
WO1993022053A1 (en) * 1992-05-01 1993-11-11 Trustees Of The University Of Pennsylvania Microfabricated detection structures
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices

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AU3968097A (en) 1998-02-20
ATE347692T1 (de) 2006-12-15

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