AU726597B2 - N6 heterocyclic substituted adenosine derivatives - Google Patents

N6 heterocyclic substituted adenosine derivatives Download PDF

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Publication number
AU726597B2
AU726597B2 AU40809/97A AU4080997A AU726597B2 AU 726597 B2 AU726597 B2 AU 726597B2 AU 40809/97 A AU40809/97 A AU 40809/97A AU 4080997 A AU4080997 A AU 4080997A AU 726597 B2 AU726597 B2 AU 726597B2
Authority
AU
Australia
Prior art keywords
substituted
group
compound
lower alkyl
mammal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU40809/97A
Other languages
English (en)
Other versions
AU4080997A (en
Inventor
Robert T Lum
Marek G. Nelson
Jurg R. Pfister
Steven R. Schow
George F. Schreiner
Michael M. Wick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Palo Alto Inc
Original Assignee
CV Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CV Therapeutics Inc filed Critical CV Therapeutics Inc
Publication of AU4080997A publication Critical patent/AU4080997A/en
Application granted granted Critical
Publication of AU726597B2 publication Critical patent/AU726597B2/en
Assigned to GILEAD PALO ALTO, INC. reassignment GILEAD PALO ALTO, INC. Request to Amend Deed and Register Assignors: CV THERAPEUTICS, INC.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU40809/97A 1996-08-27 1997-08-20 N6 heterocyclic substituted adenosine derivatives Ceased AU726597B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/702234 1996-08-27
US08702234 US5789416B1 (en) 1996-08-27 1996-08-27 N6 mono heterocyclic substituted adenosine derivatives
PCT/US1997/014724 WO1998008855A2 (en) 1996-08-27 1997-08-20 N6 heterocyclic substituted adenosine derivatives

Publications (2)

Publication Number Publication Date
AU4080997A AU4080997A (en) 1998-03-19
AU726597B2 true AU726597B2 (en) 2000-11-16

Family

ID=24820367

Family Applications (1)

Application Number Title Priority Date Filing Date
AU40809/97A Ceased AU726597B2 (en) 1996-08-27 1997-08-20 N6 heterocyclic substituted adenosine derivatives

Country Status (25)

Country Link
US (1) US5789416B1 (pt)
EP (3) EP0992510B1 (pt)
JP (1) JP3157842B2 (pt)
KR (1) KR100331775B1 (pt)
CN (1) CN100363377C (pt)
AT (2) ATE202361T1 (pt)
AU (1) AU726597B2 (pt)
BR (1) BR9711444A (pt)
CA (1) CA2264155C (pt)
CZ (1) CZ296855B6 (pt)
DE (2) DE69705312T2 (pt)
DK (2) DK0992510T3 (pt)
ES (2) ES2157593T3 (pt)
GE (1) GEP20012419B (pt)
GR (1) GR3036332T3 (pt)
HK (1) HK1020967A1 (pt)
HU (1) HU226057B1 (pt)
IL (2) IL128652A0 (pt)
NO (3) NO312679B1 (pt)
NZ (3) NZ505428A (pt)
PL (1) PL187635B1 (pt)
PT (1) PT920438E (pt)
TR (2) TR199900377T2 (pt)
UA (1) UA62936C2 (pt)
WO (1) WO1998008855A2 (pt)

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EP1420021A1 (en) * 1999-05-25 2004-05-19 The Penn State Research Foundation DNA Methyltransferase inhibitors
US6180615B1 (en) * 1999-06-22 2001-01-30 Cv Therapeutics, Inc. Propargyl phenyl ether A2A receptor agonists
US6784165B1 (en) 1999-11-23 2004-08-31 Aderis Pharmaceuticals, Inc. Treatment of heart rhythm disturbances with N6-substituted-5′-(N-substituted) carboxamidoadenosines
AU4138601A (en) * 1999-12-03 2001-06-12 Cv Therapeutics, Inc. Method of identifying partial adenosine a1 receptor agonists and their use in the treatment of arrhythmias
US6605597B1 (en) * 1999-12-03 2003-08-12 Cv Therapeutics, Inc. Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives
US6258793B1 (en) * 1999-12-03 2001-07-10 Cv Therapeutics, Inc. N6 heterocyclic 5′ modified adenosine derivatives
US6294522B1 (en) * 1999-12-03 2001-09-25 Cv Therapeutics, Inc. N6 heterocyclic 8-modified adenosine derivatives
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US20050227933A1 (en) * 2001-11-29 2005-10-13 Benkovic Stephen J Treatment of bacterial induced diseases using DNA methyl transferase inhibitors
CN1325504C (zh) * 2002-01-10 2007-07-11 宾夕法尼亚州研究基金会 制备二芳基硼酸烷基酯和络合的二芳基硼酸的方法
MXPA04008008A (es) 2002-02-19 2005-03-23 Cv Therapeutics Inc Agonistas parciales y completos de receptores de adenosina a1.
EP1494685B1 (en) * 2002-04-18 2008-12-31 Cv Therapeutics, Inc. Method of treating arrhythmias comprising administration of an a1 adenosine agonist with a beta blocker
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NZ541651A (en) * 2003-02-03 2009-01-31 Cv Therapeutics Inc Partial and full agonists of A1 adenosine receptors
WO2004092173A2 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. A2a adenosine receptor antagonists
US7285550B2 (en) 2003-04-09 2007-10-23 Biogen Idec Ma Inc. Triazolotriazines and pyrazolotriazines and methods of making and using the same
US7674791B2 (en) 2003-04-09 2010-03-09 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
MXPA05011428A (es) * 2003-04-24 2006-05-31 Aderis Pharmaceuticals Inc Metodo de tratamiento de fibrilacion atrial o trepidacion auricular.
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US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
US6881851B1 (en) * 2004-04-21 2005-04-19 Eastman Chemical Company Preparation of tetrahydro-3-furoic acid
US7423144B2 (en) * 2004-05-26 2008-09-09 Inotek Pharmaceuticals Corporation Purine Derivatives as adenosine A1 receptor agonists and methods of use thereof
EP1802316B1 (en) * 2004-09-20 2011-11-02 Inotek Pharmaceuticals Corporation Purine derivatives and methods of use thereof
CN100451010C (zh) * 2004-12-21 2009-01-14 厦门大学 一种合成(r)-3-氨基四氢呋喃的方法
JP5042996B2 (ja) * 2005-05-19 2012-10-03 ギリアード・パロ・アルト・インコーポレイテッド Ａ１アデノシンレセプターアゴニスト
EP2218442A1 (en) 2005-11-09 2010-08-18 CombinatoRx, Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
CN100344768C (zh) * 2005-11-24 2007-10-24 东华大学 一种3－(s)－氨基四氢呋喃的酶法合成方法
AU2006320578B2 (en) * 2005-11-30 2013-01-31 Inotek Pharmaceuticals Corporation Purine derivatives and methods of use thereof
CN104975020B (zh) 2008-02-11 2020-01-17 菲奥医药公司 经修饰的RNAi多核苷酸及其用途
WO2010008582A2 (en) 2008-07-18 2010-01-21 Rxi Pharmaceuticals Corporation Phagocytic cell drug delivery system
JP6209309B2 (ja) 2008-09-22 2017-10-04 アールエックスアイ ファーマシューティカルズ コーポレーション サイズが減少した自己送達用ＲＮＡｉ化合物
US9074211B2 (en) 2008-11-19 2015-07-07 Rxi Pharmaceuticals Corporation Inhibition of MAP4K4 through RNAI
US9493774B2 (en) 2009-01-05 2016-11-15 Rxi Pharmaceuticals Corporation Inhibition of PCSK9 through RNAi
WO2010090762A1 (en) 2009-02-04 2010-08-12 Rxi Pharmaceuticals Corporation Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
CN102711771B (zh) 2010-01-11 2016-05-18 伊诺泰克制药公司 降低眼压的组合、试剂盒和方法
EP3578183B1 (en) 2010-03-24 2021-09-08 Phio Pharmaceuticals Corp. Rna interference in ocular indications
US9340786B2 (en) 2010-03-24 2016-05-17 Rxi Pharmaceuticals Corporation RNA interference in dermal and fibrotic indications
RU2615143C2 (ru) 2010-03-24 2017-04-04 Адвирна Самодоставляющие PHKi соединения уменьшенного размера
CN102933593A (zh) 2010-03-26 2013-02-13 伊诺泰克制药公司 使用n6-环戊基腺苷（cpa）、cpa衍生物或其前药降低人眼内压的方法
DE102011005232A1 (de) 2011-03-08 2012-09-13 AristoCon GmbH & Co. KG Adenosin und seine Derivate zur Verwendung in der Schmerztherapie
EA027109B1 (ru) 2012-01-26 2017-06-30 Инотек Фармасьютикалс Корпорейшн Безводные полиморфы [(2r,3s,4r,5r)-5-(6-(циклопентиламино)-9h-пурин-9-ил)-3,4-дигидрокситетрагидрофуран-2-ил]метилнитрата и способы их получения
MX2015013234A (es) 2013-03-15 2016-04-15 Inotek Pharmaceuticals Corp Formulaciones oftalmicas.
US10934550B2 (en) 2013-12-02 2021-03-02 Phio Pharmaceuticals Corp. Immunotherapy of cancer
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CA2947270A1 (en) 2014-04-28 2015-11-05 Rxi Pharmaceuticals Corporation Methods for treating cancer using nucleic acids targeting mdm2 or mycn
US20170051290A1 (en) 2014-05-01 2017-02-23 Rxi Pharmaceuticals Corporation Methods for treatment of disorders in the front of the eye utilizing nucleic acid molecules
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WO2017007825A1 (en) 2015-07-06 2017-01-12 Rxi Pharmaceuticals Corporation Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
CA3002744A1 (en) 2015-10-19 2017-04-27 Rxi Pharmaceuticals Corporation Reduced size self-delivering nucleic acid compounds targeting long non-coding rna
CN105218490B (zh) * 2015-11-10 2017-05-03 山东川成医药股份有限公司 一种（r）‑3‑氨基四氢呋喃的制备方法
US20230002766A1 (en) 2019-11-08 2023-01-05 Phio Pharmaceuticals Corp. Chemically modified oligonucleotides targeting bromodomain containing protein 4 (brd4) for immunotherapy
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WO2023015264A1 (en) 2021-08-04 2023-02-09 Phio Pharmaceuticals Corp. Immunotherapy of cancer utilizing natural killer cells treated with chemically modified oligonucleotides
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EP0062921A1 (en) * 1981-04-15 1982-10-20 Fujisawa Pharmaceutical Co., Ltd. Adenosine derivatives
EP0402752A1 (en) * 1989-06-09 1990-12-19 Hoechst-Roussel Pharmaceuticals Incorporated N-heteroaryl-purin-6-amines, a process for their preparation and their use as medicaments
WO1993008206A1 (en) * 1991-10-24 1993-04-29 Novo Nordisk A/S Novel 2,6-disubstituted purine derivatives

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EP0402752A1 (en) * 1989-06-09 1990-12-19 Hoechst-Roussel Pharmaceuticals Incorporated N-heteroaryl-purin-6-amines, a process for their preparation and their use as medicaments
WO1993008206A1 (en) * 1991-10-24 1993-04-29 Novo Nordisk A/S Novel 2,6-disubstituted purine derivatives

Also Published As

Publication number Publication date
PL187635B1 (pl) 2004-08-31
CA2264155A1 (en) 1998-03-05
ES2157593T3 (es) 2001-08-16
EP1081155A3 (en) 2003-05-02
NO990787L (no) 1999-02-19
DE69705312D1 (de) 2001-07-26
HK1020967A1 (en) 2000-05-26
AU4080997A (en) 1998-03-19
NZ505428A (en) 2005-03-24
NO990787D0 (no) 1999-02-19
HU226057B1 (en) 2008-04-28
NO20020758D0 (no) 2002-02-15
JP3157842B2 (ja) 2001-04-16
PL331853A1 (en) 1999-08-16
EP1081155A2 (en) 2001-03-07
EP0992510A1 (en) 2000-04-12
CZ61499A3 (cs) 1999-10-13
US5789416A (en) 1998-08-04
ATE202361T1 (de) 2001-07-15
TR199900377T2 (xx) 1999-05-21
CN1234803A (zh) 1999-11-10
KR100331775B1 (ko) 2002-04-09
ATE234323T1 (de) 2003-03-15
WO1998008855A2 (en) 1998-03-05
WO1998008855A3 (en) 1998-09-03
DE69719816T2 (de) 2003-12-18
EP0920438B1 (en) 2001-06-20
NO20020759L (no) 1999-02-19
DE69719816D1 (de) 2003-04-17
NO20020759D0 (no) 2002-02-15
NO312679B1 (no) 2002-06-17
NO20020758L (no) 1999-02-19
GEP20012419B (en) 2001-04-25
DK0992510T3 (da) 2003-07-07
GR3036332T3 (en) 2001-11-30
CA2264155C (en) 2003-11-18
US5789416B1 (en) 1999-10-05
HUP0001640A3 (en) 2002-04-29
IL128652A (en) 2008-06-05
UA62936C2 (en) 2004-01-15
PT920438E (pt) 2001-10-30
ES2189330T3 (es) 2003-07-01
NZ334095A (en) 2000-10-27
CZ296855B6 (cs) 2006-07-12
DE69705312T2 (de) 2001-10-11
CN100363377C (zh) 2008-01-23
BR9711444A (pt) 2000-01-18
NZ512242A (en) 2004-01-30
DK0920438T3 (da) 2001-09-10
EP0920438A2 (en) 1999-06-09
HUP0001640A2 (hu) 2001-05-28
TR200202287T2 (tr) 2003-01-21
NO322459B1 (no) 2006-10-09
IL128652A0 (en) 2000-01-31
JP2000501426A (ja) 2000-02-08
KR20000035867A (ko) 2000-06-26
EP0992510B1 (en) 2003-03-12

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