AU656859B2 - Aryl group- or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-HIV agent - Google Patents

Aryl group- or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-HIV agent Download PDF

Info

Publication number
AU656859B2
AU656859B2 AU39815/93A AU3981593A AU656859B2 AU 656859 B2 AU656859 B2 AU 656859B2 AU 39815/93 A AU39815/93 A AU 39815/93A AU 3981593 A AU3981593 A AU 3981593A AU 656859 B2 AU656859 B2 AU 656859B2
Authority
AU
Australia
Prior art keywords
group
substituted
formula
ethyl
difluoromethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU39815/93A
Other languages
English (en)
Other versions
AU3981593A (en
Inventor
Tetsushi Katsube
Tomio Kimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ube Corp
Original Assignee
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ube Industries Ltd filed Critical Ube Industries Ltd
Publication of AU3981593A publication Critical patent/AU3981593A/en
Application granted granted Critical
Publication of AU656859B2 publication Critical patent/AU656859B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU39815/93A 1992-05-27 1993-05-26 Aryl group- or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-HIV agent Ceased AU656859B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15891292 1992-05-27
JP4-158912 1992-05-27

Publications (2)

Publication Number Publication Date
AU3981593A AU3981593A (en) 1993-12-02
AU656859B2 true AU656859B2 (en) 1995-02-16

Family

ID=15682065

Family Applications (1)

Application Number Title Priority Date Filing Date
AU39815/93A Ceased AU656859B2 (en) 1992-05-27 1993-05-26 Aryl group- or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-HIV agent

Country Status (18)

Country Link
US (2) US5519016A (cg-RX-API-DMAC10.html)
EP (1) EP0572259A1 (cg-RX-API-DMAC10.html)
KR (1) KR100266305B1 (cg-RX-API-DMAC10.html)
CN (1) CN1042936C (cg-RX-API-DMAC10.html)
AU (1) AU656859B2 (cg-RX-API-DMAC10.html)
CA (1) CA2096998A1 (cg-RX-API-DMAC10.html)
CZ (1) CZ99693A3 (cg-RX-API-DMAC10.html)
FI (1) FI932412L (cg-RX-API-DMAC10.html)
HU (1) HUT64051A (cg-RX-API-DMAC10.html)
ID (1) ID20476A (cg-RX-API-DMAC10.html)
IL (1) IL105806A (cg-RX-API-DMAC10.html)
MX (1) MX9303158A (cg-RX-API-DMAC10.html)
NO (1) NO304832B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ247720A (cg-RX-API-DMAC10.html)
PH (1) PH31078A (cg-RX-API-DMAC10.html)
RU (1) RU2124510C1 (cg-RX-API-DMAC10.html)
TW (1) TW234121B (cg-RX-API-DMAC10.html)
ZA (1) ZA933732B (cg-RX-API-DMAC10.html)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4329600A1 (de) * 1993-09-02 1995-03-09 Bayer Ag Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate
MX9700497A (es) * 1994-07-18 1997-04-30 Ube Industries Derivado de acido trifluorometilquinolinocarboxilico.
DE4425660A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 7-substituierte 1-[4-(1H-1,2,4-triazol-1-yl-methyl)phenyl] substituierte Chinoloncarbonsäuren
DE4425647A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Heterocyclyl-1-phenyl substituierte Chinoloncarbonsäuren
DE4425649A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Neue 1-[4-(Aminomethyl)phenyl] substituierte Chinoloncarbonsäuren
KR100417508B1 (ko) * 1994-11-24 2004-03-18 바실리어 파마슈티카 아게 신규한벤질피리미딘
US5620997A (en) * 1995-05-31 1997-04-15 Warner-Lambert Company Isothiazolones
KR100299430B1 (ko) * 1995-09-22 2001-09-06 기스케 와구나가, 구사이 요시히로 신규피리돈카르복실산유도체또는그염및이물질을유효성분으로하는항균제
US6001863A (en) * 1996-11-26 1999-12-14 Warner-Lambert Company Isothiazolones
JP4669607B2 (ja) 1997-09-15 2011-04-13 ザ プロクター アンド ギャンブル カンパニー 抗微生物キノロン類、その組成物およびその使用
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
DE19751948A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
WO2000009472A1 (en) * 1998-08-12 2000-02-24 Ihara Chemical Industry Co., Ltd. N-cyclopropyl-2-difluoromethoxy-3-halogenoanilines and intermediates for the preparation thereof
ES2216606T3 (es) * 1998-12-21 2004-10-16 Aventis Pharma S.A. Derivados de la benzo-1,8-naftiridina.
RU2299205C2 (ru) * 2000-02-09 2007-05-20 Дайити Фармасьютикал Ко., Лтд. Средство против кислотоустойчивых бактерий, содержащее пиридонкарбоновые кислоты в качестве активного компонента
US6514529B2 (en) 2000-03-22 2003-02-04 Pharmacia & Upjohn Company Oxazolidinone tablet formulation
MY127336A (en) * 2000-03-22 2006-11-30 Upjohn Co Container for linezolid iv solution
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
PE20020578A1 (es) 2000-10-10 2002-08-14 Upjohn Co Una composicion de antibiotico topico para el tratamiento de infecciones oculares
WO2002048143A2 (en) 2000-12-14 2002-06-20 The Procter & Gamble Company Antimicrobial 2-pyridones, their compositions and uses
AU2002230891B2 (en) 2000-12-14 2005-04-07 The Procter & Gamble Company Antimicrobial quinolones
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
EP1476135A1 (en) * 2002-02-22 2004-11-17 Pharmacia Corporation Ophthalmic formulation with gum system
JP2005521691A (ja) * 2002-02-22 2005-07-21 ファルマシア・コーポレーション シクロデキストリン化合物及び塩化セチルピリジニウムを含有する眼科用抗菌性薬物製剤
WO2003099815A1 (en) 2002-05-28 2003-12-04 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
SI1564210T1 (sl) * 2002-11-20 2010-01-29 Japan Tobacco Inc 4-oksokinolinske spojine in njihova uporaba kot inhibitorji HIV integraze
TW200510425A (en) * 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
DK1660495T3 (da) 2003-09-04 2007-11-05 Wockhardt Ltd Benzoquinolizin-2-carboxylsyreargininsalt,tetrahydrat
ES2232309B1 (es) * 2003-11-13 2006-08-01 Quimica Sintetica, S.A. Procedimiento simplificado para la obtencion de gatifloxacino.
DE602005023717D1 (de) * 2004-03-10 2010-11-04 Usa Chinolin-4-one als inhibitoren der retroviralen integrase zur behandlung von hiv, aids und aids-related complex (arc)
MY134672A (en) * 2004-05-20 2007-12-31 Japan Tobacco Inc Stable crystal of 4-oxoquinoline compound
WO2005113509A1 (en) * 2004-05-20 2005-12-01 Japan Tobacco Inc. Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor
KR100589429B1 (ko) 2004-08-31 2006-06-14 한국화학연구원 Ｎ-1 위치에 아미노피리딜기가 치환된 퀴놀론 유도체의 제조방법
US7732612B2 (en) * 2004-09-09 2010-06-08 Janssen Pharmaceutica, N.V. 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US20090156577A1 (en) * 2004-09-09 2009-06-18 Benjamin Davis 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
RU2349586C2 (ru) * 2004-09-17 2009-03-20 Сайлин Фармасьютикалз, Инк. Аналоги хинолона
US20060100215A1 (en) * 2004-11-11 2006-05-11 Bradbury Barton J 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents
WO2006074317A1 (en) * 2005-01-05 2006-07-13 Achillion Pharmaceuticals, Inc. 1-thia-2,4a-diaza-cyclopenta[b]naphthalene-3,4-diones and related compounds as anti-infective agents
US7199128B2 (en) * 2005-02-02 2007-04-03 Achillion Pharmaceuticals, Inc. 8-N-substituted-2H-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents
JP5142730B2 (ja) * 2005-02-16 2013-02-13 アキリオン ファーマシューティカルズ，インコーポレーテッド 抗感染薬としての新規なイソチアゾロキノロンおよび関連化合物
NZ566209A (en) * 2005-07-27 2011-03-31 Achillion Pharmaceuticals Inc 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents
JP4669040B2 (ja) * 2006-03-06 2011-04-13 日本たばこ産業株式会社 ４−オキソキノリン化合物の製造方法
HRP20110558T1 (hr) 2006-03-28 2011-09-30 Warner Chilcott Company Malatne soli i polimorfi od (3s, 5s)-7-[3-amino-5-metil-piperidinil]-1-ciklopropil-1, 4-dihidro-8-metoksi-4-okso-3-kinolinkarboksilne kiseline
CN101045724B (zh) * 2006-03-28 2011-08-17 宝洁公司 用于制备喹诺酮中间体的偶联方法
WO2007110836A1 (en) * 2006-03-28 2007-10-04 The Procter & Gamble Company A hydride reduction process for preparing quinolone intermediates
US7456279B2 (en) 2006-03-28 2008-11-25 The Procter & Gamble Company Coupling process for preparing quinolone intermediates
US20080318938A1 (en) * 2007-06-22 2008-12-25 Ryckman David M Methods for treating aberrant cell proliferation disorders
WO2009002838A1 (en) * 2007-06-22 2008-12-31 Cylene Pharmaceuticals, Inc. Methods for treating ophthalmic disorders
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
MX2010002667A (es) * 2007-09-11 2010-04-01 Activx Biosciences Inc Cianoaminoquinolonas y tetrazoloaminoquinolonas como inhibidores de gsk-3.
WO2009035684A1 (en) 2007-09-12 2009-03-19 Activx Biosciences, Inc. Spirocyclic aminoquinolones as gsk-3 inhibitors
WO2009049030A1 (en) * 2007-10-09 2009-04-16 Triton Biopharma, Llc Method to use compositions having antidepressant anxiolytic and other neurological activity and compositions of matter
US20100273787A1 (en) * 2007-11-15 2010-10-28 Robert Schwarcz Kynurenine-aminotransferase inhibitors
WO2009089263A2 (en) * 2008-01-07 2009-07-16 Ardea Biosciences Inc. Novel compositions and methods of use
MX2011010434A (es) * 2009-04-03 2012-01-20 Achillion Pharmaceuticals Inc Hidroxitienoquinolonas y compuestos relacionados como agentes antiinfecciosos.
KR20120025519A (ko) 2009-05-15 2012-03-15 레드엑스 파마 리미티드 산화환원 약물 유도체
CN116444491A (zh) * 2023-03-30 2023-07-18 浙江工业大学 一种喹诺酮类衍生物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0422485A2 (de) * 1989-10-12 1991-04-17 Bayer Ag Chinoloncarbonsäurederivate, Verfahren zu ihrer Herstellung sowie ihre Verwendung als antivirale Mittel
AU1887292A (en) * 1991-05-28 1993-01-08 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivative

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5097032A (en) * 1984-07-20 1992-03-17 Warner-Lambert Company Antibacterial agents - II
US5210193A (en) * 1986-01-17 1993-05-11 American Cyanamid Company Piperazine derivatives
US4840956A (en) * 1986-02-18 1989-06-20 Warner-Lambert Company Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
IT1197841B (it) * 1986-10-14 1988-12-06 Mediolanum Farmaceutici Srl Derivati pirido-benzotiazinici ad attivita' antibatterica ed a lunga durata di azione
JPH0751579B2 (ja) * 1987-11-07 1995-06-05 日本新薬株式会社 キノリンカルボン酸誘導体
WO1990013542A1 (en) * 1989-04-28 1990-11-15 Daiichi Pharmaceutical Co., Ltd. Anti-hiv drug
JPH0754830Y2 (ja) * 1990-01-24 1995-12-18 株式会社ユニシアジェックス 荷重センサ取付構造
KR920004385A (ko) * 1990-08-09 1992-03-27 와꾸나가 기스께 신규 삼환화합물 또는 그의 염, 이의 제조방법 및 이를 함유하는 항균제

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0422485A2 (de) * 1989-10-12 1991-04-17 Bayer Ag Chinoloncarbonsäurederivate, Verfahren zu ihrer Herstellung sowie ihre Verwendung als antivirale Mittel
AU1887292A (en) * 1991-05-28 1993-01-08 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivative

Also Published As

Publication number Publication date
IL105806A (en) 1998-02-22
NO931867L (no) 1993-11-29
NO931867D0 (no) 1993-05-24
KR100266305B1 (ko) 2000-09-15
AU3981593A (en) 1993-12-02
HUT64051A (en) 1993-11-29
IL105806A0 (en) 1993-09-22
PH31078A (en) 1998-02-05
FI932412A0 (fi) 1993-05-26
CN1042936C (zh) 1999-04-14
TW234121B (cg-RX-API-DMAC10.html) 1994-11-11
MX9303158A (es) 1994-04-29
RU2124510C1 (ru) 1999-01-10
US5688791A (en) 1997-11-18
CA2096998A1 (en) 1993-11-28
FI932412A7 (fi) 1993-11-28
CN1086515A (zh) 1994-05-11
CZ99693A3 (en) 1993-12-15
ID20476A (id) 1998-12-24
NZ247720A (en) 1994-09-27
ZA933732B (en) 1993-12-15
FI932412L (fi) 1993-11-28
KR930023360A (ko) 1993-12-18
EP0572259A1 (en) 1993-12-01
NO304832B1 (no) 1999-02-22
HU9301536D0 (en) 1993-09-28
US5519016A (en) 1996-05-21

Similar Documents

Publication Publication Date Title
AU656859B2 (en) Aryl group- or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-HIV agent
KR100219957B1 (ko) 피라졸로 피리딘 화합물 및 그 제조방법
US4576952A (en) Pyrazolopyridine derivatives and their use as anti-inflammatory and/or anti-allergic agents
EP0232328B1 (en) Zwitterionic bicyclic compounds and their salts, solvates, hydrates and esters
EP0290153A1 (en) Heterobicyclic quinolone derivatives
JPS60260579A (ja) プリン誘導体
DE69713255T2 (de) Pharmazeutische Pyridin-Derivate, ihre Herstellungsverfahren und Zwischenprodukte dafür
KR900003368B1 (ko) 신규한 인데노티아졸 유도체의 제조방법
JP2993316B2 (ja) アリール基又は複素芳香環基置換アミノキノロン誘導体及びエイズ治療剤
WO1996002512A1 (en) Trifluoromethylquinolinecarboxylic acid derivative
JP2930539B2 (ja) トリフルオロメチルキノリンカルボン酸誘導体
EP0244352B1 (en) Pyrido[4,3-d]pyrimidine derivatives
JPH01319487A (ja) イミダゾ［２，１−ｂ］ベンゾチアゾール誘導体及び該化合物を有効成分とする抗潰瘍剤
JP2000516206A (ja) 新規な化合物
EP0362299A1 (en) Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation
JP2875605B2 (ja) ３―エキソメチレンピロロ［２，１―ｂ］チアゾール誘導体
JPS6097984A (ja) セフエム誘導体、その製造方法および医薬組成物
US4720496A (en) Pyridotriazoloquinazolines and triazolopyridoquinazolines useful as antiallergics
NZ208968A (en) Propan-2-ol derivatives,a method for their preparation and pharmaceutical preparations which contain them
JPH01319488A (ja) テトラヒドロイミダゾ［２，１−ｂ］ベンゾチアゾール誘導体及び該化合物を有効成分とする抗潰瘍剤
JPH04244081A (ja) １，４−ジヒドロピリジン誘導体およびそれを有効成分とするアレルギー性または炎症性疾患治療剤
JPH09249568A (ja) トリフルオロメチルキノリンカルボン酸誘導体を含有する医薬組成物
EP0206623B1 (en) Pyridine derivatives
JPS61161283A (ja) 新規イミダゾピリジン及びイミダゾピリミジン誘導体並びにその製法

Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired