AU651637B2 - Indole derivatives - Google Patents

Indole derivatives

Info

Publication number
AU651637B2
AU651637B2 AU89504/91A AU8950491A AU651637B2 AU 651637 B2 AU651637 B2 AU 651637B2 AU 89504/91 A AU89504/91 A AU 89504/91A AU 8950491 A AU8950491 A AU 8950491A AU 651637 B2 AU651637 B2 AU 651637B2
Authority
AU
Australia
Prior art keywords
indole
alkyl
ylmethyl
aryl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired, expires
Application number
AU89504/91A
Other languages
English (en)
Other versions
AU8950491A (en
Inventor
John Eugene Macor
Martin James Wythes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24393510&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU651637(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of AU8950491A publication Critical patent/AU8950491A/en
Application granted granted Critical
Publication of AU651637B2 publication Critical patent/AU651637B2/en
Adjusted expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Electroluminescent Light Sources (AREA)
  • Lasers (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU89504/91A 1990-10-15 1991-10-08 Indole derivatives Expired AU651637B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59792890A 1990-10-15 1990-10-15
US597928 1990-10-15
PCT/US1991/007194 WO1992006973A1 (en) 1990-10-15 1991-10-08 Indole derivatives

Publications (2)

Publication Number Publication Date
AU8950491A AU8950491A (en) 1992-05-20
AU651637B2 true AU651637B2 (en) 1994-07-28

Family

ID=24393510

Family Applications (1)

Application Number Title Priority Date Filing Date
AU89504/91A Expired AU651637B2 (en) 1990-10-15 1991-10-08 Indole derivatives

Country Status (33)

Country Link
EP (1) EP0592438B1 (pt)
JP (2) JP2575272B2 (pt)
KR (1) KR0179053B1 (pt)
CN (1) CN1039322C (pt)
AT (1) ATE157361T1 (pt)
AU (1) AU651637B2 (pt)
BG (1) BG61975B1 (pt)
BR (2) BR9106978A (pt)
CA (1) CA2091562C (pt)
DE (3) DE9190141U1 (pt)
DK (1) DK0592438T5 (pt)
EG (1) EG20224A (pt)
ES (1) ES2104733T3 (pt)
FI (1) FI105812B (pt)
GR (1) GR3025087T3 (pt)
HU (2) HU225055B1 (pt)
IE (1) IE913555A1 (pt)
IL (3) IL99701A (pt)
LU (1) LU90902I2 (pt)
MX (1) MX9101606A (pt)
MY (1) MY111683A (pt)
NL (1) NL300070I2 (pt)
NO (3) NO305121B1 (pt)
NZ (2) NZ240217A (pt)
OA (1) OA09874A (pt)
PL (3) PL170330B1 (pt)
PT (1) PT99218B (pt)
RO (1) RO111767B1 (pt)
RU (1) RU2095360C1 (pt)
SG (1) SG54270A1 (pt)
WO (1) WO1992006973A1 (pt)
YU (1) YU48088B (pt)
ZA (1) ZA918156B (pt)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
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US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
DE69230803T2 (de) * 1991-11-25 2000-12-07 Pfizer Inc., New York 5-(hetero- oder carbocyclylamino)-indol derivate, deren herstellung und deren verwendung als 5-ht1 agonisten
TW288010B (pt) * 1992-03-05 1996-10-11 Pfizer
BR9306201A (pt) * 1992-04-07 1998-06-23 Pfizer Derivados de indol como agonistas 5-ht1
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
ATE148465T1 (de) * 1992-04-10 1997-02-15 Pfizer Acylaminoindolderivate als 5-ht1 agonisten
GB9208161D0 (en) * 1992-04-14 1992-05-27 Pfizer Ltd Indoles
GB9210400D0 (en) * 1992-05-15 1992-07-01 Merck Sharp & Dohme Therapeutic agents
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
TW251284B (pt) * 1992-11-02 1995-07-11 Pfizer
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
IT1271352B (it) * 1993-04-08 1997-05-27 Boehringer Ingelheim Italia Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale
ATE144773T1 (de) * 1993-04-22 1996-11-15 Pfizer Res & Dev Indol-derivate als 5-ht1-ähnliche antagonisten zur behandlung von migräne
AP486A (en) * 1993-04-27 1996-04-16 Pfizer Indole derivatives.
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
EP0716649B1 (en) * 1993-08-31 1998-09-09 Pfizer Inc. 5-arylindole derivatives
EP0775131A2 (de) * 1994-08-03 1997-05-28 ASTA Medica Aktiengesellschaft Indol-, indazol-, pyridopyrrol- und pyridopyrazol-derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender wirkung
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9420529D0 (en) * 1994-10-12 1994-11-30 Pfizer Ltd Indoles
CA2213241C (en) * 1994-10-12 2001-07-10 Pfizer Research And Development Company, N.V./S.A. Indole derivative for the treatment of migraine
AU726560B2 (en) * 1994-10-12 2000-11-09 Pfizer Research And Development Company, N.V./S.A. Use of indole derivatives for the treatment of various diseases
GB9424471D0 (en) * 1994-12-03 1995-01-18 Pfizer Ltd Treatment of emesis
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GB9510223D0 (en) * 1995-05-20 1995-07-19 Pfizer Ltd Therapeutic agent
US5945118A (en) * 1995-09-29 1999-08-31 Pfizer Inc Indole derivative for the treatment of migraine
GB9714383D0 (en) * 1997-07-08 1997-09-10 Pfizer Ltd Improved process
WO1999053956A1 (fr) * 1998-04-16 1999-10-28 Yamanouchi Pharmaceutical Co., Ltd. Remedes contre l'obesite
GB9816556D0 (en) * 1998-07-30 1998-09-30 Pfizer Ltd Therapy
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
GB9825988D0 (en) 1998-11-27 1999-01-20 Pfizer Ltd Indole derivatives
GB9922963D0 (en) * 1999-09-28 1999-12-01 Pfizer Ltd Polymorphic salt
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GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
CN1382123A (zh) * 1999-08-26 2002-11-27 藤泽药品工业株式会社 吲哚衍生物或其盐的制造方法
GB9923314D0 (en) * 1999-10-01 1999-12-08 Pfizer Ltd Acylation process
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GB0031094D0 (en) * 2000-12-20 2001-01-31 Pfizer Ltd New Process
US20030166704A1 (en) 2000-12-20 2003-09-04 Pfizer Inc. New process
US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
EP1419151B1 (en) 2001-08-15 2014-02-26 Pharmacia & Upjohn Company LLC Chrystals including a malic acid salt of n-[2-(diethylamino)ethyl] -5-[(5-fluoro-1,2-dihydro-2-oxo-3h-indole-3-ylidene)methyl] -2,4-dimethyl-1h-pyrrole-3-carboxamide, processes for its preparation and compositions thereof
US7132549B2 (en) 2003-05-30 2006-11-07 Pfizer Inc. Process
GB0312478D0 (en) * 2003-05-30 2003-07-09 Pfizer Ltd Improved process
WO2004112723A2 (en) 2003-06-20 2004-12-29 Ronald Aung-Din Tropical therapy for the treatment of migraines, muscle sprains, muscle spasm, spasticity and related conditions
ATE456557T1 (de) 2005-06-15 2010-02-15 Pfizer Ltd Substituierte arylpyrazole zur verwendung gegen parasiten
US7645786B2 (en) 2005-06-15 2010-01-12 Pfizer Inc. Substituted arylpyrazoles
WO2006079999A2 (en) * 2006-04-09 2006-08-03 Barth Frederik H Induction of a novel state of mind with a 5-ht2a agonist and a nmda antagonist
US20090299077A1 (en) * 2008-05-22 2009-12-03 Vinod Kumar Kansal Salts of (R)-5-(2phenylsulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole, 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indole and of eletriptan
US8592424B2 (en) 2008-06-30 2013-11-26 Afgin Pharma Llc Topical regional neuro-affective therapy
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IT1393700B1 (it) 2009-04-22 2012-05-08 F S I Fabbrica Italiana Sint Sintesi di 3-{[(2r)-1-metilpirrolidin-2-il]metil}-5-[2-(fenilsulfonil)etil]-1h-indolo
WO2011004391A2 (en) 2009-06-25 2011-01-13 Matrix Laboratories Ltd An improved process for the preparation of eletriptan and its salt thereof
WO2011024039A1 (en) * 2009-08-25 2011-03-03 Ramesh Babu Potluri Synthesis of novel 5-(2-(phenylsulfonyl)ethyl)-1h-indole derivatives
WO2011089614A1 (en) * 2010-01-19 2011-07-28 Sms Pharmaceuticals Limited PROCESS FOR PREPARING ELETRIPTAN HYDROBROMIDE HAVING α-FORM
CN102606426B (zh) * 2012-03-02 2014-05-21 王仲彦 踏步健身发电装置
WO2014063752A1 (en) 2012-10-26 2014-05-01 Synthon Bv Process for making crystalline form alpha of eletriptan hydrobromide
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN103408535B (zh) * 2013-08-13 2016-03-02 张家港威胜生物医药有限公司 一种依来曲普坦中间体-5-溴-3-(n-甲基吡咯啉-2-基甲基)-1h-吲哚合成工艺
EP3265081A4 (en) 2015-03-02 2018-11-21 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoids
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
JP2019502761A (ja) 2016-01-21 2019-01-31 ラボラトリオス レヴィ エセエレ （（ｒ）−３−［（−１−メチルピロリジン−２−イル）メチル］−５−（２−フェニルスルホニルエチル）−１ｈ−インドールを作製する方法
CN106065008B (zh) * 2016-06-16 2018-06-05 黑龙江中医药大学 一种具有改善睡眠作用的吲哚-2-酰胺类化合物及其应用
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
TR201616365A1 (tr) 2016-11-14 2018-05-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Deksketoprofen ve eletri̇ptanin oral farmasöti̇k kompozi̇syonlari
TR201619983A2 (tr) 2016-12-29 2018-07-23 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Di̇klofenak ve eletri̇ptanin farmasöti̇k formülasyonlari
KR102129947B1 (ko) 2018-06-08 2020-07-03 김종창 콘크리트 타설을 위한 입체형 와이어 메쉬
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan
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Citations (2)

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US2773875A (en) * 1952-03-28 1956-12-11 Hoffmann La Roche Indole derivatives and method for producing same
GB851780A (en) * 1958-02-25 1960-10-19 Rhone Poulenc Sa New indole derivatives

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GB851780A (en) * 1958-02-25 1960-10-19 Rhone Poulenc Sa New indole derivatives

Also Published As

Publication number Publication date
HU225055B1 (en) 2006-05-29
NO2001019I1 (no) 2001-12-03
MX9101606A (es) 1992-06-05
PT99218A (pt) 1992-09-30
EP0592438A1 (en) 1994-04-20
ES2104733T3 (es) 1997-10-16
NZ240217A (en) 1995-05-26
CN1062529A (zh) 1992-07-08
KR0179053B1 (ko) 1999-03-20
RU2095360C1 (ru) 1997-11-10
DE10299004I2 (de) 2006-03-16
OA09874A (en) 1994-09-15
CA2091562C (en) 2001-03-27
BG97632A (bg) 1994-03-31
PT99218B (pt) 1999-04-30
SG54270A1 (en) 1998-11-16
WO1992006973A1 (en) 1992-04-30
BG61975B1 (bg) 1998-11-30
AU8950491A (en) 1992-05-20
FI931667A0 (fi) 1993-04-14
NO931378L (no) 1993-04-14
RO111767B1 (ro) 1997-01-30
FI105812B (fi) 2000-10-13
JP2575272B2 (ja) 1997-01-22
ZA918156B (en) 1993-04-14
CN1039322C (zh) 1998-07-29
NL300070I1 (nl) 2002-02-01
DE10299004I1 (de) 2002-05-08
IL99701A (en) 1996-10-31
HUT64326A (en) 1993-12-28
YU48088B (sh) 1997-01-08
PL170330B1 (pl) 1996-11-29
LU90902I2 (fr) 2002-06-26
EG20224A (en) 1997-12-31
DE9190141U1 (de) 1993-07-15
BR9106978A (pt) 1993-09-28
HU9301098D0 (en) 1993-07-28
PL169987B1 (en) 1996-09-30
IL115117A0 (en) 1995-12-08
NO985607D0 (no) 1998-12-01
DE69127468D1 (de) 1997-10-02
FI931667A (fi) 1993-04-14
DK0592438T3 (da) 1997-09-29
JPH05507288A (ja) 1993-10-21
MY111683A (en) 2000-11-30
ATE157361T1 (de) 1997-09-15
IE913555A1 (en) 1992-04-22
DE69127468T2 (de) 1998-01-02
IL115117A (en) 1996-11-14
DK0592438T5 (da) 1999-12-06
BR1100080A (pt) 2000-06-06
YU165391A (sh) 1994-01-20
NO931378D0 (no) 1993-04-14
PL168919B1 (pl) 1996-05-31
CA2091562A1 (en) 1992-04-16
EP0592438B1 (en) 1997-08-27
IL99701A0 (en) 1992-08-18
NZ270675A (en) 1997-07-27
NO305121B1 (no) 1999-04-06
JP2677777B2 (ja) 1997-11-17
GR3025087T3 (en) 1998-01-30
NL300070I2 (nl) 2002-03-01
JPH093063A (ja) 1997-01-07
NO985607L (no) 1998-12-01

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Legal Events

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NDA Extension of term for standard patent accepted (sect.70)

Free format text: PRODUCT NAME: RELPAX ELETRIPTAN HYDROBROMIDE

Extension date: 20151013

NDB Extension of term for standard patent granted (sect.76)

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