AU613661B2 - Substituted 2-phenyl-4-quinolinecarboxylic acids - Google Patents

Substituted 2-phenyl-4-quinolinecarboxylic acids Download PDF

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Publication number
AU613661B2
AU613661B2 AU21678/88A AU2167888A AU613661B2 AU 613661 B2 AU613661 B2 AU 613661B2 AU 21678/88 A AU21678/88 A AU 21678/88A AU 2167888 A AU2167888 A AU 2167888A AU 613661 B2 AU613661 B2 AU 613661B2
Authority
AU
Australia
Prior art keywords
hydroxy
acid
phenyl
methyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU21678/88A
Other languages
English (en)
Other versions
AU2167888A (en
Inventor
Ralph Grassing Child
Dennis W Powell
Adolph E. Sloboda
Leslie H Sutherland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of AU2167888A publication Critical patent/AU2167888A/en
Application granted granted Critical
Publication of AU613661B2 publication Critical patent/AU613661B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU21678/88A 1987-08-31 1988-08-30 Substituted 2-phenyl-4-quinolinecarboxylic acids Ceased AU613661B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US090996 1987-08-31
US07/090,996 US4847381A (en) 1987-08-31 1987-08-31 2-Phenyl-4-quinoline carboxylic acids

Publications (2)

Publication Number Publication Date
AU2167888A AU2167888A (en) 1989-03-02
AU613661B2 true AU613661B2 (en) 1991-08-08

Family

ID=22225261

Family Applications (1)

Application Number Title Priority Date Filing Date
AU21678/88A Ceased AU613661B2 (en) 1987-08-31 1988-08-30 Substituted 2-phenyl-4-quinolinecarboxylic acids

Country Status (24)

Country Link
US (1) US4847381A (en, 2012)
EP (1) EP0305952B1 (en, 2012)
JP (1) JP2760379B2 (en, 2012)
KR (1) KR970005909B1 (en, 2012)
AR (1) AR245698A1 (en, 2012)
AT (1) ATE90079T1 (en, 2012)
AU (1) AU613661B2 (en, 2012)
CA (1) CA1333606C (en, 2012)
CS (1) CS274434B2 (en, 2012)
DD (1) DD282225A5 (en, 2012)
DE (1) DE3881456T2 (en, 2012)
DK (1) DK169473B1 (en, 2012)
ES (1) ES2058191T3 (en, 2012)
FI (1) FI92692C (en, 2012)
GR (1) GR3008033T3 (en, 2012)
HU (1) HU202498B (en, 2012)
IE (1) IE65148B1 (en, 2012)
IL (1) IL87457A (en, 2012)
NO (1) NO174961C (en, 2012)
NZ (1) NZ225924A (en, 2012)
PH (1) PH26258A (en, 2012)
PL (1) PL156232B1 (en, 2012)
PT (1) PT88365B (en, 2012)
ZA (1) ZA886443B (en, 2012)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968701A (en) * 1988-04-26 1990-11-06 E. I. Du Pont De Nemours And Company 4-Quinoline carboxylic acid derivatives useful as immunosuppressive agents
US4918077A (en) * 1989-01-25 1990-04-17 E. I. Du Pont De Nemours & Co., Inc. 3-phenyl-5,6-dihydrobenz(c)acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents
US5204329A (en) * 1990-06-11 1993-04-20 Du Pont Merck Pharmaceutical Company Treatment of organ transplantation rejection
US5135934A (en) * 1990-07-06 1992-08-04 Du Pont Merck Pharmaceutical Company 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents
US5409886A (en) * 1993-02-18 1995-04-25 Mitsui Toatsu Chemicals, Incorporated 3-pyrroline-2-one derivatives and herbicidal compositions containing same
US5428040A (en) * 1993-08-31 1995-06-27 The Du Pont Merck Pharmaceutical Company Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents
US5578609A (en) * 1994-03-25 1996-11-26 The Dupont Merck Pharmaceutical Company 2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof useful as immunosuppressive agents
ID18663A (id) * 1996-04-12 1998-04-30 Novartis Ag Komposisi farmasi berlapis enterik
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6207679B1 (en) 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto
HUP0003364A3 (en) 1997-06-19 2002-03-28 Sepracor Inc Marlborough Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6376670B1 (en) 1997-06-19 2002-04-23 Sepracor Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
AU2108099A (en) * 1998-01-30 1999-08-16 Procept, Inc. Immunosuppressive agents
SE9901366D0 (sv) * 1999-04-16 1999-04-16 Pharmacia & Upjohn Ab Injector device and method for its operation
US20020121638A1 (en) * 2000-06-30 2002-09-05 Vladimir Grushin Electroluminescent iridium compounds with fluorinated phenylpyridines, phenylpyrimidines, and phenylquinolines and devices made with such compounds
WO2009016812A1 (ja) * 2007-07-27 2009-02-05 Kowa Company, Ltd. ２－フェニルキノリン－４－カルボン酸誘導体を有効成分とする貧血の予防及び／又は治療剤
CN105916522A (zh) 2013-11-22 2016-08-31 建新公司 用于治疗神经变性疾病的新方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776290A (en) * 1957-01-01 Hydroxy cevchoninates and carboxylic
US2008923A (en) * 1931-07-09 1935-07-23 Graham Patmore L Cinchoninic acid salts of piperazines
US2077903A (en) * 1933-12-15 1937-04-20 Gen Aniline Works Inc Process of preparing 3-amino-quinolines
US2486440A (en) * 1946-01-10 1949-11-01 Gen Aniline & Film Corp Production of phenazonium dyestuff images
BE502610A (en, 2012) * 1950-04-18
US2888346A (en) * 1955-08-22 1959-05-26 Gen Aniline & Film Corp Ultra-violet absorbing compounds
DE1049701B (en, 2012) * 1957-02-21
FR6592M (en, 2012) * 1967-10-31 1968-12-30
BE794945A (fr) * 1972-02-04 1973-08-02 Sandoz Sa Application de derives de la quinoleine pour stabiliser des matieres organiques contre les effets de la lumiere ultraviolette
US4009020A (en) * 1975-05-06 1977-02-22 Amchem Products, Inc. Method of regulating plant growth
SU1109402A1 (ru) * 1982-10-12 1984-08-23 Предприятие П/Я Р-6496 Способ получени производных 2-(хинолил-4)-5-арилоксазола
ZA845594B (en) * 1983-07-22 1986-03-26 Du Pont Phenylquinolinecarboxylic acids and derivatives as antitumor agents
US4680299A (en) * 1984-04-30 1987-07-14 E.I. Du Pont De Nemours And Company 2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
DK169473B1 (da) 1994-11-07
IE65148B1 (en) 1995-10-04
EP0305952A1 (en) 1989-03-08
PH26258A (en) 1992-04-01
NO883865L (no) 1989-03-01
ATE90079T1 (de) 1993-06-15
AR245698A1 (es) 1994-02-28
IE882628L (en) 1989-02-28
FI92692B (fi) 1994-09-15
ZA886443B (en) 1989-04-26
DK482688A (da) 1989-03-01
DD282225A5 (de) 1990-09-05
NO174961B (no) 1994-05-02
FI883997L (fi) 1989-03-01
JPH01110673A (ja) 1989-04-27
JP2760379B2 (ja) 1998-05-28
PT88365B (pt) 1995-03-31
IL87457A0 (en) 1989-01-31
DE3881456D1 (de) 1993-07-08
NZ225924A (en) 1991-07-26
AU2167888A (en) 1989-03-02
KR890003703A (ko) 1989-04-17
FI92692C (fi) 1994-12-27
CS274434B2 (en) 1991-04-11
FI883997A0 (fi) 1988-08-30
CS587588A2 (en) 1990-06-13
PL274471A1 (en) 1989-05-02
US4847381A (en) 1989-07-11
CA1333606C (en) 1994-12-20
ES2058191T3 (es) 1994-11-01
DE3881456T2 (de) 1994-01-13
NO174961C (no) 1994-08-10
HU202498B (en) 1991-03-28
KR970005909B1 (ko) 1997-04-22
GR3008033T3 (en, 2012) 1993-09-30
PT88365A (pt) 1989-06-30
IL87457A (en) 1994-08-26
DK482688D0 (da) 1988-08-30
HUT48597A (en) 1989-06-28
PL156232B1 (en) 1992-02-28
NO883865D0 (no) 1988-08-30
EP0305952B1 (en) 1993-06-02

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Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired