AU599091B2 - Expression and purification of an htlv-iii gag/env gene protein - Google Patents

Expression and purification of an htlv-iii gag/env gene protein

Info

Publication number
AU599091B2
AU599091B2 AU71032/87A AU7103287A AU599091B2 AU 599091 B2 AU599091 B2 AU 599091B2 AU 71032/87 A AU71032/87 A AU 71032/87A AU 7103287 A AU7103287 A AU 7103287A AU 599091 B2 AU599091 B2 AU 599091B2
Authority
AU
Australia
Prior art keywords
leu
lys
protein
gin
arg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU71032/87A
Other languages
English (en)
Other versions
AU7103287A (en
Inventor
Robert Mitchell Crowl
Daru Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU7103287A publication Critical patent/AU7103287A/en
Application granted granted Critical
Publication of AU599091B2 publication Critical patent/AU599091B2/en
Assigned to F. HOFFMANN-LA ROCHE AG reassignment F. HOFFMANN-LA ROCHE AG Alteration of Name(s) in Register under S187 Assignors: F. HOFFMANN-LA ROCHE AG
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
    • C12N2740/14022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/974—Aids related test
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • AIDS & HIV (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU71032/87A 1986-04-04 1987-04-03 Expression and purification of an htlv-iii gag/env gene protein Ceased AU599091B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US848671 1986-04-04
US06/848,671 US4925784A (en) 1986-04-04 1986-04-04 Expression and purification of an HTLV-III gag/env gene protein

Publications (2)

Publication Number Publication Date
AU7103287A AU7103287A (en) 1987-10-08
AU599091B2 true AU599091B2 (en) 1990-07-12

Family

ID=25303966

Family Applications (1)

Application Number Title Priority Date Filing Date
AU71032/87A Ceased AU599091B2 (en) 1986-04-04 1987-04-03 Expression and purification of an htlv-iii gag/env gene protein

Country Status (23)

Country Link
US (1) US4925784A (show.php)
JP (1) JP2625118B2 (show.php)
KR (1) KR930001118B1 (show.php)
AT (1) AT400442B (show.php)
AU (1) AU599091B2 (show.php)
BE (1) BE1001973A5 (show.php)
BR (1) BR8701528A (show.php)
CA (1) CA1341249C (show.php)
CH (1) CH676004A5 (show.php)
DE (3) DE3744825C2 (show.php)
DK (1) DK172274B1 (show.php)
ES (3) ES2004133A6 (show.php)
FR (1) FR2606422B1 (show.php)
GB (1) GB2188639B (show.php)
IL (1) IL82088A (show.php)
IT (1) IT1203851B (show.php)
NL (1) NL192275C (show.php)
NO (1) NO871409L (show.php)
NZ (1) NZ219837A (show.php)
SE (1) SE8701413L (show.php)
SG (1) SG102792G (show.php)
SU (1) SU1644720A3 (show.php)
ZA (1) ZA871724B (show.php)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9309574B1 (en) 1984-08-22 2016-04-12 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Molecular cloning of HIV-1 from immortalized cell lines
ES2054616T3 (es) * 1985-12-17 1994-08-16 Akzo Nv Reactivo inmunoquimico.
JPS62502868A (ja) * 1985-12-24 1987-11-19 アメリカ合衆国 ヒトｔリンパ球指向性ウイルスタイプ３のプラスミド及びファ−ジクロ−ン
US4925784A (en) * 1986-04-04 1990-05-15 Hoffmann-La Roche Inc. Expression and purification of an HTLV-III gag/env gene protein
US4983387A (en) * 1986-05-19 1991-01-08 Viral Technologies Inc. HIV related peptides, immunogenic antigens, and use therefor as subunit vaccine for AIDS virus
US5142025A (en) * 1986-08-01 1992-08-25 Repligen Corporation Recombinant HTLV-III proteins and uses thereof
US5166050A (en) * 1986-08-20 1992-11-24 Bristol-Myers Squibb Company Monoclonal antibodies and peptides useful in treating and diagnosing HIV infections
NZ221440A (en) * 1986-08-20 1991-11-26 Genetic Systems Corp Composition containing monoclonal antibodies/peptides useful in treating and diagnosing hiv infections
US5041385A (en) * 1986-11-01 1991-08-20 Oxford Gene Systems Limited Vector expressing fusion proteins and particles
WO1988007375A1 (en) * 1987-03-23 1988-10-06 Hiver Limited Novel vaccines
IE63455B1 (en) * 1987-09-04 1995-04-19 Int Murex Tech Corp Immunoassay and biological constructs for use therein
NO881501L (no) * 1987-10-09 1989-04-10 Repligen Corp Rekombinante htlv-111-proteiner og anvendelser av disse.
EP0311228A3 (en) * 1987-10-09 1990-05-02 Repligen Corporation Recombinant polypeptides and their uses, including assay for aids virus
US5780038A (en) * 1987-11-16 1998-07-14 Roche Diagnostic Systems, Inc. HIV-2 envelope polypeptides
EP0316695B1 (de) * 1987-11-16 1993-03-31 F. Hoffmann-La Roche Ag Rekombinante HIV-2 Polypeptide
JPH01179687A (ja) * 1987-12-30 1989-07-17 Chemo Sero Therapeut Res Inst Ｈｉｖ融合蛋白質
JP2559482B2 (ja) * 1988-01-12 1996-12-04 ジーンラブズ テクノロジーズ，インコーポレイテッド Ｈｔｌｖーｉペプチド抗原および分析法
DE68917520T2 (de) * 1988-05-06 1995-01-05 Ferropas Ag Verfahren und Systeme zur Herstellung von HIV-Antigenen.
US5204259A (en) * 1988-05-06 1993-04-20 Pharmacia Genetic Engineering, Inc. Methods and systems for producing HIV antigens
FR2632310B1 (fr) * 1988-06-06 1992-04-10 Pasteur Institut Peptides ayant des proprietes protectrices d'un virus pathogene du type hiv dans des cellules sensibles
US6197496B1 (en) 1988-06-09 2001-03-06 Institut Pasteur Immunological reagents and diagnostic methods for the detection of human immunodeficiency virus type 2 utilizing multimeric forms of the envelope proteins gp300, p200, and p90/80
CA2003383A1 (en) 1988-11-23 1990-05-23 Sushil G. Devare Synthetic dna derived recombinant hiv antigens
US5817318A (en) * 1989-05-03 1998-10-06 Connaught Laboratories Limited Synthetic peptides for an HIV-1 vaccine
GB8923123D0 (en) * 1989-10-13 1989-11-29 Connaught Lab A vaccine for human immunodeficiency virus
ATE183235T1 (de) * 1990-03-21 1999-08-15 Wolf Hans Joachim Prof Dr Für abgeänderte retrovirale gag-polypeptide kodierende dna-sequenzen und diese enthaltende impfstoffe oder aggregate davon
US6228608B1 (en) 1991-02-28 2001-05-08 Aquila Biopharmaceuticals, Inc. Recombinant FIV glycoprotein 160 and P24 gag protein
EP0600018B1 (en) * 1991-08-21 2001-07-11 Abbott Laboratories Hepatitis c assay utilizing recombinant antigens to c-100 region
GB9208218D0 (en) * 1992-04-14 1992-05-27 British Bio Technology Hybrid particles
CA2084386C (en) * 1992-06-04 2001-02-20 Atsushi Saito Hiv antigen
US5580773A (en) * 1992-06-17 1996-12-03 Korea Green Cross Corporation Chimeric immunogenic gag-V3 virus-like particles of the human immunodeficiency virus (HIV)
KR0172970B1 (ko) * 1992-06-17 1999-02-01 김영길 Aids백신에 유용한 키메릭 단백 및 그의 제조방법
ATE243755T1 (de) * 1992-08-07 2003-07-15 Wyeth Corp Rekombinente adenoviren-impfstoffe
AU693098B2 (en) * 1993-06-09 1998-06-25 Connaught Laboratories Limited Tandem synthetic HIV-1 peptides
DK0638316T3 (da) * 1993-08-11 2003-09-22 Wyeth Corp Rekombinante adenovirusvacciner
WO1995016040A2 (en) * 1993-12-10 1995-06-15 The Canadian Red Cross Society Immunofluorescence assay for the detection of antibodies using recombinant antigens in insoluble form
DE4405810A1 (de) 1994-02-23 1995-08-24 Behringwerke Ag Von einem Retrovirus aus der HIV-Gruppe abgeleitete Peptide und deren Verwendung
WO1995032000A1 (en) * 1994-05-20 1995-11-30 Microgenesys, Inc. Hiv polyprotein immunogens
FR2726576B1 (fr) * 1994-11-07 1997-01-31 Pf Medicament Production de peptides analogues de peptides hydrophobes, peptide recombinant, sequence d'adn correspondante
RU2126048C1 (ru) * 1997-01-28 1999-02-10 Институт молекулярной генетики РАН Способ определения генетической устойчивости обследуемых к инфицированию вирусом иммунодефицита человека первого типа (вич-1)
US6846905B2 (en) 1997-08-15 2005-01-25 Abbott Laboratories Antigen constructs useful in the detection and differentiation of antibodies to HIV
NO311807B1 (no) 1999-03-04 2002-01-28 Bionor Immuno As HIV-peptider, antigener, vaksinepreparater, immunoassay- testsett og en metode for påvisning av antistoffer fremkalt av HIV
DE10106295C1 (de) * 2001-02-02 2002-08-22 Gaifar German American Inst Fo Protein mit mehreren Antigen-Epitop-Sequenzen, welches immobilisiert ist
US20150174235A1 (en) 2012-06-06 2015-06-25 Bionor Immuno As Vaccine
EP3166633A1 (en) 2014-07-11 2017-05-17 Bionor Immuno AS Method for reducing and/or delaying pathological effects of human immunodeficiency virus i (hiv) or for reducing the risk of developing acquired immunodeficiency syndrome (aids)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2188639A (en) * 1986-04-04 1987-10-07 Hoffmann La Roche Expression and purification of an HTLV-111 GAG/ENV gene protein

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237224A (en) * 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
DE2814039C3 (de) * 1978-03-31 1981-02-19 Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig Verfahren zur Herstellung von Hybrid-Bakterien
GB8423659D0 (en) * 1984-09-19 1984-10-24 Pasteur Institut Cloned dna sequences
GB8324800D0 (en) * 1983-09-15 1983-10-19 Pasteur Institut Antigens
NZ228756A (en) * 1984-04-23 1990-10-26 Us Health Detection of hiv antigen using competition immune assay or western blot assay
WO1986000930A1 (en) * 1984-07-20 1986-02-13 Worcester Foundation For Experimental Biology Retroviral vaccines and vectors and methods for their construction
IL76082A (en) * 1984-08-22 1991-07-18 Us Health Molecular clones of the genome of htlv-iii and a process for the preparation thereof
CA1340878C (en) * 1984-10-26 2000-01-25 Takis S. Papas Production of human t-cell leukemia (lymphotropic) retrovirus (htlv-i) envelope protein fragments in bacteria and use in seroepidemiological survey of human lymphoid malignancies
CA1341482C (en) * 1984-10-31 2005-05-10 Paul A. Luciw Process for preparing fragments of aids-associated retroviruses
ATE138100T1 (de) * 1984-12-24 1996-06-15 Genentech Inc Fusionen von aids-verwandten polypeptiden
US4774175A (en) * 1985-03-01 1988-09-27 Centocor, Inc. Immunochemical methods for the detection of antibody against HTLV-III
US4751180A (en) * 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
ATE109512T1 (de) * 1985-04-08 1994-08-15 Genetic Systems Corp Expression und diagnose mit gag-kodierten peptiden, die mit antikörpern gegen lav immunologisch reaktiv sind.
NZ215867A (en) * 1985-04-19 1989-10-27 Hoffmann La Roche Aids envelope protein, dna vectors and method of production
KR910002374B1 (ko) * 1985-04-29 1991-04-20 제네틱 시스템즈 코포레이션 Aids 관련질병의 검출을 위한 합성항원
AU6170486A (en) * 1985-08-23 1987-02-26 Advanced Genetics Research Institute Defective viral vaccines
JP2564268B2 (ja) * 1985-08-28 1996-12-18 協和醗酵工業株式会社 融合抗原ポリペプチド
JP2702911B2 (ja) * 1985-09-11 1998-01-26 ユナイテツド・バイオメデイカル・インコ−ポレ−テツド 合成ペプチド、並びにそれを用いたエイズおよびプリ・エイズの検出方法
NZ217645A (en) * 1985-09-25 1991-11-26 Oncogen Recombinant viruses expressing lav/htlv-iii related epitopes and vaccine formulations
GB8525615D0 (en) * 1985-10-17 1985-11-20 Hoffmann La Roche Polypeptides
EP0245362B1 (en) * 1985-10-24 1994-06-29 Ronald C. Kennedy Synthetic peptides and use for diagnosis and vaccination for aids and arc
JPS62164696A (ja) * 1986-01-06 1987-07-21 エフ．ホフマン　―　ラ　ロシュ　アーゲー ＨＴＬＶ−３ｇａｇ遺伝子の発現
US4753873A (en) * 1986-02-03 1988-06-28 Cambridge Bioscience Corporation Peptides for the diagnosis of HTLV-III antibodies, their preparation and use
US4734362A (en) * 1986-02-03 1988-03-29 Cambridge Bioscience Corporation Process for purifying recombinant proteins, and products thereof
US4808536A (en) * 1986-02-27 1989-02-28 Centocor, Inc. Immunochemical method for detection of antibody against HTLV-III core protein based upon recombinant HTLV-III gag gene encoded protein
GB8629116D0 (en) * 1986-12-05 1987-01-14 Hoffmann La Roche Env/gag polypeptides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2188639A (en) * 1986-04-04 1987-10-07 Hoffmann La Roche Expression and purification of an HTLV-111 GAG/ENV gene protein

Also Published As

Publication number Publication date
NO871409L (no) 1987-10-05
ES2016426A6 (es) 1990-11-01
BR8701528A (pt) 1988-01-19
ZA871724B (en) 1987-11-25
NL192275C (nl) 1997-04-03
AU7103287A (en) 1987-10-08
US4925784A (en) 1990-05-15
KR930001118B1 (ko) 1993-02-18
BE1001973A5 (fr) 1990-05-02
IT1203851B (it) 1989-02-23
DE3744825C2 (show.php) 1990-10-25
NL8700795A (nl) 1987-11-02
GB2188639A (en) 1987-10-07
DE3711016A1 (de) 1987-10-08
IT8719973A0 (it) 1987-04-03
JPS62244393A (ja) 1987-10-24
NZ219837A (en) 1990-09-26
FR2606422B1 (fr) 1991-01-04
SU1644720A3 (ru) 1991-04-23
DK172274B1 (da) 1998-02-16
DK166087D0 (da) 1987-04-01
KR870010189A (ko) 1987-11-30
NO871409D0 (no) 1987-04-03
SE8701413L (sv) 1987-10-05
CH676004A5 (show.php) 1990-11-30
DE3744827C2 (show.php) 1990-08-09
NL192275B (nl) 1996-12-02
ES2004133A6 (es) 1988-12-01
ES2009350A6 (es) 1989-09-16
IL82088A (en) 1991-11-21
JP2625118B2 (ja) 1997-07-02
DK166087A (da) 1987-10-05
FR2606422A1 (fr) 1988-05-13
AT400442B (de) 1995-12-27
IL82088A0 (en) 1987-10-30
SG102792G (en) 1993-01-29
GB8707971D0 (en) 1987-05-07
DE3711016C2 (show.php) 1990-08-02
CA1341249C (en) 2001-06-12
SE8701413D0 (sv) 1987-04-03
ATA82487A (de) 1995-05-15
GB2188639B (en) 1990-09-26

Similar Documents

Publication Publication Date Title
AU7103287A (en) Expression and purification of an htlv-iii gag/env gene protein
AU586758B2 (en) Purification of pichia-produced lipophilic proteins
AU7984287A (en) Proteins of aids envelope gene
ZA894137B (en) Expression of retrovirus gag protein eukaryotic cells
AU6713287A (en) Expression of htlv-iii gag-gene
AU7436987A (en) Immobilised enzyme electrodes
GB8715059D0 (en) Genetic modification of yeast
AU617088B2 (en) Peptides involved in the pathogenesis of hiv infection
DE3760912D1 (en) Retrovirus of the type hiv-2 capable of inducing aids, and the antigenic and nucleic acid components thereof
AU589868B2 (en) Viral inactivation and purification of active proteins
AU5553290A (en) Dissemination of hiv-1 infected cells
AU6979487A (en) Treatment of gases
AU3006789A (en) Expression of hiv binding proteins
AU6595986A (en) Aids virus gene expression
AU594519B2 (en) Electrochemical removal of chromium from chlorate solutions
AU604793B2 (en) Env/gag-polypeptides
AU586355B2 (en) Purification process of tpa
AU3836489A (en) Treatment of immunodeficiency
AU569826B2 (en) Treatment of gases
AU7811787A (en) Purification of deacetoxycephalosporin C synthetase and process therefor
AU7993087A (en) Protein purification
AU1668988A (en) Purification of tpa
AU1792788A (en) Rubradirin derivatives for treatment of hiv infection
AU3864489A (en) Novel protein and coding sequence for detection and differentiation of siv and hiv-2 group of viruses
IE882454L (en) Novel hiv proteins and peptides useful for diagnosis or¹treatment of aids

Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired