BE1001973A5 - Expression et purification d'une proteine du gene htlv-iii gag/env. - Google Patents
Expression et purification d'une proteine du gene htlv-iii gag/env. Download PDFInfo
- Publication number
- BE1001973A5 BE1001973A5 BE8700350A BE8700350A BE1001973A5 BE 1001973 A5 BE1001973 A5 BE 1001973A5 BE 8700350 A BE8700350 A BE 8700350A BE 8700350 A BE8700350 A BE 8700350A BE 1001973 A5 BE1001973 A5 BE 1001973A5
- Authority
- BE
- Belgium
- Prior art keywords
- protein
- htlv
- expression
- gag
- iii
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108700004025 env Genes Proteins 0.000 title 1
- 101150030339 env gene Proteins 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 208000030507 AIDS Diseases 0.000 abstract 2
- 101710177291 Gag polyprotein Proteins 0.000 abstract 2
- 102100034353 Integrase Human genes 0.000 abstract 2
- 101710125418 Major capsid protein Proteins 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 2
- 108010078428 env Gene Products Proteins 0.000 abstract 2
- 101710091045 Envelope protein Proteins 0.000 abstract 1
- 102100034349 Integrase Human genes 0.000 abstract 1
- 101710188315 Protein X Proteins 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/702—Specific hybridization probes for retroviruses
- C12Q1/703—Viruses associated with AIDS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
- C12N2740/14022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/974—Aids related test
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- AIDS & HIV (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Méthodes et compositions pour le clonage et l'expression de plasmides portant des gènes codant pour une nouvelle protéine dérivée de HTLV-III. Cette protéine, qui est appelée protéine gag/env et qui contient des déterminants antigéniques à la fois des protéines de la particule centrale et de l'enveloppe du HTLV-III, peut être purifiée jusqu'à l'état homogène et utilisée comme base pour des tests diagnostiques pour la détection de la présence d'anticorps dirigés contre les virus associés au SIDA ou des virus eux-mêmes dans les sérums humains et d'autres liquides biologiques. La protéine gag/env peut également être préparée pour être utilisée comme vaccin pour la protection contre le SIDA par immunisation préventive.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/848,671 US4925784A (en) | 1986-04-04 | 1986-04-04 | Expression and purification of an HTLV-III gag/env gene protein |
Publications (1)
Publication Number | Publication Date |
---|---|
BE1001973A5 true BE1001973A5 (fr) | 1990-05-02 |
Family
ID=25303966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE8700350A BE1001973A5 (fr) | 1986-04-04 | 1987-04-03 | Expression et purification d'une proteine du gene htlv-iii gag/env. |
Country Status (23)
Country | Link |
---|---|
US (1) | US4925784A (fr) |
JP (1) | JP2625118B2 (fr) |
KR (1) | KR930001118B1 (fr) |
AT (1) | AT400442B (fr) |
AU (1) | AU599091B2 (fr) |
BE (1) | BE1001973A5 (fr) |
BR (1) | BR8701528A (fr) |
CA (1) | CA1341249C (fr) |
CH (1) | CH676004A5 (fr) |
DE (3) | DE3744825C2 (fr) |
DK (1) | DK172274B1 (fr) |
ES (3) | ES2004133A6 (fr) |
FR (1) | FR2606422B1 (fr) |
GB (1) | GB2188639B (fr) |
IL (1) | IL82088A (fr) |
IT (1) | IT1203851B (fr) |
NL (1) | NL192275C (fr) |
NO (1) | NO871409L (fr) |
NZ (1) | NZ219837A (fr) |
SE (1) | SE8701413L (fr) |
SG (1) | SG102792G (fr) |
SU (1) | SU1644720A3 (fr) |
ZA (1) | ZA871724B (fr) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9309574B1 (en) | 1984-08-22 | 2016-04-12 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Molecular cloning of HIV-1 from immortalized cell lines |
DE3688051T2 (de) * | 1985-12-17 | 1993-06-24 | Akzo Nv | Immunochemisches reagenz. |
WO1987003908A1 (fr) * | 1985-12-24 | 1987-07-02 | United States Of America, Represented By The Unite | Clones de plasmides et de phages du virus lymphotrope des cellules t humaines de type iii |
US4925784A (en) * | 1986-04-04 | 1990-05-15 | Hoffmann-La Roche Inc. | Expression and purification of an HTLV-III gag/env gene protein |
US4983387A (en) * | 1986-05-19 | 1991-01-08 | Viral Technologies Inc. | HIV related peptides, immunogenic antigens, and use therefor as subunit vaccine for AIDS virus |
US5142025A (en) * | 1986-08-01 | 1992-08-25 | Repligen Corporation | Recombinant HTLV-III proteins and uses thereof |
US5166050A (en) * | 1986-08-20 | 1992-11-24 | Bristol-Myers Squibb Company | Monoclonal antibodies and peptides useful in treating and diagnosing HIV infections |
NZ221440A (en) * | 1986-08-20 | 1991-11-26 | Genetic Systems Corp | Composition containing monoclonal antibodies/peptides useful in treating and diagnosing hiv infections |
US5041385A (en) * | 1986-11-01 | 1991-08-20 | Oxford Gene Systems Limited | Vector expressing fusion proteins and particles |
EP0287226A1 (fr) * | 1987-03-23 | 1988-10-19 | Hiver Limited | Vaccin |
PT88416B (pt) * | 1987-09-04 | 1992-10-30 | Wellcome Found | Processo para determinacao imunologica de anticorpos e processo para a preparacao de uma proteina com capacidade de ligacao a anticorpos e de composicoes farmaceuticas que a contem |
NO881501L (no) * | 1987-10-09 | 1989-04-10 | Repligen Corp | Rekombinante htlv-111-proteiner og anvendelser av disse. |
EP0311228A3 (fr) * | 1987-10-09 | 1990-05-02 | Repligen Corporation | Polypeptides recombinants et leur utilisation, y compris un diagnostic pour le virus du SIDA |
DE3879881D1 (de) * | 1987-11-16 | 1993-05-06 | Hoffmann La Roche | Rekombinante hiv-2 polypeptide. |
US5780038A (en) * | 1987-11-16 | 1998-07-14 | Roche Diagnostic Systems, Inc. | HIV-2 envelope polypeptides |
JPH01179687A (ja) * | 1987-12-30 | 1989-07-17 | Chemo Sero Therapeut Res Inst | Hiv融合蛋白質 |
JP2559482B2 (ja) * | 1988-01-12 | 1996-12-04 | ジーンラブズ テクノロジーズ,インコーポレイテッド | Htlvーiペプチド抗原および分析法 |
EP0343132B1 (fr) * | 1988-05-06 | 1994-08-17 | Ferropas Ag | Procédés et méthodes de production d'antigènes HIV |
US5204259A (en) * | 1988-05-06 | 1993-04-20 | Pharmacia Genetic Engineering, Inc. | Methods and systems for producing HIV antigens |
FR2632310B1 (fr) * | 1988-06-06 | 1992-04-10 | Pasteur Institut | Peptides ayant des proprietes protectrices d'un virus pathogene du type hiv dans des cellules sensibles |
US6197496B1 (en) * | 1988-06-09 | 2001-03-06 | Institut Pasteur | Immunological reagents and diagnostic methods for the detection of human immunodeficiency virus type 2 utilizing multimeric forms of the envelope proteins gp300, p200, and p90/80 |
CA2003383A1 (fr) | 1988-11-23 | 1990-05-23 | Sushil G. Devare | Antigenes de hiv recombinants derives d'adn synthetique |
US5817318A (en) * | 1989-05-03 | 1998-10-06 | Connaught Laboratories Limited | Synthetic peptides for an HIV-1 vaccine |
GB8923123D0 (en) * | 1989-10-13 | 1989-11-29 | Connaught Lab | A vaccine for human immunodeficiency virus |
EP0449116B2 (fr) * | 1990-03-21 | 2004-08-25 | Geneart GmbH | Séquences d'ADN codant pour des polypeptides rétroviraux modifiés et vaccins les contenant ou aggrégats de ceux-ci |
US6228608B1 (en) | 1991-02-28 | 2001-05-08 | Aquila Biopharmaceuticals, Inc. | Recombinant FIV glycoprotein 160 and P24 gag protein |
WO1993004087A1 (fr) * | 1991-08-21 | 1993-03-04 | Abbott Laboratories | Depistage de l'hepatite c a l'aide d'antigenes recombines diriges contre la region c-100 |
GB9208218D0 (en) * | 1992-04-14 | 1992-05-27 | British Bio Technology | Hybrid particles |
DE69231705T2 (de) * | 1992-06-04 | 2001-10-18 | Univ Osaka Res Found | Gag-Env Fusion-Antigen aus HIV |
KR0172970B1 (ko) * | 1992-06-17 | 1999-02-01 | 김영길 | Aids백신에 유용한 키메릭 단백 및 그의 제조방법 |
US5580773A (en) * | 1992-06-17 | 1996-12-03 | Korea Green Cross Corporation | Chimeric immunogenic gag-V3 virus-like particles of the human immunodeficiency virus (HIV) |
DK0586076T3 (da) * | 1992-08-07 | 2003-10-20 | Wyeth Corp | Rekombinant adenovirus-vacciner |
CN1111540C (zh) * | 1993-06-09 | 2003-06-18 | 康诺特实验室有限公司 | 串联的合成hiv-1肽类 |
SG43029A1 (en) * | 1993-08-11 | 1997-10-17 | American Home Prod | Recombinant adenovirus vaccines |
US6025141A (en) * | 1993-12-10 | 2000-02-15 | The Canadian Red Cross Society | Immunofluorescence assay for the detection of antibodies using recombinant antigens in insoluble form |
DE4405810A1 (de) | 1994-02-23 | 1995-08-24 | Behringwerke Ag | Von einem Retrovirus aus der HIV-Gruppe abgeleitete Peptide und deren Verwendung |
WO1995032000A1 (fr) * | 1994-05-20 | 1995-11-30 | Microgenesys, Inc. | Immunogenes de polyproteines de vih |
FR2726576B1 (fr) * | 1994-11-07 | 1997-01-31 | Pf Medicament | Production de peptides analogues de peptides hydrophobes, peptide recombinant, sequence d'adn correspondante |
US6846905B2 (en) | 1997-08-15 | 2005-01-25 | Abbott Laboratories | Antigen constructs useful in the detection and differentiation of antibodies to HIV |
NO311807B1 (no) | 1999-03-04 | 2002-01-28 | Bionor Immuno As | HIV-peptider, antigener, vaksinepreparater, immunoassay- testsett og en metode for påvisning av antistoffer fremkalt av HIV |
DE10106295C1 (de) * | 2001-02-02 | 2002-08-22 | Gaifar German American Inst Fo | Protein mit mehreren Antigen-Epitop-Sequenzen, welches immobilisiert ist |
US10335482B2 (en) | 2012-06-06 | 2019-07-02 | Bionor Immuno As | Method of inducing an anti-HIV-1 immune response comprising administering a C5/TM-GP41 peptide dimer |
WO2016005508A1 (fr) | 2014-07-11 | 2016-01-14 | Bionor Immuno As | Procédé permettant de réduire et/ou de retarder les effets pathologiques du virus de l'immunodéficience humaine i (vih) ou de réduire le risque de développer le syndrome d'immunodéficience acquise (sida) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0270114A2 (fr) * | 1986-12-05 | 1988-06-08 | F. Hoffmann-La Roche Ag | Polypeptides ENV/GAG |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4237224A (en) * | 1974-11-04 | 1980-12-02 | Board Of Trustees Of The Leland Stanford Jr. University | Process for producing biologically functional molecular chimeras |
DE2814039C3 (de) * | 1978-03-31 | 1981-02-19 | Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig | Verfahren zur Herstellung von Hybrid-Bakterien |
GB8324800D0 (en) * | 1983-09-15 | 1983-10-19 | Pasteur Institut | Antigens |
GB8423659D0 (en) * | 1984-09-19 | 1984-10-24 | Pasteur Institut | Cloned dna sequences |
NZ228756A (en) * | 1984-04-23 | 1990-10-26 | Us Health | Detection of hiv antigen using competition immune assay or western blot assay |
EP0188574A1 (fr) * | 1984-07-20 | 1986-07-30 | Worcester Foundation For Experimental Biology | Vaccins et vecteurs retroviraux, et methodes pour leur construction |
IL76082A (en) * | 1984-08-22 | 1991-07-18 | Us Health | Molecular clones of the genome of htlv-iii and a process for the preparation thereof |
CA1340878C (fr) * | 1984-10-26 | 2000-01-25 | Takis S. Papas | Production bacterienne de fragments de proteine de l'enveloppe du retrovirus de la leucemie (lymphotropique) des cellules t de l'humain (htlu-i), que son usage dans le depisage seroepidemiologique de tumeurs malignes lymphatiques chez les humains |
CA1341482C (fr) * | 1984-10-31 | 2005-05-10 | Paul A. Luciw | Procede de preparation de fragments de retrovirus du groupe du sida |
DE3588134T2 (de) * | 1984-12-24 | 1997-03-20 | Genentech Inc | Fusionen von AIDS-verwandten Polypeptiden |
US4774175A (en) * | 1985-03-01 | 1988-09-27 | Centocor, Inc. | Immunochemical methods for the detection of antibody against HTLV-III |
US4751180A (en) * | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
GR860915B (en) * | 1985-04-08 | 1986-07-11 | Genetic Systems Corp | Expression and diagnostic use of gag encoded peptides which are immunologically reactive with antibodies to lav |
NZ215867A (en) * | 1985-04-19 | 1989-10-27 | Hoffmann La Roche | Aids envelope protein, dna vectors and method of production |
DE3650175T3 (de) * | 1985-04-29 | 2007-09-06 | Bio-Rad Laboratories, Inc., Hercules | Synthetische antigene zum nachweis von aids. |
EP0213894A3 (fr) * | 1985-08-23 | 1987-10-21 | Advanced Genetics Research Institute | Vaccins à particules virales imparfaites et méthodes d'utilisation |
JP2564268B2 (ja) * | 1985-08-28 | 1996-12-18 | 協和醗酵工業株式会社 | 融合抗原ポリペプチド |
JP2702911B2 (ja) * | 1985-09-11 | 1998-01-26 | ユナイテツド・バイオメデイカル・インコ−ポレ−テツド | 合成ペプチド、並びにそれを用いたエイズおよびプリ・エイズの検出方法 |
GR862412B (en) * | 1985-09-25 | 1987-01-23 | Oncogen | Vaccines and immuinoassays for acquired immune deficiency syndrome |
GB8525615D0 (en) * | 1985-10-17 | 1985-11-20 | Hoffmann La Roche | Polypeptides |
WO1987002775A1 (fr) * | 1985-10-24 | 1987-05-07 | Southwest Foundation For Biomedical Research | Peptides synthetiques et leur utilisation pour le diagnostic et la vaccination contre le sida et son complexe associe |
JPS62164696A (ja) * | 1986-01-06 | 1987-07-21 | エフ.ホフマン ― ラ ロシュ アーゲー | HTLV−3gag遺伝子の発現 |
US4734362A (en) * | 1986-02-03 | 1988-03-29 | Cambridge Bioscience Corporation | Process for purifying recombinant proteins, and products thereof |
US4753873A (en) * | 1986-02-03 | 1988-06-28 | Cambridge Bioscience Corporation | Peptides for the diagnosis of HTLV-III antibodies, their preparation and use |
US4808536A (en) * | 1986-02-27 | 1989-02-28 | Centocor, Inc. | Immunochemical method for detection of antibody against HTLV-III core protein based upon recombinant HTLV-III gag gene encoded protein |
US4925784A (en) * | 1986-04-04 | 1990-05-15 | Hoffmann-La Roche Inc. | Expression and purification of an HTLV-III gag/env gene protein |
-
1986
- 1986-04-04 US US06/848,671 patent/US4925784A/en not_active Expired - Lifetime
-
1987
- 1987-03-05 CH CH816/87A patent/CH676004A5/de not_active IP Right Cessation
- 1987-03-10 ZA ZA871724A patent/ZA871724B/xx unknown
- 1987-04-01 NZ NZ219837A patent/NZ219837A/xx unknown
- 1987-04-01 DK DK166087A patent/DK172274B1/da not_active IP Right Cessation
- 1987-04-01 CA CA000533563A patent/CA1341249C/fr not_active Expired - Fee Related
- 1987-04-02 FR FR878704625A patent/FR2606422B1/fr not_active Expired - Lifetime
- 1987-04-02 DE DE3744825A patent/DE3744825C2/de not_active Expired - Lifetime
- 1987-04-02 DE DE3744827A patent/DE3744827C2/de not_active Expired - Lifetime
- 1987-04-02 IL IL82088A patent/IL82088A/xx not_active IP Right Cessation
- 1987-04-02 DE DE19873711016 patent/DE3711016A1/de active Granted
- 1987-04-02 JP JP62082197A patent/JP2625118B2/ja not_active Expired - Lifetime
- 1987-04-03 AU AU71032/87A patent/AU599091B2/en not_active Ceased
- 1987-04-03 ES ES8700968A patent/ES2004133A6/es not_active Expired
- 1987-04-03 BE BE8700350A patent/BE1001973A5/fr not_active IP Right Cessation
- 1987-04-03 SE SE8701413A patent/SE8701413L/xx not_active Application Discontinuation
- 1987-04-03 AT AT0082487A patent/AT400442B/de not_active IP Right Cessation
- 1987-04-03 NL NL8700795A patent/NL192275C/nl not_active IP Right Cessation
- 1987-04-03 BR BR8701528A patent/BR8701528A/pt not_active Application Discontinuation
- 1987-04-03 NO NO871409A patent/NO871409L/no unknown
- 1987-04-03 SU SU874202330A patent/SU1644720A3/ru active
- 1987-04-03 IT IT19973/87A patent/IT1203851B/it active
- 1987-04-03 KR KR1019870003168A patent/KR930001118B1/ko not_active IP Right Cessation
- 1987-04-03 GB GB8707971A patent/GB2188639B/en not_active Expired - Lifetime
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1988
- 1988-10-14 ES ES8803113A patent/ES2016426A6/es not_active Expired - Fee Related
- 1988-10-14 ES ES8803112A patent/ES2009350A6/es not_active Expired
-
1992
- 1992-10-07 SG SG1027/92A patent/SG102792G/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0270114A2 (fr) * | 1986-12-05 | 1988-06-08 | F. Hoffmann-La Roche Ag | Polypeptides ENV/GAG |
Non-Patent Citations (2)
Title |
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ANALYTICAL BIOCHEMISTRY, vol. 161, no. 2, mars 1987, pages 370-379, Academic Press Inc.; R.L. SHOEMAN et al.: "Comparison of recombinant human immunodeficiency virus gag precursor and gag/env fusion proteins and a synthetic env peptide as diagnostic reagents" * |
BIO/TECHNOLOGY, vol. 4, no. 2, février 1986, pages 128-133; C.D. CABRADILLA et al.: "Serodiagnosis of antibodies to the human aids retrovirus with a bacterially synthesized ENV polypeptide" * |
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Date | Code | Title | Description |
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RE | Patent lapsed |
Effective date: 20030430 |