AU585561B2 - New peptide-aldehydes, process for the preparation thereof and pharmaceutical compositions containing the same - Google Patents

New peptide-aldehydes, process for the preparation thereof and pharmaceutical compositions containing the same

Info

Publication number
AU585561B2
AU585561B2 AU51553/85A AU5155385A AU585561B2 AU 585561 B2 AU585561 B2 AU 585561B2 AU 51553/85 A AU51553/85 A AU 51553/85A AU 5155385 A AU5155385 A AU 5155385A AU 585561 B2 AU585561 B2 AU 585561B2
Authority
AU
Australia
Prior art keywords
aldehydes
preparation
same
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU51553/85A
Other languages
English (en)
Other versions
AU5155385A (en
Inventor
Daniel Bagdy
Sandor Bajusz
Eva Barabas
Mariann Dioszegi
Zsuzsa Fittler
Gyula Horvath
Ferencz Jozsa
Erzsebet Szell
Eva Tomori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Hungary Pharmaceutical Marketing PLC
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of AU5155385A publication Critical patent/AU5155385A/en
Application granted granted Critical
Publication of AU585561B2 publication Critical patent/AU585561B2/en
Assigned to GYOGYSZERKUTATO INTEZET KFT reassignment GYOGYSZERKUTATO INTEZET KFT Alteration of Name(s) in Register under S187 Assignors: RICHTER GEDEON VEGYESZETI GYAR RT
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU51553/85A 1984-12-21 1985-12-20 New peptide-aldehydes, process for the preparation thereof and pharmaceutical compositions containing the same Ceased AU585561B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU4763/84 1984-12-21
HU844763A HU192646B (en) 1984-12-21 1984-12-21 Process for preparing new n-alkyl-peptide aldehydes

Publications (2)

Publication Number Publication Date
AU5155385A AU5155385A (en) 1986-06-26
AU585561B2 true AU585561B2 (en) 1989-06-22

Family

ID=10968854

Family Applications (1)

Application Number Title Priority Date Filing Date
AU51553/85A Ceased AU585561B2 (en) 1984-12-21 1985-12-20 New peptide-aldehydes, process for the preparation thereof and pharmaceutical compositions containing the same

Country Status (18)

Country Link
US (1) US4703036A (en, 2012)
EP (1) EP0185390B1 (en, 2012)
JP (1) JPH0680078B2 (en, 2012)
CN (1) CN1025738C (en, 2012)
AR (1) AR241710A1 (en, 2012)
AT (1) ATE68002T1 (en, 2012)
AU (1) AU585561B2 (en, 2012)
CA (1) CA1261547A (en, 2012)
DE (1) DE3584281D1 (en, 2012)
DK (1) DK171403B1 (en, 2012)
ES (1) ES8708237A1 (en, 2012)
FI (1) FI85980C (en, 2012)
GR (1) GR853121B (en, 2012)
HU (1) HU192646B (en, 2012)
IL (1) IL77416A (en, 2012)
PT (1) PT81746B (en, 2012)
SU (1) SU1384203A3 (en, 2012)
ZA (1) ZA859756B (en, 2012)

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GB2244994B (en) * 1990-06-12 1994-01-19 Richter Gedeon Vegyeszet Improved process for the preparation of tripeptide aldehydes
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US5430023A (en) * 1990-09-28 1995-07-04 Eli Lilly And Company Tripeptide antithrombotic agents
EP0503203A1 (en) * 1991-03-15 1992-09-16 Merrell Dow Pharmaceuticals Inc. Novel thrombin inhibitors
US5391705A (en) * 1991-03-15 1995-02-21 Merrell Dow Pharmaceuticals Inc. Polyfluorinated tripeptide thrombin inhibitors
CA2071621C (en) * 1991-06-19 1996-08-06 Ahihiko Hosoda Aldehyde derivatives
CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
US5252566A (en) * 1991-11-12 1993-10-12 Eli Lilly And Company Antithrombotic agents
ZA928581B (en) * 1991-11-12 1994-05-06 Lilly Co Eli Antithrombotic agents
US5416093A (en) * 1991-11-12 1995-05-16 Eli Lilly And Company Antithrombotic agents
AU663169B2 (en) * 1992-03-04 1995-09-28 Gyogyszerkutato Intezet Kft New anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for the preparation thereof
IL108031A0 (en) * 1992-12-22 1994-04-12 Procter & Gamble Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
US5455229A (en) * 1992-12-23 1995-10-03 Eli Lilly And Company Method for minimizing and containing ischemic and reperfusion injury
US5672582A (en) * 1993-04-30 1997-09-30 Merck & Co., Inc. Thrombin inhibitors
ATE227581T1 (de) * 1993-04-30 2002-11-15 Merck & Co Inc Thrombin-inhibitoren
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US5783563A (en) * 1993-06-03 1998-07-21 Astra Aktiebolag Method for treatment or prophylaxis of venous thrombosis
US6984627B1 (en) 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
US5436229A (en) * 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
US5488037A (en) * 1994-03-04 1996-01-30 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5484772A (en) * 1994-03-04 1996-01-16 Eli Lilly And Company Antithrombotic agents
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
AU701503B2 (en) * 1994-06-17 1999-01-28 Corvas International, Inc. Methods of synthesis of peptidyl argininals
DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US5514777A (en) * 1994-06-17 1996-05-07 Corvas International, Inc. Methods of synthesis of peptidyl argininals
SE9404196D0 (sv) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
US6025472A (en) * 1994-12-21 2000-02-15 Corvas International, Inc. N-substituted glycine derivatives as enzyme inhibitors
US5696231A (en) * 1994-12-21 1997-12-09 Corvas International, Inc. N-substituted glycine derivatives as enzyme inhibitors
AU708001B2 (en) * 1995-02-17 1999-07-29 Abbott Gmbh & Co. Kg Novel thrombin inhibitors
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
US6069232A (en) * 1995-10-02 2000-05-30 Hoechst Marion Roussel, Inc. Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
AR005245A1 (es) 1995-12-21 1999-04-28 Astrazeneca Ab Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion
DE19549118C2 (de) * 1995-12-29 2000-07-13 Thomas W Stief Hämostaseaktivierungs-Inhibitor und Verfahren zum Hemmen der Hämostaseaktivierung in Blut oder anderen biologischen Flüssigkeiten
DE19605039A1 (de) 1996-02-12 1997-08-14 Hoechst Ag Verfahren zur Herstellung von Oligopeptid-Aldehyden
US5739354A (en) * 1996-03-26 1998-04-14 Hoechst Marion Roussel, Inc. Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide
HU224315B1 (hu) * 1996-06-05 2005-07-28 Gyógyszerkutató Intézet Kft. Véralvadásgátló hatású peptidil-arginin-aldehid-származékok és a vegyületeket tartalmazó gyógyszerkészítmények
HU222199B1 (hu) * 1996-06-05 2003-05-28 Gyógyszerkutató Intézet Kft. Véralvadásgátló hatású peptid-aldehid-származékok és a vegyületeket tartalmazó gyógyszerkészítmények
SE9602263D0 (sv) * 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
US6165966A (en) * 1996-09-24 2000-12-26 The Procter & Gamble Company Liquid detergents containing proteolytic enzyme and protease inhibitors
JP2000506931A (ja) * 1996-09-24 2000-06-06 ザ、プロクター、エンド、ギャンブル、カンパニー タンパク質分解酵素とプロテアーゼインヒビターを含有した液体洗剤
BR9712114A (pt) 1996-09-24 1999-08-31 Procter & Gamble Composições detergente líquidas para lavanderia contendo enzima proteolítica e inibidores de protease.
US5798377A (en) * 1996-10-21 1998-08-25 Merck & Co., Inc. Thrombin inhibitors
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
WO1999037668A1 (de) 1998-01-26 1999-07-29 Basf Aktiengesellschaft Thrombininhibitoren
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
JP2002535250A (ja) 1999-01-13 2002-10-22 アストラゼネカ アクチボラグ 新規アミジノベンジルアミン誘導体およびトロンビン阻害物質としてのそれらの使用
AU3192500A (en) * 1999-03-16 2000-10-04 C & C Research Laboratories Substituted proline derivatives and medicinal compositions containing the same
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
AR035216A1 (es) 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
WO2002050056A1 (en) 2000-12-18 2002-06-27 Merck & Co., Inc. Benzylamine derivatives and their use as thrombin inhibitors
US6528503B2 (en) 2000-12-18 2003-03-04 Merck & Co., Inc. Thrombin inhibitors
JP2005504003A (ja) 2001-02-09 2005-02-10 メルク　エンド　カムパニー　インコーポレーテッド トロンビン阻害剤
AR034517A1 (es) * 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
CZ2004265A3 (cs) * 2001-08-21 2004-08-18 Ivaxáinstituteáforádrugáresearchźáltd Peptidové arginaly a způsoby léčby diseminované intravaskulární koagulace
US7084134B2 (en) * 2002-05-02 2006-08-01 Merk & Co., Inc. Thrombin inhibitors
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201661D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab New salts
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US7795205B2 (en) 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
TW200827336A (en) 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
WO2009068926A1 (en) 2007-11-30 2009-06-04 University Of Debrecen Use of urokinase type plasminogen activator inhibitors for the treatment of corneal disorders
ES2539504T3 (es) 2011-07-01 2015-07-01 Novozymes A/S Composición de subtilisina estabilizada
US20170121646A1 (en) 2014-07-03 2017-05-04 Novozymes A/S Improved Stabilization of Non-Protease Enzyme
CN107469379B (zh) * 2016-06-07 2020-03-06 中国科学院大连化学物理研究所 一种样品中残留水溶性有机溶剂的去除方法
MX2021015894A (es) 2019-07-01 2022-02-03 Basf Se Peptidos acetales para estabilizar enzimas.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3039384A (en) * 1983-07-12 1985-01-17 F. Hoffmann-La Roche Ag Peptides amides and aldehydes
AU544492B2 (en) * 1981-01-13 1985-05-30 Gyogyszerkutato Intezet Kft D-phenylalanyl-l-prolyl-l-arginine aldehyde sulfate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU177098B (en) * 1979-01-04 1981-07-28 Gyogyszerkutato Intezet Process for producing new peptidyl-n-carboxy-l-arginin-a
CA1161431A (en) * 1979-05-11 1984-01-31 Lars G. Svendsen Tripeptide derivatives
US4434096A (en) * 1981-06-30 1984-02-28 E. I. Du Pont De Nemours And Company Substrates for the quantitative determination of proteolytic enzymes
US4448717A (en) * 1982-11-12 1984-05-15 Eli Lilly And Company Pharmacologically active peptides
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU544492B2 (en) * 1981-01-13 1985-05-30 Gyogyszerkutato Intezet Kft D-phenylalanyl-l-prolyl-l-arginine aldehyde sulfate
AU3039384A (en) * 1983-07-12 1985-01-17 F. Hoffmann-La Roche Ag Peptides amides and aldehydes

Also Published As

Publication number Publication date
DK596385D0 (da) 1985-12-20
EP0185390B1 (de) 1991-10-02
AU5155385A (en) 1986-06-26
DE3584281D1 (de) 1991-11-07
AR241710A1 (es) 1992-11-30
DK596385A (da) 1986-06-22
DK171403B1 (da) 1996-10-14
CN85109736A (zh) 1987-03-18
PT81746B (pt) 1987-11-11
EP0185390A2 (de) 1986-06-25
HUT38954A (en) 1986-07-28
FI855118A0 (fi) 1985-12-20
JPH0680078B2 (ja) 1994-10-12
FI855118L (fi) 1986-06-22
FI85980C (fi) 1992-06-25
GR853121B (en, 2012) 1986-04-22
ES550296A0 (es) 1987-10-01
PT81746A (en) 1986-01-01
US4703036A (en) 1987-10-27
ZA859756B (en) 1986-09-24
IL77416A (en) 1990-04-29
HU192646B (en) 1987-06-29
CA1261547A (en) 1989-09-26
FI85980B (fi) 1992-03-13
ES8708237A1 (es) 1987-10-01
ATE68002T1 (de) 1991-10-15
JPS61152699A (ja) 1986-07-11
SU1384203A3 (ru) 1988-03-23
CN1025738C (zh) 1994-08-24
EP0185390A3 (en) 1988-09-07

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired