AU547586B2 - Carbostyril compounds,composition containing same,and processfor their preparation - Google Patents

Carbostyril compounds,composition containing same,and processfor their preparation

Info

Publication number
AU547586B2
AU547586B2 AU78085/81A AU7808581A AU547586B2 AU 547586 B2 AU547586 B2 AU 547586B2 AU 78085/81 A AU78085/81 A AU 78085/81A AU 7808581 A AU7808581 A AU 7808581A AU 547586 B2 AU547586 B2 AU 547586B2
Authority
AU
Australia
Prior art keywords
processfor
preparation
composition containing
containing same
carbostyril compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU78085/81A
Other languages
English (en)
Other versions
AU7808581A (en
Inventor
Kazuyuki Nakagawa
Hidenori Ogawa
Michiaki Tominaga
Yung-Hsiung Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP55159016A external-priority patent/JPS5782390A/ja
Priority claimed from JP55179950A external-priority patent/JPS57102888A/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of AU7808581A publication Critical patent/AU7808581A/en
Application granted granted Critical
Publication of AU547586B2 publication Critical patent/AU547586B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/227Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/24Oxygen atoms attached in position 8
    • C07D215/26Alcohols; Ethers thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/24Oxygen atoms attached in position 8
    • C07D215/26Alcohols; Ethers thereof
    • C07D215/28Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/24Oxygen atoms attached in position 8
    • C07D215/26Alcohols; Ethers thereof
    • C07D215/32Esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU78085/81A 1980-11-11 1981-11-11 Carbostyril compounds,composition containing same,and processfor their preparation Ceased AU547586B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP55159016A JPS5782390A (en) 1980-11-11 1980-11-11 Carbostyril derivative
JP55-159016 1980-11-11
JP55-179950 1980-12-18
JP55179950A JPS57102888A (en) 1980-12-18 1980-12-18 Carbostyril derivative

Publications (2)

Publication Number Publication Date
AU7808581A AU7808581A (en) 1982-06-07
AU547586B2 true AU547586B2 (en) 1985-10-24

Family

ID=26485945

Family Applications (1)

Application Number Title Priority Date Filing Date
AU78085/81A Ceased AU547586B2 (en) 1980-11-11 1981-11-11 Carbostyril compounds,composition containing same,and processfor their preparation

Country Status (19)

Country Link
US (1) US4414390A (no)
EP (1) EP0052016B1 (no)
KR (1) KR880001657B1 (no)
AT (1) AT382376B (no)
AU (1) AU547586B2 (no)
CA (1) CA1164459A (no)
CH (1) CH653684A5 (no)
DE (1) DE3152512T1 (no)
DK (1) DK157193C (no)
ES (1) ES507545A0 (no)
FI (1) FI71145C (no)
IT (1) IT8149680A0 (no)
MX (1) MX6802E (no)
NO (1) NO157819C (no)
PH (1) PH17158A (no)
PT (1) PT73959B (no)
SE (1) SE440653B (no)
SU (1) SU1215621A3 (no)
WO (1) WO1982001706A1 (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537889A (en) * 1982-12-27 1985-08-27 Eli Lilly And Company Inotropic agents
US4636502A (en) * 1982-12-27 1987-01-13 Eli Lilly And Company Methods of producing a positive inotropic effect or vasodilation by administration of 2-phenyl imidazo pyrimidines and pyrazines
GB8305245D0 (en) * 1983-02-25 1983-03-30 Fujisawa Pharmaceutical Co Imidazo-heterocyclic compounds
US4533734A (en) * 1983-11-10 1985-08-06 Eli Lilly And Company Inotropic agents
PT79699B (en) * 1983-12-22 1986-12-10 Pfizer Process for preparing quinolone inotropic agents
NZ212209A (en) * 1984-05-29 1988-08-30 Pfizer Quinolone derivatives and pharmaceutical compositions
US4721721A (en) * 1984-12-18 1988-01-26 Rorer Pharmaceutical Corporation 6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses
FR2580646A1 (fr) * 1985-04-19 1986-10-24 Synthelabo Derives de 2(1h)-quinolinone, leur preparation et leur application en therapeutique
US4666913A (en) * 1985-11-22 1987-05-19 William H. Rorer, Inc. Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses
GB8529362D0 (en) * 1985-11-28 1986-01-02 Pfizer Ltd Quinolone cardiac stimulants
GB8619902D0 (en) * 1986-08-15 1986-09-24 Pfizer Ltd Quinolone cardiac stimulants
GB8709448D0 (en) * 1987-04-21 1987-05-28 Pfizer Ltd Heterobicyclic quinoline derivatives
WO1995035296A1 (en) * 1994-06-20 1995-12-28 Takeda Chemical Industries, Ltd. Condensed imidazole compounds, their production and use
DE10117184A1 (de) * 2001-04-05 2002-10-17 Gruenenthal Gmbh Substituierte Imidazol[1,2-a]-pyridin-3-yl-amid- und -aminverbindungen
DE10247271A1 (de) * 2002-10-10 2004-08-26 Grünenthal GmbH Substituierte C-Imidazo[1,2-a]pyridin-3-yle
TWI324151B (en) * 2003-04-02 2010-05-01 Novartis Ag Process for the preparation of 5-(haloacetyl)-8-substituted oxy-(1h)-quinolin-2-ones
DE102005019181A1 (de) * 2005-04-25 2006-10-26 Novartis Ag Peptid-Deformylase (PDF) Inhibitoren 1
EP2334675B1 (en) * 2008-09-16 2014-03-26 Csir Imidazopyridines and imidazopyrimidines as hiv-i reverse transcriptase inhibitors
ES2362894B1 (es) * 2009-11-16 2012-05-21 Ferrer Internacional S.A. Procedimiento de preparación del �?cido 4-nitro-oxi-metil-benzoico.
BR112017021408B1 (pt) 2015-04-08 2022-05-17 Bayer Cropscience Aktiengesellschaft Derivados de heterociclo bicíclico condensado, método para controlar pragas animais, e formulação agroquímica
CN108137514A (zh) 2015-07-30 2018-06-08 百时美施贵宝公司 芳基取代的二环杂芳基化合物
KR102460385B1 (ko) * 2016-07-14 2022-10-27 브리스톨-마이어스 스큅 컴퍼니 비시클릭 헤테로아릴 치환된 화합물
WO2018013776A1 (en) 2016-07-14 2018-01-18 Bristol-Myers Squibb Company Tricyclic heteroaryl-substituted quinoline and azaquinoline compounds as par4 inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1473819A (en) * 1976-01-28 1977-05-18 Gallardo Antonio Sa Derivatives of imidazo 1,2-a pyridine
ES8100016A1 (es) * 1978-07-18 1980-04-01 Hoechst Ag Procedimiento para la preparacion de nuevos derivados de 1-(4-aminopiperidino)-3,4-dihidroisoquinoleina.
ES8100015A1 (es) * 1978-07-18 1980-04-01 Hoechst Ag Procedimiento para la preparacion de nuevos derivados de 2-(4-aminopiperidino)-3,4-dihidroquinoleina.
JPS5553284A (en) * 1978-10-12 1980-04-18 Yoshitomi Pharmaceut Ind Ltd Pyridazinone derivative
GB2031404A (en) * 1978-10-17 1980-04-23 Yoshitomi Pharmaceutical Pyridazinone compounds

Also Published As

Publication number Publication date
ES8301967A1 (es) 1983-02-01
SE8204237D0 (sv) 1982-07-08
IT8149680A0 (it) 1981-11-11
FI71145B (fi) 1986-08-14
NO157819B (no) 1988-02-15
SE440653B (sv) 1985-08-12
DK307482A (da) 1982-07-08
DK157193C (da) 1990-04-09
DK157193B (da) 1989-11-20
CH653684A5 (fr) 1986-01-15
KR880001657B1 (ko) 1988-09-05
FI822471A0 (fi) 1982-07-12
NO157819C (no) 1988-05-25
KR830007644A (ko) 1983-11-04
FI822471L (fi) 1982-07-12
AU7808581A (en) 1982-06-07
EP0052016A1 (en) 1982-05-19
ATA908381A (de) 1986-07-15
FI71145C (fi) 1986-11-24
PT73959A (en) 1981-12-01
CA1164459A (en) 1984-03-27
DE3152512C2 (no) 1991-01-03
DE3152512T1 (de) 1982-11-18
PH17158A (en) 1984-06-13
PT73959B (en) 1983-04-18
EP0052016B1 (en) 1984-09-05
US4414390A (en) 1983-11-08
MX6802E (es) 1986-07-29
NO822391L (no) 1982-07-09
SE8204237L (sv) 1982-07-08
ES507545A0 (es) 1983-02-01
SU1215621A3 (ru) 1986-02-28
AT382376B (de) 1987-02-25
WO1982001706A1 (en) 1982-05-27

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