AU518569B2 - 4-benzyl- and 4-benzoyl imidazole derivatives - Google Patents
4-benzyl- and 4-benzoyl imidazole derivativesInfo
- Publication number
- AU518569B2 AU518569B2 AU61071/80A AU6107180A AU518569B2 AU 518569 B2 AU518569 B2 AU 518569B2 AU 61071/80 A AU61071/80 A AU 61071/80A AU 6107180 A AU6107180 A AU 6107180A AU 518569 B2 AU518569 B2 AU 518569B2
- Authority
- AU
- Australia
- Prior art keywords
- hydrogen
- carbon atoms
- compounds
- hydroxy
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- DECHVIXTYBTMBL-UHFFFAOYSA-N 1h-imidazol-5-yl(phenyl)methanone Chemical class C=1C=CC=CC=1C(=O)C1=CN=CN1 DECHVIXTYBTMBL-UHFFFAOYSA-N 0.000 title 1
- HREUGOAZLRNTEM-UHFFFAOYSA-N 5-benzyl-1h-imidazole Chemical group C=1C=CC=CC=1CC1=CN=CN1 HREUGOAZLRNTEM-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 chloro, bromo, fluoro, methyl Chemical group 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000000767 anti-ulcer Effects 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 239000003699 antiulcer agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/48—Preparation of compounds having groups
- C07C41/50—Preparation of compounds having groups by reactions producing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/313—Compounds having groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
- C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
- C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/258—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6457579A | 1979-08-07 | 1979-08-07 | |
| US064575 | 1979-08-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU6107180A AU6107180A (en) | 1981-02-12 |
| AU518569B2 true AU518569B2 (en) | 1981-10-08 |
Family
ID=22056899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU61071/80A Expired AU518569B2 (en) | 1979-08-07 | 1980-03-05 | 4-benzyl- and 4-benzoyl imidazole derivatives |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4443466A (enExample) |
| EP (1) | EP0024829B1 (enExample) |
| JP (1) | JPS5632463A (enExample) |
| AT (1) | ATE7226T1 (enExample) |
| AU (1) | AU518569B2 (enExample) |
| BG (1) | BG60426B2 (enExample) |
| CA (1) | CA1154780A (enExample) |
| DD (1) | DD152548A1 (enExample) |
| DE (1) | DE3067618D1 (enExample) |
| DK (2) | DK155794C (enExample) |
| FI (1) | FI70709C (enExample) |
| HK (1) | HK68587A (enExample) |
| HU (1) | HU184809B (enExample) |
| IE (1) | IE50080B1 (enExample) |
| IL (1) | IL60723A (enExample) |
| NO (1) | NO153220C (enExample) |
| NZ (1) | NZ194536A (enExample) |
| SG (1) | SG34987G (enExample) |
| SU (2) | SU997607A3 (enExample) |
| UA (1) | UA5559A1 (enExample) |
| ZA (1) | ZA804787B (enExample) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2069481B (en) * | 1980-02-13 | 1983-07-27 | Farmos Oy | Substituted imidazole derivatives |
| US4374843A (en) * | 1980-10-14 | 1983-02-22 | Pfizer Inc. | 2-Guanidino-4-heteroarylthiazoles |
| GB2092569B (en) * | 1981-02-05 | 1984-09-19 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
| GB2101114B (en) * | 1981-07-10 | 1985-05-22 | Farmos Group Ltd | Substituted imidazole derivatives and their preparation and use |
| GB2110663B (en) * | 1981-12-04 | 1985-08-07 | Farmos Group Ltd | Imidazole derivatives |
| FI833794A0 (fi) * | 1983-10-18 | 1983-10-18 | Farmos Oy | Substituerade 2-merkapto-imidazoler |
| JPH0658947B2 (ja) * | 1984-02-24 | 1994-08-03 | 株式会社日立製作所 | 半導体メモリ装置の製法 |
| DE3539629A1 (de) * | 1985-11-08 | 1987-05-14 | Basf Ag | Dialkoxyketone und ein verfahren zu ihrer herstellung |
| GB8626287D0 (en) * | 1986-11-04 | 1986-12-03 | Ucb Sa | Substituted 1h-imidazoles |
| JPS63150266A (ja) * | 1986-12-12 | 1988-06-22 | Mitsui Petrochem Ind Ltd | ベンジルイミダゾ−ル誘導体 |
| GB2206880B (en) * | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
| GB8810067D0 (en) * | 1988-04-28 | 1988-06-02 | Ucb Sa | Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides |
| US5255225A (en) * | 1989-04-05 | 1993-10-19 | Hitachi, Ltd. | Semiconductor integrated circuit device and memory consisting of semiconductor integrated circuit |
| US5073566A (en) * | 1989-11-30 | 1991-12-17 | Eli Lilly And Company | Angiotensin ii antagonist 1,3-imidazoles and use thereas |
| US5086064A (en) * | 1990-03-27 | 1992-02-04 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxyphenyl thiazolyl, oxazolyl, and imidazolyl methanones and related compounds as antiinflammatory agents |
| GB2256135B (en) | 1991-05-31 | 1995-01-18 | Orion Yhtymae Oy | Transdermal administration of 4-substituted imidazoles |
| US5401851A (en) * | 1992-06-03 | 1995-03-28 | Eli Lilly And Company | Angiotensin II antagonists |
| ES2076085B1 (es) * | 1993-06-15 | 1997-03-01 | Lilly Co Eli | Antagonistas de angiotensina ii. |
| DE69432263T2 (de) * | 1993-11-15 | 2003-12-04 | Schering Corp., Kenilworth | Phenylalkyl-imidazole als h3-rezeptor-antagonisten |
| US5922751A (en) * | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
| KR100385095B1 (ko) * | 1997-07-15 | 2003-08-19 | 주식회사 엘지생명과학 | 파네실전이효소저해효능을갖는2환또는3환방향족화합물 |
| US6329369B1 (en) | 1997-12-04 | 2001-12-11 | Allergan Sales, Inc. | Methods of treating pain and other conditions |
| US6841684B2 (en) | 1997-12-04 | 2005-01-11 | Allergan, Inc. | Imidiazoles having reduced side effects |
| US6503935B1 (en) | 1998-08-07 | 2003-01-07 | Abbott Laboratories | Imidazoles and related compounds as α1A agonists |
| WO2000069823A1 (en) * | 1999-05-12 | 2000-11-23 | Neurosearch A/S | Ion channel modulating agents |
| TWI283669B (en) * | 1999-06-10 | 2007-07-11 | Allergan Inc | Compounds and method of treatment having agonist-like activity selective at alpha 2B or 2B/2C adrenergic receptors |
| JP2002262119A (ja) * | 2001-02-28 | 2002-09-13 | Sharp Corp | 画像処理装置、画像処理方法、画像処理プログラムを記録した機械読取可能な記録媒体および画像処理プログラム |
| FR2825926A1 (fr) * | 2001-06-14 | 2002-12-20 | Sod Conseils Rech Applic | Derives d'imidazoles modulant les canaux sodiques |
| MX2007015917A (es) * | 2005-06-22 | 2008-03-10 | Chemocentryx Inc | Compuestos de azaindazol y metodos de uso. |
| US7777035B2 (en) * | 2005-06-22 | 2010-08-17 | Chemocentryx, Inc. | Azaindazole compounds and methods of use |
| CN101374832B (zh) | 2006-01-27 | 2013-03-06 | 弗·哈夫曼-拉罗切有限公司 | 4-咪唑衍生物用于cns病症的用途 |
| US20090252779A1 (en) * | 2006-06-22 | 2009-10-08 | Chemocentryx, Inc. | Azaindazole compounds and methods of use |
| CA2666762C (en) | 2006-10-19 | 2014-12-30 | F. Hoffmann-La Roche Ag | Aminomethyl-4-imidazoles |
| EP2086959B1 (en) | 2006-11-02 | 2011-11-16 | F. Hoffmann-La Roche AG | Substituted 2-imidazoles as modulators of the trace amine associated receptors |
| MX2009005047A (es) | 2006-11-16 | 2009-05-25 | Hoffmann La Roche | 4-imidazoles sustituidos. |
| MX2009005920A (es) | 2006-12-13 | 2009-06-16 | Hoffmann La Roche | Nuevos 2-imidazoles como ligandos para receptores asociados con trazas de amina. |
| US20080146523A1 (en) | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
| US8013169B2 (en) | 2007-01-12 | 2011-09-06 | Allergan, Inc | Naphthylmethylimidizoles as therapeutic agents |
| WO2008088937A1 (en) * | 2007-01-12 | 2008-07-24 | Allergan, Inc. | Quinolynylmethylimidizoles as therapeutic agents |
| WO2008088936A1 (en) * | 2007-01-12 | 2008-07-24 | Allergan, Inc. | Quinolynylmethylimidizoles as therapeutic agents |
| MX2009008255A (es) | 2007-02-02 | 2009-08-12 | Hoffmann La Roche | Nuevas 2-aminooxazolinas como ligandos taar1. |
| KR101222412B1 (ko) | 2007-02-15 | 2013-01-15 | 에프. 호프만-라 로슈 아게 | Ｔａａｒ1 리간드로서의 2-아미노옥사졸린 |
| EA015529B1 (ru) | 2007-05-22 | 2011-08-30 | Кемосентрикс, Инк. | 3-(имидазолил)пиразоло[3,4-b]пиридины |
| CN101687812A (zh) | 2007-07-02 | 2010-03-31 | 弗·哈夫曼-拉罗切有限公司 | 对痕量胺相关受体(taar)具有良好亲和性的2-咪唑啉化合物 |
| WO2009003867A1 (en) | 2007-07-03 | 2009-01-08 | F. Hoffmann-La Roche Ag | 4-imidazolines and their use as antidepressants |
| WO2009016048A1 (en) | 2007-07-27 | 2009-02-05 | F. Hoffmann-La Roche Ag | 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands |
| BRPI0814758A2 (pt) | 2007-08-03 | 2015-03-03 | Hoffmann La Roche | Piridinacarboxamida e derivados de benzamida como ligantes taar1 |
| CA2724293A1 (en) * | 2008-05-13 | 2009-11-19 | Allergan, Inc. | Quinolynylmethylimidizoles as therapeutic agents |
| US8258167B2 (en) * | 2008-05-13 | 2012-09-04 | Allergan, Inc | Naphthylmethylimidizoles as therapeutic agents |
| US8242153B2 (en) | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
| DK2323663T3 (en) | 2008-09-11 | 2015-06-01 | Chemocentryx Inc | 4-amino-3- (imidazolyl) pyrazolo [3,4-d] pyrimidines |
| CN101747280B (zh) * | 2008-11-28 | 2011-11-09 | 上海迪赛诺医药发展有限公司 | 制备地托咪定及其中间体的方法 |
| US8354441B2 (en) | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
| US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| CN101941944A (zh) * | 2010-09-07 | 2011-01-12 | 江阴希迪医药科技有限公司 | 兽药麻醉剂盐酸地托咪啶盐的合成方法 |
| RU2448095C1 (ru) * | 2010-12-09 | 2012-04-20 | Олег Геннадьевич Еремин | Способ получения детомидина или его нетоксичных фармацевтически приемлемых солей |
| RU2448094C1 (ru) * | 2010-12-09 | 2012-04-20 | Олег Геннадьевич Еремин | Улучшенный способ получения медетомидина или его нетоксичных фармацевтически приемлемых солей |
| MX2014008856A (es) * | 2012-02-13 | 2014-12-15 | Hoffmann La Roche | Derivados de imidazolilcetona como inhibidores de aldosterona sintasa. |
| RU2478622C1 (ru) * | 2012-02-16 | 2013-04-10 | Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) | (1-гидрокси-4,5-диметил-1н-имидазол-2-ил)(фенил)метаноноксим, проявляющий антиаритмические свойства |
| CN107922399A (zh) * | 2015-07-16 | 2018-04-17 | 内布拉斯加大学董事委员会 | 吡咯霉素及其使用方法 |
| HK1257353A1 (en) * | 2015-12-25 | 2019-10-18 | Otsuka Pharmaceutical Factory, Inc. | Phenylimidazole compound |
| JP6814814B2 (ja) | 2016-03-17 | 2021-01-20 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｔａａｒのアゴニストとしての活性を有する５−エチル−４−メチル−ピラゾール−３−カルボキサミド誘導体 |
| CN107814771A (zh) * | 2017-11-14 | 2018-03-20 | 安徽诺全药业有限公司 | 一种盐酸地托咪定的制备方法 |
| US20210323929A1 (en) * | 2018-07-18 | 2021-10-21 | Clexio Biosciences Ltd. | Purified Detomidine, Process of Preparing and Methods of Use |
| EP4688717A1 (en) * | 2023-03-30 | 2026-02-11 | Bayer Aktiengesellschaft | Palladium-catalyzed chemoselective mono-alpha-arylation of o-protected hydroxyacetone |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE553516A (enExample) * | 1955-12-19 | |||
| US2946804A (en) * | 1958-12-29 | 1960-07-26 | Abbott Lab | (5-methyl-4-imidazolyl)-diphenyl carbinol salts and lower alkyl quaternaries |
| US3177223A (en) * | 1961-12-22 | 1965-04-06 | Air Prod & Chem | Preparation of substituted imidazoles |
| SE7608611L (sv) * | 1975-07-31 | 1977-02-01 | Wellcome Found | Sett att framstella en oralt intagbar farmaceutisk komposition |
-
1980
- 1980-03-05 AU AU61071/80A patent/AU518569B2/en not_active Expired
- 1980-08-01 AT AT80302637T patent/ATE7226T1/de not_active IP Right Cessation
- 1980-08-01 EP EP80302637A patent/EP0024829B1/en not_active Expired
- 1980-08-01 IL IL60723A patent/IL60723A/xx unknown
- 1980-08-01 DE DE8080302637T patent/DE3067618D1/de not_active Expired
- 1980-08-01 NZ NZ194536A patent/NZ194536A/xx unknown
- 1980-08-01 FI FI802404A patent/FI70709C/fi not_active IP Right Cessation
- 1980-08-05 IE IE1626/80A patent/IE50080B1/en not_active IP Right Cessation
- 1980-08-06 SU SU802959548A patent/SU997607A3/ru active
- 1980-08-06 UA UA2959548A patent/UA5559A1/uk unknown
- 1980-08-06 CA CA000357663A patent/CA1154780A/en not_active Expired
- 1980-08-06 HU HU801955A patent/HU184809B/hu unknown
- 1980-08-06 NO NO802352A patent/NO153220C/no unknown
- 1980-08-06 DK DK338580A patent/DK155794C/da not_active IP Right Cessation
- 1980-08-06 ZA ZA00804787A patent/ZA804787B/xx unknown
- 1980-08-06 JP JP10878680A patent/JPS5632463A/ja active Granted
- 1980-08-07 DD DD80223182A patent/DD152548A1/de not_active IP Right Cessation
-
1981
- 1981-03-10 US US06/242,234 patent/US4443466A/en not_active Expired - Lifetime
- 1981-05-28 SU SU813289249A patent/SU1014472A3/ru active
-
1986
- 1986-12-29 DK DK630586A patent/DK157491C/da active
-
1987
- 1987-04-14 SG SG34987A patent/SG34987G/en unknown
- 1987-09-24 HK HK685/87A patent/HK68587A/en not_active IP Right Cessation
-
1994
- 1994-01-18 BG BG098381A patent/BG60426B2/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL60723A (en) | 1985-02-28 |
| CA1154780A (en) | 1983-10-04 |
| US4443466A (en) | 1984-04-17 |
| IE50080B1 (en) | 1986-02-05 |
| JPS5632463A (en) | 1981-04-01 |
| SG34987G (en) | 1988-03-04 |
| AU6107180A (en) | 1981-02-12 |
| HU184809B (en) | 1984-10-29 |
| FI70709B (fi) | 1986-06-26 |
| NO153220B (no) | 1985-10-28 |
| ZA804787B (en) | 1981-07-29 |
| DD152548A1 (de) | 1981-12-02 |
| DK338580A (da) | 1981-02-08 |
| DK630586D0 (da) | 1986-12-29 |
| DK630586A (da) | 1986-12-29 |
| SU1014472A3 (ru) | 1983-04-23 |
| UA5559A1 (uk) | 1994-12-28 |
| JPS624387B2 (enExample) | 1987-01-30 |
| DK155794B (da) | 1989-05-16 |
| IE801626L (en) | 1981-02-07 |
| NZ194536A (en) | 1983-06-17 |
| DK157491C (da) | 1990-06-25 |
| EP0024829A1 (en) | 1981-03-11 |
| NO153220C (no) | 1986-02-05 |
| FI802404A7 (fi) | 1981-02-08 |
| EP0024829B1 (en) | 1984-04-25 |
| HK68587A (en) | 1987-10-02 |
| FI70709C (fi) | 1986-10-06 |
| DK157491B (da) | 1990-01-15 |
| DE3067618D1 (en) | 1984-05-30 |
| SU997607A3 (ru) | 1983-02-15 |
| ATE7226T1 (de) | 1984-05-15 |
| BG60426B2 (bg) | 1995-03-31 |
| DK155794C (da) | 1989-11-06 |
| NO802352L (no) | 1981-02-09 |
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| NO158017C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazolderivater. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |