AU2019257749B2 - Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy - Google Patents

Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy

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Publication number
AU2019257749B2
AU2019257749B2 AU2019257749A AU2019257749A AU2019257749B2 AU 2019257749 B2 AU2019257749 B2 AU 2019257749B2 AU 2019257749 A AU2019257749 A AU 2019257749A AU 2019257749 A AU2019257749 A AU 2019257749A AU 2019257749 B2 AU2019257749 B2 AU 2019257749B2
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tils
population
day
expansion
gene
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AU2019257749A1 (en
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Cecile Chartier-Courtaud
Krit RITTHIPICHAI
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Iovance Biotherapeutics Inc
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Iovance Biotherapeutics Inc
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
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    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N2501/20—Cytokines; Chemokines
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AU2019257749A 2018-04-27 2019-04-26 Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy Active AU2019257749B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862663885P 2018-04-27 2018-04-27
US62/663,885 2018-04-27
US201862680821P 2018-06-05 2018-06-05
US62/680,821 2018-06-05
PCT/US2019/029286 WO2019210131A1 (en) 2018-04-27 2019-04-26 Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy

Publications (2)

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AU2019257749A1 AU2019257749A1 (en) 2020-10-22
AU2019257749B2 true AU2019257749B2 (en) 2026-02-12

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US (6) US20210130779A1 (enExample)
EP (1) EP3784254A1 (enExample)
JP (1) JP2021521846A (enExample)
KR (1) KR20210005138A (enExample)
CN (1) CN112368003A (enExample)
AU (1) AU2019257749B2 (enExample)
BR (1) BR112020021660A2 (enExample)
CA (1) CA3098303A1 (enExample)
IL (1) IL278231A (enExample)
MA (1) MA52533A (enExample)
MX (1) MX2020011134A (enExample)
SG (1) SG11202010319RA (enExample)
TW (2) TWI911643B (enExample)
WO (1) WO2019210131A1 (enExample)

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