AU2018348241B2 - Solid forms of a compound for modulating kinases - Google Patents

Solid forms of a compound for modulating kinases Download PDF

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Publication number
AU2018348241B2
AU2018348241B2 AU2018348241A AU2018348241A AU2018348241B2 AU 2018348241 B2 AU2018348241 B2 AU 2018348241B2 AU 2018348241 A AU2018348241 A AU 2018348241A AU 2018348241 A AU2018348241 A AU 2018348241A AU 2018348241 B2 AU2018348241 B2 AU 2018348241B2
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Australia
Prior art keywords
compound
free acid
disease
subject
inhibitor
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AU2018348241A
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English (en)
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AU2018348241A1 (en
Inventor
Prabha N. Ibrahim
Marika Nespi
Rashmin PATEL
Ben Powell
Hamid REZAEI
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Opna Bio SA
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Opna Bio SA
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Publication of AU2018348241A1 publication Critical patent/AU2018348241A1/en
Assigned to Opna Immuno-Oncology, SA reassignment Opna Immuno-Oncology, SA Request for Assignment Assignors: PLEXXIKON INC.
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Publication of AU2018348241B2 publication Critical patent/AU2018348241B2/en
Assigned to Opna Bio SA reassignment Opna Bio SA Amend patent request/document other than specification (104) Assignors: Opna Immuno-Oncology, SA
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Control Of Indicators Other Than Cathode Ray Tubes (AREA)
  • Quinoline Compounds (AREA)
AU2018348241A 2017-10-13 2018-10-11 Solid forms of a compound for modulating kinases Active AU2018348241B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762572099P 2017-10-13 2017-10-13
US62/572,099 2017-10-13
PCT/US2018/055473 WO2019075243A1 (en) 2017-10-13 2018-10-11 SOLID FORMS OF A COMPOUND FOR MODULATING KINASES

Publications (2)

Publication Number Publication Date
AU2018348241A1 AU2018348241A1 (en) 2020-04-02
AU2018348241B2 true AU2018348241B2 (en) 2023-01-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018348241A Active AU2018348241B2 (en) 2017-10-13 2018-10-11 Solid forms of a compound for modulating kinases

Country Status (7)

Country Link
US (3) US10717735B2 (https=)
EP (1) EP3694855A1 (https=)
JP (1) JP7675519B2 (https=)
CN (1) CN111194318B (https=)
AU (1) AU2018348241B2 (https=)
TW (1) TW201922742A (https=)
WO (1) WO2019075243A1 (https=)

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US12509444B2 (en) 2019-12-06 2025-12-30 Plexxikon Inc. Compounds and methods for CD73 modulation and indications therefor
KR102267519B1 (ko) * 2020-01-08 2021-06-21 경희대학교 산학협력단 뇌암세포 표적용 펩타이드로 표면 개질된 약물 전달용 나노입자, 이의 제조방법 및 이의 용도
US11807626B2 (en) 2020-04-23 2023-11-07 Opna Bio SA Compounds and methods for CD73 modulation and indications therefor
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WO2022125869A1 (en) * 2020-12-11 2022-06-16 Board Of Regents, The University Of Texas System Compositions and methods of making cocrystals using dielectric heating with dispersive and distributive mixing
CN113456626B (zh) * 2021-08-16 2022-05-06 吉林大学 一种黄嘌呤氧化酶抑制剂及其筛选方法和应用
CN116473968B (zh) * 2022-01-24 2026-04-07 华中科技大学 Ezh2特异性抑制剂在治疗哮喘的用途
CN114984011A (zh) * 2022-07-11 2022-09-02 中南大学湘雅二医院 吡咯并吡啶类化合物在制备治疗狼疮药物中的应用
JP2025542349A (ja) * 2022-12-20 2025-12-25 コンステレーション・ファーマシューティカルズ・インコーポレイテッド 比較的低リスクの骨髄異形成症候群を治療する方法
CN120457109A (zh) 2022-12-30 2025-08-08 阿维森纳生物科学公司 氮杂吲哚rock抑制剂
KR20250044972A (ko) * 2023-09-25 2025-04-01 주식회사 마스터메디텍 이델라리십 함유 경구투여용 고형제제 및 그 제조방법
CN119219631B (zh) * 2024-12-04 2025-04-18 山东大学 一种bet蛋白溴结构域bd1选择性共价抑制剂及其制备方法与应用

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